J. Jemielity

发表

Magnetic-nanoparticle-decorated polypyrrole microvessels: toward encapsulation of mRNA cap analogues.

Daria Kępińska, J. Stolarski, Katarzyna Wiktorska, 2013, Biomacromolecules.

Synthesis of Novel mRNA 5′ Cap‐Analogues: Dinucleoside P1, P3‐Tri‐, P1, P4‐Tetra‐, and P1, P5‐Pentaphosphates

R. Rhoads, J. Stȩpiński, E. Darżynkiewicz, 2004 .

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

Ö. Türeci, U. Şahin, M. Diken, 2010, Gene Therapy.

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding.

K. Ginalski, E. Darżynkiewicz, J. Kowalska, 2015, Biochemical and biophysical research communications.

Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation.

J. Kowalska, J. Jemielity, Natalia Baran, 2020, Bioorganic & medicinal chemistry.

Enzymatic Assays to Explore Viral mRNA Capping Machinery

J. Jemielity, R. Kasprzyk, 2021, Chembiochem : a European journal of chemical biology.

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

A. Lamond, V. Cowling, E. Darżynkiewicz, 2021, Nucleic acids research.

ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions.

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2018, Chemical communications.

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

E. Nowak, J. Gross, J. Kowalska, 2021, ACS chemical biology.

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma.

J. Dufour, J. Kowalska, J. Jemielity, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding

A. Milac, E. Darżynkiewicz, J. Kowalska, 2013, The FEBS journal.

Dual activity of certain HIT‐proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5′‐phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP)

J. Kowalska, J. Jemielity, A. Guranowski, 2010, FEBS letters.

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

U. Şahin, E. Darżynkiewicz, J. Kowalska, 2016, Nucleic acids research.

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues

J. Kowalska, J. Jemielity, Dominika Strzelecka, 2017, Scientific Reports.

Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells.

J. Kowalska, J. Jemielity, A. Guranowski, 2019, Plant physiology and biochemistry : PPB.

Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9

J. Gross, J. Kowalska, J. Jemielity, 2022, ACS chemical biology.

Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA.

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2017, Bioconjugate chemistry.

Introducing SuFNucs: Sulfamoyl-Fluoride-Functionalized Nucleosides That Undergo Sulfur Fluoride Exchange Reaction

J. Kowalska, J. Jemielity, M. Chrominski, 2022, Organic letters.

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

J. Neyts, J. Kowalska, J. Jemielity, 2021, Antiviral Research.

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells.

R. Rhoads, E. Darżynkiewicz, J. Kowalska, 2007, RNA.

Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2021, Scientific Reports.

Interaction Between Yeast Eukaryotic Initiation Factor eIF4E and mRNA 5′ Cap Analogues Differs from That for Murine eIF4E

A. Niedzwiecka, J. Stȩpiński, E. Darżynkiewicz, 2003, Nucleosides, nucleotides & nucleic acids.

Influence of the Length of the Phosphate Chain in mRNA 5′ Cap Analogues on Their Interaction with Eukaryotic Initiation Factor 4E

A. Niedzwiecka, J. Stȩpiński, A. Wysłouch-Cieszyńska, 2003, Nucleosides, nucleotides & nucleic acids.

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks

J. Kowalska, J. Jemielity, Marcin Warmiński, 2022, The Journal of organic chemistry.

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

Z. Darżynkiewicz, J. Trylska, E. Darżynkiewicz, 2019, RNA.

Phosphodiester modifications in mRNA poly(A) tail prevent deadenylation without compromising protein expression

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2020, RNA.

Functional and LC-MS/MS analysis of in vitro transcribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2020, bioRxiv.

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety--fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis.

Z. Darżynkiewicz, M. Kulis, E. Darżynkiewicz, 2012, Bioorganic & medicinal chemistry.

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5',5' bridge containing methylenebis(phosphonate) modification.

Z. Darżynkiewicz, E. Darżynkiewicz, J. Kowalska, 2009, Organic & biomolecular chemistry.

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation.

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2009, Bioorganic & medicinal chemistry letters.

The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro.

L. Beeren, T. Preiss, R. Rhoads, 2005, RNA.

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2017, Topics in Current Chemistry.

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

C. I. Smith, R. Strömberg, E. Darżynkiewicz, 2016 .

Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5',5'-triphosphate bridge.

A. Niedzwiecka, E. Darżynkiewicz, J. Kowalska, 2014, Organic & biomolecular chemistry.

Vaccinations against COVID-19 . Innovative technologies and efficiency.

J. Jemielity, R. Flisiak, A. Fal, 2021 .

Synthesis of RNA 5'-Azides from 2'-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide-Alkyne Cycloaddition Reactions.

J. Kowalska, J. Jemielity, Marcin Warmiński, 2017, Organic letters.

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

J. Kowalska, J. Jemielity, J. Basquin, 2022, Pharmaceuticals.

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring.

Z. Wieczorek, R. Stolarski, J. Kowalska, 2016, Organic & biomolecular chemistry.

Synthesis of tritium labeled [3R‐3H]‐, and [3S‐3H]‐L‐phenylalanine

J. Jemielity, M. Kańska, R. Kański, 2001 .

Enzymatic Synthesis of [1-13C]- and [1-14C]-L-Phenyl-Alanine

J. Jemielity, M. Kańska, R. Kański, 1998 .

Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications

K. Kwapiszewska, J. Kowalska, J. Jemielity, 2021, Chemical science.

Synthesis of Novel mRNA 5′ Cap-Analogues: Dinucleoside P1, P3-Tri-, P1, P4-Tetra-, and P1, P5-Pentaphosphates

R. Rhoads, J. Stȩpiński, E. Darżynkiewicz, 2003, Nucleosides, nucleotides & nucleic acids.

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.

R. Rhoads, E. Darżynkiewicz, J. Kowalska, 2010, New journal of chemistry = Nouveau journal de chimie.

Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability.

R. Rhoads, J. Stȩpiński, E. Darżynkiewicz, 2007, Methods in enzymology.

SYNTHESIS AND PROPERTIES OF mRNA CAP ANALOGS CONTAINING PHOSPHOROTHIOATE MOIETY IN 5′,5′-TRIPHOSPHATE CHAIN

J. Stȩpiński, E. Darżynkiewicz, R. Stolarski, 2005, Nucleosides, nucleotides & nucleic acids.

Chemical synthesis and binding activity of the trypanosomatid cap-4 structure.

R. Kierzek, M. Shapira, J. Stȩpiński, 2004, RNA.

Synthesis of fluorophosphate nucleotide analogues and their characterization as tools for ¹⁹F NMR studies.

J. Kowalska, J. Jemielity, A. Nowicka, 2015, The Journal of organic chemistry.

Synthesis and evaluation of fluorescent cap analogues for mRNA labelling.

R. Rhoads, Z. Wieczorek, E. Darżynkiewicz, 2013, RSC advances.

Direct High‐Throughput Screening Assay for mRNA Cap Guanine‐N7 Methyltransferase Activity

V. Cowling, J. Kowalska, J. Jemielity, 2020, Chemistry.

Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus.

J. Stȩpiński, M. Dadlez, E. Darżynkiewicz, 2004, Biochemistry.

Hint2, the mitochondrial nucleoside 5'-phosphoramidate hydrolase; properties of the homogeneous protein from sheep (Ovis aries) liver.

J. Kowalska, J. Jemielity, A. Guranowski, 2013, Acta biochimica Polonica.

Methylene analogues of adenosine 5′‐tetraphosphate

M. Thompson, E. Darżynkiewicz, J. Kowalska, 2006 .

Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases.

M. Thompson, E. Darżynkiewicz, J. Kowalska, 2006, The FEBS journal.

Gold-decorated polymer vessel structures as carriers of mRNA cap analogs

Paulina Głowala, Daria Kępińska, K. Janiszewska, 2015 .

Fluorescence Anisotropy Assay with Guanine Nucleotides Provides Access to Functional Analysis of Gαi1 Proteins.

J. Kowalska, J. Jemielity, D. Imhof, 2022, Analytical chemistry.

Synthesis of nucleoside phosphosulfates.

J. Kowalska, J. Jemielity, J. Zuberek, 2012, Bioorganic & medicinal chemistry letters.

Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties.

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2015, Bioorganic & medicinal chemistry.

Differential Inhibition of mRNA Degradation Pathways by Novel Cap Analogs*

R. Rhoads, E. Darżynkiewicz, J. Jemielity, 2006, Journal of Biological Chemistry.

A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides

J. Stȩpiński, E. Darżynkiewicz, R. Stolarski, 2005 .

Fluorescent Turn-On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap-Recognizing Proteins.

J. Kowalska, J. Jemielity, R. Kasprzyk, 2019, Chemistry.

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins

J. Kowalska, J. Jemielity, M. Kopcial, 2019, Molecules.

Exploring the potential of phosphotriazole 5' mRNA cap analogues as efficient translation initiators.

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2018, Organic & biomolecular chemistry.

A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry† †Electronic supplementary information (ESI) available: Tables S1–S6 and Fig. S1–S10, experimental procedures, HPLC profiles, NMR and HRMS spectra. See DOI: 10.1039/c6sc02437h Cli

J. Kowalska, J. Jemielity, A. Nowicka, 2016, Chemical science.

Cap analogs containing 6-thioguanosine--reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules.

F. Martin, E. Darżynkiewicz, J. Kowalska, 2014, Organic & biomolecular chemistry.

The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation.

U. Şahin, E. Darżynkiewicz, J. Kowalska, 2013, Bioorganic & medicinal chemistry letters.

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH.

R. Rhoads, M. Kulis, E. Darżynkiewicz, 2011, RNA.

Phosphoroselenoate Dinucleotides for Modification of mRNA 5′ End

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2009, Chembiochem : a European journal of chemical biology.

Assignment of the Absolute Configuration of P-Chiral 5′Mrna Cap Analogues Containing Phosphorothioate Moiety

J. Stȩpiński, E. Darżynkiewicz, R. Stolarski, 2007, Nucleosides, nucleotides & nucleic acids.

Synthesis of Leishmania Cap-4 Intermediates, Cap-2 and Cap-3

R. Kierzek, M. Shapira, J. Stȩpiński, 2007, Nucleosides, nucleotides & nucleic acids.

Solid-Supported Synthesis of 5′-mRNA CAP-4 from Trypanosomatids

R. Kierzek, M. Shapira, J. Stȩpiński, 2007, Nucleosides, nucleotides & nucleic acids.

NOVEL DINUCLEOSIDE 5′,5′-TRIPHOSPHATE CAP ANALOGUES. SYNTHESIS AND AFFINITY FOR MURINE TRANSLATION FACTOR eIF4E

J. Stȩpiński, E. Darżynkiewicz, R. Stolarski, 2005, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS AND BIOCHEMICAL PROPERTIES OF NOVEL mRNA 5′ CAP ANALOGS RESISTANT TO ENZYMATIC HYDROLYSIS

R. Rhoads, J. Stȩpiński, E. Darżynkiewicz, 2005, Nucleosides, nucleotides & nucleic acids.

Binding Studies of Eukaryotic Initiation Factor eIF4E with Novel mRNA Dinucleotide Cap Analogues

R. Rhoads, A. Niedzwiecka, J. Stȩpiński, 2003, Nucleosides, nucleotides & nucleic acids.

A NOVEL APPROACH TO SOLID PHASE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDE mRNA CAP ANALOGS

E. Darżynkiewicz, J. Jemielity, H. Lönnberg, 2005, Nucleosides, nucleotides & nucleic acids.

A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2007 .

Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex

R. Rhoads, J. Gross, J. Kowalska, 2016, RNA.

SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

D. Nowis, J. Gołąb, J. Kowalska, 2022, bioRxiv.

Tritium secondary kinetic isotope effect on phenylalanine ammonia-lyase-catalyzed reaction.

J. Jemielity, J. Zoń, M. Kańska, 1999, Archives of biochemistry and biophysics.

Synthesis of biotin labelled cap analogue--incorporable into mRNA transcripts and promoting cap-dependent translation.

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2012, Organic & biomolecular chemistry.

A fluorescent HTS assay for phosphohydrolases based on nucleoside 5'-fluorophosphates: its application in screening for inhibitors of mRNA decapping scavenger and PDE-I.

J. Kowalska, J. Jemielity, A. Nowicka, 2016, Organic & biomolecular chemistry.

Ethylenediamine derivatives efficiently react with oxidized RNA 3' ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation.

J. Kowalska, J. Jemielity, P. D. de Witte, 2021, Nucleic acids research.

Kinetic and solvent isotope effects on biotransformation of aromatic amino acids and their derivatives.

J. Jemielity, M. Kańska, M. Pająk, 2016, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of tritium labeled isotopomers of L-tyrosine

J. Jemielity, M. Kańska, W. Augustyniak, 2002 .

Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins.

E. Darżynkiewicz, J. Jemielity, J. Zuberek, 2012, RNA.

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs.

J. Kowalska, J. Jemielity, Ewa M. Grudzien-Nogalska, 2018, Organic letters.

Enzymatic syntheses of carbon-14 labeled isotopomers of L-phenylalanine

J. Jemielity, W. Augustyniak, R. Kański, 2001 .

Efficient Synthesis of Trifluoromethylated Purine Ribonucleosides and Ribonucleotides

J. Kowalska, J. Jemielity, M. Chrominski, 2020, Current protocols in nucleic acid chemistry.

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes

J. Kowalska, J. Jemielity, M. Chrominski, 2020, The Journal of organic chemistry.

Preparation of synthetically challenging nucleotides using cyanoethyl P-imidazolides and microwaves.

J. Kowalska, J. Jemielity, M. Ziemniak, 2012, Organic letters.

mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation

J. Kowalska, J. Jemielity, Marcin Warmiński, 2015 .

Azido-Functionalized 5' Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells.

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2017, Angewandte Chemie.

Solid‐Phase Synthesis of RNA 5′‐Azides and Their Application for Labeling, Ligation, and Cyclization Via Click Chemistry

J. Kowalska, J. Jemielity, Marcin Warmiński, 2020, Current protocols in nucleic acid chemistry.

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression.

M. Hentze, T. Preiss, Kent E Duncan, 2009, Molecular cell.

eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation.

In Young Lee, Je-Hyun Yoon, E. Choi, 2017, Biochimica et biophysica acta. Gene regulatory mechanisms.

mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end.

Michael K. Slevin, R. Rhoads, E. Darżynkiewicz, 2013, RNA.

Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins.

J. Stȩpiński, E. Darżynkiewicz, J. Jemielity, 2009, RNA.

Structural analysis of 5′‐mRNA–cap interactions with the human AGO2 MID domain

N. Sonenberg, B. Nagar, M. Fabian, 2011, EMBO reports.

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

J. Gross, J. Kowalska, J. Jemielity, 2021, Nature Chemical Biology.

Preparation of RNAs with non-canonical 5′ ends using novel di- and trinucleotide reagents for co-transcriptional capping

J. Kowalska, J. Jemielity, Ewa M. Grudzien-Nogalska, 2022, Frontiers in Molecular Biosciences.

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

D. Nowis, J. Kowalska, J. Jemielity, 2019, bioRxiv.

Novel "anti-reverse" cap analogs with superior translational properties.

R. Rhoads, A. Niedzwiecka, J. Stȩpiński, 2003, RNA.

mRNA decapping is promoted by an RNA-binding channel in Dcp2.

Brittnee N Jones, S. Floor, M. Deshmukh, 2008, Molecular cell.

RNA Ligation for Mono and Dually Labeled RNAs.

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2021, Chemistry.

Efficient and Rapid Synthesis of Nucleoside Diphosphate Sugars from Nucleoside Phosphorimidazolides

J. Kowalska, J. Jemielity, P. Dabrowski-Tumanski, 2013 .

Potential therapeutic applications of RNA cap analogs.

J. Kowalska, J. Jemielity, M. Ziemniak, 2013, Future medicinal chemistry.

Weak binding affinity of human 4EHP for mRNA cap analogs.

N. Sonenberg, J. Stȩpiński, E. Darżynkiewicz, 2007, RNA.

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses*

L. Platanias, E. Fish, B. Kroczynska, 2015, The Journal of Biological Chemistry.

The Strategies to Support the COVID-19 Vaccination with Evidence-Based Communication and Tackling Misinformation

K. Simon, K. Pyrć, A. Mastalerz-Migas, 2021, Vaccines.

Structural basis of mRNA cap recognition by Dcp1–Dcp2

J. Gross, J. Jemielity, J. Mugridge, 2016, Nature Structural &Molecular Biology.

Biomolecular condensates amplify mRNA decapping by coupling protein interactions with conformational changes in Dcp1/Dcp2

J. Gross, J. Kowalska, J. Jemielity, 2020, bioRxiv.

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

J. Gross, J. Jemielity, J. Mugridge, 2018, Nature Communications.

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

E. Nowak, E. Darżynkiewicz, J. Kowalska, 2017, Nucleic acids research.

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Joao C. Guimaraes, J. Hackermüller, M. Zavolan, 2018, Nature Communications.

Affinity of Dinucleotide Cap Analogues for Human Decapping Scavenger (hDcpS)

Z. Darżynkiewicz, J. Stȩpiński, M. Jankowska-Anyszka, 2007, Nucleosides, nucleotides & nucleic acids.

Interaction of human decapping scavenger with 5′ mRNA cap analogues: structural requirements for catalytic activity

Z. Darżynkiewicz, J. Stȩpiński, E. Darżynkiewicz, 2007 .

Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by 19F NMR Spectroscopy

J. Kowalska, J. Jemielity, M. Chrominski, 2022, ACS Chemical Biology.

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

Z. Darżynkiewicz, R. Rhoads, U. Şahin, 2014, Nucleic acids research.

Synthetic mRNAs with superior translation and stability properties.

R. Rhoads, U. Şahin, E. Darżynkiewicz, 2013, Methods in molecular biology.

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.

R. Rhoads, J. Stȩpiński, E. Darżynkiewicz, 2008, RNA.

mRNAs biotinylated within the 5′ cap and protected against decapping: new tools to capture RNA–protein complexes

R. Bartenschlager, Vanesa Madan, J. Kowalska, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation

J. Kowalska, J. Jemielity, J. Zuberek, 2021, Pharmaceutics.

Synthetic Capped mRNAs for Cap-Specific Photo-Cross-Linking Experiments.

F. Martin, J. Kowalska, J. Jemielity, 2016, Methods in molecular biology.

Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis.

J. Gross, J. Jemielity, J. Peters, 2022, Structure.

Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins

Paulina Głowala, M. Mazur, J. Kowalska, 2021, Scientific Reports.

5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

J. Kowalska, J. Jemielity, Marcin Warmiński, 2020, Nucleic acids research.

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion

D. Cysewski, J. Kowalska, J. Jemielity, 2022, bioRxiv.

Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2010 .

Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis

J. Gross, J. Jemielity, J. Peters, 2021, bioRxiv.

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2010 .

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses*

B. Su, L. Platanias, E. Eklund, 2017, The Journal of Biological Chemistry.

Adenosine 5′-Tetraphosphate Is a Highly Potent Purinergic Endothelium-Derived Vasoconstrictor

C. Loddenkemper, J. Jankowski, J. Kowalska, 2008, Circulation research.

Plant nucleoside 5'-phosphoramidate hydrolase; simple purification from yellow lupin (Lupinus luteus) seeds and properties of homogeneous enzyme.

J. Stȩpiński, J. Jemielity, A. Guranowski, 2011, Acta biochimica Polonica.

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Joao C. Guimaraes, J. Hackermüller, M. Zavolan, 2018, Nature Communications.

5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.

E. Nowak, J. Kowalska, J. Jemielity, 2018, Journal of the American Chemical Society.

Synthesis and Evaluation of Diguanosine Cap Analogs Modified at the C8-Position by Suzuki–Miyaura Cross-Coupling: Discovery of 7-Methylguanosine-Based Molecular Rotors

J. Kowalska, J. Jemielity, Pawel J. Sikorski, 2023, The Journal of organic chemistry.

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

S. Olsen, J. Jemielity, Linlin Zhang, 2023, Scientific reports.

Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies

J. Stȩpiński, M. Jankowska-Anyszka, E. Darżynkiewicz, 2010, The FEBS journal.

7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.

J. Stȩpiński, E. Darżynkiewicz, J. Jemielity, 2012, Biochemistry.

Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC.

J. Kowalska, J. Jemielity, M. Nowakowska, 2015, Organic letters.

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

J. Neyts, J. Kowalska, J. Jemielity, 2021, Antiviral Research.

mRNA decapping is promoted by an RNA-binding channel in Dcp2.

Brittnee N Jones, S. Floor, M. Deshmukh, 2008, Molecules and Cells.

Synthesis of biotin labelled cap analogue--incorporable into mRNA transcripts and promoting cap-dependent translation.

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2012, Organic & biomolecular chemistry.

Synthesis of nucleoside phosphosulfates.

J. Kowalska, J. Jemielity, J. Zuberek, 2012, Bioorganic & medicinal chemistry letters.

Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA.

E. Darżynkiewicz, J. Kowalska, J. Jemielity, 2017, Bioconjugate chemistry.

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring.

Z. Wieczorek, R. Stolarski, J. Kowalska, 2016, Organic & biomolecular chemistry.

Magnetic-nanoparticle-decorated polypyrrole microvessels: toward encapsulation of mRNA cap analogues.

Daria Kępińska, J. Stolarski, Katarzyna Wiktorska, 2013, Biomacromolecules.

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH.

R. Rhoads, M. Kulis, E. Darżynkiewicz, 2011, RNA.

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses*

L. Platanias, E. Fish, B. Kroczynska, 2015, The Journal of Biological Chemistry.

Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates.

Martin D. Eastgate, J. Kowalska, J. Jemielity, 2023, Nature chemistry.

Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex

R. Micura, J. Jemielity, Marcin Warmiński, 2024, bioRxiv.

Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal

C. I. Smith, R. Strömberg, E. Darżynkiewicz, 2016 .

Plenary lectures MORPHOLOGY AND MOLECULAR ORGANIZATION OF AMPHOTERICIN B AND ITS COPPER COMPLEX IN MODEL MEMBRANE SYSTEM STUDIED BY BREWSTER ANGLE MICROSCOPY

Z. Darżynkiewicz, J. Trylska, B. Wielgus-Kutrowska, 2016 .

An MST-based assay reveals new binding preferences of IFIT1 for canonically and non-canonically capped RNAs

J. Jemielity, Marcin Warmiński, Kamil Ziemkiewicz, 2024, bioRxiv.

Chemical Modifications of mRNA Ends for Therapeutic Applications

J. Kowalska, J. Jemielity, Marcin Warmiński, 2023, Accounts of chemical research.