A. Mudher

发表

Modelling neurodegenerative diseases in vitro : Recent advances in 3D iPSC technologies

S. Willaime-Morawek, Elodie J. Siney, Ksenia Kurbatskaya, 2018 .

A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies

D. Shepherd, A. Mudher, K. Ubhi, 2007, Invertebrate Neuroscience.

Are Tau Aggregates Toxic or Protective in Tauopathies?

C. Cowan, A. Mudher, 2013, Front. Neurol..

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Caleb Webber, Guy B. Williams, Mara Cercignani, 2019, Brain : a journal of neurology.

Conformational Evolution of Molecular Signatures during Amyloidogenic Protein Aggregation.

A. Mudher, I. Nandhakumar, S. Mahajan, 2019, ACS chemical neuroscience.

Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase

S. Lovestone, P. Soden, T. Golde, 2001, The Journal of Neuroscience.

The use of human neurons for novel drug discovery in dementia research

V. Perry, S. Willaime-Morawek, M. Vargas-Caballero, 2016, Expert opinion on drug discovery.

Twice is better: highlights of the second meeting focused on tau biology and pathology.

A. Mudher, E. Skoulakis, 2012, Biochemical Society transactions.

Curcumin as a Holistic Treatment for Tau Pathology

A. Mudher, Lovesha Sivanantharajah, 2022, Frontiers in Pharmacology.

Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?

C. Masters, Ying Ding, Wei Chen, 2015, Journal of Alzheimer's disease : JAD.

Induction of hyperphosphorylated tau in living slices of rat hippocampal formation and subsequent detection using an ELISA

V. Perry, A. Mudher, J. Greene, 1999, Journal of Neuroscience Methods.

Using okadaic acid as a tool for the in vivo induction of hyperphosphorylated tau

V. Perry, A. Mudher, 1998, Neuroscience.

Erratum: GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila (Molecular Psychiatry (2004) 9 (522-530) DOI:10.1038/sj.mp.4001483)

S. Lovestone, D. Shepherd, R. Bhat, 2004 .

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Tobias C. Wood, Karen H. Adams, C. Webber, 2019, Brain : a journal of neurology.

Heparin injection into the adult rat hippocampus induces seizures in the absence of macroscopic abnormalities

V. Perry, A. Mudher, J. Greene, 1999, Neuroscience.

Suppression of tau‐induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity

C. Cowan, A. Mudher, M. Sealey, 2020, Journal of neurochemistry.

Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy

C. Cowan, A. Mudher, E. Skoulakis, 2017, Neurobiology of Disease.

A 3D-induced pluripotent stem cell-derived human neural culture model to study certain molecular and biochemical aspects of Alzheimer’s disease

S. Willaime-Morawek, Elodie J. Siney, Shreyasi Chatterjee, 2022, In vitro models.

The Biology of Tau and its Role in Tauopathies The Biology of Tau and its Role in Tauopathies

A. Mudher, E. Skoulakis, 2010 .

Alzheimer's disease – do tauists and baptists finally shake hands?

Simon Lovestone, S. Lovestone, A. Mudher, 2002, Trends in Neurosciences.

Atypical, non-standard functions of the microtubule associated Tau protein

L. Buée, E. Mandelkow, E. Mandelkow, 2017, Acta neuropathologica communications.

Tau-Centric Therapies for Treating Alzheimer’s Disease

C. Cowan, A. Mudher, S. Quraishe, 2017 .

Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

David Shepherd, A. Page, D. Shepherd, 2010, Acta Neuropathologica.

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

D. Shepherd, C. Cowan, A. Mudher, 2010, Experimental Neurology.

Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits

Shreyasi Chatterjee, A. Mudher, 2018, Front. Neurosci..

M. Vargas-Caballero, C. Proud, D. Bulters, 2021, bioRxiv.

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

A. Mudher, D. Boche, J. Nicoll, 2018, Acta neuropathologica communications.

Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease.

A. Mudher, A. Wyttenbach, S. Quraishe, 2013, Journal of Alzheimer's disease : JAD.

Microtubule stabilising peptides rescue tau phenotypes in-vivo

A. Mudher, S. Quraishe, M. Sealey, 2016, Scientific Reports.

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy

C. Cowan, A. Mudher, S. Quraishe, 2013, Molecular Psychiatry.

Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells

Shreyasi Chatterjee, A. Mudher, Surendra S. Ambegaokar, 2019, Front. Neurosci..

Drug repositioning for Alzheimer's disease

Paul Edison, Anne Corbett, Cornelius Katona, 2012, Nature Reviews Drug Discovery.

An evaluation of Drosophila as a model system for studying tauopathies such as Alzheimer’s disease

D. Shepherd, A. Mudher, Lovesha Sivanantharajah, 2019, Journal of Neuroscience Methods.

An assessment of the translational relevance of Drosophila in drug discovery

A. Mudher, E. Skoulakis, K. Papanikolopoulou, 2019, Expert opinion on drug discovery.

Conformational fingerprinting of tau variants and strains by Raman spectroscopy

B. Hyman, Z. Fan, A. Mudher, 2021, RSC advances.

What is the pathological significance of tau oligomers?

C. Cowan, A. Mudher, S. Quraishe, 2012, Biochemical Society transactions.

Potential mechanisms and implications for the formation of tau oligomeric strains

R. Kayed, A. Mudher, J. Gerson, 2016, Critical reviews in biochemistry and molecular biology.

What is the evidence that tau pathology spreads through prion-like propagation?

Luc Buée, Michel Goedert, L. Buée, 2017, Acta neuropathologica communications.

Using Drosophila models of neurodegenerative diseases for drug discovery

A. Mudher, T. Newman, M. Sealey, 2011, Expert opinion on drug discovery.

Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions

S. Lovestone, M. Cuttle, D. Shepherd, 2005, Neurobiology of Disease.

Modelling Tauopathies in Drosophila: Insights from the Fruit Fly

C. Cowan, D. Allan, A. Mudher, 2011, International journal of Alzheimer's disease.

Microtubule stabilising peptides rescue tau phenotypes in-vivo

A. Mudher, S. Quraishe, M. Sealey, 2016, Scientific Reports.

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers

C. Cowan, D. Allan, A. Mudher, 2015, Scientific Reports.

Increased throughput assays of locomotor dysfunction in Drosophila larvae

C. Cowan, A. Mudher, A. Wyttenbach, 2012, Journal of Neuroscience Methods.

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

J. Marsh, L. Thompson, A. Mudher, 2009, Neurobiology of Disease.

GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

S Lovestone, S. Lovestone, D. Shepherd, 2004, Molecular Psychiatry.

Presenilin 1 Independently Regulates β-Catenin Stability and Transcriptional Activity*

A. Levey, S. Lovestone, R. Cowburn, 2001, The Journal of Biological Chemistry.

Tau-mediated axonal degeneration is prevented by activation of the WldS pathway

V. Perry, A. Mudher, T. Newman, 2020, bioRxiv.

GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

S. Lovestone, D. Shepherd, R. Bhat, 2004, Molecular Psychiatry.

Deafferentation of the hippocampus results in the induction of AT8 positive ‘granules’ in the rat

V. Perry, A. Smith, A. Mudher, 2001, Neuroscience Letters.

Disruption of neuronal function by soluble hyperphosphorylated tau in a Drosophila model of tauopathy.

D. Shepherd, C. Cowan, A. Mudher, 2010, Biochemical Society transactions.

Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis.

Sumeet Mahajan, A. Mudher, S. Mahajan, 2018, ACS chemical neuroscience.

EuroTau: towing scientists to tau without tautology

L. Buée, J. Ávila, A. Mudher, 2017, Acta neuropathologica communications.

Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer’s disease and other Tauopathies

N. Fullwood, M. Hasegawa, D. Allsop, 2021, bioRxiv.

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

A. Mudher, D. Boche, J. Nicoll, 2018, Acta Neuropathologica Communications.

Keeping it Together. Axonal Transport to the Synapse and the Effects of Molecular Chaperones in Health and Disease

A. Mudher, C. Sinadinos, 2011 .

Insights from Drosophila models of Alzheimer's disease.

D. Shepherd, C. Cowan, A. Mudher, 2010, Biochemical Society transactions.

Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions.

S. Lovestone, M. Cuttle, D. Shepherd, 2006, Biochemical Society Transactions.

EuroTau: towing scientists to tau without tautology

Luc Buée, Jean-Pierre Brion, Miguel Medina, 2017, Acta Neuropathologica Communications.

Insights from Drosophila models of Alzheimer's disease.

D. Shepherd, C. Cowan, A. Mudher, 2010, Biochemical Society transactions.

What is the pathological significance of tau oligomers?

C. Cowan, A. Mudher, S. Quraishe, 2012, Biochemical Society transactions.

Potential mechanisms and implications for the formation of tau oligomeric strains

R. Kayed, A. Mudher, J. Gerson, 2016, Critical reviews in biochemistry and molecular biology.

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

T. Hromádka, A. Mudher, I. Dewachter, 2024, Acta neuropathologica communications.