D. Naisbitt

发表

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Challenges and approaches for the development of safer immunomodulatory biologics

M. Pirmohamed, S. Holgate, R. Weaver, 2013, Nature Reviews Drug Discovery.

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors.

B. K. Park, D. Naisbitt, G. Dear, 2018, Chemical research in toxicology.

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2007, The Journal of allergy and clinical immunology.

Sulfamethoxazole and Its Metabolite Nitroso Sulfamethoxazole Stimulate Dendritic Cell Costimulatory Signaling1

Charlotte A. Ashby, M. Pirmohamed, M. Rieder, 2007, The Journal of Immunology.

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1.

B. K. Park, C. Goldring, D. Naisbitt, 2009, Toxicology and applied pharmacology.

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

Chris S. Pridgeon, R. Pieters, M. Ingelman-Sundberg, 2017 .

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells

C. Goldring, D. Naisbitt, D. Antoine, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity

B. K. Park, D. Naisbitt, B. K. Park, 2008, Current opinion in allergy and clinical immunology.

The Generation, Detection, and Effects of Reactive Drug Metabolites

Dominic P. Williams, T. Baillie, N. Kitteringham, 2013, Medicinal research reviews.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Ursula Klingmüller, Bob van de Water, K. G. Jensen, 2019, Nature Reviews Drug Discovery.

Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis.

D. Sheffield, N. Kitteringham, D. Naisbitt, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin.

D. Sheffield, N. Kitteringham, D. Naisbitt, 2015, Toxicology letters.

Nonimmediate &bgr;-lactam reactions in patients with cystic fibrosis

D. Naisbitt, D. Peckham, P. Whitaker, 2012, Current opinion in allergy and clinical immunology.

Activation of Human Dendritic Cells by p-Phenylenediamine

K. L. Mathews, D. Basketter, B. K. Park, 2007, Journal of Pharmacology and Experimental Therapeutics.

Detection of drug bioactivation in vivo: mechanism of nevirapine-albumin conjugate formation in patients.

B. K. Park, D. Naisbitt, R. Jenkins, 2013, Chemical research in toxicology.

Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 1997, The Journal of pharmacology and experimental therapeutics.

Human leukocyte antigen and idiosyncratic adverse drug reactions.

D. Naisbitt, Toru Usui, 2017, Drug metabolism and pharmacokinetics.

T-cell activation by low molecular weight drugs and factors that influence susceptibility to drug hypersensitivity.

D. Naisbitt, M. Ogese, Paul J Thomson, 2020, Chemical research in toxicology.

Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01

Andrew Gibson, Jianjun Liu, Hong Liu, 2019, Allergy.

Immune pathomechanism of drug hypersensitivity reactions.

B. K. Park, D. Naisbitt, W. Pichler, 2011, The Journal of allergy and clinical immunology.

Immunological principles of T-cell-mediated adverse drug reactions in skin

M. Pirmohamed, B. K. Park, D. Naisbitt, 2007, Expert opinion on drug safety.

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.

M. Pirmohamed, D. Chadwick, M. Britschgi, 2003, Molecular pharmacology.

Characterization of Sulfamethoxazole and Sulfamethoxazole Metabolite-Specific T-Cell Responses in Animals and Humans

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003, Journal of Pharmacology and Experimental Therapeutics.

Idiosyncratic Adverse Drug Reactions: Current Concepts

D. Naisbitt, J. Uetrecht, 2013, Pharmacological Reviews.

Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism

B. K. Park, D. Naisbitt, W. Pichler, 2010, The Journal of Immunology.

Immune Cell Formation of a Functional Antigen through Costimulatory Signaling: Evidence for Drug Antigenicity, Immunogenicity, and

B. K. Park, D. Naisbitt, W. Pichler, 2010 .

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients

B. K. Park, D. Naisbitt, R. Jenkins, 2017, The Journal of Immunology.

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients.

B. K. Park, D. Naisbitt, R. Jenkins, 2016, Chemical research in toxicology.

The importance of hapten–protein complex formation in the development of drug allergy

B. K. Park, D. Naisbitt, L. Faulkner, 2014, Current opinion in allergy and clinical immunology.

“Danger” Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells

B. K. Park, D. Naisbitt, S. Lavergne, 2009, Journal of Pharmacology and Experimental Therapeutics.

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, Journal of Pharmacology and Experimental Therapeutics.

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, The Journal of Immunology.

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.

M. Pirmohamed, Andrew Gibson, B. Kevin Park, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests.

D. Naisbitt, 2004, Toxicology.

Drug‐specific CD4+ T‐cell immune responses are responsible for antituberculosis drug‐induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome

D. Naisbitt, G. Hur, Y. Ye, 2017, The British journal of dermatology.

Characterization of amoxicillin and clavulanic acid specific T‐cell clones from patients with immediate drug hypersensitivity

D. Naisbitt, M. Ogese, M. Torres, 2020, Allergy.

Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK

Ashley P Jones, C. Gamble, L. Farrell, 2021, BMC Infectious Diseases.

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, AIDS research and human retroviruses.

The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury

B. K. Park, D. Naisbitt, A. Tailor, 2015, Human & experimental toxicology.

Costimulatory Signaling Sulfamethoxazole Stimulate Dendritic Cell Sulfamethoxazole and Its Metabolite Nitroso

Charlotte A. Ashby, M. Pirmohamed, M. Rieder, 2007 .

Immunopharmacology of hypersensitivity reactions to drugs

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003, Current allergy and asthma reports.

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2002, Molecular pharmacology.

Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility.

D. Naisbitt, Paul J. Thomson, J. Line, 2022, Current opinion in allergy and clinical immunology.

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01

M. Pirmohamed, A. Lister, B. K. Park, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Shedding light on drug-induced liver injury: activation of T-cells from drug naive human donors with tolvaptan and a hydroxybutyric acid metabolite.

Andrew Gibson, D. Naisbitt, Kanoot Jaruthamsophon, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Immune dysregulation increases the incidence of delayed‐type drug hypersensitivity reactions

Andrew Gibson, D. Naisbitt, M. Ogese, 2019, Allergy.

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation

A. Purcell, D. Naisbitt, N. Berry, 2020, Allergy.

The skin as a metabolic and immune-competent organ: Implications for drug-induced skin rash

Yoshiro Saito, D. Naisbitt, J. Uetrecht, 2018, Journal of immunotoxicology.

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

B. K. Park, D. Naisbitt, A. Owen, 2015, AIDS.

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.

B. K. Park, D. Naisbitt, W. Pichler, 2011, The Journal of allergy and clinical immunology.

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

Andrew R. Jones, M. Pirmohamed, B. K. Park, 2012, Genome Medicine.

Drug‐specific T‐cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat

D. Naisbitt, L. Leclercq, A. de Bondt, 2020, Allergy.

Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury.

Amy E. Chadwick, B. K. Park, D. Naisbitt, 2020, Chemical research in toxicology.

Identification of flucloxacillin-haptenated HLA-B*57:01 ligands: evidence of antigen processing and presentation.

A. Purcell, D. Naisbitt, R. Jenkins, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Immune drug-induced liver disease and drugs

B. K. Park, D. Naisbitt, X. Meng, 2017, Current Opinion in Toxicology.

Mechanisms leading to T-cell activation in drug hypersensitivity

D. Naisbitt, X. Meng, D. Yerly, 2018, Current opinion in allergy and clinical immunology.

The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors

M. Pirmohamed, B. K. Park, Andrew Gibson, 2017, The Journal of Immunology.

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury

D. Naisbitt, Seung-Hyun Kim, 2015, Allergy, asthma & immunology research.

Promiscuous T-cell responses to drugs and drug-haptens.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2015, The Journal of allergy and clinical immunology.

Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury

M. Pirmohamed, B. K. Park, D. Naisbitt, 2015, Hepatology.

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.

A. Kipar, B. K. Park, D. Naisbitt, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22–Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

Andrew Gibson, B. K. Park, D. Naisbitt, 2014, The Journal of Immunology.

Cell Function Cells and the Influence of PD-1 on Effector T Secreting T − Drug-Specific Priming of IL-22 Negative Regulation by PD-L 1 during

Andrew Gibson, B. K. Park, D. Naisbitt, 2014 .

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Chemical research in toxicology.

The development of in vitro culture methods to characterize primary T-cell responses to drugs.

B. K. Park, D. Naisbitt, I. Schuppe-Koistinen, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Carbamazepine‐induced acute liver failure as part of the DRESS syndrome

M. Pirmohamed, D. Naisbitt, W. Syn, 2005, International journal of clinical practice.

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis1

Munir, Manal, Pirmohamed, 2011 .

from Piperacillin in Patients with Cystic Fibrosis Circulating and Functional Antigens Derived Mass Spectrometric Characterization of

M. Pirmohamed, D. Naisbitt, R. Jenkins, 2011 .

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer

W. Greenhalf, Eithne Costello, J. Neoptolemos, 2010, Expert review of vaccines.

Investigation of the immunogenicity of diclofenac and diclofenac metabolites.

B. K. Park, D. Naisbitt, X. Meng, 2007, Toxicology letters.

Are chemically reactive metabolites responsible for adverse reactions to drugs?

M. Pirmohamed, D. Smith, N. Kitteringham, 2002, Current drug metabolism.

Fibrosisfrom Piperacillin in Patients with Cystic Circulating and Functional Antigens Derived Mass Spectrometric Characterization of

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011 .

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

M. Pirmohamed, B. K. Park, D. Naisbitt, 1998, Chemical research in toxicology.

Influence of reduced glutathione on the proliferative response of sulfamethoxazole‐specific and sulfamethoxazole‐metabolite‐specific human CD4+ T‐cells

M. Britschgi, D. Naisbitt, W. Pichler, 2001, British journal of pharmacology.

A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals.

D. Naisbitt, W. Pichler, A. Cerny, 2004, Toxicology.

Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals1

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, The Journal of Immunology.

16 – Drug hypersensitivity

P. Demoly, D. Naisbitt, B. K. Park, 2012 .

Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse.

B. Kevin Park, D. Naisbitt, J. Maggs, 2009, Toxicology letters.

The 2nd International Drug Hypersensitivity Meeting

D. Naisbitt, A. Alfirevic, 2006, Expert opinion on drug safety.

Characterisation of Sulfamethoxazole and Sulfamethoxazole Metabolite-Specific T-cell Responses in Animals and Man

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003 .

T Cells from Allergic Individuals + Reactive Metabolites by Drug-Specific CD 4 Recognition of Sulfamethoxazole and Its

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000 .

Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites

B. K. Park, D. Naisbitt, J. Maggs, 2008, Drug Metabolism and Disposition.

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells.

Andrew Gibson, B. K. Park, D. Naisbitt, 2017, The Journal of allergy and clinical immunology.

In vitro diagnosis of delayed-type drug hypersensitivity: mechanistic aspects and unmet needs.

D. Naisbitt, M. Ogese, Ryan G Nattrass, 2014, Immunology and allergy clinics of North America.

Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2010, The Journal of investigative dermatology.

Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base.

M. Pirmohamed, D. Basketter, D. Naisbitt, 2008, The Journal of investigative dermatology.

Cellular and Molecular Pathophysiology of Cutaneous Drug Reactions

M. Britschgi, D. Naisbitt, W. Pichler, 2002, American journal of clinical dermatology.

Advances in Our Understanding of the Interaction of Drugs with T-cells: Implications for the Discovery of Biomarkers in Severe Cutaneous Drug Reactions.

D. Naisbitt, M. Moreno-Eutimio, C. Gómez-Castro, 2022, Chemical research in toxicology.

Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2012, Pharmacogenomics.

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals.

Andrew A. White, Dominic P. Williams, M. Pirmohamed, 2010, The Journal of investigative dermatology.

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component

B. K. Park, D. Naisbitt, S. Ward, 1996, Antimicrobial agents and chemotherapy.

verapamil-sensitive chloroquine resistance amodiaquine to overcome the Manipulation of the N-alkyl substituent in

B. K. Park, D. Naisbitt, P. O’Neill, 1996 .

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity

M. Pirmohamed, Andrew Gibson, D. Naisbitt, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

From the Cover: Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury

B. Kevin Park, D. Naisbitt, Neil S French, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers

M. Monshouwer, B. K. Park, Andrew Gibson, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

&bgr;‐Lactam hypersensitivity involves expansion of circulating and skin‐resident TH22 cells

D. Naisbitt, L. Faulkner, J. Farrell, 2018, The Journal of allergy and clinical immunology.

In Vitro Priming of Naı̈ve T-cells with p-Phenylenediamine and Bandrowski's Base.

M. Pirmohamed, Andrew Gibson, D. Naisbitt, 2015, Chemical research in toxicology.

Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK

Ashley P Jones, C. Gamble, L. Farrell, 2021, BMC Infectious Diseases.

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat.

M. Pirmohamed, Research Fellow, N. Kitteringham, 1997, The Journal of pharmacology and experimental therapeutics.

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Chemical research in toxicology.

Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase.

B. K. Park, D. Naisbitt, R. Jenkins, 2015, Chemical research in toxicology.

Pathology of drug hypersensitivity reactions and mechanisms of immune tolerance

D. Naisbitt, Sean L. Hammond, Paul J. Thomson, 2022, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives.

B. K. Park, D. Naisbitt, P. O’Neill, 2010, Chemical research in toxicology.

Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol

Ashley P Jones, I. Buchan, W. Greenhalf, 2021, BMJ Open.

Immunological Principles of Adverse Drug Reactions

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, Drug safety.

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo

M. Pirmohamed, B. K. Park, D. Naisbitt, 2001, British journal of pharmacology.

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

M Pirmohamed, M. Pirmohamed, N. Kitteringham, 1999, British journal of pharmacology.

HLA‐DQ allele‐restricted activation of nitroso sulfamethoxazole‐specific CD4‐positive T lymphocytes from patients with cystic fibrosis

M. Pirmohamed, A. Sette, B. K. Park, 2015, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Reactive metabolites and their role in drug reactions

Dominic P. Williams, M. Pirmohamed, N. Kitteringham, 2001, Current opinion in allergy and clinical immunology.

Metabolic activation in drug allergies.

M. Pirmohamed, N. Kitteringham, B. K. Park, 2001, Toxicology.

Metabolism of lamotrigine to a reactive arene oxide intermediate.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, Chemical research in toxicology.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

K. G. Jensen, Amy E. Chadwick, Dominic P. Williams, 2019, Nature Reviews Drug Discovery.

Drug hypersensitivity reactions in patients with HIV disease

M. Pirmohamed, B. K. Park, D. Naisbitt, 2007, Expert review of clinical immunology.

The danger hypothesis--potential role in idiosyncratic drug reactions.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2002, Toxicology.

Managing the challenge of chemically reactive metabolites in drug development

Ian D. Wilson, Alan Boobis, Chris E. P. Goldring, 2011, Nature Reviews Drug Discovery.

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

H. Laverty, B. K. Park, D. Naisbitt, 2011, Chemico-biological interactions.

No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury.

B. K. Park, D. Naisbitt, C. Spraggs, 2016, Chemical research in toxicology.

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2018, Chemical research in toxicology.

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

D. Naisbitt, J. L. Castrejón-Flores, Noé V. Durán-Figueroa, 2015 .

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients

M. Pirmohamed, T. Rungrotmongkol, D. Naisbitt, 2021, Frontiers in Immunology.

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 2000, Molecular pharmacology.

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 1997, The Journal of pharmacology and experimental therapeutics.

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2012, Journal of Pharmacology and Experimental Therapeutics.

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial.

T. Hickish, W. Greenhalf, Eithne Costello, 2014, The Lancet. Oncology.

Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.

L. Trepanier, S. Mallal, F. Finkelman, 2015, The Journal of allergy and clinical immunology.

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.

M. Pirmohamed, D. Naisbitt, C. Sukasem, 2021, Annual review of pharmacology and toxicology.

Drug hapten‐specific T‐cell activation: Current status and unanswered questions

D. Naisbitt, X. Meng, Kareena Adair, 2021, Proteomics.

Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug‐specific T cells

D. Naisbitt, W. Pichler, B. K. Park, 2012, Allergy.

In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs

D. Naisbitt, X. Meng, Sean L. Hammond, 2021, Frontiers in Immunology.

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

P. Klenerman, M. Pirmohamed, A. Sette, 2020, Nature Communications.

Clinical application of whole-genome sequenc- ing in patients with primary immunodeficiency

B. K. Park, D. Naisbitt, R. Jenkins, 2015 .

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

M. Pirmohamed, B. K. Park, D. Naisbitt, 2012, Genome Medicine.

Drug-Specific T Cells in An HIV-Positive Patient with Nevirapine-Induced Hepatitis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2005, Antiviral Therapy.

Characterization of drug-specific T cells in lamotrigine hypersensitivity.

M. Pirmohamed, D. Chadwick, C. A. Gibney, 2003, The Journal of allergy and clinical immunology.

Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions

B. K. Park, D. Naisbitt, A. Sullivan, 2018, Expert opinion on drug metabolism & toxicology.

Immune Mechanisms in Drug-Induced Liver Injury

H. Jaeschke, D. Naisbitt, 2018 .

Human leukocyte antigen (HLA)‐B*57:01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury

M. Pirmohamed, Andrew Gibson, B. K. Park, 2013, Hepatology.

Activation of T cells by carbamazepine and carbamazepine metabolites.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2006, The Journal of allergy and clinical immunology.

Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01

M. Pirmohamed, D. Naisbitt, C. Sukasem, 2021, Frontiers in Immunology.

Immunological Mechanisms of Drug Hypersensitivity.

D. Naisbitt, X. Meng, Kevin B. Park, 2017, Current pharmaceutical design.

T cell responses to drugs and drug metabolites.

B. K. Park, D. Naisbitt, C. Earnshaw, 2014, Experientia supplementum.

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan

M. Pirmohamed, D. Naisbitt, J. Farrell, 2006, The British journal of dermatology.

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

Andreas Luch, Thomas Rustemeyer, Andrea Cavani, 2010, Cellular and Molecular Life Sciences.

Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells.

B. K. Park, D. Naisbitt, N. Humphreys, 2005, Toxicology.

Characterization of Clozapine-Responsive Human T Cells

M. Pirmohamed, B. K. Park, D. Naisbitt, 2020, The Journal of Immunology.

Trimethoprim-induced aseptic meningism.

D. Naisbitt, M. Ogese, H. Gooi, 2017, British journal of hospital medicine.

New Approaches to Investigate Drug-Induced Hypersensitivity.

M. Pirmohamed, Andrew Gibson, A. Norris, 2017, Chemical research in toxicology.

Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System

Hong Liu, Yonghu Sun, Furen Zhang, 2023, Chemical research in toxicology.

HLA Class II-restricted CD8+ T cells contribute to the promiscuous immune response in dapsone hypersensitive patients.

M. Pirmohamed, Jianjun Liu, Hong Liu, 2021, The Journal of investigative dermatology.

Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4+ T lymphocytes.

D. Naisbitt, M. Ogese, M. Mall, 2020, The Journal of allergy and clinical immunology.

T‐cell‐mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis

M. Pirmohamed, D. Naisbitt, M. Ogese, 2022, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Selective Haptenation of Cellular or Extracellular Protein by Chemical Allergens: Association with Cytokine Polarization

N. Kitteringham, B. K. Park, D. Naisbitt, 2005 .

Biopsy Pathology and Immunohistochemistry of a Case of Immune‐Mediated Drug‐Induced Liver Injury With Atabecestat

K. Washington, D. Naisbitt, Jason Aligo, 2020, Hepatology.

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

P. Lio’, K. Okkenhaug, D. Adams, 2023, bioRxiv.

Characterisation of healthy donor-derived T-cell responses specific to telaprevir

M. Monshouwer, B. K. Park, Andrew Gibson, 2018 .

Role of bioactivation in drug-induced hypersensitivity reactions

B. K. Park, D. Naisbitt, Joseph P. Sanderson, 2006, The AAPS Journal.

Characterization of Drug-Specific CD4+ T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions

M. Pirmohamed, D. Naisbitt, A. Alfirevic, 2023, Chemical research in toxicology.

Corrections

M. Pirmohamed, B. K. Park, Andrew Gibson, 2008, The Lancet Neurology.

Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients

M. Pirmohamed, D. Naisbitt, C. Sukasem, 2022, Chemical research in toxicology.

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts.

B. K. Park, D. Naisbitt, R. Jenkins, 2017, Chemical research in toxicology.

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003, Journal of HIV therapy.

Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization.

N. Kitteringham, B. K. Park, D. Naisbitt, 2005, Chemical research in toxicology.

Toxicophores: groups and metabolic routes associated with increased safety risk.

Dominic P. Williams, D. Naisbitt, Dominic P Williams, 2002, Current opinion in drug discovery & development.

Characterization of Flucloxacillin-specific CD8+ T-cells in a mouse model

A. Kipar, D. Naisbitt, D. Antoine, 2014, Clinical and Translational Allergy.

Prevalence and mechanism of adverse reactions to colistin in patients with cystic fibrosis

D. Naisbitt, D. Peckham, S. Lavergne, 2010 .

Characterization of the T-Cell Response in a Patient with Phenindione Hypersensitivity

M. Pirmohamed, B. K. Park, D. Naisbitt, 2005, Journal of Pharmacology and Experimental Therapeutics.

A mechanistic investigation into the irreversible protein binding and antigenicity of p-phenylenediamine.

N. Kitteringham, B. K. Park, D. Naisbitt, 2009, Chemical research in toxicology.

Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation.

B. K. Park, D. Naisbitt, R. Jenkins, 2009, Chemical research in toxicology.

Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications?

D. Naisbitt, A. Olsson-Brown, Sean L. Hammond, 2022, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement☆

M. Pirmohamed, M. Wadhwa, S. Sethu, 2013, Clinical immunology.

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, The Journal of allergy and clinical immunology.

HLA DRB1*15:01-DQB1*06:02-restricted human CD4+ T-cells are selectively activated with amoxicillin-peptide adducts.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Food , drug , insect sting allergy , and anaphylaxis Stimulation of human T cells with sulfonamides and sulfonamide metabolites

B. K. Park, D. Naisbitt, W. Pichler, 2022 .

Detection of drug‐responsive B lymphocytes and antidrug IgG in patients with β‐lactam hypersensitivity

D. Naisbitt, L. Faulkner, X. Meng, 2017, Allergy.

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin.

B. K. Park, D. Naisbitt, J. Maggs, 2015, Chemical research in toxicology.

Exosomal Transport of Hepatocyte‐Derived Drug‐Modified Proteins to the Immune System

N. Kitteringham, B. K. Park, C. Goldring, 2019, Hepatology.

Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?

D. Naisbitt, A. Gibson, B. K. Park, 2015, Expert opinion on drug metabolism & toxicology.

Current perspective of the etiopathogenesis of delayed-type, and T cell-mediated drug related skin diseases.

D. Naisbitt, J. Nicolas, M. Vocanson, 2020, The Journal of allergy and clinical immunology.

Investigation of toxic metabolites during drug development.

Dominic P. Williams, M. Pirmohamed, N. Kitteringham, 2005, Toxicology and applied pharmacology.

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Journal of Allergy and Clinical Immunology.

State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop.

L. Gribaldo, M. Pallardy, D. Naisbitt, 2018, ALTEX.

What’s been Hapten-ing over the last 88 years?

D. Naisbitt, X. Meng, Sean Hammond, 2023, Medicinal Chemistry Research.

Cutaneous immunopathology of long‐standing complex regional pain syndrome

R. Moots, S. Edwards, A. Goebel, 2015, European journal of pain.

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury

C. Goldring, D. Naisbitt, R. Sison-Young, 2023, Toxicological sciences : an official journal of the Society of Toxicology.

Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4+ T-Cells from Hypersensitive Patients.

D. Naisbitt, J. L. Castrejón-Flores, S. Méndez-Flores, 2018, Chemical research in toxicology.

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

M. Pirmohamed, D. Naisbitt, P. O’Neill, 1996 .

7th Drug hypersensitivity meeting: part two

S. Mallal, A. Borobia, P. Korošec, 2016, Clinical and Translational Allergy.

T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab

M. Pirmohamed, D. Naisbitt, D. Carr, 2021, Journal for ImmunoTherapy of Cancer.

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

D. Naisbitt, A. Owen, K. Strebel, 2015, AIDS.

Nonimmediate &bgr;-lactam reactions in patients with cystic fibrosis

D. Naisbitt, D. Peckham, P. Whitaker, 2012, Current opinion in allergy and clinical immunology.

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.

D. Naisbitt, J. Farrell, S. Lavergne, 2011, The Journal of allergy and clinical immunology.

Drug metabolite-specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis.

D. Naisbitt, D. Peckham, S. Lavergne, 2010, Chemical research in toxicology.

Food , drug , insect sting allergy , and anaphylaxis Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

D. Naisbitt, W. Pichler, J. Farrell, 2011 .

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms.

M. Pirmohamed, D. Naisbitt, A. Alfirevic, 2013, Chemical research in toxicology.

Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions

D. Naisbitt, J. Line, Eleanor Saville, 2023, Frontiers in toxicology.

Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells.

D. Naisbitt, P. O’Neill, J. Maggs, 2013, Chemical research in toxicology.

Dapsone hypersensitivity syndrome

Hong Liu, Yonghu Sun, Furen Zhang, 2023, Chinese Medical Journal.

Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors.

D. Naisbitt, M. Ogese, J. Maggs, 2017, Chemical research in toxicology.

Patients with naproxen‐induced liver injury display T‐cell memory responses toward an oxidative (S)‐O‐desmethyl naproxen metabolite but not the acyl glucuronide

M. Pirmohamed, A. Odermatt, G. Aithal, 2023, Allergy.

Stimulation of human T cells with sulfonamides and sulfonamide metabolites.

D. Naisbitt, Sabah H. El-Ghaiesh, J. Castrejon, 2010, The Journal of allergy and clinical immunology.