K. Bitar

发表

Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering.

S. Raghavan, E. Zakhem, R. Gilmont, 2012, Biomaterials.

The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets.

Shreya Raghavan, Khalil N Bitar, S. Raghavan, 2014, Biomaterials.

Tissue engineering and regenerative medicine as applied to the gastrointestinal tract.

E. Zakhem, K. Bitar, 2013, Current opinion in biotechnology.

Age Effects on Internal Anal Sphincter Thickness and Diameter in Nulliparous Females

J. Ashton-Miller, D. Fenner, J. DeLancey, 2007, Diseases of the colon and rectum.

Design Strategies of Biodegradable Scaffolds for Tissue Regeneration

E. Zakhem, K. Bitar, 2014, Biomedical engineering and computational biology.

Is bioengineering a possibility in gastrointestinal disorders?

E. Zakhem, K. Bitar, 2015, Expert review of gastroenterology & hepatology.

Treatment of Fecal Incontinence: State of the Science Summary for the National Institute of Diabetes and Digestive and Kidney Diseases Workshop

W. Whitehead, A. Bharucha, K. Bitar, 2015, The American Journal of Gastroenterology.

Bioengineering functional human sphincteric and non-sphincteric gastrointestinal smooth muscle constructs.

E. Zakhem, K. Bitar, G. Orlando, 2016, Methods.

IGF-I induces collagen and IGFBP-5 mRNA in rat intestinal smooth muscle.

K. Bitar, G. Christman, E. Zimmermann, 1997, American journal of physiology. Gastrointestinal and liver physiology.

Activation of MAP kinase and translocation with HSP27 in bombesin-induced contraction of rectosigmoid smooth muscle.

J. Strahler, M. Welsh, K. Bitar, 1995, The American journal of physiology.

Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells.

D. Teitelbaum, E. Miyasaka, S. Raghavan, 2014, Surgery.

p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.

D. Fingar, K. Bitar, J. Solway, 2010, American journal of respiratory cell and molecular biology.

Transforming growth factor-β induces airway smooth muscle hypertrophy

D. Fingar, K. Bitar, M. Hershenson, 2006 .

Bioengineered three-dimensional physiological model of colonic longitudinal smooth muscle in vitro.

S. Takayama, S. Raghavan, R. Gilmont, 2010, Tissue engineering. Part C, Methods.

Transforming growth factor-beta induces airway smooth muscle hypertrophy.

D. Fingar, K. Bitar, M. Hershenson, 2006, American journal of respiratory cell and molecular biology.

Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of asthma.

W. Henderson, D. Fingar, K. Bitar, 2009, American journal of physiology. Lung cellular and molecular physiology.

Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3 phosphorylation in a mouse model of asthma

W. Henderson, D. Fingar, K. Bitar, 2009 .

Neural Release of Vasoactive Intestinal Peptide from the Gut

G. Weir, K. Bitar, S. Said, 1980 .

MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.

U. Sohn, W. Cao, K. Harnett, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Differential regulation of smooth muscle contraction in rabbit internal anal sphincter by substance P and bombesin.

K. Bitar, C. Hillemeier, P. Biancani, 1990, Life sciences.

Modulation of smooth muscle contraction by sphingosylphosphorylcholine.

K. Bitar, H. Yamada, 1995, The American journal of physiology.

Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27.

K. Bitar, P. Wang, Pinglang Wang, 1998, The American journal of physiology.

Cellular Physiology of Gastrointestinal Smooth Muscle

S. Raghavan, R. Gilmont, K. Bitar, 2012 .

Ectopic expression of caveolin-1 restores physiological contractile response of aged colonic smooth muscle.

R. Gilmont, K. Bitar, S. Somara, 2007, American journal of physiology. Gastrointestinal and liver physiology.

kinase C and Src in CCK-stimulated pancreatic acini Involvement of RhoA and its interaction with protein

K. Bitar, C. Owyang, Y. Tsunoda, 2016 .

endothelin and ceramide in colonic smooth muscle cells Differential activation of phosphoinositide 3-kinase by

K. Bitar, A. Ibitayo, Xuehui Su, 2016 .

Involvement of RhoA and its interaction with protein kinase C and Src in CCK-stimulated pancreatic acini.

K. Bitar, C. Owyang, Y. Tsunoda, 1999, American journal of physiology. Gastrointestinal and liver physiology.

Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells.

K. Bitar, A. Ibitayo, Xuehui Su, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle.

K. Bitar, C. Owyang, Y. Tsunoda, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle.

K. Bitar, C. Owyang, Y. Tsunoda, 1998, The American journal of physiology.

Real-time dynamic movement of caveolin-1 during smooth muscle contraction of human colon and aged rat colon transfected with caveolin-1 cDNA.

R. Gilmont, K. Bitar, Daniela Bashllari, 2011, American journal of physiology. Gastrointestinal and liver physiology.

Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin.

M. Kaminski, K. Cease, J. Strahler, 1991, Biochemical and biophysical research communications.

IGF-I increases IGFBP-5 and collagen alpha1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells.

K. Bitar, G. Christman, E. Zimmermann, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Tropomyosin interacts with phosphorylated HSP27 in agonist-induced contraction of smooth muscle.

K. Bitar, S. Somara, 2004, American journal of physiology. Cell physiology.

colon in muscle cells of the α translocated RhoA and PKC- HSP27 modulates agonist-induced association of

S. Rattan, K. Bitar, J. Paul, 2015 .

Direct association of RhoA with specific domains of PKC-alpha.

K. Bitar, Haiyan Pang, 2005, American journal of physiology. Cell physiology.

Translocation and association of ROCK-II with RhoA and HSP27 during contraction of rabbit colon smooth muscle cells.

S. Patil, K. Bitar, Mercy D Pawar, 2004, Biochemical and biophysical research communications.

Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKCalpha.

S. Patil, K. Bitar, Mercy D Pawar, 2004, American journal of physiology. Gastrointestinal and liver physiology.

HSP27 modulates agonist-induced association of translocated RhoA and PKC-alpha in muscle cells of the colon.

K. Bitar, A. Ibitayo, S. Patil, 2002, Journal of applied physiology.

Specific G proteins mediate endothelin induced contraction.

K. Bitar, G. Omann, S. Stein, 1992, Life sciences.

In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival

D. Teitelbaum, E. Miyasaka, S. Raghavan, 2011, Pediatric Surgery International.

rat colon transfected with caveolin-1 cDNA smooth muscle contraction of human colon and aged Real-time dynamic movement of caveolin-1 during

R. Gilmont, K. Bitar, Daniela Bashllari, 2011 .

Inhibition of Glycogen Synthase Kinase-3β Is Sufficient for Airway Smooth Muscle Hypertrophy*

D. Fingar, K. Bitar, Gregoriy A Dokshin, 2008, Journal of Biological Chemistry.

Access to Intracellular Calcium during Development in the Feline Gastric Antrum

K. Bitar, D. Deutsch, A. C. Hillemeier, 1998, Pediatric Research.

Isolation and Culture of Human Intestinal Smooth Muscle Cells

R. Diegelmann, C. Elson, K. Bitar, 1984, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

in colonic smooth muscle α kinase C Agonist-induced association of tropomyosin with protein

K. Bitar, Haiyan Pang, S. Somara, 2016 .

Agonist-induced association of tropomyosin with protein kinase Calpha in colonic smooth muscle.

K. Bitar, Haiyan Pang, S. Somara, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Biomechanical properties of an implanted engineered tubular gut‐sphincter complex

E. Zakhem, K. Bitar, G. Orlando, 2017, Journal of tissue engineering and regenerative medicine.

VIP induces PKA-mediated rapid and sustained phosphorylation of HSP20.

R. Gilmont, K. Bitar, S. Somara, 2008, Biochemical and biophysical research communications.

Phosphorylated HSP27 modulates the association of phosphorylated caldesmon with tropomyosin in colonic smooth muscle.

K. Bitar, S. Somara, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Tissue engineering for neuromuscular disorders of the gastrointestinal tract.

K. Koch, K. Bitar, J. Fortunato, 2012, World journal of gastroenterology.

Functional restoration of ex vivo model of pylorus: Co‐injection of neural progenitor cells and interstitial cells of Cajal

K. Bitar, Prabhash Dadhich, 2020, Stem cells translational medicine.

Successful implantation of bioengineered, intrinsically innervated, human internal anal sphincter.

S. Srinivasan, D. Teitelbaum, E. Miyasaka, 2011, Gastroenterology.

Successful implantation of physiologically functional bioengineered mouse internal anal sphincter.

D. Teitelbaum, E. Miyasaka, S. Raghavan, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Bioengineered Human Pyloric Sphincters Using Autologous Smooth Muscle and Neural Progenitor Cells.

E. Zakhem, K. Bitar, G. Orlando, 2016, Tissue engineering. Part A.

Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold.

S. Raghavan, E. Zakhem, K. Bitar, 2014, Biomaterials.

Aging and neural control of the GI tract: V. Aging and gastrointestinal smooth muscle: from signal transduction to contractile proteins.

K. Bitar, 2003, American journal of physiology. Gastrointestinal and liver physiology.

HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction.

K. Bitar, 2002, American journal of physiology. Gastrointestinal and liver physiology.

HSP 27 phosphorylation and interaction with actin-myosin in smooth muscle contraction

K. Bitar, 2002 .

Direct association and translocation of PKC-α with calponin

S. Patil, K. Bitar, Mercy D Pawar, 2004 .

Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle.

R. Gilmont, K. Bitar, Saranya Varadarajan, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Function of gastrointestinal smooth muscle: from signaling to contractile proteins.

K. Bitar, 2003, The American journal of medicine.

Stem Cell Therapy for GI Neuromuscular Disorders

S. Raghavan, K. Bitar, 2014, Current Gastroenterology Reports.

Cell and organ bioengineering technology as applied to gastrointestinal diseases

S. Soker, A. Atala, J. Neuberger, 2012, Gut.

Bioengineering the gut: future prospects of regenerative medicine

E. Zakhem, K. Bitar, 2016, Nature Reviews Gastroenterology &Hepatology.

Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells.

Louise Hecker, Keith Baar, Khalil N Bitar, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Regenerative medicine as applied to general surgery.

Kyle W. Binder, Pedro M. Baptista, G. Christ, 2012, Annals of surgery.

Aging and gastrointestinal neuromuscular function: insights from within and outside the gut

K. Bitar, B. Greenwood-Van Meerveld, J. Wiley, 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

HSP27 in signal transduction and association with contractile proteins in smooth muscle cells.

M. Welsh, K. Bitar, S. Tuteja, 1999, American journal of physiology. Gastrointestinal and liver physiology.

Tissue Engineering and Regenerative Medicine

E. Zakhem, K. Bitar, 2016 .

Calcium requirements for acetylcholine-induced contraction of cat esophageal circular muscle cells.

U. Sohn, J. Behar, P. Biancani, 1994, The American journal of physiology.

Protein kinase C mediates spontaneous tone in the cat lower esophageal sphincter.

U. Sohn, K. Bitar, C. Hillemeier, 1996, The Journal of pharmacology and experimental therapeutics.

Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh.

U. Sohn, B. Rhim, K. Harnett, 1994, The American journal of physiology.

Calcium requirements for acetylcholine (Ach) and diacylglycerol induced contraction of cat esophageal circular muscle cells

U. Sohn, J. Behar, P. Biancani, 1992 .

Transplantation of a Human Tissue-Engineered Bowel in an Athymic Rat Model.

K. Koch, E. Zakhem, K. Bitar, 2017, Tissue engineering. Part C, Methods.

Tissue engineering in the gut: developments in neuromusculature.

S. Raghavan, E. Zakhem, K. Bitar, 2014, Gastroenterology.

Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction

K. Bitar, Xiao-xiang Zhu, 1993 .

Regulation of smooth muscle contraction in rabbit internal anal sphincter by protein kinase C and Ins(1,4,5)P3.

K. Bitar, K. Balazovich, C. Hillemeier, 1991, The American journal of physiology.

Aging and gastrointestinal smooth muscle

S. Patil, K. Bitar, Suresh B. Patil, 2004, Mechanisms of Ageing and Development.

Bioengineering of the digestive tract: approaching the clinic.

K. Bitar, R. Ciccocioppo, G. Orlando, 2021, Cytotherapy.

BioSphincter a Regenerative Medicine Approach to Treat FI

K. Bitar, Prabhash Dadhich, 2019, Current Topics in Faecal Incontinence.

BioSphincters to treat Fecal Incontinence in Nonhuman Primates

E. Zakhem, K. Bitar, N. Kock, 2019, Scientific Reports.

Aging and Gi smooth muscle fecal incontinence: is bioengineering an option

K. Bitar, 2005, Experimental Gerontology.

contractile proteins in smooth muscle cells HSP27 in signal transduction and association with

M. Welsh, K. Bitar, S. Tuteja, 2016 .

HSP 27 in signal transduction and association with contractile proteins in smooth muscle cells

M. Welsh, K. Bitar, S. Tuteja, 1999 .

Intestinal Regeneration: The Bioengineering Approach

S. Raghavan, K. Bitar, 2014 .

Expression of bombesin receptor subtypes and their differential regulation of colonic smooth muscle contraction

K. Bitar, X. Zhu, 1992, Regulatory Peptides.

Successful Treatment of Passive Fecal Incontinence in an Animal Model Using Engineered Biosphincters: A 3‐Month Follow‐Up Study

E. Zakhem, K. Bitar, J. Bohl, 2017, Stem cells translational medicine.

Distraction-Induced Intestinal Enterogenesis: Preservation of Intestinal Function and Lengthening After Reimplantation Into Normal Jejunum

Sita Somara, Keisuke Nose, Daniel H. Teitelbaum, 2012, Annals of surgery.

Bioengineering and regeneration of gastrointestinal tissue: where are we now and what comes next?

S. Raghavan, E. Zakhem, K. Bitar, 2019, Expert opinion on biological therapy.

Surgical implantation of a bioengineered internal anal sphincter.

D. Teitelbaum, E. Miyasaka, S. Raghavan, 2010, Journal of pediatric surgery.

Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27.

K. Bitar, Pinglang Wang, 1998, American journal of physiology. Gastrointestinal and liver physiology.

RhoA- and PKC-alpha-mediated phosphorylation of MYPT and its association with HSP27 in colonic smooth muscle cells.

S. Patil, K. Bitar, Suresh B. Patil, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs.

S. Raghavan, R. Gilmont, K. Bitar, 2014, Tissue engineering. Part A.

Contraction mediated by Ca2+ influx in esophageal muscle and by Ca2+ release in the LES.

G. Makhlouf, P. Biancani, K. Bitar, 1987, The American journal of physiology.

Antiserum to Tumor Necrosis Factor and Failure to Prevent Murine Colitis

D. Remick, K. Bitar, A. Olson, 1995, Journal of pediatric gastroenterology and nutrition.

RHO a regulates sustaned smooth muscle contraction through cytoskeletal reorganization of the actin binding protein HSP27

K. Bitar, P. Wang, 1998 .

Origin of molecular species of diacylglycerol induced by bombesin in smooth muscle cells from rabbit rectosigmoid.

K. Bitar, D. Sbrissa, A. Hajra, 1998, The American journal of physiology.

Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition.

S. Raghavan, R. Gilmont, K. Bitar, 2013, Biomaterials.

Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut

S. Raghavan, K. Bitar, K. N. Bitar, 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Bioengineered internal anal sphincter derived from isolated human internal anal sphincter smooth muscle cells.

R. Gilmont, K. Bitar, R. Dennis, 2009, Gastroenterology.

Direct association of calponin with specific domains of PKC-alpha.

K. Bitar, S. Somara, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Advances in Neo-Innervation of the Gut

S. Raghavan, E. Zakhem, K. Bitar, 2015 .

Enteric neural differentiation in innervated, physiologically functional, smooth muscle constructs is modulated by bone morphogenic protein 2 secreted by sphincteric smooth muscle cells

S. Raghavan, E. Zakhem, K. Bitar, 2017, Journal of tissue engineering and regenerative medicine.

785 IAS Smooth Muscle Cells Direct the Differentiation of Neuronal Progenitor Cells Into Mature Neurons

S. Srinivasan, S. Raghavan, R. Gilmont, 2010 .

Implantation of Autologous Biosphincters in a Non-Human Primate (NHP) Model of Fecal Incontinence

E. Zakhem, K. Bitar, Riccardo Tamburrini, 2017 .