D. Kochhar

发表

Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud.

H. Jiang, D. Kochhar, 1992, Teratology.

The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.

H. Jiang, D. Kochhar, R. Chandraratna, 1998, The International journal of developmental biology.

In Vitro Methods in Developmental Toxicology:

G. Kimmel, D. Kochhar, 1990 .

Analysis of high dysmorphogenic activity of Ro 13-6307, a tetramethylated tetralin analog of retinoic acid.

D. Kochhar, J. Penner, 1992, Teratology.

Retinamides: hydrolytic conversion of retinoylglycine to retinoic acid in pregnant mice contributes to teratogenicity.

H. Jiang, D. Kochhar, J. Penner, 1992, Teratology.

PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.

D. Kochhar, D. Soprano, K. Soprano, 2002, Teratology.

Susceptible stages and abnormal morphogenesis in the developing mouse limb, analysed in organ culture after transplacental exposure to vitamin A (retinoic acid).

D. Kochhar, M. Aydelotte, 1974, Journal of embryology and experimental morphology.

The use of in vitro procedures in teratology.

D. Kochhar, 1975, Teratology.

Overview of In Vitro Teratogenicity Testing: aspects of validation and application to screening.

G. Kimmel, D. Kochhar, R. Pratt, 1982, Teratogenesis, carcinogenesis, and mutagenesis.

Limb development in mouse embryos: protection against teratogenic effects of 6-diazo-5-ox-L-norleucine (DON) in vivo and in vitro.

D. Kochhar, R. Greene, 1975, Journal of embryology and experimental morphology.

The role of morphogenetic cell death during abnormal limb-bud outgrowth in mice heterozygous for the dominant mutation Hemimelia-extra toe (Hmx).

T. Knudsen, D. Kochhar, 1981, Journal of embryology and experimental morphology.

Teratogenesis by retinoic acid analogs positively correlates with elevation of retinoic acid receptor-beta 2 mRNA levels in treated embryos.

H. Jiang, D. Kochhar, R. Chandraratna, 1994, Teratology.

Altered collagen fibrillogenesis in embryonic mouse limb cartilage deficient in matrix granules.

D. Kochhar, M. Aydelotte, T. Vest, 1976, Experimental cell research.

Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.

D. Kochhar, Jian Zhou, 2003, Birth defects research. Part A, Clinical and molecular teratology.

Teratogenicity of retinoic acid.

D. Kochhar, 2000, Teratology.

Chlorambucil-induced cell death in embryonic mouse limb buds.

D. Kochhar, T. Sadler, 1976, Toxicology and applied pharmacology.

Correlations of RAR isoforms and cellular retinoid-binding proteins mRNA levels with retinoid-induced teratogenesis.

H. Jiang, D. Kochhar, D. Soprano, 1993, The Journal of nutrition.

Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: consequences for teratogenicity.

H. Nau, D. Kochhar, I. Chahoud, 1991, Teratogenesis, carcinogenesis, and mutagenesis.

Low teratogenicity of 13-cis-retinoic acid (isotretinoin) in the mouse corresponds to low embryo concentrations during organogenesis: comparison to the all-trans isomer.

H. Nau, D. Kochhar, W. Scott, 1987, Toxicology and applied pharmacology.

Embryotoxic, teratogenic, and metabolic effects of ribavirin in mice.

T. Knudsen, D. Kochhar, J. Penner, 1980, Toxicology and applied pharmacology.

Retinoic acid enhances the displacement of newly synthesized hyaluronate from cell layer to culture medium during early phases of chondrogenesis.

D. Kochhar, J. Penner, T. Hickey, 1984, Cell differentiation.

Limb development in mouse embryos. II. Reduction defects, cytotoxicity and inhibition of DNA synthesis produced by cytosine arabinoside.

D. Kochhar, J. Penner, J. McDay, 1978, Teratology.

Biosynthesis of DNA, RNA and proteins by mouse embryos cultured in the presence of a teratogenic dose of chlorambucil.

D. Kochhar, T. Sadler, 1976, Journal of embryology and experimental morphology.

In vitro testing of teratogenic agents using mammalian embryos.

D. Kochhar, 1980, Teratogenesis, carcinogenesis, and mutagenesis.

Skeletal morphogenesis: comparative effects of a mutant gene and a teratogen.

D. Kochhar, 1985, Progress in clinical and biological research.

Influence of 6-diazo-5-oxo-L-norleucine (DON), a glutamine analogue, on cartilaginous differentiation in mouse limb buds in vitro.

D. Kochhar, M. Aydelotte, 1975, Differentiation; research in biological diversity.

Developmental changes in endogenous retinoids during pregnancy and embryogenesis in the mouse.

D. Kochhar, K. Ugen, M. Satre, 1992, Biology of reproduction.

Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid.

H. Jiang, D. Kochhar, J. Penner, 1996, Chemico-biological interactions.

Pharmacokinetic assessment of teratologically effective concentrations of an endogenous retinoic acid metabolite.

D. Kochhar, J. Penner, M. Satre, 1989, Teratology.

Morphological and autoradiographic studies of cleft palate induced in rat embryos by maternal hypervitaminosis A.

D. Kochhar, E. Johnson, 1965, Journal of embryology and experimental morphology.

Murine toxicology and pharmacology of UAB-8, a conformationally constrained analog of retinoic acid.

D. Kochhar, D. Hill, T. H. Lin, 1996, Toxicology and applied pharmacology.

Tretinoin: a review of the nonclinical developmental toxicology experience.

D. Kochhar, M. Christian, 1997, Journal of the American Academy of Dermatology.

Teratogenesis and Reproductive Toxicology

D. Kochhar, E. M. Johnson, S. Chao, 2011, Handbook of Experimental Pharmacology.

Biotransformation of etretinate and developmental toxicity of etretin and other aromatic retinoids in teratogenesis bioassays.

D. Kochhar, J. Penner, L. Minutella, 1989, Drug metabolism and disposition: the biological fate of chemicals.

The synthetic retinoid AGN 193109 but not retinoic acid elevates CYP1A1 levels in mouse embryos and Hepa-1c1c7 cells.

D. Kochhar, J. Gabriel, R. Chandraratna, 2001, Toxicology and applied pharmacology.

Alterations in the Metabolism of Glycosaminoglycans and Collagen

D. Kochhar, K. Larsson, 1977 .

Derivation of retinoic acid and metabolites from a teratogenic dose of retinol (vitamin A) in mice.

D. Kochhar, J. Penner, M. Satre, 1988, Toxicology and applied pharmacology.

Surface coat on the epithelium of developing palatine shelves in the mouse as revealed by electron microscopy.

D. Kochhar, R. Greene, By R. M. Greene, 1974, Journal of embryology and experimental morphology.

Spatial relations in the oral cavity of cortisone-treated mouse fetuses during the time of secondary palate closure.

D. Kochhar, R. Greene, 1973, Teratology.

Palatal closure in the mouse as demonstrated in frozen sections.

D. Kochhar, R. Greene, 1973, The American journal of anatomy.

Studies of vitamin A-induced teratogenesis: effects on embryonic mesenchyme and epithelium, and on incorporation of H3-thymidine.

D. Kochhar, 1968, Teratology.

"Chemical surgery" as an approach to study morphogenetic events in embryonic mouse limb.

D. Kochhar, N. Agnish, 1977, Developmental biology.

Abnormal Organogenesis in the Limbs

D. Kochhar, 1977 .

Limb development in mouse embryos. III. Cellular events underlying the determination of altered skeletal patterns following treatment with 5'fluoro-2-deoxyuridine.

T. Knudsen, D. Kochhar, 1981, Teratology.

Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid.

D. Kochhar, 1973, Teratology.

Developmental effects of isotretinoin and 4-oxo-isotretinoin: the role of metabolism in teratogenicity.

D M Kochhar, D. Kochhar, J. Penner, 1987, Teratology.

Comparative teratogenic activities of two retinoids: effects on palate and limb development.

D. Kochhar, J. Penner, C. Tellone, 1984, Teratogenesis, carcinogenesis, and mutagenesis.

Teratogenic effects of chlorambucil on in vivo and in vitro organogenesis in mice.

D. Kochhar, T. W. Salder., 1975, Teratology.

A selection of candidate compounds for in vitro teratogenesis test validation.

M K Smith, G L Kimmel, D M Kochhar, 1983, Teratogenesis, carcinogenesis, and mutagenesis.

Production of congenital limb defects with retinoic acid: Phenomenological evidence of progressive differentiation during limb morphogenesis

D. Kochhar, T. E. Kwasigroch, 2004, Anatomy and Embryology.

The role of somites in the growth and early development of mouse limb buds.

D. Kochhar, N. Agnish, 1977, Developmental biology.

Development of mouse limb buds in organ culture: chondrogenesis in the presence of a proline analog, L-azetidine-2-carboxylic acid.

D. Kochhar, M. Aydelotte, D. M. Kochhar, 1972, Developmental biology.

Some aspects of corticosteroid-induced cleft palate: a review.

D. Kochhar, R. Greene, 1975, Teratology.

Embryonic limb bud organ culture in assessment of teratogenicity of environmental agents.

D. Kochhar, 1982, Teratogenesis, carcinogenesis, and mutagenesis.

Transplacental passage of label after administration of (3H) retinoic acid (vitamin A acid) to pregnant mice.

D. Kochhar, 1976, Teratology.

Locomotory behavior of limb bud cells. Effect of excess vitamin A in vivo and in vitro.

D. Kochhar, T. E. Kwasigroch, T. Kwasigroch, 1975, Experimental cell research.

Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors.

S. Li, H. Jiang, D. Kochhar, 1995, The International journal of developmental biology.

Induction of RAR-β2 Gene Expression in Embryos and RAR-β2 Transactivation by the Synthetic Retinoid Ro 13-6307 Correlates with Its High Teratogenic Potency

H. Jiang, D. Kochhar, D. Soprano, 1993 .

Retinoic acid receptor β2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid‐gestation mouse embryos

H. Jiang, D. Kochhar, D. Soprano, 1992 .

Effects of retinoic acid treatment on release of arachidonic acid by chondrogenic cells in response to ionophore A23187.

D. Kochhar, K. Chepenik, P. Moon, 1986, Life sciences.

Criteria for identifying and listing substances known to cause developmental toxicity under California's Proposition 65.

D. Mattison, D. Kochhar, K. S. Rao, 1989, Reproductive toxicology.

Teratogenic activity of retinoic acid.

D. Kochhar, 2009, Acta pathologica et microbiologica Scandinavica.

Cellular anomalies underlying retinoid-induced phocomelia.

D. Kochhar, Jian Zhou, 2004, Reproductive toxicology.

Tretinoin: A review of the toxicology experience nonclinical developmental

D. Kochhar, M. Christian, 1997 .

Vitamin A alters the internal viscosity of fragments of limb-bud mesenchyme.

D. Kochhar, T. E. Kwasigroch, 1980, Journal of embryology and experimental morphology.

Influence of trypan blue and related compounds on 35S-sulfate metabolism of cartilage in vitro

D. Kochhar, K. Larsson, H. Boström, 1967 .

Elevations in the endogenous levels of the putative morphogen retinoic acid in embryonic mouse limb-buds associated with limb dysmorphogenesis.

D. Kochhar, M. Satre, 1989, Developmental biology.

An updated history of the Teratology Society.

R. Brent, D. Kochhar, J. M. Rogers, 2010, Birth defects research. Part A, Clinical and molecular teratology.

A sustained elevation in retinoic acid receptor-β2 mRNA and protein occurs during retinoic acid-induced fetal dysmorphogenesis

D. Kochhar, K. Ugen, D. Soprano, 1994, Mechanisms of Development.

Direct exposure of postimplantation mouse embryos to 5-bromodeoxyuridine in vitro and its effect on subsequent chondrogenesis in the limbs.

D. Kochhar, N. Agnish, 1976, Journal of embryology and experimental morphology.

Effects of exposure to high concentrations of ribavirin in developing embryos

D. Kochhar, 1990, The Pediatric infectious disease journal.

Effects of exposure to high concentrations of ribavirin in developing embryos

D. Kochhar, 1990, The Pediatric infectious disease journal.

Embryonic Organs in Culture

D. Kochhar, 1983 .

Embryonic uptake of S35-sulfate: change in level following treatment with some teratogenic agents.

D. Kochhar, K. Larsson, H. Boström, 1968, Biologia neonatorum. Neo-natal studies.

Placental transfer and developmental effects of 9-cis retinoic acid in mice.

H. Jiang, D. Kochhar, J. Penner, 1995, Teratology.

The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis.

T. Knudsen, D. Kochhar, 2010, Birth defects research. Part C, Embryo today : reviews.

Transplacental pharmacokinetics of teratogenic doses of etretinate and other aromatic retinoids in mice.

H. Nau, D. Kochhar, J. Reiners, 1988, Reproductive toxicology.

Computer-automated structure evaluation (CASE) of retinoids in teratogenesis bioassays.

M. Frierson, D. Kochhar, Manton R. Frierson, 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid.

D. Kochhar, 1973, Teratology.

Retinoid-induced limb malformations.

D. Kochhar, M. Collins, Grace S Lee, 2004, Current pharmaceutical design.

A history of the Teratology Society.

R. Brent, D. Kochhar, W. Scott, 2000, Teratology.

Elevated rate of DNA synthesis and its correlation to cAMP-phosphodiesterase activity during induction of polydactyly in mouse embryos heterozygous for Hemimelia-extra toe (Hmx).

T. Knudsen, D. Kochhar, W. A. Elmer, 1985, Teratology.

Retinoids and Retinoid Receptors in Teratogenesis *

D. Kochhar, 1995 .

Evidence that retinoic acid-induced apoptosis in the mouse limb bud core mesenchymal cells is gene-mediated.

H. Jiang, D. Kochhar, D. Soprano, 1993, Progress in clinical and biological research.

Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.

D. Kochhar, R. Chandraratna, P. Davies, 1996, Journal of medicinal chemistry.

Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids.

H. Jiang, D. Kochhar, R. Chandraratna, 1995, Biochemical pharmacology.

Direct exposure of mouse embryonic limb-buds to 5-bromodeoxyuridine in vitro and its effect on chondrogenesis: increasing resistance to the analog at successive stages of development.

D. Kochhar, N. Agnish, 1976, Journal of embryology and experimental morphology.

An updated history of the Teratology Society.

R. Brent, D. Kochhar, W. Scott, 2010, Birth defects research. Part A, Clinical and molecular teratology.