D. Christini

发表

Time series modeling of heart rate dynamics

Jeffrey M. Hausdorff, David J. Christini, Kenneth R. Lutchen, 1993, Proceedings of Computers in Cardiology Conference.

Application of linear and nonlinear time series modeling to heart rate dynamics analysis

K. Lutchen, J. Hausdorff, D. Christini, 1995, IEEE Transactions on Biomedical Engineering.

DYNAMIC CONTROL OF CARDIAC ALTERNANS

L. Glass, J. Collins, D. Christini, 1997 .

NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria

D. Christini, P. Heerdt, Ritu Kant, 2013, PloS one.

Therapies for ventricular cardiac arrhythmias.

Peter N. Jordan, D. Christini, P. N. Jordan, 2005, Critical reviews in biomedical engineering.

Exploiting mathematical models to illuminate electrophysiological variability between individuals

Amrita X. Sarkar, E. Sobie, D. Christini, 2012, The Journal of physiology.

The Relative Influences of Phosphometabolites and pH on Action Potential Morphology during Myocardial Reperfusion: A Simulation Study

D. Christini, B. N. Roberts, 2012, PloS one.

A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms

N. Trayanova, C. Ripplinger, Lianguo Wang, 2011, Science Translational Medicine.

Slow [Na+]i dynamics impacts arrhythmogenesis and spiral wave reentry in cardiac myocyte ionic model.

D. Christini, T. Krogh-Madsen, 2017, Chaos.

Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia.

Francis A. Ortega, R. Coronel, E. Vigmond, 2020, Journal of molecular and cellular cardiology.

Calibration of ionic and cellular cardiac electrophysiology models

Gary R. Mirams, Dominic G. Whittaker, G. Mirams, 2020, Wiley interdisciplinary reviews. Systems biology and medicine.

The role of nonlinear dynamics in cardiac arrhythmia control.

B B Lerman, K M Stein, S M Markowitz, 1999, Heart disease.

A Human Embryonic Stem Cell Reporter Line for Monitoring Chemical-induced Cardiotoxicity.

Francis A. Ortega, D. Christini, T. Evans, 2019, Cardiovascular research.

Mechanism Underlying Initiation of Paroxysmal Atrial Flutter/Atrial Fibrillation by Ectopic Foci: A Simulation Study

Alan Garfinkel, David J Christini, Fagen Xie, 2007, Circulation.

Critical role of inhomogeneities in pacing termination of cardiac reentry.

David J. Christini, Sitabhra Sinha, Kenneth M. Stein, 2002, Chaos.

Influence of autoregressive model parameter uncertainty on spectral estimates of heart rate dynamics

Jeffrey M. Hausdorff, David J. Christini, Kenneth R. Lutchen, 1995, Annals of Biomedical Engineering.

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility

Trine Krogh-Madsen, Francis A. Ortega, Eric A Sobie, 2017, The Journal of physiology.

Direct biologically based biosensing of dynamic physiological function.

D. Christini, J. Edelberg, J. Walden, 2001, American journal of physiology. Heart and circulatory physiology.

Voltage and calcium dynamics both underlie cellular alternans in cardiac myocytes.

Trine Krogh-Madsen, Francis A. Ortega, Willemijn Groenendaal, 2014, Biophysical journal.

Non-Linear Dynamics of Cardiac Alternans: Subcellular to Tissue-Level Mechanisms of Arrhythmia

David J. Christini, D. Christini, S. Gaeta, 2012, Front. Physio..

Action potential voltage alternans: an indicator of calcium handling dysfunction during heart failure?

D. Christini, 2010, Heart rhythm.

Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model

David J. Christini, Bruce B. Lerman, Anil Maybhate, 2005, IEEE Transactions on Biomedical Engineering.

Improving the utility of T-wave alternans by quantifying its relationship to underlying action-potential duration alternans.

D. Christini, 2009, Heart rhythm.

Implantable cardioverter-defibrillator detection of repolarization alternans: uncovering a marker of electrical instability.

B. Lerman, D. Christini, 2006, Heart rhythm.

Anthropomorphizing the mouse cardiac action potential via a novel dynamic clamp method.

D. Christini, R. Ahrens-Nicklas, 2009, Biophysical journal.

Antispiral waves cannot occur in the heart: implications for the leading-circle theory of reentry

D. Christini, Y. Gong, 2003, 2003 IEEE 29th Annual Proceedings of Bioengineering Conference.

Structural Barrier Increases QT-peak Dispersion in Swine Left Ventricle in Vivo

B. Lerman, D. Christini, K. Stein, 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

Off-site control of repolarization alternans in cardiac fibers.

A. Karma, R. Gilmour, D. Christini, 2010, Physical review. E, Statistical, nonlinear, and soft matter physics.

Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis

D. Christini, T. Krogh-Madsen, Tashalee R. Brown, 2015, BioMed research international.

Detection of repolarization alternans with an implantable cardioverter defibrillator lead

B. Lerman, A. Maybhate, D. Christini, 2003, 2003 IEEE 29th Annual Proceedings of Bioengineering Conference.

An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms

D. Christini, T. Krogh-Madsen, DA Kalola, 2022, British journal of pharmacology.

Leak current, even with gigaohm seals, can cause misinterpretation of stem-cell derived cardiomyocyte action potential recordings

G. Mirams, D. Christini, T. Krogh-Madsen, 2022, bioRxiv.

Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy.

D. Christini, P. Heerdt, Ritu Kant, 2012, Journal of molecular and cellular cardiology.

Time Course and Predictors of Autonomic Dysfunction After Ablation of the Slow Atrioventricular Nodal Pathway

S. Markowitz, B. Lerman, D. Christini, 2004, Pacing and clinical electrophysiology : PACE.

Pacing-induced spatiotemporal dynamics can be exploited to improve reentry termination efficacy.

D. Christini, T. Krogh-Madsen, Trine Krogh-Madsen, 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

NHE Inhibition Does Not Improve Na+ or Ca2+ Overload During Reperfusion: Using Modeling to Illuminate the Mechanisms Underlying a Therapeutic Failure

David J. Christini, Byron N. Roberts, D. Christini, 2011, PLoS Comput. Biol..

Nonlinear-dynamical arrhythmia control in humans

B B Lerman, D J Christini, K M Stein, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study

Trine Krogh-Madsen, David J. Christini, Geoffrey W. Abbott, 2012, PLoS Comput. Biol..

Functional reentrant waves propagate outwardly in cardiac tissue

D. Christini, Y. Gong, 2004 .

Control of Action Potential Duration Alternans in Canine Cardiac Ventricular Tissue

David J. Christini, Robert F. Gilmour, Shahriar Iravanian, 2011, IEEE Transactions on Biomedical Engineering.

A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance.

H. Ostrer, W. Chung, C. Basson, 2008, Cardiovascular research.

Kcne2 Deletion Creates a Multisystem Syndrome Predisposing to Sudden Cardiac Death

Elizabeth C. King, D. Christini, Ritu Kant, 2014, Circulation. Cardiovascular genetics.

MinK-dependent internalization of the IKs potassium channel.

D. Christini, G. Abbott, T. K. Roepke, 2009, Cardiovascular research.

Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f

D. Christini, G. Abbott, F. Akar, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death.

Elizabeth C. King, D. Christini, Ritu Kant, 2014 .

A ug 2 00 0 Restricted feedback control of one-dimensional maps

D. Christini, K. Hall, 2008 .

Termination of reentry in an inhomogeneous ring of model cardiac cells.

Sitabhra Sinha, David J Christini, S. Sinha, 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI)

David J. Christini, Robert J. Butera, John A. White, 2017, PLoS Comput. Biol..

Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.

Colleen E Clancy, David J Christini, D. Christini, 2009, Cardiovascular research.

Practical Real-Time Computing System for Biomedical Experiment Interface

David J. Christini, Bruce B. Lerman, Kenneth M. Stein, 1999, Annals of Biomedical Engineering.

Cell-Specific Cardiac Electrophysiology Models

Trine Krogh-Madsen, Francis A. Ortega, David J. Christini, 2015, PLoS Comput. Biol..

Real-Time Linux Dynamic Clamp: A Fast and Flexible Way to Construct Virtual Ion Channels in Living Cells

David J. Christini, John A. White, Alan D. Dorval, 2001, Annals of Biomedical Engineering.

Introduction: Mapping and control of complex cardiac arrhythmias.

David J. Christini, Leon Glass, L. Glass, 2002, Chaos.

Genetically Engineered Biologically Based Hemostatic Bioassay

D. Christini, J. Edelberg, Lilong Tang, 2003, Annals of Biomedical Engineering.

Enhanced myocyte-based biosensing of the blood-borne signals regulating chronotropy.

D. Christini, J. Edelberg, J. Jacobson, 2002, Journal of applied physiology.

Chapter 6 Controlling cardiac arrhythmias: The relevance of nonlinear dynamics

David J. Christini, Leon Glass, James J. Collins, 2001 .

Real-time, adaptive, model-independent control of low-dimensional chaotic and nonchaotic dynamical systems

David J. Christini, J. Collins, D. Christini, 1997 .

Determining the effects of memory and action potential duration alternans on cardiac restitution using a constant-memory restitution protocol.

Peter N. Jordan, D. Christini, 2004, Physiological measurement.

Action potential duration dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier.

Trine Krogh-Madsen, David J Christini, D. Christini, 2007, Biophysical journal.

Spatiotemporal dynamics of pacing in models of anatomical reentry

S. Sinha, D. Christini, 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Nonlinear dynamics in cardiology.

Trine Krogh-Madsen, David J Christini, D. Christini, 2012, Annual review of biomedical engineering.

Light-Activated Dynamic Clamp Using iPSC-Derived Cardiomyocytes.

E. Entcheva, D. Christini, T. Krogh-Madsen, 2018, Biophysical journal.

Real-time Experiment Interface for biological control applications

David J. Christini, Robert J. Butera, John A. White, 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans.

Peter N. Jordan, David J Christini, D. Christini, 2006, Biophysical journal.

Adaptive cardiac arrhythmia control: what are the prospects?

David J. Christini, D. Christini, 2003, Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).

Endocardial detection of repolarization alternans

David J. Christini, David J. Slotwiner, Bruce B. Lerman, 2003, IEEE Transactions on Biomedical Engineering.

Endocardial detection of repolarization alternans

S. Markowitz, B. Lerman, D. Christini, 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes

Francis A. Ortega, R. Robinson, D. Christini, 2017, PloS one.

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

Trine Krogh-Madsen, David J. Christini, Eric A. Sobie, 2016, The Journal of physiology.

Optical mapping system with real-time control capability.

Shahriar Iravanian, David J Christini, S. Iravanian, 2007, American journal of physiology. Heart and circulatory physiology.

Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study.

Trine Krogh-Madsen, David J Christini, D. Christini, 2010, Journal of theoretical biology.

Dynamical Mechanism for Subcellular Alternans in Cardiac Myocytes

Gil Bub, David J Christini, D. Christini, 2009, Circulation research.

REAL-TIME EXPERIMENTAL CONTROL OF A SYSTEM IN ITS CHAOTIC AND NONCHAOTIC REGIMES

Visarath In, David J. Christini, William L. Ditto, 1997 .

A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells

Francis A. Ortega, D. Christini, L. Studer, 2022, iScience.

Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

Trine Krogh-Madsen, Francis A. Ortega, David J. Christini, 2018, Front. Physiol..

Effect of β-adrenergic blockade on dynamic electrical restitution in vivo

David J. Christini, Bruce B. Lerman, Peter N. Jordan, 2004 .

Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp.

Trine Krogh-Madsen, David J Christini, D. Christini, 2016, Biophysical journal.

Dynamic clamp in cardiac and neuronal systems using RTXI.

Francis A. Ortega, Alan D Dorval, David J Christini, 2014, Methods in molecular biology.

Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans.

Peter N. Jordan, David J Christini, D. Christini, 2007, American journal of physiology. Heart and circulatory physiology.

Control of chaos in excitable physiological systems: A geometric analysis.

David J. Christini, J. Collins, D. Christini, 1997, Chaos.

Peter N. Jordan, D. Christini, G. Abbott, 2003, The Journal of Neuroscience.

Cardiac myocyte model parameter sensitivity analysis and model transformation using a genetic algorithm

Francis A. Ortega, David J. Christini, Armen Kherlopian, 2011, GECCO.

Rapid Genetic Algorithm Optimization of a Mouse Computational Model: Benefits for Anthropomorphization of Neonatal Mouse Cardiomyocytes

Trine Krogh-Madsen, Francis A. Ortega, David J. Christini, 2012, Front. Physio..

A model-guided pipeline for drug cardiotoxicity screening with human stem-cell derived cardiomyocytes

D. Christini, T. Krogh-Madsen, Siyu Wei, 2021 .

Dependence of phase-2 reentry and repolarization dispersion on epicardial and transmural ionic heterogeneity: a simulation study.

D. Christini, T. Krogh-Madsen, Anat Maoz, 2014, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Instability in action potential morphology underlies phase 2 reentry: a mathematical modeling study.

D. Christini, T. Krogh-Madsen, Anat Maoz, 2009, Heart rhythm.

Optimization of a Cardiomyocyte Model Illuminates Role of Increased INaL in Repolarization Reserve

D. Christini, T. Krogh-Madsen, Alexander P. Clark, 2023, bioRxiv.

Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes

Trine Krogh-Madsen, Anna F. Jacobson, Francis A. Ortega, 2017, Front. Physiol..

Antispiral waves in reaction-diffusion systems.

David J Christini, Yunfan Gong, D. Christini, 2003, Physical review letters.

Control of electrical alternans in canine cardiac purkinje fibers.

Robert F Gilmour, Alain Karma, David J Christini, 2006, Physical review letters.

Complex AV nodal dynamics during ventricular-triggered atrial pacing in humans.

S. Markowitz, B. Lerman, D. Christini, 2001, American journal of physiology. Heart and circulatory physiology.

Nonlinear dynamics in cardiology.

D. Christini, Trine Krogh-Madsen, 2012, Annual review of biomedical engineering.

Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.

D. Christini, C. Clancy, Rebecca C Ahrens-Nicklas, 2009, Cardiovascular Research.

Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study

D. Christini, G. Abbott, Trine Krogh-Madsen, 2012, PLoS Comput. Biol..

Resetting and termination of reentry in a loop-and-tail cardiac model.

Trine Krogh-Madsen, David J Christini, D. Christini, 2008, Physical review. E, Statistical, nonlinear, and soft matter physics.

A Class of Monte-Carlo-Based Statistical Algorithms for Efficient Detection of Repolarization Alternans

David J. Christini, Shahriar Iravanian, Uche B. Kanu, 2012, IEEE Transactions on Biomedical Engineering.

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

E. Sobie, D. Christini, Trine Krogh-Madsen, 2016, The Journal of physiology.