D. Newcomb

发表

Association of estrogen receptor α polymorphism rs1999805 with asthma.

L. Bastarache, Melissa H. Bloodworth, Mark Rusznak, 2019, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation.

K. Boyd, R. Peebles, Melissa H. Bloodworth, 2017, Cell reports.

Estrogen receptor‐α signaling increases allergen‐induced IL‐33 release and airway inflammation

H. Kita, D. Newcomb, R. Shah, 2020, Allergy.

Hormones, sex, and asthma.

D. Newcomb, Hubaida Fuseini, Jeffrey A. Yung, 2018, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

E. Morrisey, D. Newcomb, T. Blackwell, 2011, Proceedings of the National Academy of Sciences.

Birth control medications decrease asthma incidence.

D. Newcomb, 2020, The Journal of allergy and clinical immunology.

Syncytial Virus Infection Il-4 Expression Induced by Respiratory Stat1 Negatively Regulates Lung Basophil Stat1 Negatively Regulates Lung Basophil Il-4 Expression Induced by Respiratory Syncytial Virus Infection Il-4 Contributes to Immunopathology Induced in Mice by Primary Respiratory Syncytial Vir

Vrajesh V. Parekh, L. Kaer, D. Mitchell, 2022 .

STAT1 Negatively Regulates Lung Basophil IL-4 Expression Induced by Respiratory Syncytial Virus Infection1

Vrajesh V. Parekh, D. Mitchell, J. Boyce, 2009, The Journal of Immunology.

Bugs and asthma: a different disease?

R. Peebles, D. Newcomb, 2009, Proceedings of the American Thoracic Society.

STAT 6-Independent Allergic Lung CD 4 T Cell Activation , and Proinflammatory Chemokine Expression , Suppresses 2 Prostaglandin

Pingsheng Wu, M. Boothby, R. Peebles, 2016 .

Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation

Pingsheng Wu, M. Boothby, R. Peebles, 2016, The Journal of Immunology.

Identification of Residues in the Human Respiratory Syncytial Virus Fusion Protein That Modulate Fusion Activity and Pathogenesis

R. Plemper, J. Crowe, R. Peebles, 2014, Journal of Virology.

PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.

J. Morrow, S. Biswal, Pingsheng Wu, 2011, American journal of physiology. Lung cellular and molecular physiology.

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.

F. Polack, S. Kleeberger, M. Boothby, 2015, The Journal of clinical investigation.

State of the Art Bugs and Asthma A Different Disease?

R. Peebles, D. Newcomb, 2009 .

IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation

J. Kolls, R. Peebles, D. Newcomb, 2013, Thorax.

Cooperative effects of rhinovirus and TNF-α on airway epithelial cell chemokine expression

D. Newcomb, M. Hershenson, U. Sajjan, 2007 .

Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.

S. Johnston, S. Nanua, D. Newcomb, 2008, American journal of respiratory and critical care medicine.

Estrogen and progesterone decrease Let-7f miRNA expression and increase IL-23/IL-23R signaling and IL-17A production in severe asthma

Weisong, J. Fahrenholz, J. Kolls, 2015 .

The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2 – mediated Allergic Airway In ﬂ ammation

Eric P. Skaar, W. Chazin, K. Boyd, 2019 .

Phosphatidylinositol 3-Kinase Is Required for Rhinovirus-induced Airway Epithelial Cell Interleukin-8 Expression*

S. Nanua, D. Newcomb, M. Hershenson, 2005, Journal of Biological Chemistry.

The PGI2 Analog Cicaprost Inhibits IL-33–Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells

R. Peebles, Melissa H. Bloodworth, D. Newcomb, 2018, The Journal of Immunology.

Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model.

R. Peebles, D. Newcomb, W. Lawson, 2018, Prostaglandins & other lipid mediators.

Glucagon‐like peptide 1 signaling inhibits allergen‐induced lung IL‐33 release and reduces group 2 innate lymphoid cell cytokine production in vivo

A. Galli, K. Boyd, R. Peebles, 2018, The Journal of allergy and clinical immunology.

Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

S. Mallal, D. Broide, R. Peebles, 2015, American journal of respiratory and critical care medicine.

Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.

G. FitzGerald, Pingsheng Wu, G. Milne, 2014, The Journal of allergy and clinical immunology.

PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells

G. FitzGerald, R. Peebles, D. Newcomb, 2013, Journal of leukocyte biology.

PGI2 as a regulator of CD4+ subset differentiation and function.

R. Peebles, D. Newcomb, Weisong Zhou, 2011, Prostaglandins & other lipid mediators.

Cyclooxygenase Inhibition during Allergic Sensitization Increases STAT6-Independent Primary and Memory Th2 Responses1

R. Peebles, D. Newcomb, M. Moore, 2008, The Journal of Immunology.

β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin.

Peter F. Crossno, L. Gleaves, D. Newcomb, 2013, American journal of respiratory and critical care medicine.

Running Title: Allergic inflammation decreases lung Klebsiella burden

K. Boyd, J. Kolls, R. Peebles, 2014 .

Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD.

A. Gaggar, J. Blalock, C. Lal, 2020, The Journal of clinical investigation.

IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow

R. Peebles, Mark Rusznak, D. Newcomb, 2018, The Journal of experimental medicine.

STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection

K. Boyd, J. Kolls, R. Peebles, 2017, The Journal of Immunology.

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

K. Boyd, T. Hartert, R. Peebles, 2016, The Journal of allergy and clinical immunology.

IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia.

S. Brody, K. Boyd, J. Kolls, 2013, American journal of respiratory cell and molecular biology.

Differential Pathogenesis of Respiratory Syncytial Virus Clinical Isolates in BALB/c Mice

R. Peebles, D. Newcomb, M. Moore, 2011, Journal of Virology.

A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction

J. Crowe, R. Peebles, D. Newcomb, 2009, Journal of Virology.

Proliferation of the airway epithelium in asthma: are inflammatory cells required?

K. Adler, D. Newcomb, J. Bonner, 2003, Chest.

Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.

D. Newcomb, M. Hershenson, U. Sajjan, 2007, American journal of physiology. Lung cellular and molecular physiology.

STAT6 Signaling Attenuates Interleukin-17-Producing (cid:2)(cid:3) T Cells during Acute Klebsiella pneumoniae Infection

J. Kolls, R. Peebles, Melissa H. Bloodworth, 2016 .

COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice

Pingsheng Wu, H. Kita, K. Boyd, 2020, The Journal of Immunology.

Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production.

J. Kolls, R. Peebles, D. Newcomb, 2011, The Journal of allergy and clinical immunology.

R. Peebles, D. Newcomb, Joyce Cheung-Flynn, 2016, American journal of respiratory cell and molecular biology.

Metabolic Reprogramming of Nasal Airway Epithelial Cells Following Infant Respiratory Syncytial Virus Infection

T. Hartert, D. Newcomb, S. Berdnikovs, 2021, Viruses.

A Functional IL-13 Receptor is Expressed on Polarized Murine CD4 + Th17 Cells and IL-13 Signaling Negatively Regulates Th17 Cytokine Production

J. Kolls, R. Peebles, D. Newcomb, 2009 .

Th17-mediated inflammation in asthma.

R. Peebles, D. Newcomb, Dawn C Newcomb, 2013, Current opinion in immunology.

Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation

J. Beckman, O. Boutaud, R. Printz, 2022, JACC. Basic to translational science.

Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species

J. Netterville, C. Stratton, J. Gaddy, 2016, The Laryngoscope.

Idiopathic subglottic stenosis is associated with activation of the inflammatory IL‐17A/IL‐23 axis

J. Netterville, C. Stratton, J. Gaddy, 2016, The Laryngoscope.

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

I. Noth, G. Bernard, G. Ayers, 2018, Science Translational Medicine.

Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD

Lei Jin, D. Newcomb, T. Blackwell, 2020, Mucosal immunology.

Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice

J. W. Lee, J. Loyd, L. Ware, 2012, Experimental lung research.

A Functional IL-13 Receptor Is Expressed on Polarized Murine CD4+ Th17 Cells and IL-13 Signaling Attenuates Th17 Cytokine Production1

Martin L. Moore, Jay K. Kolls, J. Kolls, 2009, The Journal of Immunology.

Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.

L. Bastarache, K. Boyd, T. Hartert, 2018, The Journal of allergy and clinical immunology.

Mechanisms Driving Gender Differences in Asthma

D. Newcomb, Hubaida Fuseini, 2017, Current Allergy and Asthma Reports.

IL-13 Regulates Th17 Secretion of IL-17A in an IL-10–Dependent Manner

J. Kolls, R. Peebles, D. Newcomb, 2012, The Journal of Immunology.

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

J. Locasale, Pingsheng Wu, W. Rathmell, 2018, Cell.

Testosterone Decreases House Dust Mite–Induced Type 2 and IL-17A–Mediated Airway Inflammation

R. Peebles, D. Newcomb, Hubaida Fuseini, 2018, The Journal of Immunology.

H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM‐1 and TLR3 expression

D. Newcomb, J. Lipuma, N. Lukacs, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation

J. Bastarache, L. Ware, D. Newcomb, 2022, The Journal of clinical investigation.

Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming.

T. Chatila, D. Aronoff, L. Bastarache, 2021, The Journal of clinical investigation.

STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8+ T Cell Immune Response to Secondary Challenge

J. Crowe, J. Bates, K. Boyd, 2014, Journal of Virology.

Sex and gender in asthma

D. Newcomb, M. Wechsler, V. Guntur, 2021, European Respiratory Review.

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.

J. Rabinowitz, J. Rathmell, John Karijolich, 2021, Immunity.

Glucagon‐like peptide‐1 receptor agonist inhibits aeroallergen‐induced activation of ILC2 and neutrophilic airway inflammation in obese mice

R. Printz, K. Boyd, R. Peebles, 2021, Allergy.

Hormones, sex, and asthma.

D. Newcomb, Hubaida Fuseini, Jeffrey A. Yung, 2018, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Sex Bias in Asthma Prevalence and Pathogenesis

D. Newcomb, R. Shah, Ruchi Shah, 2018, Front. Immunol..

Sex-specific association between prenatal life stress exposure and infant pro-inflammatory cytokine levels during acute respiratory infection

L. Anderson, T. Hartert, T. Gebretsadik, 2019, Brain, Behavior, and Immunity.

STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection

J. Kolls, R. Peebles, Melissa H. Bloodworth, 2016, Infection and Immunity.

Production IL-13 Signaling Attenuates Th 17 Cytokine Th 17 Cells and + Polarized Murine CD 4 A Functional IL-13 Receptor Is Expressed

J. Kolls, R. Peebles, D. Newcomb, 2009 .

Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation

Sierra M. Barone, Kellen L. Olszewski, J. Locasale, 2021, The Journal of Immunology.

Allergic Airway Inflammation Decreases Lung Bacterial Burden following Acute Klebsiella pneumoniae Infection in a Neutrophil- and CCL8-Dependent Manner

K. Boyd, J. Kolls, R. Peebles, 2014, Infection and Immunity.

IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development

R. Mitra, C. M. Eischen, R. Peebles, 2019, The Journal of Immunology.

TSLP and IL‐33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type‐2 airway inflammation

Kelli L Boyd, H. Kita, K. Boyd, 2020, Allergy.

Deficiency of gp91phox inhibits allergic airway inflammation.

K. Boyd, R. Peebles, D. Newcomb, 2013, American journal of respiratory cell and molecular biology.

Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease

L. Crofford, W. Drake, L. Lancaster, 2023, bioRxiv.

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism

J. Rathmell, R. Peebles, D. Newcomb, 2023, bioRxiv.

Repetitive Sulfur Dioxide Exposure in Mice Models Post-Deployment Respiratory Syndrome

Wei Han, D. Newcomb, T. Blackwell, 2023, bioRxiv.

ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

Pingsheng Wu, J. Rathmell, D. Newcomb, 2019, Front. Immunol..

Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.

J. Fahrenholz, J. Kolls, R. Peebles, 2015, The Journal of allergy and clinical immunology.

Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice.

D. Mitchell, H. Yin, R. Peebles, 2010, American journal of respiratory cell and molecular biology.

Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.

E. Eves, M. Rosner, D. Newcomb, 2004, American journal of respiratory and critical care medicine.

The Innate Immune Protein S100A9 Protects from Th2-Mediated Allergic Airway Inflammation.

Eric P. Skaar, W. Chazin, K. Boyd, 2019, American journal of respiratory cell and molecular biology.

Sex Differences in Adaptive Immunity in Chronic Lung Disease

D. Newcomb, Vivek D. Gandhi, Nowrin U. Chowdhury, 2021 .

Sex, Gender, and Asthma

D. Newcomb, 2016 .

The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation

K. Boyd, R. Peebles, Melissa H. Bloodworth, 2016, Thorax.

Rhinovirus Activates Interleukin-8 Expression via a Src/p110β Phosphatidylinositol 3-Kinase/Akt Pathway in Human Airway Epithelial Cells

D. Newcomb, M. Hershenson, U. Sajjan, 2006, Journal of Virology.

Prostaglandin I2 Signaling Drives Th17 Differentiation and Exacerbates Experimental Autoimmune Encephalomyelitis

G. FitzGerald, Pingsheng Wu, R. Breyer, 2012, PloS one.

Running Title: Rhinovirus, Src and PI 3-kinase

D. Newcomb, M. Hershenson, U. Sajjan, 2006 .

Effect of Infant RSV Infection on Memory T Cell Responses at Age 2-3 Years

P. Gergen, W. Dupont, T. Hartert, 2022, Frontiers in Immunology.

Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease

L. Crofford, W. Drake, L. Lancaster, 2023, Cells.

Cellular and systemic energy metabolic dysregulation in asthma development- a hypothesis-generating approach.

T. Hartert, T. Gebretsadik, D. Newcomb, 2021, The Journal of allergy and clinical immunology.

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

J. Rabinowitz, J. Rathmell, John Karijolich, 2021, bioRxiv.

Sex hormones, gender and asthma

D. Newcomb, Hubaida Fuseini, Jeffrey A. Yung, 2018 .

Th17-mediated inflammation in asthma.

R. Peebles, D. Newcomb, 2013, Current opinion in immunology.

Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

D. Broide, Melissa H. Bloodworth, D. Newcomb, 2015, American journal of respiratory and critical care medicine.

Association of estrogen receptor α polymorphism rs1999805 with asthma.

L. Bastarache, Melissa H. Bloodworth, Mark Rusznak, 2019, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.

J. Fahrenholz, D. Newcomb, J. Cephus, 2015, The Journal of allergy and clinical immunology.

Dual GIPR and GLP-1R agonist tirzepatide inhibits aeroallergen-induced allergic airway inflammation in mouse model of obese asthma

R. Printz, R. Peebles, K. Niswender, 2022, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Repetitive Sulfur Dioxide Exposure in Mice Models Post-Deployment Respiratory Syndrome.

Wei Han, D. Newcomb, T. Blackwell, 2024, American journal of physiology. Lung cellular and molecular physiology.

Building Career Paths for Ph.D., Basic and Translational Scientists in Clinical Departments in the United States: An Official American Thoracic Society Workshop Report

V. Keshamouni, T. Mariani, S. Violette, 2023, Annals of the American Thoracic Society.