Shijie Chen

发表

Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening.

Hualiang Jiang, M. Zheng, Yan Liu, 2015, Journal of medicinal chemistry.

Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.

Hualiang Jiang, M. Zheng, T. Lu, 2014, Journal of medicinal chemistry.

Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family.

Hao Jiang, Cheng Luo, Mingyue Zheng, 2017, Journal of medicinal chemistry.

Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors.

Kaixian Chen, C. Luo, Na Liu, 2018, Bioorganic chemistry.

Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay.

Kaixian Chen, Hualiang Jiang, C. Luo, 2018, Bioorganic & medicinal chemistry.

Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening.

Hong Liu, Shien Liu, C. Luo, 2018, European journal of medicinal chemistry.

Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.

Hao Jiang, Cheng Luo, Fei Ye, 2017, Journal of medicinal chemistry.

Metadynamics Simulation Study on the Conformational Transformation of HhaI Methyltransferase: An Induced-Fit Base-Flipping Hypothesis

Hualiang Jiang, M. Zheng, Lu Jin, 2014, BioMed research international.

Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors.

Hao Jiang, C. Luo, Na Liu, 2018, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of 2-aminopyridine derivatives as USP7 inhibitors.

Kaixian Chen, Xiaoming Xu, Na Liu, 2022, Bioorganic chemistry.

Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties

X. Kong, C. Luo, Shijie Chen, 2022, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of protein arginine methyltransferase 1 alleviates liver fibrosis by attenuating the activation of hepatic stellate cells in mice

F. Liu, Shijie Chen, Fang Yan, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments

Zhenguo Chen, Shijie Chen, Zhenghong Yuan, 2022, Nature Communications.

FMRP phosphorylation modulates neuronal translation through YTHDF1

P. Jin, Hailing Shi, X. Zhuang, 2022, bioRxiv.

Design and synthesis of novel benzimidazole-iminosugars linked a substituted phenyl group and their inhibitory activities against β-glucosidase.

Xiaoming Xu, Shijie Chen, Xiao-liu Li, 2022, Bioorganic chemistry.

Spiroarborin, an ent-Clerodane Homodimer from Callicarpa arborea as an Inhibitor of the Eleven-Nineteen Leukemia (ENL) Protein by Targeting the YEATS Domain.

C. Luo, Shijie Chen, Debing Pu, 2022, Journal of natural products.

The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

C. Luo, Shijie Chen, Kai-xian Chen, 2018, Molecular Cancer.

Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC.

Hualiang Jiang, Xiaoming Xu, C. Luo, 2023, European journal of medicinal chemistry.

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors

Leping Li, Min Huang, Lin-jiang Tong, 2022, Cell Research.

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

H. Ding, Shijie Chen, Yuanyuan Zhang, 2021, Acta Pharmacologica Sinica.

Discovery of New Small Molecule Inhibitors of the BPTF Bromodomain

N. Lu, Shijie Chen, Naixia Zhang, 2023, Bioorganic Chemistry.

Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.

Hao Jiang, Cheng Luo, Zhifeng Chen, 2017, Organic & biomolecular chemistry.

Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism

C. Luo, Shijie Chen, Bing Zhou, 2020, Cancer Research.

High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases

Kaixian Chen, Hualiang Jiang, C. Luo, 2021, Nucleic acids research.

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.

Cheng Luo, Jing Chen, Chuan He, 2015, Nature chemistry.

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.

S. Baylin, Kunqian Yu, Hualiang Jiang, 2018, ACS chemical biology.

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Hao Jiang, C. Luo, H. Ding, 2018, Acta Pharmacologica Sinica.

Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays.

Cheng Luo, Rukang Zhang, Zhiyuan Shao, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a novel 53BP1 inhibitor through AlphaScreen-based high-throughput screening.

C. Luo, Shijie Chen, Hua Lin, 2021, Bioorganic & medicinal chemistry.

Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays

Jin Zhang, Yuanyuan Zhang, Shijie Chen, 2016, J. Chem. Inf. Model..

Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α

Jingwei Shao, Jin Ding, Jifeng Feng, 2019, Theranostics.

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

C. Luo, H. Ding, Shijie Chen, 2021, Acta Pharmacologica Sinica.

Selective PPARγ modulator diosmin improves insulin sensitivity and promotes browning of white fat

Shijie Chen, Junjie Xiao, Jin Li, 2023, The Journal of biological chemistry.

Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity.

Yonghui Wang, Shijie Chen, Ming-cheng Yu, 2023, European journal of medicinal chemistry.

Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and “long” inverse agonists

Xiao-min Luo, C. Luo, Shijie Chen, 2020, Acta Pharmacologica Sinica.

Discovery of betulinaldehyde as a natural RORγt agonist.

Xiaomin Luo, C. Luo, Shijie Chen, 2019, Fitoterapia.

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

Kaixian Chen, Hualiang Jiang, C. Luo, 2020, Advanced science.

YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.

R. Weichselbaum, Chuan He, C. Luo, 2023, Cancer cell.

Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-terminal (BET) Bromodomain Inhibitors.

Hualiang Jiang, C. Luo, Shijie Chen, 2020, Journal of medicinal chemistry.

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Hao Jiang, C. Luo, H. Ding, 2018, Acta Pharmacologica Sinica.

Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists.

Yonghui Wang, Shijie Chen, Ming-cheng Yu, 2023, European journal of medicinal chemistry.

Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF).

Shijie Chen, C. Luo, Mingchen Wang, 2023, Bioorganic chemistry.

Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma

Kaixian Chen, Hualiang Jiang, M. Zheng, 2018, Oncogenesis.

Discovery of GPX4 inhibitors through FP-based high-throughput screening

Shijie Chen, Hua Lin, C. Luo, 2023, European Journal of Medicinal Chemistry.

Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays

Kaixian Chen, Hualiang Jiang, M. Zheng, 2016, J. Chem. Inf. Model..