D. Drexler

发表

Beyond classical derivatization: analyte 'derivatives' in the bioanalysis of endogenous and exogenous compounds.

Omar S Barnaby, Yulia Benitex, Joseph L. Cantone, 2015, Bioanalysis.

Normalization strategies for metabonomic analysis of urine samples.

B. Warrack, M. Reily, K. Ott, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Acoustic Sample Deposition MALDI-MS (ASD-MALDI-MS)

D. Drexler, Jefferson Chin, Elizabeth Wood, 2016, Journal of laboratory automation.

Normalization strategy for the LC-MS bioanalysis of protein kinetics assays via internal proteolytic analyte utilized as control standard: application in studies of HIV-1 protease cleavage of HIV-1 Gag polyprotein in HIV maturation inhibition research

Zeyu Lin, Joseph L. Cantone, D. Drexler, 2017 .

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

N. Meanwell, Hong Yang, Zeyu Lin, 2016, PLoS pathogens.

Ionization sources and mass analyzers in MS imaging.

D. Drexler, R. Yost, T. Garrett, 2015, Bioanalysis.

The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery

Yulia Benitex, T. Olah, D. Drexler, 2013 .

Extraction, Identification, and Functional Characterization of a Bioactive Substance From Automated Compound-Handling Plastic Tips

John E Leet, James V Belcastro, Martyn Banks, 2009, Journal of biomolecular screening.

Labware Additives Identified to Be Selective Monoamine Oxidase-B Inhibitors

C. Mcnaney, D. Drexler, J. Leet, 2014, Journal of biomolecular screening.

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

W. Humphreys, S. Mandlekar, P. Marathe, 2017, Drug Metabolism and Disposition.

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

W. Humphreys, P. Marathe, Joseph L. Cantone, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry–Based Screening

D. Drexler, T. Zvyaga, P. Picard, 2016, Journal of biomolecular screening.

Bioanalysis of biomarkers in support of drug discovery and development

H. Soares, M. Reily, T. Olah, 2014 .

An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.

James V Belcastro, K. Dickinson, C. Mcnaney, 2007, Assay and drug development technologies.

Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC-mass spectrometry.

C. Mcnaney, D. Drexler, E. Schaeffer, 2015, Biomedical chromatography : BMC.

P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

J. Macor, J. Marcinkeviciene, M. Ford, 2008, Journal of Pharmacology and Experimental Therapeutics.

Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane

Joseph L. Cantone, D. Drexler, J. Leet, 2016, Drug Metabolism and Disposition.

Analysis of large peptides by MALDI using a linear quadrupole ion trap with mass range extension.

D. Drexler, R. Yost, T. Garrett, 2010, Analytical chemistry.

Development of an Automated “Just-in-Time” Derivatization Process for Gas Chromatography-Mass Spectrometry Analysis Applied to Metabolomics Samples

C. Mcnaney, D. Drexler, Ommega Internationals, 2016 .

Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs.

D. Drexler, S. Tannehill-Gregg, Lifei Wang, 2011, Journal of pharmacological and toxicological methods.

Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.

D. Drexler, C. Cianci, Jun Zhang, 2016, Journal of pharmaceutical sciences.

Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.

Stella Huang, Joseph L. Cantone, D. Drexler, 2003, The Journal of antibiotics.

Assessing the risk of drug crystallization in vivo.

E. Janovitz, D. Drexler, S. Ruepp, 2019, Journal of pharmacological and toxicological methods.

Synergistic inhibition of A&bgr; production by combinations of &ggr;‐secretase modulators

M. Banks, M. Ahlijanian, D. Drexler, 2017, European journal of pharmacology.

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies

A. Cacace, J. Macor, Tai-Hsien Ou Yang, 2022, Molecular therapy. Nucleic acids.

An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion.

James V Belcastro, C. Mcnaney, D. Drexler, 2008, Assay and drug development technologies.

Improvements to the Sample Manipulation Design of a LEAP CTC HTS PAL Autosampler Used for High-Throughput Qualitative and Quantitative Liquid Chromatography–Mass Spectrometry Assays

D. Drexler, K. Edinger, J. Mongillo, 2007 .

Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.

D. Drexler, Jun Zhang, W. Shou, 2012, Bioanalysis.

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

D. Drexler, T. Zvyaga, J. Grace, 2012, Bioanalysis.

Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides.

Petia Shipkova, Dieter M Drexler, D. Drexler, 2008, Rapid communications in mass spectrometry : RCM.

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.

Stella Huang, D. Kingston, C. Fairchild, 2008, Journal of natural products.

Separation of chlorophyll a and metalloporphyrins by HPLC in normal-phase mode using a diol-phase

D. Drexler, K. Ballschmiter, 1994 .

Interactions of Diclofop-Methyl and 2,4-D in Cultivated Oats (Avena sativa)

D. Drexler, R. Fletcher, 1980, Weed Science.

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

H. Soares, J. Macor, R. Berman, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Advances in mass spectrometry applied to pharmaceutical metabolomics

Michael D Reily, Dieter M Drexler, M. Reily, 2011, Analytical and bioanalytical chemistry.

Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development

D. Drexler, A. Tymiak, X. Huang, 2017, Journal of pharmaceutical and biomedical analysis.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

J. Macor, M. Ahlijanian, Joseph L. Cantone, 2014, International journal of Alzheimer's disease.

GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile

N. Meanwell, Zeyu Lin, Joseph L. Cantone, 2021, Antimicrobial Agents and Chemotherapy.

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

H. Soares, J. Macor, M. Ahlijanian, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Tissue analysis by imaging MS.

Stacey R Oppenheimer, Dieter M Drexler, D. Drexler, 2012, Bioanalysis.

Mass spectrometry techniques for qualitative and quantitative analysis of biomarkers.

D. Drexler, M. Sanders, J. Feyen, 2004, Drug discovery today. Technologies.

Utility of high resolution accurate mass spectrometry (HRMS) in the mass isotopomer distribution analysis (MIDA) of CSF proteins modified by stable isotope labeling in mammals (SILAM) methodology applied to neurodegenerative diseases

M. Ahlijanian, Joseph L. Cantone, D. Drexler, 2017 .

A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen.

D. Drexler, Jun Zhang, T. Zvyaga, 2009, Rapid Communications in Mass Spectrometry.

AUTOMATED IDENTIFICATION OF ISOTOPICALLY LABELED PESTICIDES AND METABOLITES BY INTELLIGENT 'REAL TIME' LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY USING A BENCH-TOP ION TRAP MASS SPECTROMETER

J. Schwartz, D. Drexler, F. Q. Bramble, 1998 .

Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.

Joseph L. Cantone, D. Drexler, R. Yost, 2007, Journal of pharmacological and toxicological methods.

Mass Spectrometric Imaging for Drug Distribution in Tissues

D. Drexler, R. Yost, T. Garrett, 2012 .

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.

Donald G Robertson, Michael D Reily, Dieter M Drexler, 2016, Analytical biochemistry.

The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression*

Michael G. Yang, J. Macor, M. Ford, 2008, Journal of Biological Chemistry.

Analysis of L-serine-O-phosphate in cerebrospinal spinal fluid by derivatization-liquid chromatography/mass spectrometry.

Yulia Benitex, C. Mcnaney, T. Olah, 2014, Analytical Biochemistry.

Addressing the need for biomarker liquid chromatography/mass spectrometry assays: a protocol for effective method development for the bioanalysis of endogenous compounds in cerebrospinal fluid.

Yulia Benitex, C. Mcnaney, T. Olah, 2013, Rapid communications in mass spectrometry : RCM.

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

Timothy Olah, Dieter M Drexler, Jonathan L Josephs, 2014, Analytical chemistry.

Qualitative and quantitative characterization of the amyloid β peptide (Aβ) population in biological matrices using an immunoprecipitation–LC/MS assay

M. Ford, Joseph L. Cantone, D. Drexler, 2008, Journal of Neuroscience Methods.

An Empirical Process for the Design of High-Throughput Screening Deck Filters

Andrew C. Good, David A. Stock, Bradley C. Pearce, 2006, J. Chem. Inf. Model..

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures.

Joseph L. Cantone, D. Drexler, C. Polson, 2014, Analytical biochemistry.

Bioanalysis of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) in rat plasma using derivatization liquid chromatography/mass spectrometry.

Yulia Benitex, C. Mcnaney, T. Olah, 2014, Bioanalysis.

P2-346: PGP efflux and other factors limit brain Aβ reduction by BACE1 inhibitors in mice

J. Macor, J. Marcinkeviciene, M. Ford, 2008, Alzheimer's & Dementia.

Development of an on-line automated sample clean-up method and liquid chromatography–tandem mass spectrometry analysis: application in an in vitro proteolytic assay

B. Warrack, Joseph L. Cantone, D. Drexler, 2006, Analytical and bioanalytical chemistry.

Application of quantitative LC–MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Aβ) biosynthetic intermediate protein APP–βCTF

Joseph L. Cantone, D. Drexler, J. Toyn, 2009, Journal of Neuroscience Methods.

Improving the LC-MS bioanalysis of hydrophilic peptides utilizing vacuum-based sample preparation

Joseph L. Cantone, D. Drexler, J. Leet, 2014 .

Tissue analysis by imaging MS.

D. Drexler, Stacey R. Oppenheimer, 2012, Bioanalysis.

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 - small molecules, peptides and small molecule biomarkers by LCMS).

Stephanie Cape, Scott Summerfield, Amanda Wilson, 2016, Bioanalysis.

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

D. Drexler, T. Zvyaga, James E Grace, 2012, Bioanalysis.