C. Dingwall

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High sequence specificity of micrococcal nuclease.

R A Laskey, R. Laskey, C. Dingwall, 1981, Nucleic acids research.

Genetic transformation of HeLa cells by Agrobacterium.

T. Tzfira, V. Citovsky, C. Dingwall, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Sequence Features of the Nucleoplasmin Tail Region and Evidence for a Selective Entry Mechanism for Transport into the Cell Nucleus

R. Laskey, C. Dingwall, T. Bürglin, 1986 .

Protein import into the cell nucleus.

R A Laskey, R. Laskey, C. Dingwall, 1986, Annual review of cell biology.

The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen

W. Richardson, C. Dingwall, B. Roberts, 1988, The Journal of cell biology.

Accumulation of the isolated carboxy‐terminal domain of histone H1 in the Xenopus oocyte nucleus.

C. Dingwall, J. Allan, 1984, The EMBO journal.

Nuclear targeting sequences--a consensus?

R. Laskey, C. Dingwall, 1991, Trends in biochemical sciences.

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

R. Laskey, C. Dingwall, J. Robbins, 1991, Cell.

An editing mechanism for the methionyl-tRNA synthetase in the selection of amino acids in protein synthesis.

A. Fersht, C. Dingwall, 1979, Biochemistry.

BACE1 Cytoplasmic Domain Interacts with the Copper Chaperone for Superoxide Dismutase-1 and Binds Copper*

K. Freeman, C. Dennison, K. Lau, 2005, Journal of Biological Chemistry.

Identification of a novel aspartic protease (Asp 2) as beta-secretase.

C. Southan, F. Walsh, T. Smith, 1999, Molecular and cellular neurosciences.

Neurite‐like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP

J. E. Mermoud, C. Dingwall, S. Trousil, 2010, Journal of neurochemistry.

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

David G. Tew, C. Southan, F. Walsh, 1999, Molecular and Cellular Neuroscience.

Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines*

J. Trill, C. Dingwall, J. Skehel, 2001, The Journal of Biological Chemistry.

Prodomain Processing of Asp1 (BACE2) Is Autocatalytic*

C. Dingwall, S. Moore, I. Hussain, 2001, The Journal of Biological Chemistry.

Exclusively targeting beta-secretase to lipid rafts byGPI-anchor addition up-regulates beta-site processing ofthe amyloid precursor protein

N. Hooper, C. Dingwall, I. Hussain, 2003 .

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

A. Lamond, A. Lamond, C. Dingwall, 1996, The EMBO journal.

Nuclear import: A tale of two sites

R. Laskey, C. Dingwall, 1998, Current Biology.

Developmental inactivity of 5S RNA genes persists when chromosomes are cut between genes

L. J. Korn, J. Gurdon, R. Laskey, 1982, Nature.

Caspase-7 Gene Disruption Reveals an Involvement of the Enzyme during the Early Stages of Apoptosis*

W. Earnshaw, D. Loegering, S. Kaufmann, 2004, Journal of Biological Chemistry.

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.

C. Southan, P. Murdock, F. Walsh, 2000, Molecular and cellular neurosciences.

RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus

C. Dingwall, K. Weis, I. Mattaj, 1996, The Journal of cell biology.

A copper-binding site in the cytoplasmic domain of BACE1 identifies a possible link to metal homoeostasis and oxidative stress in Alzheimer's disease.

C. Dingwall, 2007, Biochemical Society transactions.

Nucleoplasmin: the archetypal molecular chaperone.

R. Laskey, C. Dingwall, 1990, Seminars in cell biology.

Introduction: The nuclear envelope

R. Laskey, C. Dingwall, 1992 .

The role of nucleoplasmin in chromatin assembly and disassembly.

A. Philpott, R. Laskey, C. Dingwall, 1993, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Characterisation of the nuclear location sequence of Xenopus nucleoplasmin

C. Dingwall, S. Dilworth, J. Robbins, 1989, Journal of Cell Science.

Transportin nuclear proteins

C. Dingwall, 1996, Nature.

Cyclin-Dependent Kinase-5/p35 Phosphorylates Presenilin 1 to Regulate Carboxy-Terminal Fragment Stability

K. Lau, Christopher C. J. Miller, D. McLoughlin, 2002, Molecular and Cellular Neuroscience.

Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization*

B. de Strooper, D. Townsend, K. Tew, 2011, The Journal of Biological Chemistry.

Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.

Christopher C. J. Miller, C. Dingwall, K. D. De Vos, 2010, Journal of Alzheimer's disease : JAD.

Nuclear shuttling: The default pathway for nuclear proteins?

R. Laskey, C. Dingwall, 1993, Cell.

Molecular characterization of a karyophilic, histone‐binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis.

J. Kleinschmidt, C. Dingwall, W. Franke, 1986, The EMBO journal.

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

C. Shaw, P. Leigh, M. Ward, 2004, Molecular and cellular neurosciences.

Chromosome replication in cell-free systems from Xenopus eggs.

J. Blow, R. Laskey, C. Dingwall, 1987, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

BACE1 (β-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

M. Pangalos, N. Upton, C. Dingwall, 2003, Molecular and Cellular Neuroscience.

High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.

J. Karn, P. Butler, C. Dingwall, 1993, Journal of molecular biology.

HIV‐1 tat protein stimulates transcription by binding to a U‐rich bulge in the stem of the TAR RNA structure.

M. Singh, J. Karn, I. Ernberg, 1990, The EMBO journal.

Evidence for the double-sieve editing mechanism in protein synthesis. Steric exclusion of isoleucine by valyl-tRNA synthetases.

A. Fersht, C. Dingwall, 1979, Biochemistry.

Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals.

L. Cox, R. Laskey, C. Dingwall, 1987, The EMBO journal.

HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region

I. Ernberg, C. Dingwall, M. Skinner, 1990, Cell.

The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif*

J. Downward, N. Lemoine, I. Iaccarino, 2002, The Journal of Biological Chemistry.

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

W. Richardson, R. Laskey, C. Dingwall, 1988, Cell.

Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1

Kevin M. McBride, N. Reich, C. Dingwall, 2000, Molecular and Cellular Biology.

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

C. Southan, G. P. Livi, E. Karran, 2000, European journal of biochemistry.

Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids

R. Laskey, C. Dingwall, J. Makkerh, 1996, Current Biology.

A polypeptide domain that specifies migration of nucleoplasmin into the nucleus

R. Laskey, C. Dingwall, S. Sharnick, 1982, Cell.

The accumulation of proteins in the nucleus

C. Dingwall, 1985 .

ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site

C. Southan, P. Murdock, F. Walsh, 2000, Molecular and Cellular Neuroscience.

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production in vivo

P. Jeffrey, C. Dingwall, E. Demont, 2007 .

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.

P. Jeffrey, C. Dingwall, E. Demont, 2007, Journal of neurochemistry.

Soluble factors and solid phases

C. Dingwall, 1992, Current Biology.

Characterization of the Ectodomain Shedding of the β-Site Amyloid Precursor Protein-cleaving Enzyme 1 (BACE1)*

D. Riddell, C. Dingwall, A. Faller, 2003, Journal of Biological Chemistry.

The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly.

C. Akey, T. Laue, I. V. Akey, 2001, Molecular cell.

Regulation of hiv 1 gene expression by the rna binding proteins tat and rev

J. Karn, C. Dingwall, M. Skinner, 1991 .

p38α stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis

Jonathan D Cooper, C. Shaw, P. Leigh, 2004, Molecular and Cellular Neuroscience.

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

R. Kraft, S. Kostka, E. Hartmann, 1995, Current Biology.

Chromatin assembly in vitro and in vivo

C. Dingwall, S. Dilworth, 1988, BioEssays : news and reviews in molecular, cellular and developmental biology.

Caspase‐6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

W. Earnshaw, S. Kaufmann, C. Dingwall, 2002, The EMBO journal.

Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

N. Hooper, C. Dingwall, I. Hussain, 2003, Proceedings of the National Academy of Sciences of the United States of America.

A genetic system for detection of protein nuclear import and export

V. Citovsky, C. Dingwall, Y. Gafni, 2000, Nature Biotechnology.

In vitro systems for the reconstitution of snRNP and protein nuclear import.

C. Dingwall, I. Palacios, Colin Dingwall, 1998, Methods in cell biology.

Transport across the nuclear envelope: Enigmas and explanations

C. Dingwall, 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.

If the cap fits…

C. Dingwall, 1991, Current Biology.

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

J. Karn, I. Ernberg, C. Dingwall, 1989, Proceedings of the National Academy of Sciences of the United States of America.

RETRACTED: γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo

M. Fortini, J. Ávila, C. Dingwall, 2006, Neuron.

ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein*

Miles A. Miller, D. Lauffenburger, B. de Strooper, 2011, The Journal of Biological Chemistry.

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

D. Riddell, C. Dingwall, I. Hussain, 2001, Current Biology.

Neuronal membrane cholesterol loss enhances amyloid peptide generation

A. Delacourte, B. de Strooper, K. Craessaerts, 2004, The Journal of cell biology.

Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

A. Delacourte, C. Dingwall, C. Dotti, 2003, EMBO reports.

Chromatin Assembly and the Co-ordination of DNA Replication in the Eukaryotic Chromosome

W. Earnshaw, R. Harland, C. Dingwall, 1981 .

Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions.

A. Fersht, C. Dingwall, 1979, Biochemistry.

Plugging the nuclear pore

C. Dingwall, 1990, Nature.

Genetic transformation of HeLa cells by

T. Tzfira, V. Citovsky, C. Dingwall, 2001 .

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction

P. Murdock, C. Dingwall, J. Owen, 2005, Neurobiology of Aging.

Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons

P. Maycox, R. Prinjha, S. Burbidge, 2003, Molecular and Cellular Neuroscience.

Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease

R. Prinjha, P. Soden, H. Koistinen, 2006, Muscle & nerve.

In search of an enzyme: the β-secretase of Alzheimer's disease is an aspartic proteinase

C. Dingwall, D. Simmons, D. Howlett, 2000, Trends in Neurosciences.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

Functional dissection of a viral transactivator.

C. Dingwall, 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296

C. Howes, C. Dingwall, J. Mosley, 2010 .

A family of Ran binding proteins that includes nucleoporins.

B. Séraphin, S. Kandels-Lewis, C. Dingwall, 1995, Proceedings of the National Academy of Sciences of the United States of America.

RNA binding by the tat and rev proteins of HIV-1.

J T Finch, J. Karn, J. Finch, 1991, Biochimie.

Trans-Activation Requires the Binding of the HIV-1 Tat Protein to Tar RNA

J. Karn, I. Ernberg, C. Dingwall, 1991 .

Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.

C. Dingwall, C. Dingwall, 2001, The Journal of clinical investigation.

Establishing the misacylation/deacylation of the tRNA pathway for the editing mechanism of prokaryotic and eukaryotic valyl-tRNA synthetases.

A. Fersht, C. Dingwall, 1979, Biochemistry.

Fingers in the pore

C. Dingwall, 1993, Current Biology.

Human immunodeficiency virus 1 tat protein binds transactivation-responsive region ( TAR ) RNA in vitro ( transactivation / RNA-binding proteins / gene synthesis / andsense RNA )

J. Karn, I. Ernberg, C. Dingwall, 2022 .

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.