D. Nicholls

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Determination of the mitochondrial protonmotive force in isolated hepatocytes.

J. Hoek, J. Williamson, D. Nicholls, 1980, The Journal of biological chemistry.

S. Budd, D. Nicholls, D G Nicholls, 2000, Physiological reviews.

Synaptic Vesicle Recycling in Cultured Cerebellar Granule Cells: Role of Vesicular Acidification and Refilling

M. Cousin, D. Nicholls, M. Cousin, 1997, Journal of neurochemistry.

The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution.

D. Nicholls, 1974, European journal of biochemistry.

Energy-dependent control of the tricarboxylic acid cycle by fatty acid oxidation in rat liver mitochondria.

P. Garland, D. Nicholls, J. Ontko, 1968, Advances in enzyme regulation.

4‐Aminobutyrate Can Be Released Exocytotically from Guinea‐Pig Cerebral Cortical Synaptosomes

D. Nicholls, T. Sihra, 1987, Journal of neurochemistry.

Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium‐induced de‐ and hyperpolarization of neuronal mitochondria

C. Chinopoulos, M. Brand, D. Nicholls, 2012, The Journal of physiology.

Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts

S. Melov, D. Nicholls, E. Samper, 2003, Aging cell.

Mitochondrial and Plasma Membrane Potential of Cultured Cerebellar Neurons during Glutamate-Induced Necrosis, Apoptosis, and Tolerance

H. Düssmann, J. Prehn, M. Ward, 2007, The Journal of Neuroscience.

Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

M. Ward, D. Nicholls, 2000, Trends in Neurosciences.

Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

M. Ward, D. Nicholls, 2000, Trends in Neurosciences.

Fluorescence Measurement of Mitochondrial Membrane Potential Changes in Cultured Cells.

D. Nicholls, 2018, Methods in molecular biology.

No Consistent Bioenergetic Defects in Presynaptic Nerve Terminals Isolated from Mouse Models of Alzheimer's Disease

S. Melov, B. Gibson, D. Bredesen, 2012, The Journal of Neuroscience.

Mitochondrial ion circuits.

D. Nicholls, 2010, Essays in biochemistry.

Simultaneous Monitoring of Ionophore- and Inhibitor-mediated Plasma and Mitochondrial Membrane Potential Changes in Cultured Neurons*

D. Nicholls, 2006, Journal of Biological Chemistry.

Mitochondrial membrane potential and aging

D. Nicholls, 2004, Aging cell.

Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

B. Frenguelli, M. Ward, D. Nicholls, 2000, The Journal of Neuroscience.

Inter-relationships between proton electrochemical gradient, adenine-nucleotide phosphorylation potential and respiration, during substrate-level and oxidative phosphorylation by mitochondria from brown adipose tissue of cold-adapted guinea-pigs.

D. Nicholls, V. Bernson, 1977, European journal of biochemistry.

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria.

D. Nicholls, David G. Nicholls, 1978, The Biochemical journal.

Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ.

D. Nicholls, I. Scott, I. D. Scott, 1980, The Biochemical journal.

Oxidative Stress, Mitochondrial Function, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

M. Ward, D. Nicholls, R. F. Castilho, 1999, Journal of neurochemistry.

Brown-adipose-tissue mitochondria: the regulation of the 32000-Mr uncoupling protein by fatty acids and purine nucleotides.

D. Nicholls, E. Rial, A. Poustie, 1983, European journal of biochemistry.

Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons*

D. Nicholls, M. Jekabsons, S. Vesce, 2005, Journal of Biological Chemistry.

Brown adipose tissue

D. Nicholls, P. Trayhurn, 1986 .

Assessing Mitochondrial Dysfunction in Cells

M. Brand, D. Nicholls, 2022 .

Cellular Mechanisms of Heat Dissipation

D. Nicholls, R. Locke, 1983 .

Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.

J. Andersen, D. Nicholls, N. Yadava, 2009, Free radical biology & medicine.

Oxidative Stress and Energy Crises in Neuronal Dysfunction

D. Nicholls, 2008, Annals of the New York Academy of Sciences.

Forty years of Mitchell's proton circuit: From little grey books to little grey cells.

D. Nicholls, 2008, Biochimica et biophysica acta.

The Non-Ohmic Proton Leak—25 Years On

D. Nicholls, 1997, Bioscience reports.

Modulation of Ion Gradients and Glutamate Release in Cultured Cerebellar Granule Cells by Ouabain

M. Cousin, D. Nicholls, J. Pocock, 1995, Journal of neurochemistry.

Hamster Brown-Adipose-Tissue Mitochondria

D. Nicholls, 1974 .

Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neurones

M. Cousin, D. Nicholls, J. Pocock, 1993, Brain Research.

The physiological regulation of uncoupling proteins.

D. Nicholls, 2006, Biochimica et biophysica acta.

Real‐time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity

Ajit S. Divakaruni, A. Hubbard, A. Hubbard, 2009, Journal of neurochemistry.

Mitochondria and Cell Death

C. Cooper, D. Nicholls, Guy C. Brown, 2000 .

Plasma Membrane Potential Oscillations in Insulin Secreting Ins-1 832/13 Cells Do Not Require Glycolysis and Are Not Initiated by Fluctuations in Mitochondrial Bioenergetics*

H. Mulder, M. Brand, D. Nicholls, 2012, The Journal of Biological Chemistry.

Glutamate Excitotoxicity and Neuronal Energy Metabolism

M. Ward, S. Budd, D. Nicholls, 1999, Annals of the New York Academy of Sciences.

The Uncoupling Protein UCP1 Does Not Increase the Proton Conductance of the Inner Mitochondrial Membrane by Functioning as a Fatty Acid Anion Transporter*

D. Nicholls, C. Fleury, E. Rial, 1998, The Journal of Biological Chemistry.

A History of the First Uncoupling Protein, UCP1

D. Nicholls, E. Rial, 1999, Journal of bioenergetics and biomembranes.

Assessing mitochondrial dysfunction in cells

M. Brand, D. Nicholls, 2011, The Biochemical journal.

Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line

R. Scharfmann, P. Spégel, H. Mulder, 2015, PloS one.

Synaptosomal bioenergetics. The role of glycolysis, pyruvate oxidation and responses to hypoglycaemia.

R. Kauppinen, D. Nicholls, 1986, European journal of biochemistry.

The characterization and energetic potential of brown adipose tissue in man.

D. Hopwood, D. Nicholls, R. Jung, 1985, Clinical science.

A novel regulatory mechanism for the brown-fat uncoupling protein?

D. Nicholls, E. Rial, 2016, Nature Structural &Molecular Biology.

Energy expenditure in normal and diabetic man: the role of brown adipose tissue.

D. Nicholls, R. Jung, S. Cunningham, 1988, Health bulletin.

The uncoupling protein from brown adipose tissue mitochondria.

D. Nicholls, E. Rial, 1987, Revisiones sobre biologia celular : RBC.

Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation.

D. Nicholls, R. Wagenvoord, A. Kemp, 1978, European journal of biochemistry.

Hamster brown-adipose-tissue mitochondria. The control of respiration and the proton electrochemical potential gradient by possible physiological effectors of the proton conductance of the inner membrane.

D. Nicholls, 1974, European journal of biochemistry.

The acute regulation of mitochondrial proton conductance in cells and mitochondria from the brown fat of cold-adapted and warm-adapted guinea pigs.

D. Nicholls, E. Rial, R. Locke, 1982, European journal of biochemistry.

InducibleAlterationsofGlutathioneLevelsinAdult DopaminergicMidbrainNeuronsResultinNigrostriatal Degeneration

D. Nicholls, S. Chinta, M. J. Kumar, 2007 .

Inducible Alterations of Glutathione Levels in Adult Dopaminergic Midbrain Neurons Result in Nigrostriatal Degeneration

J. Andersen, D. Nicholls, Deepinder Kaur, 2007, The Journal of Neuroscience.

Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease.

J. Andersen, D. Nicholls, M. J. Kumar, 2003, The Journal of biological chemistry.

Mitochondrial membrane potential and hydroethidine‐monitored superoxide generation in cultured cerebellar granule cells

S. Budd, D. Nicholls, R. F. Castilho, 1997, FEBS letters.

Correction: MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

J. Andersen, D. D. Di Monte, D. Nicholls, 2012, PLoS ONE.

Involvement of Calcium Influx in Muscarinic Cholinergic Regulation of Phospholipase C in Cerebellar Granule Cells

C. Downes, D. Nicholls, E. D. del Río, 1994, Journal of neurochemistry.

The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation.

D. Nicholls, V. Bernson, G. M. Heaton, 1978, Experientia. Supplementum.

The thermogenic mechanism of brown adipose tissue

D. Nicholls, 1983, Bioscience reports.

Mitochondrial proton leaks and uncoupling proteins.

D. Nicholls, 2021, Biochimica et biophysica acta. Bioenergetics.

The hunt for the molecular mechanism of brown fat thermogenesis.

D. Nicholls, 2017, Biochimie.

Mitochondria from Hamster Brown‐Adipose Tissue

D. Nicholls, O. Lindberg, H. Grav, 1972 .

The structural specificity of the nucleotide-binding site and the reversible nature of the inhibition of proton conductance induced by bound nucleotides in brown-adipose-tissue mitochondria.

D. Nicholls, G. M. Heaton, G. Heaton, 1977, Biochemical Society transactions.

Hamster brown-adipose-tissue mitochondria. The chloride permeability of the inner membrane under respiring conditions, the influence of purine nucleotides.

D. Nicholls, 1974, European journal of biochemistry.

The effective proton conductance of the inner membrane of mitochondria from brown adipose tissue. Dependency on proton electrochemical potential gradient.

D. Nicholls, 1977, European journal of biochemistry.

Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria.

D. Nicholls, E. Rial, I. Scott, 1982, European journal of biochemistry.

Quantification of fatty acid activation of the uncoupling protein in brown adipocytes and mitochondria from the guinea-pig.

D. Nicholls, S. Cunningham, H. Wiesinger, 1986, European journal of biochemistry.

Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site.

D. Nicholls, 1976, European journal of biochemistry.

Brown adipose tissue mitochondria.

D. Nicholls, David G. Nicholls, Olov Lindberg, 1973, Biochimica et biophysica acta.

Stoicheiometries of proton translocation by mitochondria.

D. Nicholls, 1977, Biochemical Society transactions.

A role for the mitochondrion in the protection of cells against calcium overload?

D. Nicholls, 1985, Progress in Brain Research.

Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells

P. Spégel, H. Mulder, D. Nicholls, 2013, The Journal of Biological Chemistry.

Adenosine is an Antiinflammatory Autocoid: Adenosine Receptor Occupancy Promotes Neutrophil Chemotaxis and Inhibits Superoxide Anion Generation

B. Cronstein, D. Nicholls, M. Williams, 1990 .

α‐Latrotoxin Releases Both Vesicular and Cytoplasmic Glutamate from Isolated Nerve Terminals

J. Meldolesi, D. Nicholls, H. McMahon, 1990, Journal of neurochemistry.

The mitochondrial uncoupling protein from guinea-pig brown adipose tissue. Synchronous increase in structural and functional parameters during cold-adaptation.

D. Nicholls, E. Rial, 1984, The Biochemical journal.

The regulation of the proton conductance of brown fat mitochondria

D. Nicholls, E. Rial, 1983, FEBS letters.

The inhibition of pyruvate and Ls(+)-isocitrate oxidation by succinate oxidation in rat liver mitochondria.

P. Garland, D. Nicholls, T. König, 1969, The Biochemical journal.

Barium‐Evoked Glutamate Release from Guinea‐Pig Cerebrocortical Synaptosomes

D. Nicholls, H. McMahon, 1993, Journal of neurochemistry.

Transmitter Glutamate Release from Isolated Nerve Terminals: Evidence for Biphasic Release and Triggering by Localized Ca2+

D. Nicholls, H. McMahon, 1991, Journal of neurochemistry.

Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures.

D. Nicholls, 2004, Current molecular medicine.

Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action.

M. Verhage, D. Nicholls, J. Dolly, 1992, The Journal of biological chemistry.

UCPs — unlikely calcium porters

M. Brand, A. Vidal-Puig, D. Nicholls, 2008, Nature Cell Biology.

The bioenergetics of brown adipose tissue mitochondria

D. Nicholls, 1976, FEBS letters.

A toxin (Aga-GI) from the venom of the spider Agelenopsis aperta inhibits the mammalian presynaptic Ca2+ channel coupled to glutamate exocytosis.

D. Nicholls, J. Pocock, 1992, European journal of pharmacology.

The mechanism of action of beta-bungarotoxin at the presynaptic plasma membrane.

D. Nicholls, M. Rugolo, J. Dolly, 1986, The Biochemical journal.

Localized Ca2+ entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release.

D. Nicholls, T. Sihra, E. Bogónez, 1992, The Journal of biological chemistry.

Ca2+-dependent and Ca2+- independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: Possible relevance to hyoglycaemia and anoxia

R. Kauppinen, D. Nicholls, H. McMahon, 1988, Neuroscience.

Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons

E. Lo, Chenggang Zhang, Xiaoying Wang, 2009, Journal of neuroscience research.

Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells.

H. Mulder, D. Nicholls, A. Gerencser, 2015, The Biochemical journal.

[The relationship between palmitoyl-coenzyme A synthetase activity and esterification of sn-glycerol 3-phosphate in rat liver mitochondria].

D. Nicholls, D. Brindley, M. Sánchez, 1973, The Biochemical journal.

The ATP synthase

D. Nicholls, S. Ferguson, 2003 .

Characterization of the Release of Cholecystokinin‐8 from Isolated Nerve Terminals and Comparison with Exocytosis of Classical Transmitters

M. Verhage, D. Nicholls, V. Wiegant, 1991, Journal of neurochemistry.

The calcium channel coupled to the exocytosis of l-glutamate from cerebellar granule cells is inhibited by the spider toxin, Aga-GI

M. Cousin, D. Nicholls, J. Pocock, 1993, Neuropharmacology.

Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements

M. Brand, D. Nicholls, S. Mookerjee, 2016, PloS one.

Effect of hydrophobic sulphydryl reagents on the uncoupling protein and inner-membrane anion channel of brown-adipose-tissue mitochondria.

D. Nicholls, I. Arechaga, E. Rial, 1989, European journal of biochemistry.

A history of UCPI

D. Nicholls, 2001 .

A history of UCP1.

D. Nicholls, 2001, Biochemical Society transactions.

Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

S. Budd, D. Nicholls, D G Nicholls, 1996, Journal of neurochemistry.

Brain mitochondrial calcium transport: Origins of the set-point concept and its application to physiology and pathology

D. Nicholls, 2017, Neurochemistry International.

Exocytotic and Nonexocytotic Modes of Glutamate Release from Cultured Cerebellar Granule Cells During Chemical Ischaemia

D. Nicholls, J. Pocock, J. Pocock, 1998, Journal of neurochemistry.

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms.

D. Nicholls, I. Scott, I. D. Scott, 1980, The Biochemical journal.

Calcium Transport by Intact Synaptosomes

D. Nicholls, K. Åkerman, 2005 .

Biochemical approaches to the study of cytosolic calcium regulation in nerve endings.

D. Nicholls, K. Åkerman, David G. Nicholls, 1981, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Use of potentiometric fluorophores in the measurement of mitochondrial reactive oxygen species.

D. Nicholls, B. Roelofs, B. Polster, 2014, Methods in enzymology.

Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones

J. Mccormack, D. Budd, D. Nicholls, 1996, British journal of pharmacology.

Bioenergetic actions of beta-bungarotoxin, dendrotoxin and bee-venom phospholipase A2 on guinea-pig synaptosomes.

D. Nicholls, O. Dolly, R. Snelling, 1985, The Biochemical journal.

Release of glutamate, aspartate, and gamma-aminobutyric acid from isolated nerve terminals.

D. Nicholls, 1989, Journal of neurochemistry.

The role of mitochondria in the regulation of calcium ion transport in synaptosomes.

D. Nicholls, I. Scott, 1980, Biochemical Society transactions.

Regulation of Calcium in Isolated Nerve Terminals (Synaptosomes): Relationship to Neurotransmitter Release a

D. Nicholls, 1989, Annals of the New York Academy of Sciences.

Differential coupling of G‐protein‐linked receptors to Ca2+ mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture

C. Downes, D. Nicholls, M. Mclaughlin, 1999, The European journal of neuroscience.

The Integration of Mitochondrial Calcium Transport and Storage

D. Nicholls, S. Chalmers, 2004, Journal of bioenergetics and biomembranes.

Mitochondrial calcium function and dysfunction in the central nervous system.

D. Nicholls, 2009, Biochimica et biophysica acta.

Ward MW, Rego AC, Frenguelli BG and Nicholls DGMitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurosci. 20: 7208-7219

B. Frenguelli, M. Ward, D. Nicholls, 2000 .

The role of phosphate in the regulation of the independent calcium-efflux pathway of liver mitochondria.

F. Zoccarato, D. Nicholls, David G. Nicholls, 1982, European journal of biochemistry.

Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

O. Hansson, M. Ward, S. Budd, 1998, The Journal of Neuroscience.

Failure to Maintain Glycolysis in Anoxic Nerve Terminals

R. Kauppinen, D. Nicholls, 1986, Journal of neurochemistry.

Mechanisms of thermogenesis in brown adipose tissue.

D. Nicholls, S. Cunningham, H. Wiesinger, 1986, Biochemical Society transactions.

A continuous recording technique for the measurement of carbon dioxide, and its application to mitochondrial oxidation and decarboxylation reactions.

P. Garland, D. Nicholls, D. Shepherd, 1967, The Biochemical journal.

Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential.

D. Nicholls, K. Åkerman, I. Scott, 1980, The Biochemical journal.

Dendrotoxin, 4‐Aminopyridine, and β‐Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+‐Dependent Release of Glutamate from Guinea‐Pig Cerebrocortical Synaptosomes

D. Nicholls, J. Dolly, G. Tibbs, 1989, Journal of neurochemistry.

Inhibited respiration and ATPase activity of rat liver mitochondria under conditions of matrix condensation

D. Nicholls, O. Lindberg, 1972, FEBS letters.

Measurement of transported calcium in synaptosomes.

D. Nicholls, 1989, Methods in enzymology.

Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment

D. Nicholls, G. Gibson, C. Peterson, 1985, Neurobiology of Aging.

Subsynaptosomal Calcium Distribution During Hypoxia and 3,4‐Diaminopyridine Treatment

D. Nicholls, G. Gibson, C. Peterson, 1985, Journal of neurochemistry.

The Calmodulin Antagonists, Trifluoperazine and R24571, Depolarize the Mitochondria Within Guinea Pig Cerebral Cortical Synaptosomes

D. Nicholls, R. Snelling, 1984, Journal of neurochemistry.

Phosphate‐independent calcium efflux from liver mitochondria

F. Zoccarato, D. Nicholls, 1981, FEBS letters.

Intrasynaptosomal compartmentation of calcium during depolarization-induced calcium uptake across the plasma membrane.

D. Nicholls, K. Åkerman, 1981, Biochimica et biophysica acta.

Commentary on: ‘Old and new data, new issues: The mitochondrial Δψ’ by H. Tedeschi

D. Nicholls, 2005 .

Commentary on : F Old and new data , new issues : The mitochondrial D w _ by H .

D. Nicholls, Tedeschi, 2005 .

ReviewBrown fat mitochondria

D. Nicholls, E. Rial, 1984 .

A re‐evaluation of the role of fatty acids in the physiological regulation of the proton conductance of brown adipose tissue mitochondria

D. Nicholls, R. Locke, 1981, FEBS letters.

Brown fat mitochondria

D. Nicholls, 1976 .

The calcium conductance of the inner membrane of rat liver mitochondria and the determination of the calcium electrochemical gradient.

D. Nicholls, G. M. Heaton, G. Heaton, 1976, The Biochemical journal.

Acetate, a major end product of fatty-acid oxidation in hamster brown-adipose-tissue mitochondria.

D. Nicholls, S. Bernson, 1974, European journal of biochemistry.

Presynaptic calcium channels and field-evoked transmitter exocytosis from cultured cerebellar granule cells

M. Cousin, D. Nicholls, H. Hurst, 1997, Neuroscience.

Cold adaptation in guinea pig at level of isolated brown adipocyte.

D. Nicholls, J. Rafael, W. Fesser, 1986, The American journal of physiology.

1.1 Bioenergetics

D. Nicholls, 2007 .

1 – Chemiosmotic energy transduction

D. Nicholls, 2003 .

Presynaptic regulation of glutamate release from guinea-pig cortical synaptosomes

D. Nicholls, A. Barrie, 1988 .

Density Gradient Separation of Human Platelets from Plasma and the Role of Plasma in Adenosine Diphosphate Induced Platelet Electrophoretic Mobility Changes

J. Hampton, D. Nicholls, 1972, Thrombosis and Haemostasis.

The ‘mitoflash’ probe cpYFP does not respond to superoxide

M. Fricker, M. Duchen, H. Forman, 2014, Nature.

Some recent advances in mitochondrial calcium transport

D. Nicholls, 1981 .

Synaptosomal Bioenergetics and Glutamate Release

D. Nicholls, 2018 .

Pyruvate utilization by synaptosomes is independent of calcium

R. Kauppinen, D. Nicholls, 1986, FEBS letters.

Apoptosis and the laws of thermodynamics

M. Brand, D. Nicholls, I. Reynolds, 2000, Nature Cell Biology.

Chapter 2 Mechanisms of energy transduction

D. Nicholls, 1984 .

Developmental profile of excitatory GABAA responses in cultured rat cerebellar granule cells

J. Lambert, D. Nicholls, A. Rego, 2001, Neuroreport.

Presynaptic receptors and the control of glutamate exocytosis

D. Budd, D. Nicholls, J. Sánchez-Prieto, 1996, Trends in Neurosciences.

Chemical modification of the brown-fat-mitochondrial uncoupling protein with tetranitromethane and N-ethylmaleimide. A cysteine residue is implicated in the nucleotide regulation of anion permeability.

D. Nicholls, E. Rial, 1986, European journal of biochemistry.

Chemical modification of the brown fat mitochondrial uncoupling protein with tetranitromethane

D. Nicholls, E. Rial, 1986, FEBS letters.

Bioenergetics an Introduction to the Chemiosmotic Theory

David G. Nicholls, D. Nicholls, 1982 .

The development of Ca2+ channel responses and their coupling to exocytosis in cultured cerebellar granule cells

D. Nicholls, W. Smith, J. Harrold, 1997, Neuroscience.

The bioenergetics of neurotransmitter release.

D. Nicholls, H. McMahon, Harvey T. McMahon, 1991, Biochimica et biophysica acta.

Phorbol ester translocation of protein kinase C in guinea-pig synaptosomes and the potentiation of calcium-dependent glutamate release.

M. Díaz-Guerra, L. Boscá, D. Nicholls, 1988, Biochimica et biophysica acta.

Thermogenic mechanisms in brown fat.

D. Nicholls, D G Nicholls, R M Locke, 1984, Physiological reviews.

PURINE NUCLEOTIDES AND FATTY ACIDS IN ENERGY COUPLING OF MITOCHONDRIA FROM BROWN ADIPOSE TISSUE

D. Nicholls, O. Lindberg, B. Cannon, 1973 .

Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals.

D. Nicholls, 2010, Biochemical Society transactions.

Bioenergetics and Transmitter Release in the Isolated Nerve Terminal

D. Nicholls, 2003, Neurochemical Research.

Arachidonic acid potentiates the duration of the metabotropic, protein kinase C-mediated, suppression of the inhibitory adenosine A1 receptor pathway in glutamatergic nerve terminals from rat cerebral cortex

D. Budd, D. Nicholls, 1998, Neuroscience Letters.

Chapter 2 Presynaptic modulation of glutamate release

D. Nicholls, 1998 .

Strategies for receptor control of neurotransmitter release.

D. Nicholls, 1998, Advances in pharmacology.

Co-existence and interaction between facilitatory and inhibitory metabotropic glutamate receptors and the inhibitory adenosine A1 receptor in cerebrocortical nerve terminals

D. Budd, D. Nicholls, J. Sánchez-Prieto, 1995, Neuropharmacology.

Protein Kinase C‐Mediated Suppression of the Presynaptic Adenosine A1 Receptor by a Facilitatory Metabotropic Glutamate Receptor

D. Budd, D. Nicholls, 1995, Journal of neurochemistry.

Glutamate Exocytosis and MARCKS Phosphorylation Are Enhanced by a Metabotropic Glutamate Receptor Coupled to a Protein Kinase C Synergistically Activated by Diacylglycerol and Arachidonic Acid

D. Nicholls, J. Sánchez-Prieto, T. Sihra, 1994, Journal of neurochemistry.

The glutamatergic nerve terminal.

D. Nicholls, David G. Nicholls, 1993, European journal of biochemistry.

A retrograde step forward

D. Nicholls, 1992, Nature.

An Ion Channel Locus for the Protein Kinase C Potentiation of Transmitter Glutamate Release from Guinea Pig Cerebrocortical Synaptosomes

D. Nicholls, J. Sánchez-Prieto, T. Sihra, 1991, Journal of neurochemistry.

Repetitive Action Potentials in Isolated Nerve Terminals in the Presence of 4‐Aminopyridine: Effects on Cytosolic Free Ca2+ and Glutamate Release

D. Nicholls, H. McMahon, F. Mieghem, 1989, Journal of neurochemistry.

Calcium‐Dependent and‐Independent Release of Glutamate from Synaptosomes Monitored by Continuous Fluorometry

D. Nicholls, J. Sánchez-Prieto, T. Sihra, 1987, Journal of neurochemistry.

Calcium transport and porton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart.

D. Nicholls, 1978, The Biochemical journal.

A Reevaluation of the Role of Mitochondria in Neuronal Ca2+ Homeostasis

S. Budd, D. Nicholls, S. L. Budd, 1996, Journal of neurochemistry.

The release and uptake of excitatory amino acids.

D. Attwell, D. Nicholls, 1990, Trends in pharmacological sciences.

The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells

J J Lambert, J. Lambert, D. Nicholls, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Glutamate Release from Guinea‐Pig Synaptosomes: Stimulation by Reuptake‐Induced Depolarization

D. Nicholls, H. McMahon, A. Barrie, 1989, Journal of neurochemistry.

Ca2+ transport by intact synaptosomes: the voltage-dependent Ca2+ channel and a re-evaluation of the role of sodium/calcium exchange.

D. Nicholls, K. Åkerman, 2005, European journal of biochemistry.

Release of Glutamate, Aspartate, and γ‐Aminobutyric Acid from Isolated Nerve Terminals

David G. Nicholls, D. Nicholls, 1989 .

Kainic Acid Inhibits the Synaptosomal Plasma Membrane Glutamate Carrier and Allows Glutamate Leakage from the Cytoplasm but Does Not Affect Glutamate Exocytosis

D. Nicholls, J. Pocock, H. Murphie, 1988, Journal of neurochemistry.

Mitochondria and calcium signaling.

D. Nicholls, 2005, Cell calcium.

Effect of trypsin on mitochondrial and microsomal enzymes.

S. Hovmöller, D. Nicholls, L. Ernster, 1970, European Journal of Biochemistry.

Divalent cation modulation of the ionic permeability of the synaptosomal plasma membrane.

R. Kauppinen, D. Nicholls, T. Sihra, 1986, Biochimica et biophysica acta.

Mitochondrial calcium transport

M. Crompton, D. Nicholls, 1980, FEBS letters.

Bioenergetics: Fourth Edition

D. Nicholls, S. Ferguson, 2013 .

Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates.

R. Kauppinen, D. Nicholls, T. Sihra, 1987, Biochimica et biophysica acta.

Protein kinase C modulates field‐evoked transmitter release from cultured rat cerebellar granule cells via a dendrotoxin‐sensitive K+ channel

D. Nicholls, M. Cousin, Mark McLaughlin, 1999, The European journal of neuroscience.

Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals

M. Verhage, F. Boomsma, D. Nicholls, 1991, Neuron.

Physiological and bioenergetic aspects of mitochondrial calcium transport

D. Nicholls, K. Åkerman, 1983 .

Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria*

D. Nicholls, J. Hardwick, G. Basañez, 2005, Journal of Biological Chemistry.

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

David G. Nicholls, Martin D. Brand, M. Brand, 2009, Analytical chemistry.

Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death

S. Duan, R. Swanson, D. Nicholls, 2002, The Journal of Neuroscience.

Mitochondria, Sodium, and Calcium in Neuronal Dysfunction

D. Nicholls, 2012 .

The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria*

D. Nicholls, S. Chalmers, 2003, Journal of Biological Chemistry.

Mitochondria and neuronal glutamate excitotoxicity.

S. Budd, D. Nicholls, 1998, Biochimica et biophysica acta.

Quantitative bioenergetics: The measurement of driving forces

D. Nicholls, S. Ferguson, 2013 .

ATP Synthases and Bacterial Flagella Rotary Motors

D. Nicholls, S. Ferguson, 2013 .

3 – Quantitative bioenergetics: The measurement of driving forces

D. Nicholls, 2003 .

MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

J. Andersen, D. D. Di Monte, D. Nicholls, 2008, PloS one.

Oxidative α-Ketoglutarate Dehydrogenase Inhibition via Subtle Elevations in Monoamine Oxidase B Levels Results in Loss of Spare Respiratory Capacity

J. Andersen, D. Nicholls, Jyothi Kumar, 2003, Journal of Biological Chemistry.

The pathogenetic role of β-cell mitochondria in type 2 diabetes.

P. Spégel, H. Mulder, D. Nicholls, 2018, The Journal of endocrinology.

‘Mild Uncoupling’ does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress

D. Nicholls, M. Jekabsons, B. Polster, 2007, Journal of neurochemistry.

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

M. Brand, D. Nicholls, A. Gerencser, 2017, The Journal of Biological Chemistry.

The contributions of respiration and glycolysis to extracellular acid production.

M. Brand, D. Nicholls, Renata L. S. Goncalves, 2015, Biochimica et biophysica acta.

Ionophore A23187, Verapamil, Protonophores, and Veratridine Influence the Release of γ‐Aminobutyric Acid from Synaptosomes by Modulation of the Plasma Membrane Potential Rather than the Cytosolic Calcium

I. G. Scott, D. Nicholls, Talvinder S. Sihra, 1984, Journal of neurochemistry.

Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals

M. Brand, D. Nicholls, A. Gerencser, 2015, Journal of Bioenergetics and Biomembranes.

Neuronal Glutamate and Gabaa Receptor Function in Health and Disease Spare Respiratory Capacity, Oxidative Stress and Excitotoxicity Glutamate as an Excitotoxin the Role of Oxidative Stress

D. Nicholls, David G Nicholls, 2022 .

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease.

D. Nicholls, David G Nicholls, 2002, The international journal of biochemistry & cell biology.

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

David G. Nicholls, D. Nicholls, A. Gerencser, 2009, Journal of neurochemistry.

Transmembrane electrical potential and transmembrane pH gradient in the acidophile Thiobacillus ferro-oxidans.

D. Nicholls, J. Cox, W. Ingledew, 1979, The Biochemical journal.

Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone

D. Nicholls, N. Yadava, David G Nicholls, 2007, The Journal of Neuroscience.

The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides.

M. Brand, D. Nicholls, 1980, The Biochemical journal.

The Pancreatic β-Cell: A Bioenergetic Perspective.

D. Nicholls, 2016, Physiological reviews.

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

David S. Park, S. Lipton, C. Culmsee, 2017, Cell Death & Differentiation.

Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons.

D. Nicholls, David G Nicholls, Akos A Gerencser, 2008, Biophysical journal.

Bioenergetic profile experiment using C2C12 myoblast cells.

Min Wu, G. Rogers, D. Nicholls, 2010, Journal of visualized experiments : JoVE.

Mitochondria in the life and death of neurons.

S. Budd, D. Nicholls, 1998, Essays in biochemistry.

Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

J. Andersen, D. Nicholls, C. Torres-Ramos, 2012, Free radical biology & medicine.

Protein kinase C and the regulation of glutamate exocytosis from cerebrocortical synaptosomes.

D. Nicholls, T. Sihra, E. Coffey, 1993, The Journal of biological chemistry.

The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells

D. Nicholls, A. Rego, S. Vesce, 2001, Cell Death and Differentiation.

Interactions Between Phospholipase C‐Coupled and N‐Methyl‐D‐Aspartate Receptors in Cultured Cerebellar Granule Cells: Protein Kinase C Mediated Inhibition of N‐Methyl‐D‐Aspartate Responses

D. Nicholls, M. Courtney, 1992, Journal of neurochemistry.

Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells.

D. Nicholls, S. Chalmers, S. Vesce, 2003, Cell calcium.

Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity

D. Nicholls, N. Yadava, M. Jekabsons, 2007, Journal of neuroscience research.

Excitotoxicity and mitochondria.

M. Ward, S. Budd, D. Nicholls, 1999, Biochemical Society symposium.

Synaptosomes possess an exocytotic pool of glutamate

D. Nicholls, T. Sihra, 1986, Nature.

Neuronal excitotoxicity: the role of mitochondria

S. Budd, D. Nicholls, 1998, BioFactors.

Bioenergetic analysis of cerebellar granule neurons undergoing apoptosis by potassium/serum deprivation

D. Nicholls, M. Jekabsons, 2006, Cell Death and Differentiation.

Unequal charge separation by different coupling spans of the mitochondrial electron transport chain

M. Brand, D. Nicholls, W.J. Ingledew, 1978, FEBS letters.

Characterization of the Effects of Lithium and Inositol on Phosphoinositide Turnover in Cerebellar Granule Cells in Primary Culture

C. Downes, D. Nicholls, E. D. del Río, 1996, Journal of neurochemistry.

Induction of functional uncoupling protein in guinea pigs infused with noradrenaline. Studies with isolated brown adipocytes.

D. Nicholls, S. Cunningham, 1987, The Biochemical journal.

Mitochondria Control AMPA/Kainate Receptor-Induced Cytoplasmic Calcium Deregulation in Rat Cerebellar Granule Cells

M. Ward, D. Nicholls, A. Rego, 2001, The Journal of Neuroscience.

Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate

D. Nicholls, S. Vesce, L. Kirk, 2004, Journal of neurochemistry.

Fluorescence measurement of mitochondrial membrane potential changes in cultured cells.

D. Nicholls, 2012, Methods in molecular biology.

Exocytosis and Selective Neurite Calcium Responses in Rat Cerebellar Granule Cells During Field Stimulation

D. Nicholls, M. Cousin, B. Held, 1995, The European journal of neuroscience.

Intrinsic Bioenergetic Properties and Stress Sensitivity of Dopaminergic Synaptosomes

J. Andersen, M. Brand, D. Nicholls, 2011, The Journal of Neuroscience.

Fifty years on: How we uncovered the unique bioenergetics of brown adipose tissue

D. Nicholls, 2023, Acta physiologica.

The control of isocitrate oxidation by rat liver mitochondria

P. Garland, D. Nicholls, 1969 .

A critical assessment of the role of creatine in brown adipose tissue thermogenesis

M. Brand, D. Nicholls, 2023, Nature Metabolism.

Assessing mitochondrial dysfunction in cells

M. Brand, D. Nicholls, M. D. Brand, 2011, The Biochemical journal.

The uncoupling protein from brown-adipose-tissue mitochondria. Chymotrypsin-induced structural and functional modifications.

D. Nicholls, E. Rial, M. Fernández, 1987, European journal of biochemistry.

Evidence for the Induction of Repetitive Action Potentials in Synaptosomes by K+‐Channel Inhibitors: An Analysis of Plasma Membrane Ion Fluxes

D. Nicholls, J. Dolly, G. Tibbs, 1996, Journal of neurochemistry.

Characterization of the Exocytotic Release of Glutamate from Guinea‐Pig Cerebral Cortical Synaptosomes

D. Nicholls, J. Sánchez-Prieto, Talvinder S. Sihra, 1987, Journal of neurochemistry.

The Effects of Experimental Anoxia on Glycolysis, Energy Status, Cytosolic Free Calcium, and Glutamate Release from Isolated Nerve Terminals

R. Kauppinen, D. Nicholls, H. McMahon, 1989 .

Botulinum toxin A blocks glutamate exocytosis from guinea-pig cerebral cortical synaptosomes.

T S Sihra, D. Nicholls, J. Dolly, 1987, European journal of biochemistry.

Dendrotoxin and charybdotoxin increase the cytosolic concentration of free Ca2+ in cerebrocortical synaptosomes: An effect not shared by apamin

D. Nicholls, J. Dolly, G. Tibbs, 1989, FEBS letters.

ATP depletion increases Ca2+ uptake by synaptosomes

D. Nicholls, Karl E.O. Åkerman, 1981, FEBS letters.

CALCIUM TRANSPORT ACROSS THE PLASMA MEMBRANE AND INNER MITOCHONDRIAL MEMBRANE IN SYNAPTOSOMES

D. Nicholls, K. Åkerman, 1981 .

alpha-latrotoxin of black widow spider venom depolarizes the plasma membrane, induces massive calcium influx, and stimulates transmitter release in guinea pig brain synaptosomes.

I. G. Scott, J. Meldolesi, D. Nicholls, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Ca2+ transport and the regulation of transmitter release in isolated nerve endings

D. Nicholls, K. Åkerman, 1983 .

Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

M. Brand, D. Nicholls, N. Yadava, 2008, Gene.

Bioenergetics and Fuel-stimulated Insulin Differentially Affect Mitochondrial Chronic High Glucose and Pyruvate Levels Metabolism :

P. Spégel, H. Mulder, D. Nicholls, 2014 .

Adenosine A1 Receptor Inhibition of Glutamate Exocytosis and Protein Kinase C‐Mediated Decoupling

D. Nicholls, Anne P. Banie, 1993, Journal of neurochemistry.

Phosphorylation of synapsin I and MARCKS in nerve terminals is mediated by Ca2+ entry via an Aga‐GI sensitive Ca2+ channel which is coupled to glutamate exocytosis

D. Nicholls, J. Pocock, T. Sihra, 1994, FEBS letters.

The relationship between cytoplasmic free Ca2+ and the release of glutamate from synaptosomes.

D. Nicholls, H. McMahon, 1990, Biochemical Society transactions.

Tight Coupling between Glucose and Mitochondrial Metabolism in Clonal β-Cells Is Required for Robust Insulin Secretion*

L. Groop, C. Ling, H. Mulder, 2009, The Journal of Biological Chemistry.

Mitochondrial membrane potential monitored in situ within isolated guinea pig brown adipocytes by a styryl pyridinium fluorescent indicator

D. Nicholls, J. Rafael, 1984, FEBS letters.

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate*

D. Nicholls, M. Jekabsons, 2004, Journal of Biological Chemistry.

Glutamine and Aspartate Loading of Synaptosomes: A Reevaluation of Effects on Calcium‐Dependent Excitatory Amino Acid Release

D. Nicholls, H. McMahon, 1990, Journal of neurochemistry.

Brown-adipose-tissue mitochondria. The influence of albumin and nucleotides on passive ion permeabilities.

D. Nicholls, O. Lindberg, 1973, European journal of biochemistry.

Ion transport across energy-conserving membranes

D. Nicholls, S. Ferguson, 2003 .

Stimulation of Exocytosis in Cultured Cerebellar Granule Cells by Electrical Field Stimulation

M. Cousin, D. Nicholls, B. Held, 1997 .

A bioenergetic approach to the nerve terminal.

D. Nicholls, 1992, Biochimica et biophysica acta.

Mechanisms of Glutamate Exocytosis from Isolated Nerve Terminals

D. Nicholls, H. McMahon, G. Tibbs, 1989 .

Compartmentation of glutamate and aspartate within cerebral cortical synaptosomes: evidence for a non-cytoplasmic origin for the calcium-releasable pool of glutamate

D. Nicholls, Rosemary Wilkinson, 1989, Neurochemistry International.

Mitochondria in the cell

D. Nicholls, S. Ferguson, 2003 .

Synaptosomal Bioenergetics and the Mechanism of Amino Acid Transmitter Release

D. Nicholls, J. Sánchez-Prieto, 1988 .

Mitochondrial bioenergetics, aging, and aging-related disease.

D. Nicholls, 2002, Science of aging knowledge environment : SAGE KE.

Metabolic Control Analysis in a Cellular Model of Elevated MAO-B: Relevance to Parkinson’s Disease

J. Andersen, D. Nicholls, S. Chinta, 2009, Neurotoxicity Research.

Presynaptic modulation of glutamate release.

D. Nicholls, 1998, Progress in brain research.

Mitochondrial dysfunction in Huntington’s disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice

L. Ellerby, D. Nicholls, Sylvia F. Chen, 2007, Journal of neurochemistry.

Homologues of a K+ channel blocker α-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration

D. Nicholls, J. Dolly, P. Bougis, 1990, Neurochemistry International.

Mitochondrial-Dependent Ca2+ Handling in Huntington's Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors

M. Hayden, L. Ellerby, C. Oliveira, 2006, The Journal of Neuroscience.

Calcium efflux and cycling across the synaptosomal plasma membrane.

D. Nicholls, R. Snelling, 1985, The Biochemical journal.

Catecholaminergic Control of Mitogen-Activated Protein Kinase Signaling in Paraventricular Neuroendocrine Neurons In Vivo and In Vitro: A Proposed Role during Glycemic Challenges

Alan G. Watts, Glenn I. Hatton, A. Thomson, 2007, The Journal of Neuroscience.

The Pancreatic β-Cell: A Bioenergetic Perspective.

D. Nicholls, 2016, Physiological reviews.

Intracellular calcium homeostasis.

D. Nicholls, D. Nicholls, D G Nicholls, 1986, British medical bulletin.

THE REGULATION OF CYTOPLASMIC CALCIUM BY LIVER MITOCHONDRIA

D. Nicholls, 1978 .

Mitochondrial dysfunction in Parkinson's disease.

T. Peng, G. Brown, D. Nicholls, 1999, Biochemical Society symposium.

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

M. Brand, D. Nicholls, A. Gerencser, 2018, The Journal of Biological Chemistry.

Glutamate exocytosis from cerebellar granule cells: The mechanism of a transition to an L-type Ca2+ channel coupling

M. Cousin, D. Nicholls, J. Pocock, 1995, Neuroscience.

Bioenergetic profile experiment using C2C12 myoblast cells.

Min Wu, G. Rogers, D. Nicholls, 2010, Journal of visualized experiments : JoVE.

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

M. Brand, D. Nicholls, A. Gerencser, 2017, The Journal of Biological Chemistry.

The ‘mitoflash’ probe cpYFP does not respond to superoxide

Iain G. Johnston, M. Fricker, M. Duchen, 2014, Nature.