I. Phillips

发表

Planning the Human Variome Project: The Spain report

Toshio Kojima, John M. Hancock, Sue Povey, 2009, Human mutation.

Maintenance of total cytochrome P-450 content in rat hepatocyte culture and the abundance of CYP1A2 and CYP2B1/2 mRNAs.

I. Phillips, E. Shephard, C. Padgham, 1992, The Biochemical journal.

Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3)

M. Shimizu, H. Yamazaki, C. Allerston, 2007, Pharmacogenetics and genomics.

A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine

I. Phillips, E. Shephard, K. Karu, 2017, MethodsX.

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

J. Timms, I. Phillips, E. Shephard, 2015, Biochemical pharmacology.

A cytochrome P‐450 gene family mapped to human chromosome 19

S. Povey, G. Kelsey, M. Davis, 1985, Annals of human genetics.

Evidence for the importance of weakly bound water for matrix metalloproteinase activity.

I. Phillips, K. Brocklehurst, G. Murphy, 1995, Biochemistry.

Cytochrome P450 Protocols

I. Phillips, E. Shephard, 1998, Methods in Molecular Biology.

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1.

I. Phillips, E. Shephard, S. Wong, 2001, The Biochemical journal.

Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450.

I. Phillips, E. Shephard, C. Dolphin, 2001, Biochemical pharmacology.

Hormonal regulation of glutathione S-transferase expression in co-cultured adult rat hepatocytes.

T. Vanhaecke, V. Rogiers, I. Phillips, 2000, The Journal of endocrinology.

Effect of ethanol on the expression of hepatic glutathione S-transferase: an in vivo/in vitro study.

T. Vanhaecke, V. Rogiers, I. Phillips, 2000, Biochemical pharmacology.

Quantification of NADPH: cytochrome P-450 reductase in liver microsomes by a specific radioimmunoassay technique.

I. Phillips, E. Shephard, B. Rabin, 1983, The Biochemical journal.

Co-cultures of rat hepatocytes in the study of valproate toxicity.

V. Rogiers, I. Phillips, E. Shephard, 1992, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

The molecular biology of the flavin-containing monooxygenases of man.

I. Phillips, E. Shephard, I. Phillips, 1995, Chemico-biological interactions.

Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine

I. Phillips, E. Shephard, J. Everett, 2020, Drug Metabolism and Disposition.

FMO1 catalyzes the production of taurine from hypotaurine

I. Phillips, E. Shephard, J. Everett, 2019, bioRxiv.

Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics*

I. Phillips, E. Shephard, D. Smirlis, 2001, The Journal of Biological Chemistry.

Isolation of mouse hepatocytes.

I. Phillips, E. Shephard, Lyndsey Houseman, 2013, Methods in molecular biology.

Transfection of liver in vivo by biolistic particle delivery

S. Wong, I. Phillips, E. Shephard, 2002, Molecular biotechnology.

Isolation and sequence of a human cytochrome P-450 cDNA clone.

A. Ashworth, I. Phillips, E. Shephard, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of cDNAs encoding the rat testis-specific E1 alpha subunit of the pyruvate dehydrogenase complex: comparison of expression of the corresponding mRNA with that of the somatic E1 alpha subunit.

I. Phillips, J. Clark, T. Cullingford, 1993, Biochimica et biophysica acta.

Differential effect of phenobarbital and β‐naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase

I. Phillips, E. Shephard, B. Rabin, 1982, FEBS letters.

GENETIC POLYMORPHISMS OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)

David E. Williams, I. Phillips, E. Shephard, 2002, Drug metabolism reviews.

Induction by phenobarbital of the mRNA for a specific variant of rat liver microsomal cytochrome P-450.

I. Phillips, E. Shephard, F. Mitani, 1981, The Biochemical journal.

Localization of cytochrome P‐450 gene expression in normal and diseased human liver by in situ hybridization of wax‐embedded archival material

S. Davies, P. Coates, I. Phillips, 1992, Hepatology.

The effect of terpenoid compounds on cytochrome P-450 levels in rat liver.

I. Phillips, E. Shephard, B. Rabin, 1988, Biochemical pharmacology.

Reassessment of histone gene expression during cell cycle in human cells by using homologous H4 histone cDNA.

G. Stein, J. Stein, I. Phillips, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for the resumption of DNA replication prior to histone synthesis in HeLa cells after release from treatment with hydroxyurea

G. Stein, J. Stein, I. Phillips, 1982, FEBS letters.

Evidence that the coupling of histone gene expression and DNA synthesis in HeLa S3 cells is not mediated at the transscriptional level.

G. Stein, J. Stein, I. Phillips, 1977, Biochemical and biophysical research communications.

Multiple forms of H4 histone mRNA in human cells.

G. Stein, J. Stein, I. Phillips, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Clinical utility gene card for: Trimethylaminuria – update 2014

I. Phillips, E. Shephard, E. Treacy, 2014, European Journal of Human Genetics.

Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice

K. Veselkov, Z. Takáts, I. Phillips, 2018, Front. Mol. Biosci..

Hormonal regulation of microsomal flavin-containing monooxygenase activity by sex steroids and growth hormone in co-cultured adult male rat hepatocytes.

V. Rogiers, I. Phillips, E. Shephard, 1998, Biochemical pharmacology.

Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos).

I. Phillips, E. Shephard, D. Hernandez, 2004, Biochemical pharmacology.

Nuclear protein kinase activities during the cell cycle of HeLa S3 cells.

G. Stein, J. Stein, L. Kleinsmith, 1979, Biochimica et biophysica acta.

Regulation of histone gene expression in HeLa S3 cells

G. Stein, J. Stein, I. Phillips, 1979 .

A novel mutation in the flavin-containing monooxygenase 3 gene (FMO3) of a Norwegian family causes trimethylaminuria.

C. Allerston, G. Houge, I. Phillips, 2009, Molecular genetics and metabolism.

Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04.

I. Phillips, E. Shephard, T. Cullingford, 1996, European journal of biochemistry.

Drug metabolism by flavin-containing monooxygenases of human and mouse

I. Phillips, E. Shephard, 2017, Expert opinion on drug metabolism & toxicology.

Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.

I. Phillips, E. Shephard, D. Hernandez, 2004, Pharmacogenetics.

Induction of cytochrome P-450 by phenobarbital is mediated at the level of transcription.

I. Phillips, E. Shephard, B. Rabin, 1985, Biochemical pharmacology.

Isolation and Culture of Mouse Hepatocytes: Gender-Specific Gene Expression Responses to Chemical Treatments.

I. Phillips, E. Shephard, Lyndsey Houseman, 2015, Methods in molecular biology.

Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA.

J. Riley, I. Phillips, E. Shephard, 1997, Genomics.

Microheterogeneity in a cytochrome P-450 multigene family

A. Ashworth, I. Phillips, E. Shephard, 1984 .

Structure and expression of human cytochrome P-450 genes

I. Phillips, E. Shephard, C. Palmer, 1987 .

Regional localization of a human cytochrome P‐450 (CYP1) to chromosome 19q 13.1–13.3

M. Davis, I. Phillips, L. West, 1986, Annals of human genetics.

Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.

I. Phillips, E. Shephard, C. Dolphin, 2000, Pharmacogenetics.

Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).

S. Povey, I. Phillips, D. Ziegler, 1991, The Journal of biological chemistry.

The Pyruvate Dehydrogenase Complex: Cloning of the Rat Somatic El α Subunit and Its Coordinate Expression with the mRNAs for the E1β E2, and E3 Catalytic Subunits in Developing Rat Brain

I. Phillips, J. Clark, T. Cullingford, 1994 .

Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis

I. Phillips, E. Shephard, K. Karu, 2018, Drug Metabolism and Disposition.

The Flavin-Containing Monoooxygenases (FMOs): Genetic Variation and its Consequences for the Metabolism of Therapeutic Drugs

I. Phillips, E. Shephard, A. Francois, 2007 .

Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease

I. Phillips, E. Shephard, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse

David E. Williams, I. Phillips, E. Shephard, 2012, Pharmaceuticals.

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism

I. Phillips, E. Shephard, 2010, Expert opinion on drug metabolism & toxicology.

Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide

I. Phillips, E. Shephard, P. D. de Montellano, 2009, Drug Metabolism and Disposition.

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

K. Veeramah, N. Mendell, M. Weale, 2008, Pharmacogenetics and genomics.

Flavin-containing monooxygenases: mutations, disease and drug response.

I. Phillips, E. Shephard, 2008, Trends in pharmacological sciences.

Cytochrome P450 Protocols

Ian R. Phillips, Ea Shephard, Pr Ortiz de Montellano, 2013, Methods in Molecular Biology.

Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5 −/− mice, decreases plasma cholesterol and epididymal fat deposition

K. Veselkov, I. Phillips, E. Shephard, 2022, Frontiers in Physiology.

Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases.

V. Rogiers, I. Phillips, E. Shephard, 1995, European journal of biochemistry.

Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase.

V. Rogiers, I. Phillips, E. Shephard, 1993, Biochemical pharmacology.

Interaction of proteins with a cytochrome P450 2B2 gene promoter: identification of two DNA sequences that bind proteins that are enriched or activated in response to phenobarbital.

I. Phillips, G. Ciaramella, E. Shephard, 1994, DNA and cell biology.

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease

I. Phillips, E. Shephard, D. Fennema, 2016, Drug Metabolism and Disposition.

Identification of regulatory protein-binding sites in cytochrome P450 genes by means of the gel-retardation assay.

E A Shephard, I R Phillips, I. Phillips, 1998, Methods in molecular biology.

Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub‐family

S. Povey, I. Phillips, E. Shephard, 1989, Annals of human genetics.

Cloning and chromosomal mapping of human cytochrome b5 reductase (DIA1)

S. Povey, I. Phillips, E. Shephard, 1988, Annals of human genetics.

The major phenobarbital‐inducible cytochrome P‐450 gene subfamily (P450IIB) mapped to the long arm of human chromosome 19

S. Povey, I. Phillips, E. Shephard, 1988, Annals of human genetics.

Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse.

I. Phillips, E. Shephard, M. Edwards, 2007, The Biochemical journal.

Transfection of Primary Cultures of Rat Hepatocytes.

S. Wong, I. Phillips, E. Shephard, 2006, Methods in molecular biology.

REGULATION OF GENE EXPRESSION IN NORMAL AND NEOPLASTIC CELLS

G. Stein, P. Laipis, J. Stein, 1978 .

Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism

I. Phillips, E. Shephard, S. Veeravalli, 2023, bioRxiv.

A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.

J. Cashman, I. Phillips, R. Hines, 1994, Archives of biochemistry and biophysics.

Hormonal Control of Carbonic Anhydrase III

I. Phillips, E. Shephard, S. Jeffery, 1984, Annals of the New York Academy of Sciences.

Sexual differentiation of rat liver carbonic anhydrase III.

I. Phillips, E. Shephard, C. Wilson, 1983, Biochimica et biophysica acta.

Androgen-linked control of rat liver carbonic anhydrase III

I. Phillips, E. Shephard, C. Wilson, 1983, Bioscience reports.

Flavin-containing monooxygenases

I. Phillips, E. Shephard, 2002 .

The Flavin-containing Monooxygenase 2 Gene (FMO2) of Humans, but Not of Other Primates, Encodes a Truncated, Nonfunctional Protein*

I. Phillips, E. Shephard, Robert L. Smith, 1998, The Journal of Biological Chemistry.

Trimethylaminuria and a human FMO3 mutation database

David A. Lee, C. Orengo, I. Phillips, 2003, Human mutation.

A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopy.

I. Phillips, R. Chalmers, H. Michelakakis, 2000, Pharmacogenetics.

Effect of Thyroid Hormones onFlavin-containing Monooxygenase Activity in Co-cultured Adult Rat Hepatocytes.

V. Rogiers, I. Phillips, E. Shephard, 1998, Toxicology in vitro : an international journal published in association with BIBRA.

Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q.

S. Povey, I. Phillips, E. Shephard, 1996, Genomics.

Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q.

M. Fox, S. Povey, I. Phillips, 1993, Genomics.

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.

D. Williams, J. Kang, J. Whetstine, 2000, Toxicology and applied pharmacology.

Organization and evolution of the flavin-containing monooxygenase genes of human and mouse

I. Phillips, E. Shephard, D. Hernandez, 2004 .

Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.

S. Povey, I. Phillips, E. Shephard, 1992, The Biochemical journal.

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.

M. Shimizu, H. Yamazaki, C. Allerston, 2014, British journal of clinical pharmacology.

Clinical utility gene card for: Trimethylaminuria

I. Phillips, E. Shephard, E. Treacy, 2011, European Journal of Human Genetics.

Determination of Cellular Localization of Expression of Flavin-Containing Monooxygenase Genes in Mouse Tissues by In Situ Hybridization.

I. Phillips, E. Shephard, A. Janmohamed, 2006, Methods in molecular biology.

Flavin-containing monooxygenases: new structures from old proteins

I. Phillips, E. Shephard, 2019, Nature Structural & Molecular Biology.

Quantification of cytochrome P450 reductase gene expression in human tissues.

I. Phillips, E. Shephard, H. Segall, 1992, Archives of biochemistry and biophysics.

Chromosomal localization of a cytochrome b5 gene to human chromosome 18 and a cytochrome b5 pseudogene to the X chromosome.

S. Povey, N. Spurr, I. Phillips, 1991, Genomics.

Endogenous Roles of Mammalian Flavin-Containing Monooxygenases

I. Phillips, E. Shephard, 2019 .

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.

I. Phillips, E. Shephard, B. Omar, 2014, Biochemical pharmacology.

Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics.

A. Ashworth, I. Phillips, E. Shephard, 1983, Gene.

Quantification of cytochrome P-450 gene expression in human tissues.

I. Phillips, E. Shephard, C. Palmer, 1990, Biochemical Society transactions.

Isolation of a human cytochrome P‐450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2

A. Ashworth, S. Povey, I. Phillips, 1989, Annals of human genetics.

Congenital diseases: Complementary genes for an adrenal enzyme deficiency

I. Phillips, E. Shephard, 1985, Nature.

Induction and repression of the major phenobarbital-induced cytochrome P-450 measured by radioimmunoassay.

I. Phillips, E. Shephard, B. Rabin, 1983, The Biochemical journal.

Effects of phenobarbital and valproate on the expression of cytochromes P-450 in co-cultured rat hepatocytes.

V. Rogiers, I. Phillips, E. Shephard, 1993, Toxicology in vitro : an international journal published in association with BIBRA.

Phosphorylation and dephosphorylation of chromosomal proteins during in vitro transcription.

G. Stein, J. Stein, I. Phillips, 1981, Cell Differentiation.

Factors controlling the expression of genes coding for drug-metabolizing enzymes.

A. Ashworth, I. Phillips, E. Shephard, 1983, Biochemical Society Transactions.

Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine

I. Phillips, E. Shephard, D. Hernandez, 2009, Pharmacogenetics and genomics.

RFLP for a human cytochrome P-450 gene at 19q13.1-qter (HGM8 provisional designation CYPI).

I. Phillips, B. Wainwright, E. Shephard, 1985, Nucleic acids research.

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.

P. Slocombe, I. Phillips, K. Brocklehurst, 1993, Biochemistry.

Effect of ethanol on glutathione S-transferase expression in co-cultured rat hepatocytes.

V. Rogiers, I. Phillips, E. Shephard, 1995, Toxicology in vitro : an international journal published in association with BIBRA.

13th International Symposium on Microsomes and Drug Oxidations

M. Bootman, I. Phillips, E. Shephard, 2000 .

Expression of cytochrome P-450 genes in rat hepatoma cells

I. Phillips, E. Shephard, A. Shiels, 1987 .

Developmental Regulation of the Pyruvate Dehydrogenase Complex in the Rat Brain

I. Phillips, J. Clark, G. Malloch, 1989 .

The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full‐length enzymes: a possible role for the C‐terminal domain

I. Phillips, K. Brocklehurst, G. Murphy, 1995, FEBS letters.

Effects of valproate on xenobiotic biotransformation in rat liver

V. Rogiers, I. Phillips, E. Shephard, 1992, Pharmaceutisch Weekblad.

Evidence for nonhistone chromosomal protein kinase activity associated with nucleosomes isolated from HeLa S3 cells

J. Stein, I. Phillips, E. Shephard, 1979, FEBS letters.

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria

I. Phillips, E. Shephard, S. Veeravalli, 2017, Drug Metabolism and Disposition.

Chapter 9 Regulation of gene expression and gene amplification

J. Hawkins, I. Phillips, 1996 .

The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci.

M. J. Coon, M. Waterman, R. Estabrook, 1989, DNA.

A rapid one-step purification of NADPH-cytochrome c (P-450) reductase from rat liver microsomes.

I. Phillips, E. Shephard, B. Rabin, 1983, Analytical biochemistry.

Hepatocyte-based in vitro models and their application in pharmacotoxicology Report of an EC DGXII meeting with representatives of the European pharmaceutical industry.

V. Rogiers, I. Phillips, E. Shephard, 1995, Toxicology in vitro : an international journal published in association with BIBRA.

Complexes of cytochrome P450 with metyrapone

I. Phillips, E. Shephard, F. Mitani, 1982, FEBS letters.

Structure and expression of genes coding for members of the human P450II family

Ian R. Phillips, Christopher J. Griffith, Ea Shephard, 1989 .

Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family.

S. Povey, I. Phillips, E. Shephard, 1989, Annals of human genetics.

Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine

I. Phillips, E. Shephard, D. Hernandez, 2009, Pharmacogenetics and genomics.

Somatic change in the estrogen receptor gene associated with altered expression of the progesterone receptor.

I. Phillips, A. Goode, J. Puddefoot, 1991, Anticancer Research.

Long-term preservation and induction of drug metabolizing enzymes in co-cultured rat hepatocytes.

V. Rogiers, I. Phillips, E. Shephard, 1994, Biochemical Society transactions.

Deletion of Genes From the Mouse Genome Using Cre/loxP Technology.

I. Phillips, E. Shephard, D. Hernandez, 2006, Methods in molecular biology.