A. Mortlock

发表

A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

Pierre Validire, Yudi Pawitan, Angel Porgador, 2015, Oncotarget.

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Stephen S. Taylor, V. L. Johnson, N. Keen, 2003, The Journal of cell biology.

Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines.

Jon Read, Andrew G. Leach, Andrew G Leach, 2008, Bioorganic & medicinal chemistry letters.

Progress in the development of selective inhibitors of Aurora kinases.

N. Keen, S. Green, R. Wilkinson, 2005, Current topics in medicinal chemistry.

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.

N. Keen, S. Wedge, S. Heaton, 2007, Journal of medicinal chemistry.

Synthesis of the Bicyclo[4.4.1]decenone Core of CP-225,917 and CP-263,114

A. Armstrong, A. Mortlock, T. Critchley, 1998 .

Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.

A. Rabow, D. M. Andrews, G. Walker, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.

N. Keen, S. Wedge, S. Heaton, 2008, Bioorganic & Medicinal Chemistry Letters.

New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides.

R. Bradbury, A. Mortlock, M. Dennis, 1997, Journal of medicinal chemistry.

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.

Jon Read, Andrew G. Leach, Andrew G Leach, 2008, Bioorganic & medicinal chemistry letters.

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Rajesh Odedra, Stephen Green, John R. Foster, 2007, Clinical Cancer Research.

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.

Rajesh Odedra, Stephen Green, Nicola Heron, 2006, Journal of medicinal chemistry.

Bifunctional chiral auxiliaries 7: Aldol reactions of enolates derived from 1,3-diacyl-imidazolidine-2-thiones and 1,3-diacylimidazolidin-2-ones

G. Evans, A. Mortlock, S. Davies, 1994 .

Bifunctional chiral auxiliaries 1: the aldol reaction between dialkylboron enolates of 1,3-dipropionyl-trans-4,5-tetramethyleneimidazolidin-2-one and aldehydes

A. Mortlock, S. Davies, 1991 .

Total Syntheses of (-)-Papuamine and (-)-Haliclonadiamine.

A. Mortlock, C. Heathcock, T. Mcdermott, 1996, The Journal of organic chemistry.

Synthetic studies on CP-225,917 and CP-263,114: concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reactionElectronic supplementary information (ESI) available: crystal data for 13a. See http://www.rsc.org/suppdata/p1/b2/b202752f/

A. Armstrong, A. Mortlock, Richard D. Kelsey, 2002 .

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.

J. Breed, R. Pauptit, S. Green, 2006, Bioorganic & medicinal chemistry letters.

Bifunctional chiral auxiliaries 5: The synthesis of 1,3-diacylimidazolidine-2-thiones and 1,3-diacylimidazolidin-2-ones from 1,2-diamines☆

A. Mortlock, S. Davies, 1993 .

Bifunctional chiral auxiliaries 2: the synthesis of 1,3-diacylimidazolidin-2-ones from 1,2-diamines

A. Mortlock, S. Davies, 1991 .

Bifunctional chiral auxiliaries 3: Synthesis of homochiral 1,3-diols via asymmetric aldol reactions of dialkylboron enolates of 1,3-dipropionyl-trans-4,5-diphenyl-imidazolidin-2-one and aldehydes

A. Mortlock, S. Davies, 1991 .

Asymmetric synthesis of (1R,8S)- and (1S,8S)-1-hydroxypyrrolizidin-3-ones via the aldol reaction between N-boc-(S)-prolinal and chiral acetate enolate equivalents derived from (S)- and (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH3]

A. Mortlock, S. Davies, R. Beckett, 1992 .

Bifunctional chiral auxiliaries 6: Alkylations of enolates derived from 1,3-diacylimidazolidine- 2-thiones and 1,3-diacylimidazolidin-2-ones☆

G. Evans, A. Mortlock, S. Davies, 1994 .

Episulfone substitution and ring-opening reactions via α-sulfonyl carbanion intermediates

A. Mortlock, N. Simpkins, Allan P. Dishington, 1997 .

Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 2.

S. Barry, J. Kendrew, D. Cross, 2012, Bioorganic & medicinal chemistry letters.

Kinase Inhibitors in Cancer

B. Aquila, A. Mortlock, J. Kettle, 2013 .

7.08 – Kinase Inhibitors for Cancer

A. Barker, A. Mortlock, 2007 .

Selective Kinase Inhibitors in Cancer

A. Mortlock, D. Wilson, J. Kettle, 2017 .

N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide; one of a class of novel benzenesulphonamides which are orally-active, ETA-selective endothelin antagonists

A. Mortlock, N. D. Wright, R. Butlin, 1997 .

Progress in the development of selective inhibitors of aurora kinases.

N. Keen, S. Green, R. Wilkinson, 2005, Current topics in medicinal chemistry.

Two New Syntheses of a 4-Aminopyrazole: Condensation of an N-Substituted Vinamidinium Salt with a Functionalized Hydrazine

A. Mortlock, G. Hill, 2007 .

A study of the aldol reaction between enolates derived from the iron acetyl complex [(η5-C5H5)Fe(CO)(PPh3)COCh3] and 2,3-O-lsopropylidene-D-glyceraldehyde

A. Mortlock, S. Davies, G. Bodwell, 1991 .

First Examples of Episulfone Substitution Reactions via .alpha.-Sulfonyl Carbanion Intermediates

A. Mortlock, N. Simpkins, Adriano B. Muccioli, 1994 .

New Non-Peptide Endothelin-A Receptor Antagonists: Synthesis, Biological Properties, and Structure-Activity Relationships of 5-( Dimethylamino)-N-pyridyl-, -N-pyrimidinyl-, -N-pyridazinyl-, and -N- pyrazinyl-1-naphthalenesulfonamides.

R. Bradbury, A. Mortlock, M. Dennis, 1997 .

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Stephen S. Taylor, V. L. Johnson, N. Keen, 2003, The Journal of cell biology.