T. Tam

发表

Thiol proteases: inhibitors and potential therapeutic targets.

Khashayar Karimian, R. Leung-Toung, Yanqing Zhao, 2006, Current medicinal chemistry.

1,2,4-thiadiazole: a novel Cathepsin B inhibitor.

R. Leung-Toung, W. Li, T. Tam, 2003, Bioorganic & medicinal chemistry.

Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase.

T. Tam, A. Krantz, L. Copp, 1990, Journal of medicinal chemistry.

Annulated sugars: the 1,2-O-isopropylidene ring as a stereo-, regio-, and chemoselective agent

T. Tam, B. Fraser-Reid, K. Sun, 1982 .

Ynenol lactones: synthesis and investigation of reactions relevant to their inactivation of serine proteases

T. Tam, A. Krantz, R. Spencer, 1986 .

4-Alkoxy-6-alkyl-2-pyrones as precursors for 4-alkoxy-6-alkyl-2-aminobenzoic acid derivatives

T. Tam, P. Coles, 1988 .

Novel suicide inhibitors of serine proteinases. Inactivation of human leukocyte elastase by ynenol lactones

T. Tam, A. Krantz, L. Copp, 1984 .

1,2-O-isopropylidene furanoses as chiral precursors for α-methylene-γ-butyrolactones

T. Tam, B. Fraser-Reid, 1980 .

Chiral models of the furenone moiety of germacranolide sesquiterpenes

T. Tam, B. Fraser-Reid, 1980 .

Iron chelator research: past, present, and future.

Yingsheng Wang, R. Leung-Toung, W. Li, 2003, Current medicinal chemistry.

Thiol-dependent enzymes and their inhibitors: a review.

Khashayar Karimian, R. Leung-Toung, W. Li, 2002, Current medicinal chemistry.

Tris(2-N-methylaminocarbonyl-3-hydroxy-1,6-dimethyl-1,4-dihydro-4-pyridinonato)iron(III) dimethylformamide disolvate

Yingsheng Wang, R. Leung-Toung, T. Tam, 2005 .

Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation.

T. Tam, A. Krantz, L. Copp, 1987, Journal of medicinal chemistry.

A synthetic route to 4-C-methyl-xylo-furanose

T. Tam, B. Fraser-Reid, 1979 .

Synthesis of 5-alkynylidene-oxazolidin-2-ones☆

T. Tam, A. Krantz, E. Thomas, 1987 .

Novel suicide inhibitors of serine proteinases. Inactivation of human leukocyte elastase by ynenol lactones

T. Tam, A. Krantz, L. Copp, 1984 .

Inhibition of serine proteases by benzoxazinones: effects of electron withdrawal and 5-substitution.

T. Tam, A. Krantz, L. Copp, 1986, Biochemical and biophysical research communications.

Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides.

T. Tam, C. Bach, A. Castelhano, 1992, Journal of medicinal chemistry.

Medicinal chemistry and properties of 1,2,4-thiadiazoles.

R. Leung-Toung, T. Tam, K. Karimian, 2005, Mini reviews in medicinal chemistry.

Tris(1-cyclopropyl-6-methyl-2-(N-methylaminocarbonyl)-4-oxo-1,4-dihydropyridin-4-olato)iron(III) dimethylformamide sesquisolvate dihydrate

Yingsheng Wang, R. Leung-Toung, T. Tam, 2005 .

Synthesis of 3‐Substituted Bicyclic Imidazo[1,2‐d][1,2,4]thiadiazoles and Tricyclic Benzo[4,5]imidazo[1,2‐d][1,2,4]thiadiazoles.

R. Leung-Toung, Yanqing Zhao, T. Tam, 2005 .

3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors.

R. Leung-Toung, Yanqing Zhao, T. Tam, 2005, Journal of medicinal chemistry.