D. Milan

发表

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Claude Bouchard, William Wheeler, Peter Kraft, 2014 .

Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders

Santosh A. Khedkar, Vassilios J. Bezzerides, Saumya Das, 2017, Scientific Reports.

Risk stratification in the long-QT syndrome.

Calum A MacRae, P. Ellinor, C. Macrae, 2003, The New England journal of medicine.

High-throughput assay for small molecules that modulate zebrafish embryonic heart rate

Wolfgang Rottbauer, Calum A MacRae, C Geoffrey Burns, 2005, Nature chemical biology.

GWAS-driven Pathway Analyses and Functional Validation Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse

Francesca N. Delling, R. Levine, P. Ellinor, 2018, bioRxiv.

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

Francesca N. Delling, Y. Bossé, R. Redon, 2015, Nature Genetics.

Mutations in DCHS1 Cause Mitral Valve Prolapse

Francesca N. Delling, X. Estivill, R. Levine, 2015, Nature.

New insights into mitral valve dystrophy: a Filamin-A genotype–phenotype and outcome study

Francesca N. Delling, R. Levine, C. Dina, 2018, European heart journal.

Patterning and Development of the Atrioventricular Canal in Zebrafish

David S. Peal, Stacey N. Lynch, D. Milan, 2011, Journal of cardiovascular translational research.

Notch1b and neuregulin are required for specification of central cardiac conduction tissue

Calum A MacRae, Randall T Peterson, R. Peterson, 2006, Development.

Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish

Calum A. MacRae, David J. Milan, J. Ruskin, 2003, Circulation.

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

Søren Brunak, Kasper Lage, Jesper V Olsen, 2014, Nature Methods.

Electrical Gridlock Trpm4-Linked Isolated Cardiac Conduction Defects : Bad Trafficking Causes

D. Milan, Circ Cardiovasc, R. Genet, 2013 .

TRPM4-linked isolated cardiac conduction defects: bad trafficking causes electrical gridlock.

Robert W. Mills, D. Milan, 2010, Circulation. Cardiovascular genetics.

Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse.

Francesca N. Delling, R. Levine, P. Ellinor, 2019, Circulation. Genomic and precision medicine.

Pluripotent Stem Cells as a Platform for Cardiac Arrhythmia Drug Screening

D. Milan, J. Leyton-Mange, 2014, Current Treatment Options in Cardiovascular Medicine.

Increased Reactive Oxygen Species–Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome

Vassilios J. Bezzerides, W. Pu, Xujie Liu, 2021, Circulation.

A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse

R. Weissleder, Y. Iwamoto, K. King, 2018, Circulation research.

Genome-wide association studies in cardiac electrophysiology: recent discoveries and implications for clinical practice.

P. Ellinor, S. Lubitz, S. Kääb, 2010, Heart rhythm.

Bad Trafficking Causes Electrical Gridlock

Robert W. Mills, D. Milan, 2010 .

Polymorphisms and atrial fibrillation: sorting the wheat from the chaff.

P. Ellinor, D. Milan, 2008, European Heart Journal.

Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation

Thomas Meitinger, Andres Metspalu, Dan M. Roden, 2010, Nature Genetics.

Mutations in DCHS1 Cause Mitral Valve Prolapse

Francesca N. Delling, Broome, Toomer, 2015, Nature.

Primary cilia defects causing mitral valve prolapse

Francesca N. Delling, Ryan L. Collins, Willian A. da Silveira, 2019, Science Translational Medicine.

Dexamethasone suppresses long QT phenotype in patient with acute promyelocytic leukemia treated with arsenic

D. Milan, J. Winterfield, 2015, HeartRhythm case reports.

Ibrutinib-Mediated Atrial Fibrillation Due to Inhibition of CSK.

P. Ellinor, G. Wojtkiewicz, Y. Iwamoto, 2020, Circulation.

Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase

P. Ellinor, G. Wojtkiewicz, Y. Iwamoto, 2020 .

Fungal infection of implantable cardioverter-defibrillators: case series of five patients managed over 22 years.

M. Mansour, J. Ruskin, P. Ellinor, 2006, Heart rhythm.

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

Robert W. Mills, C. January, P. Ellinor, 2011, Circulation.

Metabolic gene defects and risk of arrhythmia

P. Ellinor, C. Macrae, D. Milan, 2006 .

Increased incidence of subacute lead perforation noted with one implantable cardioverter-defibrillator.

Jagmeet P. Singh, E. Heist, M. Mansour, 2007, Heart rhythm.

Neutrophils incite and macrophages avert electrical storm after myocardial infarction

P. Ellinor, S. Neubauer, G. Wojtkiewicz, 2022, Nature Cardiovascular Research.

Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation

P. Ellinor, Y. Iwamoto, Saumya Das, 2021, bioRxiv.

Monogenic atrial ﬁbrillation as pathophysiological paradigms

M. Rienstra, P. Ellinor, S. Lubitz, 2011 .

OCT4-mediated inflammation induces cell reprogramming at the origin of cardiac valve development and calcification

Emily J. Farrar, M. Pucéat, J. Butcher, 2021, Science advances.

Who Should Receive the Subcutaneous Implanted Defibrillator?: Timing Is Not Right to Replace the Transvenous Implantable Cardioverter Defibrillator

D. Milan, M. R. Acha, 2013, Circulation. Arrhythmia and electrophysiology.

GWAS-driven Pathway Analyses and Functional Validation Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse

Francesca N. Delling, R. Levine, P. Ellinor, 2018, bioRxiv.

The diagnosis and treatment of cardiac ion channelopathies: Congenital long QT syndrome and Brugada syndrome

P. Ellinor, D. Milan, Ryan G. Aleong, 2007, Current treatment options in cardiovascular medicine.

Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization

Dan M Roden, Aravinda Chakravarti, Stefan Kääb, 2009, Circulation.

In Vivo Recording of the Adult Zebrafish Electrocardiogram

C. Macrae, D. Milan, 2011 .

Animal models for arrhythmias.

C. Macrae, D. Milan, 2005, Cardiovascular research.

Reprogramming the beat: kicking it up a notch.

Sean M. Wu, D. Milan, 2012, Circulation.

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

E. Price, F. Shibasaki, F. McKeon, 1996, Nature.

Mechanisms of Actions of Inhaled Anesthetics

P. Ellinor, S. Priori, P. Schwartz, 2003 .

Macrophages Facilitate Electrical Conduction in the Heart

Andrej J. Savol, P. Libby, J. Seidman, 2017, Cell.

Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation

K. Lunetta, A. Hofman, A. Uitterlinden, 2014, Circulation.

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

K. Lunetta, A. Hofman, A. Uitterlinden, 2012, Nature Genetics.

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

Robert W. Mills, Manolis Kellis, P. Ellinor, 2016, eLife.

Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1&agr; and LDHA

P. Alves, D. Milan, A. Garakani, 2018, Circulation research.

Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy

Robert W. Mills, P. Ellinor, S. Lubitz, 2017, Circulation. Cardiovascular genetics.

Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association.

Steven R Houser, Andre Terzic, Kiran Musunuru, 2018, Circulation. Genomic and precision medicine.

Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

J. Guyette, H. Ott, D. Milan, 2021, Nature Communications.

Zebrafish genetic models for arrhythmia.

Calum A Macrae, C. Macrae, D. Milan, 2008, Progress in biophysics and molecular biology.

PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance

P. Ellinor, X. Jouven, I. Kullo, 2016, PLoS genetics.

Recovery of myocardial tissue from extracted leads.

D. Milan, M. R. Acha, 2012, Heart rhythm.

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

Stuart L Schreiber, Calum A MacRae, Randall T Peterson, 2004, Nature Biotechnology.

In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation.

Calum A MacRae, P. Ellinor, C. Macrae, 2006, American journal of physiology. Heart and circulatory physiology.

Overexpression of KCNN3 results in sudden cardiac death.

Robert W. Mills, P. Ellinor, Saumya Das, 2014, Cardiovascular research.

Monogenic atrial fibrillation as pathophysiological paradigms.

M. Rienstra, P. Ellinor, S. Lubitz, 2011, Cardiovascular research.

Cardiac sodium channel mutation in atrial fibrillation.

J. Ruskin, P. Ellinor, C. Macrae, 2008, Heart rhythm.

Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential

Robert W. Mills, K. Lunetta, L. Mirny, 2017, Circulation. Cardiovascular genetics.

Small Molecule Screening in Zebrafish

David Milan, Randall T Peterson, R. Peterson, 2010 .

Efficacy of Intravenous and Oral Sotalol in Pharmacologic Conversion of Atrial Fibrillation: A Systematic Review and Meta-Analysis

J. Saul, J. Molnar, D. Milan, 2016, Cardiology.

Timing of delayed perforation with the St. Jude Riata lead: a single-center experience and a review of the literature.

Jagmeet P. Singh, E. Heist, M. Mansour, 2008, Heart rhythm.

Rapid Cellular Phenotyping of Human Pluripotent Stem Cell-Derived Cardiomyocytes using a Genetically Encoded Fluorescent Voltage Sensor

Robert W. Mills, Patrick T. Ellinor, David J. Milan, 2014, Stem cell reports.

Chondroitin sulfate expression is required for cardiac atrioventricular canal formation

C. Macrae, David S. Peal, D. Milan, 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction

Robert W. Mills, T. Lumley, R. Gibbs, 2018, Circulation. Genomic and precision medicine.

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

F. McKeon, D. Milan, J. Griffith, 1994, Cell.

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on arrhythmias and cognitive function: What is the best practice?

Daniel P. Morin, M. Chung, G. Lip, 2018, Journal of arrhythmia.

Bioengineering Human Myocardium on Native Extracellular Matrix.

Robert W. Mills, Joshua R Gershlak, Harald C Ott, 2016, Circulation research.

The genetics of conduction disease.

J. Ruskin, R. Beinart, D. Milan, 2010, Heart failure clinics.

Photochemical activation of TRPA1 channels in neurons and animals

Michael R Hamblin, Robert W. Mills, V. Setola, 2013, Nature chemical biology.

A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation.

K. Lunetta, E. Benjamin, P. Ellinor, 2014, Heart rhythm.

Catecholamine challenge unmasking high-risk features in the Wolff-Parkinson-White syndrome.

D. Milan, Ryan G. Aleong, Sheldon M. Singh, 2009, Europace.

Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis

P. Ellinor, S. Priori, A. Mazzanti, 2016, Circulation.

Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis

P. Ellinor, S. Priori, A. Mazzanti, 2015, Circulation.

Factors affecting error in integration of electroanatomic mapping with CT and MR imaging during catheter ablation of atrial fibrillation

Patrick T. Ellinor, E. Kevin Heist, Moussa Mansour, 2007, Journal of Interventional Cardiac Electrophysiology.

Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse.

Francesca N. Delling, M. Rienstra, B. Horne, 2022, European heart journal.

Embryonic Development of the Bicuspid Aortic Valve

S. Body, C. Maslen, M. Lindsay, 2015, Journal of cardiovascular development and disease.

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

David Milan, Markus Krane, Moshe Rav-Acha, 2012, Circulation research.

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata 4 , Mef 2 c , and Tbx 5 Short Communication

M. Deutsch, M. Krane, Sean M. Wu, 2012 .

Increased Reactive Oxygen Species–Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome

Vassilios J. Bezzerides, W. Pu, Xujie Liu, 2021, Circulation.

A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b

Robert W. Mills, R. Peterson, D. Milan, 2017, Scientific Reports.

Neuregulin but not endothelin signaling is required for atrioventricular conduction tissue development

R. Peterson, C. Macrae, D. Milan, 2005 .

Recruited macrophages elicit atrial fibrillation

P. Ellinor, R. Mitchell, J. Aster, 2023, Science.

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

May E. Montasser, H. M. Draisma, K. Lunetta, 2014 .

Genome-Wide Association Study to Find Modifiers for Tetralogy of Fallot in the 22q11.2 Deletion Syndrome Identifies Variants in the GPR98 Locus on 5q14.3

Robert W. Mills, A J Agopian, Jonathan H. Chung, 2017, Circulation. Cardiovascular genetics.

Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias

Robert W. Mills, P. Ellinor, D. Milan, 2023, Circulation research.

Overexpression of KCNN 3 results in sudden cardiac death

Robert W. Mills, P. Ellinor, Saumya Das, 2014 .

Gain-of-function mutations in GATA6 lead to atrial fibrillation.

E. Benjamin, P. Ellinor, D. Milan, 2017, Heart rhythm.

Author ’ s Accepted Manuscript Gain of function mutations in GATA 6 lead to atrial fibrillation

E. Benjamin, P. Ellinor, D. Milan, 2016 .

miR-21 represses Pdcd4 during cardiac valvulogenesis

P. Ellinor, R. Markwald, S. Ghatak, 2013, Development.

Abstract 15370: Genetic Study Identifies Common Variation in PHACTR1 to Associate With Fibromuscular Dysplasia (Best of Basic Science Abstract)

X. Jouven, I. Kullo, P. Galan, 2015 .

Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis

P. Ellinor, S. Priori, A. Mazzanti, 2016, Circulation.

Cardiotoxicity Studies in Zebrafish

C. Macrae, D. Milan, 2011 .

Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish

J. Ruskin, R. Peterson, C. Macrae, 2003 .

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

Robert W. Mills, C. January, P. Ellinor, 2011, Circulation.

Cellular Biology Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5 Short Communication Conclusions: Significant Challenges Remain in Our Ability to Convert Fibroblasts into Cardiomyocyte-like Cells and Results Reprogramming Tail Tip Fibroblasts by Gmt Overexpr

M. Deutsch, M. Krane, Sean M. Wu, 2022 .

CO-43: Genetic study identifies common variation in phactr1 to associate with fibromuscular dysplasia.

I. Kullo, P. Galan, N. Bouatia-Naji, 2015, Annales de cardiologie et d'angéiologie.

Cardiovascular Development and Disease Embryonic Development of the Bicuspid Aortic Valve

S. Body, M. Lindsay, R. Norris, 2022 .

Anderson-Fabry disease : an important differential diagnosis in patients with unexplained left ventricular hypertrophy

P. Ellinor, P. Elliott, C. Macrae, 2006 .

TRPM4-linked isolated cardiac conduction defects: bad trafficking causes electrical gridlock.

Robert W. Mills, D. Milan, 2010, Circulation. Cardiovascular genetics.