J. Silke

发表

Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

M. Wigler, R. Lucito, S. Lowe, 2006, Cell.

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Robert L Moritz, Richard J Simpson, Lisa M Connolly, 2000, Cell.

Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis.

D. Vaux, J. Silke, D. Vaux, 2001, Journal of cell science.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

The importance of being chaperoned: HSP90 and necroptosis.

J. Silke, A. Jacobsen, Annette V. Jacobsen, 2016, Cell chemical biology.

CARP2 deficiency does not alter induction of NF-κB by TNFα

D. Vaux, Afsar U. Ahmed, J. Silke, 2009, Current Biology.

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

P. R. Elliott, J. Bertin, T. Vanden Berghe, 2018, Molecular cell.

Methods for Studying TNF-Mediated Necroptosis in Cultured Cells.

J. Hildebrand, J. Silke, Zikou Liu, 2018, Methods in molecular biology.

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

J. Bertin, A. Strasser, A. Akarca, 2018, Nature Communications.

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

P. R. Elliott, J. Bertin, T. Vanden Berghe, 2018, Molecular cell.

The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes

J. Silke, R. Feltham, 2017, Cell Death and Differentiation.

IAPs and Necroptotic Cell Death

D. Vaux, J. Silke, 2014 .

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

D. Vaux, W. Alexander, P. Ekert, 2014, Cell.

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.

J. Martinez-Barbera, Y. Shimizu, T. Rodríguez, 2014, Cell reports.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

D. Vaux, L. Gangoda, W. Alexander, 2014, eLife.

Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation.

J. Silke, P. Meier, 2013, Cold Spring Harbor perspectives in biology.

Workshop summary: novel aspects of the functions of the TRAFs and cIAPs.

J. Silke, D. Vučić, 2011, Advances in experimental medicine and biology.

The regulation of TNF signalling: what a tangled web we weave.

J. Silke, 2011, Current opinion in immunology.

RIPK1 is not essential for TNFR1-induced activation of NF-κB

D. Vaux, J. Silke, D. Vaux, 2010, Cell Death and Differentiation.

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.

Christoph H Emmerich, David Komander, Ronald Koschny, 2009, Molecular cell.

Inhibitor of Apoptosis Proteins and Caspases

P. Ekert, J. Silke, Jai Y. Yu, 2006 .

IAPs, RINGs and ubiquitylation

David L. Vaux, D. Vaux, J. Silke, 2005, Nature Reviews Molecular Cell Biology.

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

A. Strasser, T. Mak, R. Hakem, 2009, Immunity.

Evidence for erosion of mouse CpG islands during mammalian evolution

Oliver Clay, Walter Schaffner, W. Schaffner, 1993, Somatic cell and molecular genetics.

Targeting XIAP and PPARγ in Granulosa Cell Tumors Alters Metabolic Signaling.

J. Silke, S. Chu, P. Fuller, 2019, Journal of proteome research.

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

D. Vaux, K. Schroder, Tan A Nguyen, 2017, Cell reports.

IAPs and Cell Death.

J. Silke, J. Vince, 2017, Current topics in microbiology and immunology.

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization*

D. Vaux, C. Day, J. Silke, 2011, The Journal of Biological Chemistry.

New perspectives in TNF-R1-induced NF-κB signaling.

J. Silke, I. Gentle, 2011, Advances in experimental medicine and biology.

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.

D. Vaux, J. Silke, R. Brink, 2011, Blood.

Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding

D. Vaux, C. Day, J. Silke, 2010, The Journal of Biological Chemistry.

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

Erinna F. Lee, D. Vaux, C. Day, 2009, The Journal of Biological Chemistry.

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

P. Ekert, J. Silke, A. Verhagen, 2007, Cell Death and Differentiation.

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance.

D. Vaux, P. Ekert, C. Day, 2005, Proceedings of the National Academy of Sciences of the United States of America.

IAPs – the ubiquitin connection

J. Silke, D. Vaux, John Silke, 2005, Cell Death and Differentiation.

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3– and caspase 9–interacting sites

D. Vaux, P. Ekert, C. Day, 2002, The Journal of cell biology.

Direct inhibition of caspase 3 is dispensable for the anti‐apoptotic activity of XIAP

D. Vaux, P. Ekert, C. Day, 2001, The EMBO journal.

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

B. Blagoev, T. Tenev, K. G. Rigbolt, 2010, Molecular cell.

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Stefan P. Glaser, D. Vaux, G. Salvesen, 2016, Science Translational Medicine.

Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis.

P. Angus, J. Silke, J. Torresi, 2014, The Journal of general virology.

Tankyrase-mediated ADP-ribosylation is a novel regulator of TNF-induced death

J. Sandow, J. Silke, M. Hottiger, 2021, bioRxiv.

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

I. Wicks, J. Silke, H. Anderton, 2020, Nature Reviews Rheumatology.

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

K. Rogers, Michael J. Mlodzianoski, L. Whitehead, 2020, Nature Communications.

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

S. Uemura, H. Nakano, M. Miura, 2018, Nature Communications.

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

S. Uemura, H. Nakano, M. Miura, 2018, Nature Communications.

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Brian J. Smith, J. Sandow, Weiwen Dai, 2018, Nature Communications.

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.

W. Alexander, J. Hildebrand, J. Silke, 2015, The Biochemical journal.

In vivo control of B‐cell survival and antigen‐specific B‐cell responses

J. Silke, R. Brink, T. Chan, 2010, Immunological reviews.

Is SIRT2 required for necroptosis?

D. Green, P. Vandenabeele, J. Auwerx, 2014, Nature.

RIPK3 promotes cell death NLRP3 inflammasome and interleukin-1 activation in the absence of MLKL

D. Vaux, W. Alexander, I. Wicks, 2017 .

Research Highlight Another Facet of Ubiquitylation: Death

J. Silke, W. Wong, 2009 .

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

D. Vaux, P. Ekert, J. Silke, 2001, The Journal of cell biology.

XIAP acts as a switch between type I and type II FAS-induced apoptosis signalling

C. Borner, A. Strasser, P. Bouillet, 2014 .

IAPS and ubiquitylation

J. Silke, R. Feltham, N. Khan, 2012, IUBMB life.

Masters, marionettes and modulators: intersection of pathogen virulence factors and mammalian death receptor signaling.

J. Silke, E. Hartland, 2013, Current opinion in immunology.

Antagonism of IAPs Enhances CAR T-cell Efficacy

R. Johnstone, I. Voskoboinik, C. Kearney, 2019, Cancer Immunology Research.

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF

C. Kearney, J. Silke, J. Oliaro, 2017, Cell Death and Differentiation.

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

L. Trotman, Sharad Kumar, T. Thomas, 2012, The Journal of cell biology.

Tumor immune evasion arises through loss of TNF sensitivity

K. Brown, J. Trapani, D. Knight, 2018, Science Immunology.

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

W. Alexander, J. Sandow, Simon P Preston, 2017, Cell Death & Differentiation.

Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease

J. Silke, M. Lazarou, M. Ryan, 2007, The EMBO journal.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

D. Vaux, M. Gaestel, G. Brumatti, 2016, Cancer cell.

IAP gene deletion and conditional knockout models.

D. Vaux, J. Silke, 2015, Seminars in cell & developmental biology.

TRAF 2 regulates TNF and NF-κB signalling to suppress apoptosis and skin 1 inflammation independently of Sphingosine kinase-1 2 3

D. Vaux, G. Smyth, S. Nutt, 2015 .

In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8*

D. Vaux, J. Silke, J. Lluis, 2011, The Journal of Biological Chemistry.

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

T. Tenev, J. Silke, P. Meier, 2011, Cell Death and Differentiation.

Hepatitis C‐induced hepatocyte apoptosis following liver transplantation is enhanced by immunosuppressive agents

P. Angus, J. Silke, J. Torresi, 2016, Journal of viral hepatitis.

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival

A. Scott, M. Foley, Spring Yingchun Liu, 2015, Cell.

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

D. Vaux, P. Ekert, Sharad Kumar, 2004, The Journal of cell biology.

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

C. Borner, D. Vaux, J. Heraud, 2006, Blood.

HtrA2/Omi, a Sheep in Wolf's Clothing

D. Vaux, J. Silke, 2003, Cell.

Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis

J. Silke, B. Croker, M. Gerlic, 2015, Current opinion in hematology.

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

D. Green, A. Strasser, R. Hakem, 2016, Immunity.

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

J. Murphy, J. Hildebrand, J. Silke, 2016, Cell Death and Disease.

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

J. Sandow, M. Pellegrini, J. Pearson, 2022, Science advances.

Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers

L. O'Reilly, J. Silke, Y. Ni, 2022, Frontiers in immunology.

Targeting of Fn14 prevents cachexia

Jessie, Spring Yingchun Liu, P. Schneider, 2018 .

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor

W. Alexander, M. Parker, J. Holien, 2013, The FEBS journal.

Caspase inhibitors

J. Silke, D. Vaux, P. Ekert, 1999, Cell Death and Differentiation.

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

A. Strasser, G. Smyth, Yifang Hu, 2016, Nature Communications.

Sharpin is a key regulator of skeletal homeostasis in a TNF-dependent manner.

J. Silke, J. Rickard, A. McDonald, 2014, Journal of musculoskeletal & neuronal interactions.

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

A. Strasser, N. Mailand, S. Bekker-Jensen, 2012, Molecular cell.

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

J. Bertin, A. Strasser, T. Enver, 2018, Nature.

IAPs must limit activation of RIP kinases by TNF Receptor 1 to prevent embryonic lethality

D. Vaux, A. Voss, T. Thomas, 2018 .

Ubiquitylation and cancer development.

H. Puthalakath, J. Silke, Maria Miasari, 2008, Current cancer drug targets.

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

J. Silke, Ngee Kiat Chua, S. A. Cobbold, 2022, Nature Communications.

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

M. Kauppi, C. Vinuesa, J. Pearson, 2022, bioRxiv.

TWEAK shall inherit the earth

J. Silke, J. Vince, 2006, Cell Death and Differentiation.

More than cell death: caspases and caspase inhibitors on the move.

G. Dotto, J. Silke, 2004, Developmental cell.

Necroptosis in chronic obstructive pulmonary disease, a smoking gun?

J. Silke, C. Pierotti, 2022, Immunology and cell biology.

Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke

J. Silke, J. Callaway, J. Howitt, 2012, Experimental Neurology.

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

Sharad Kumar, T. Chan-Ling, J. Silke, 2009, Proceedings of the National Academy of Sciences.

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Si Ming Man, P. Bouillet, S. Masters, 2018, Cell reports.

The Mitochondrial Apopto tic Effectors BAX / BAK Activate Caspase-3 and-7 to Trigger NLRP 3 Inflammasome and Caspase-8 Driven IL-1 b Activation Graphical

Si Ming Man, P. Bouillet, S. Masters, 2018 .

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

C. Begley, M. Pellegrini, J. Silke, 2015, Proceedings of the National Academy of Sciences.

NOD1 is required for Helicobacter pylori induction of IL‐33 responses in gastric epithelial cells

J. Silke, P. Sutton, S. Creed, 2018, Cellular microbiology.

Nedd 4 Family-interacting Protein 1 ( Ndfip 1 ) Is Required for the Exosomal Secretion of Nedd 4 Family Proteins *

Sharad Kumar, J. Silke, J. Howitt, 2008 .

Ndﬁp 1 represses cell proliferation by controlling Pten localization and signaling speciﬁcity

J. Gunnersen, J. Silke, J. Howitt, 2015 .

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.

Yigong Shi, G. Kapoor, C. Day, 2014, Journal of medicinal chemistry.

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

J. Silke, S. Chu, P. Fuller, 2018, Molecular Cancer Therapeutics.

Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis

Laura F. Dagley, D. Komander, Cheree Fitzgibbon, 2021, The EMBO journal.

Oligomerization-driven MLKL ubiquitylation antagonises necroptosis

Laura F. Dagley, D. Komander, Cheree Fitzgibbon, 2021, bioRxiv.

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity

Laura F. Dagley, J. Silke, I. Lucet, 2020, EMBO reports.

Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response*

T. Ouchi, J. Silke, J. Howitt, 2015, The Journal of Biological Chemistry.

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.

G. Varigos, J. Silke, N. Lalaoui, 2017, The Journal of investigative dermatology.

Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation

P. Angus, J. Silke, J. Torresi, 2015, PloS one.

Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism

P. Ekert, R. Foster, J. Silke, 2001, Apoptosis.

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Ashley P Ng, E. Bandala-Sanchez, J. Silke, 2018, Cell Death & Differentiation.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK 1-and RIPK 3-dependent manner

D. Vaux, A. Strasser, W. Alexander, 2014 .

TNF and CD95 promote IL-8 gene transactivation via independent elements in colon carcinoma cells.

J. Silke, A. Verhagen, M. Pakusch, 2001, Cytokine.

OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling

L. Ding, L. O'Reilly, J. Silke, 2022, Nature Communications.

The unifying catalytic mechanism of the RING-between-RING E3 ligase family

B. C. Lechtenberg, J. Silke, S. J. Trevelyan, 2022, bioRxiv.

Abstract 2278: The SMAC-mimetic birinapant regulates autocrine TNF production by caspase-8:RIPK1 complex via p38MAPK pathway

G. Kapoor, Y. Mitsuuchi, J. Silke, 2014 .

Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis*

D. Vaux, P. Ekert, J. Silke, 2004, Journal of Biological Chemistry.

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.

J. Silke, K. E. Lawlor, Che A. Stafford, 2018, Cell reports.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK 1-and RIPK 3-dependent manner

D. Vaux, A. Strasser, W. Alexander, 2014 .

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.

A. Dhillon, M. Bogoyevitch, S. Mutsaers, 2010, The Biochemical journal.

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

D. Green, J. Trapani, R. Johnstone, 2008, Cell Death and Differentiation.

Programmed cell death: Superman meets Dr Death

J. Silke, P. Meier, 2003, Nature Cell Biology.

Programmed cell death: Superman meets

J. Silke, D. Meier, 2003 .

Langerhans cells are an essential cellular intermediary in chronic dermatitis.

S. Nutt, L. Whitehead, J. Silke, 2022, Cell reports.

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

D. Vaux, C. Smith, C. Day, 2008, Cell Death and Differentiation.

Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment*

D. Vaux, C. Day, J. Silke, 2008, Journal of Biological Chemistry.

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

P. A. Harris, A. Nesvizhskii, J. Bertin, 2019, Molecular cell.

Combined PPARg Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

J. Silke, S. Chu, P. Fuller, 2019 .

Response to Heard et al

D. Vaux, A. Voss, T. Thomas, 2015, The EMBO journal.

SPATA2 – Keeping the TNF signal short and sweet

J. Silke, A. Webb, R. Feltham, 2016, The EMBO journal.

Views SPATA 2 – Keeping the TNF signal short and sweet

J. Silke, A. Webb, R. Feltham, 2016 .

Apoptosis: Regulatory Genes and Disease

J. Silke, J. Vince, 2009 .

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

J. Silke, P. Czabotar, James M. Murphy, 2018, Cell Death & Differentiation.

Irish Scholarship and the Renaissance, 1580-1673

J. Silke, 1973 .

XV. Why Aguila Landed at Kinsale

J. Silke, 1963, Irish Historical Studies.

Priests and Prelates of Armagh in the Age of Reformations, 1518-1558 by Henry A. Jefferies (review)

J. Silke, 1998 .

Outward Bound From Portnamurray

J. Silke, 2002 .

Later Relations between Primate Peter Lombard and Hugh O'neill

J. Silke, 1955 .

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

David L. Vaux, Vinay Tergaonkar, Pascal Schneider, 2007, Cell.

The Drosophila caspase DRONC is regulated by DIAP1

G. Evan, S. Leevers, J. Silke, 2000, The EMBO journal.

Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus.

H. Zentgraf, J. Silke, J. Torresi, 2010, Virus research.

Future Therapeutic Directions for Smac-Mimetics

G. Brumatti, J. Silke, Emma Morrish, 2020, Cells.

The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy

C. Kearney, J. Silke, J. Oliaro, 2020, Cells.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

J. Mullikin, D. Kastner, Dan Yang, 2019, Nature.

Linear ubiquitination prevents inflammation and regulates immune signalling

Anthony W. Purcell, Lahiru Gangoda, Andrew I. Webb, 2011, Nature.

CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex

J. Silke, M. V. van Oers, E. Eldering, 2013, Cell Death and Disease.

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

H. Gollnick, M. Leverkus, J. Silke, 2009, The Journal of cell biology.

XIAP discriminates between type I and type II FAS-induced apoptosis

Christoph Borner, Helen E. Thomas, Philipp J. Jost, 2009, Nature.

The intersection of cell death and inflammasome activation

J. Silke, J. Vince, 2016, Cellular and Molecular Life Sciences.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Toru Okamoto, Renwick C J Dobson, Donald Metcalf, 2013, Immunity.

IAPs limit activation of RIP kinases by TNF receptor 1 during development

D. Vaux, A. Voss, T. Thomas, 2012, The EMBO journal.

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

G. Brumatti, M. Pasparakis, T. Tenev, 2017, Molecular cell.

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Laura F. Dagley, M. Sunde, S. Masters, 2017, Nature Microbiology.

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

K. Rogers, Michael J. Mlodzianoski, L. Whitehead, 2020, Nature Communications.

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

K. Schroder, D. Sester, T. Roberts, 2013, Cell Death and Differentiation.

The diverse role of RIP kinases in necroptosis and inflammation

J. Silke, John Silke, M. Gerlic, 2015, Nature Immunology.

Ankyrin Repeat and Suppressors of Cytokine Signaling Box Protein Asb-9 Targets Creatine Kinase B for Degradation*

W. Alexander, D. Hilton, R. Simpson, 2007, Journal of Biological Chemistry.

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

Vinay Tergaonkar, Pascal Schneider, D. Vaux, 2007, Cell.

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

J. Silke, R. Brink, 2010, Cell Death and Differentiation.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Maryam Rashidi, Warren S. Alexander, Seth L. Masters, 2015, Nature Communications.

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

J. Bertin, A. Strasser, A. Akarca, 2018, Nature Communications.

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

Jiahuai Han, J. Silke, Jianfeng Wu, 2020, F1000Research.

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Si Ming Man, A. Strasser, R. Norton, 2022, Immunity.

NF-κB and Pancreatic Cancer; Chapter and Verse

J. Silke, L. O’Reilly, 2021, Cancers.

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.

Paul G Ekert, D. Vaux, P. Ekert, 2008, Journal of molecular biology.

Characterization of the ectromelia virus serpin, SPI-2.

S. Turner, J. Silke, J. Ruby, 2000, The Journal of general virology.

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

D. Vaux, P. Ekert, J. Silke, 1999, The EMBO journal.

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins*

Sharad Kumar, J. Silke, J. Howitt, 2008, Journal of Biological Chemistry.

Nedd4-WW Domain-Binding Protein 5 (Ndfip1) Is Associated with Neuronal Survival after Acute Cortical Brain Injury

T. Beißbarth, H. Scott, Sharad Kumar, 2006, The Journal of Neuroscience.

A type III effector antagonises death receptor signalling during bacterial gut infection

Sze Ying Ong, A. Strasser, M. Kelly, 2013, Nature.

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

J. Silke, J. Howitt, U. Putz, 2012, Science Signaling.

Complex demethylation patterns at Sp1 binding sites in F9 embryonal carcinoma cells

K. Rother, W. Schaffner, J. Silke, 1995, FEBS letters.

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

W. Alexander, R. Dobson, A. Wilks, 2014, Proceedings of the National Academy of Sciences.

Potent inhibition of Necroptosis by simultaneously targeting multiple effectors of the pathway.

Cheree Fitzgibbon, J. Hildebrand, J. Silke, 2020, ACS chemical biology.

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Brian J. Smith, J. Sandow, Weiwen Dai, 2018, Nature Communications.

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

W. Alexander, M. Kauppi, J. Hildebrand, 2021, Cell Death & Disease.

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

W. Alexander, M. Kauppi, J. Hildebrand, 2021, Cell Death & Disease.

Evolutionary divergence of the necroptosis effector MLKL

D. Vaux, J. Murphy, J. Hildebrand, 2016, Cell Death and Differentiation.

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Victoria E. Jackson, M. Brown, J. Reveille, 2020, Nature Communications.

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

S. Uemura, H. Nakano, M. Miura, 2018, Nature Communications.

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

S. Uemura, H. Nakano, M. Miura, 2018, Nature Communications.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways

J. Hildebrand, J. Silke, S. Condon, 2017, Cell Death and Differentiation.

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

Holly Anderton, Lorraine O'Reilly, J. Tschopp, 2012, Immunity.

The polycomb repressive complex 2 governs life and death of peripheral T cells.

A. Oshlack, G. Naselli, L. Harrison, 2014, Blood.

An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA

J. Silke, O. Georgiev, D. Rungger, 1998, The EMBO journal.

NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

A. Kerstan, M. Neumann, M. Leverkus, 2008, The Journal of investigative dermatology.

Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

D. Vaux, P. Ekert, J. Silke, 2000, Cell Death and Differentiation.

IAP family of cell death and signaling regulators.

J. Silke, D. Vučić, John Silke, 2014, Methods in enzymology.

HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis

C. Kearney, J. Silke, J. Oliaro, 2021, EMBO reports.

Mammalian mitochondrial IAP binding proteins.

D. Vaux, J. Silke, 2003, Biochemical and biophysical research communications.

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*

R. Moritz, D. Vaux, P. Ekert, 2002, The Journal of Biological Chemistry.

Primary CLL cells are resistant to cellular inhibitor apoptosis protein ( cIAP ) antagonists

J. Silke, E. Eldering, M. Oers, 2012 .

Lack of reproducible growth inhibition by Schlafen1 and Schlafen2 in vitro.

B. Neumann, T. Gonda, J. Silke, 2008, Blood cells, molecules & diseases.

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

M. Zvelebil, S. Lowe, W. Xue, 2008, Nature Cell Biology.

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo

G. Brumatti, M. Pellegrini, J. Silke, 2020, Viruses.

Till Death Do Us Part

J. Silke, P. Ekert, 2001, Cell Death and Differentiation.

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Matthew E. Ritchie, D. Vaux, J. Visvader, 2020, Cell Death & Differentiation.

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

D. Vaux, P. Schneider, J. Silke, 2008, The Journal of cell biology.

'Did He Who Made the Lamb Make Thee?' New Developments in Treating the 'Fearful Symmetry' of Acute Myeloid Leukemia.

G. Brumatti, A. Wei, J. Silke, 2017, Trends in molecular medicine.

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Keisuke Kuida, Liam O'Connor, David L. Vaux, 2002, Nature.

Dual roles for LUBAC signaling in thymic epithelial cell development and survival

A. Strasser, P. Bouillet, J. Silke, 2021, Cell Death & Differentiation.

In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

R. Johnstone, J. Silke, 2016, Cold Spring Harbor protocols.

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

J. Sandow, M. Parker, J. Holien, 2015, Nature Communications.

Is BID required for NOD signalling?

A. Strasser, J. Silke, J. Vince, 2012, Nature.

The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer

G. Dewson, J. Silke, 2018, Cell.

Transcriptional repression by methylation: cooperativity between a CpG cluster in the promoter and remote CpG‐rich regions

S. Rusconi, J. Silke, O. Georgiev, 1996, FEBS letters.

Unleashing TNF cytotoxicity to enhance cancer immunotherapy.

C. Kearney, J. Silke, J. Oliaro, 2021, Trends in immunology.

Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice.

J. Silke, T. Yap, M. McCullough, 2020, Oral diseases.

The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues.

W. Shi, Yang Liao, G. Smyth, 2017, Cell reports.

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity.

J. Gunnersen, J. Silke, J. Howitt, 2015, Journal of molecular cell biology.

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

D. Vaux, J. Silke, B. Callus, 2010, PloS one.

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

W. Alexander, J. Sandow, M. Pellegrini, 2017, Cell Death & Differentiation.

Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency

M. Pellegrini, S. Masters, J. Pearson, 2023, The EMBO journal.

Long Non-Stop Reading Frames on the Antisense Strand of Heat Shock Protein 70 Genes and Prion Protein (PrP) Genes Are Conserved between Species

K. Rother, W. Schaffner, J. Silke, 1997, Biological chemistry.

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Cheree Fitzgibbon, J. Silke, G. Lessene, 2022, Cell Death & Disease.

A regulatory interface on RIPK2 is required for XIAP binding and NOD signaling activity

Laura F. Dagley, J. Silke, I. Lucet, 2020, bioRxiv.

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.

W. Alexander, J. Hildebrand, J. Silke, 2014, The Biochemical journal.

IAPs, TNF, inflammation and Jürg TSCHOPP; a personal perspective

J. Silke, J. Vince, 2011, Cell Death and Differentiation.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways

J. Hildebrand, J. Silke, S. Condon, 2017, Cell Death & Differentiation.

Ars Moriendi; the art of dying well – new insights into the molecular pathways of necroptotic cell death

J. Silke, James M. Murphy, 2014, EMBO reports.

Missense mutations in the MLKL ‘brace’ region lead to lethal neonatal inflammation in mice and are present in high frequency in humans

M. Brown, J. Reveille, A. Bassuk, 2019, bioRxiv.

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells.

H. Wajant, T. Brunner, J. Silke, 2017, Gastroenterology.

The FLIP Side of Life

A. Strasser, J. Silke, 2013, Science Signaling.

Engineered Exosomes as Vehicles for Biologically Active Proteins.

Ulrich Putz, Seong-Seng Tan, J. Silke, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Erratum: The diverse role of RIP kinases in necroptosis and inflammation

J. Silke, M. Gerlic, J. Rickard, 2015, Nature Immunology.

Faculty Opinions recommendation of DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability.

J. Silke, 2020, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection.

M. Pellegrini, J. Silke, J. Boddey, 2020, Cell reports.

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Ashley P Ng, E. Bandala-Sanchez, J. Silke, 2018, Cell Death & Differentiation.

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

C. Begley, M. Pellegrini, J. Silke, 2015, Proceedings of the National Academy of Sciences.

An appointment with death, : 2013 Cold Spring Harbor Asia meeting ‘Mechanisms and Functions of Non-Apoptotic Cell Death’

J. Hildebrand, J. Silke, L. Sun, 2013, Cell Death and Differentiation.

The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family

B. C. Lechtenberg, J. Silke, S. J. Trevelyan, 2023, Nature Communications.

Some Aspects of the Reformation in Armagh Province

J. Silke, 1984 .

Kinsale: The Spanish Intervention in Ireland at the End of the Elizabethan Wars

J. Silke, 1970 .

Asymmetric recruitment of cIAPs by TRAF2.

D. Vaux, C. Day, J. Silke, 2010, Journal of molecular biology.

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

J. Silke, P. Czabotar, James M. Murphy, 2018, Cell Death & Differentiation.

Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

M. Condina, J. Sandow, P. Ekert, 2011, Cell Death and Differentiation.

Progranulin does not inhibit TNF and lymphotoxin‐α signalling through TNF receptor 1

J. Silke, A. Webb, N. Etemadi, 2013, Immunology and cell biology.

Deletion of Gpatch2 does not alter Tnf expression in mice

A. Strasser, P. Bouillet, J. Silke, 2023, Cell Death & Disease.

Cytoplasmic p53 is not required for PUMA-induced apoptosis

J. Heraud, P. Ekert, J. Silke, 2008, Cell Death and Differentiation.

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

Cheree Fitzgibbon, J. Hildebrand, J. Silke, 2023, The Biochemical journal.

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

Ashley P Ng, M. Kauppi, I. Wicks, 2023, bioRxiv.

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models.

D. Bowtell, M. Dawson, G. Brumatti, 2020, Blood advances.

The intersection of cell death and inflammasome activation

J. Silke, J. Vince, 2016, Cellular and Molecular Life Sciences.

Jekyll and Hyde; changing places, changing faces

J. Silke, A. Verhagen, 2002, Cell Death and Differentiation.

Tumor Necrosis Factor ( TNF ) Signaling , but Not TWEAK ( TNF-like Weak Inducer of Apoptosis )-triggered cIAP 1 ( Cellular Inhibitor of Apoptosis Protein 1 ) Degradation , Requires cIAP 1 RING Dimerization and E 2 Binding □

D. Vaux, C. Day, J. Silke, 2010 .

High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death

N. Cirillo, J. Silke, A. Celentano, 2023, Cell death & disease.

Ndfip 1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

L. Trotman, Sharad Kumar, T. Thomas, 2012 .

Killing Lymphoma with Smac-Mimetics: As Easy as ABC?

J. Silke, U. Nachbur, 2016, Cancer Cell.

Cornelius Denvir and the 'Spirit of Fear'

J. Silke, 1987 .

The CpG-specific methylase SssI has topoisomerase activity in the presence of Mg2+.

W. Schaffner, J. Silke, J. Silke, 1994, Nucleic acids research.

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

D. Vaux, G. Smyth, S. Nutt, 2015, eLife.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

D. Vaux, C. Day, J. Silke, 2017, The Journal of Biological Chemistry.

Faculty Opinions recommendation of Somatic mutant clones colonize the human esophagus with age.

J. Silke, 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease

J. Silke, M. Lazarou, D. Thorburn, 2013 .

Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease

J. Silke, M. Lazarou, D. Thorburn, 2013 .

Faculty of 1000 evaluation for Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

J. Silke, 2018 .

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

J. Tschopp, G. Häcker, J. Silke, 2012, Immunity.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

A. Strasser, W. Alexander, D. Hilton, 2013, Immunity.

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

D. Vaux, J. Silke, J. Lluis, 2016, Journal of Biological Chemistry.

Another facet of ubiquitylation: death.

J. Silke, Wei-Lynn Wong, Wei-Lynn Wong, 2009, Journal of molecular cell biology.

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.

Christoph H. Emmerich, T. Wenger, D. Komander, 2009, Molecular cell.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

D. Vaux, J. Silke, J. Vince, 2014, Blood.

Transplantable programmed death ligand 1 expressing gastroids from gastric cancer prone Nfkb1−/− mice

Chin Wee Tan, A. Strasser, A. Burgess, 2021, Cell Death & Disease.

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.

Y. Shimizu, T. Rodríguez, Nieves Peltzer, 2014, Cell reports.

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

A. Strasser, N. Mailand, J. Ruland, 2012, Molecular cell.

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.

G. Varigos, J. Silke, N. Lalaoui, 2017, The Journal of investigative dermatology.

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

D. Vaux, P. Ekert, J. Silke, 2001, The Journal of cell biology.

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

Erinna F. Lee, D. Vaux, C. Day, 2009, The Journal of Biological Chemistry.

Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation.

J. Silke, P. Meier, 2013, Cold Spring Harbor perspectives in biology.

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

A. Strasser, T. Mak, R. Hakem, 2009, Immunity.

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

D. Vaux, G. Smyth, S. Nutt, 2017, eLife.

Single-cell spatial proteomics identifies the JAK/STAT pathway as an actionable therapeutic target in lethal cutaneous drug reactions

J. Silke, A. Mund, M. Tanzer, 2023, medRxiv.

Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))

Stefan P. Glaser, D. Vaux, M. Gaestel, 2016 .

Cell death: Shadow Baxing

D. Vaux, J. Silke, 1998, Current Biology.

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

D. Vaux, P. Schneider, J. Silke, 2008, The Journal of cell biology.

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

A. Garnham, J. Silke, A. Samson, 2023, Cell Death & Differentiation.

Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity.

J. Silke, Pascal Meier, Arnaud J Legrand, 2024, Nature reviews. Cancer.

HAB Buoy: a new instrument for in situ monitoring and early warning of harmful algal bloom events

M Hensey, M. Hensey, Rob Williams, 2006 .

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

D. Vaux, P. Ekert, Sharad Kumar, 2004, The Journal of cell biology.

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

K. Dobbs, B. Boisson, J. Toguchida, 2024, Nature immunology.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

D. Kastner, C. Biben, S. Rosenzweig, 2019, Nature.

A type III effector antagonises death receptor signalling during bacterial gut infection

Sze Ying Ong, A. Strasser, M. Kelly, 2013, Nature.

RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation

J. Silke, J. Vince, N. Lalaoui, 2024, Cell death and differentiation.

RIPK1 and necroptosis role in premature ageing.

J. Silke, Panxue Wang, 2024, Nature cell biology.

The FLIP Side of Life

A. Strasser, J. Silke, 2013, Science Signaling.

An immunohistochemical atlas of necroptotic pathway expression

Matthew E. Ritchie, R. Bowden, L. Whitehead, 2024, bioRxiv.

Determination of Pseudokinase-ligand Interaction by a Fluorescence-based Thermal Shift Assay

J. Silke, P. Czabotar, N. Nicola, 2014 .

Jekyll & Hyde: The Other Life of the Death Ligand TRAIL.

J. Silke, N. Lalaoui, 2017, Molecular cell.