H. Chu

Kenneth Lap-Kei Wu, Jian-Piao Cai, J. Chan, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells

J. Chan, Jie Zhou, H. Chu, 2021, Emerging microbes & infections.

Targeting ACLY efficiently inhibits SARS-CoV-2 replication

Jian-Piao Cai, J. Chan, H. Chu, 2022, International journal of biological sciences.

In-Silico Analysis of Monoclonal Antibodies against SARS-CoV-2 Omicron

T. Yau, H. Chu, Jian-Dong Huang, 2022, Viruses.

An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

J. Chan, K. Yuen, H. Chu, 2022, Nature Microbiology.

Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine

K. To, Lin-Lei Chen, Kwok-Hung Chan, 2020, Vaccines.

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model

K. To, D. Lung, C. Yip, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses

J. Chan, Jie Zhou, H. Chu, 2021, Biomedicines.

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

J. Chan, K. Yuen, H. Chu, 2020, Metabolites.

Pathogenicity of SARS-CoV-2 Omicron BA.1.1 in hamsters

H. Chu, J. F. Chan, 2022, eBioMedicine.

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

K. To, Jian-Piao Cai, J. Chan, 2021, Nature.

Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway

A. Tam, Jian-Piao Cai, Kwok-Hung Chan, 2022, International journal of biological sciences.

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage

Jian-Piao Cai, Cuiting Luo, J. Chan, 2022, Emerging microbes & infections.

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

Jian-Piao Cai, J. Chan, K. Yuen, 2019, Viruses.

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy

C. Yip, J. Chan, K. Yuen, 2018, Antiviral Research.

The Tetherin/BST-2 Coiled-Coil Ectodomain Mediates Plasma Membrane Microdomain Localization and Restriction of Particle Release

H. Chu, H. Yi, P. Spearman, 2011, Journal of Virology.

Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters.

Jian-Piao Cai, Kwok-Hung Chan, Cuiting Luo, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Dual‐Functional Anti‐Pathogen Coatings

Wei Li, H. Chu, Ying Chu, 2022, Advanced Materials Interfaces.

Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2

Jian-Piao Cai, Cuiting Luo, K. Yuen, 2022, Cell Reports Medicine.

Targeting papain-like protease for broad-spectrum coronavirus inhibition

Jian-Piao Cai, Cuiting Luo, J. Chan, 2022, Protein & Cell.

Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo.

Jie Zhou, H. Chu, Shuofeng Yuan, 2016, ACS infectious diseases.

Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants

K. To, Jian-Piao Cai, K. Yuen, 2022, mBio.

PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs

You-Qiang Song, K. Yuen, Jie Zhou, 2015, Scientific Reports.

Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice

Jian-Piao Cai, J. Chan, I. Hung, 2022, JCI insight.

ROCK1 and LIM Kinase Modulate Retrovirus Particle Release and Cell-Cell Transmission Events

E. Hunter, H. Chu, P. Spearman, 2014, Journal of Virology.

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo

Dafydd G. Thomas, K. To, Jian-Piao Cai, 2021, Cell Reports Medicine.

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Jian-Piao Cai, Cuiting Luo, J. Chan, 2021, Nature Communications.

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly

Jian-Piao Cai, Cuiting Luo, J. Chan, 2022, Pharmaceuticals.

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

K. To, J. Chan, Honglin Chen, 2022, Nature Communications.

Coronaviruses exploit a host cysteine-aspartic protease for replication

Jian-Piao Cai, Cuiting Luo, J. Chan, 2022, Nature.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by intranasal or testicular inoculation induces testicular damage preventable by vaccination in golden Syrian hamsters

K. To, D. Lung, C. Yip, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2

J. Chan, K. Yuen, H. Chu, 2022, Emerging microbes & infections.

SARS-CoV-2 infects human neural progenitor cells and brain organoids

J. Chan, I. Hung, K. Yuen, 2020, Cell Research.

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

J. Chan, K. Yuen, H. Chu, 2019, Viruses.

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Dong Yang, K. To, Jian-Piao Cai, 2020, Nature Communications.

A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type– and Rab11-FIP1C–dependent incorporation into virions

E. Hunter, H. Chu, P. Spearman, 2015, Proceedings of the National Academy of Sciences.

A lethal mouse model using a mouse-adapted SARS-CoV-2 strain with enhanced binding to mouse ACE2 as an important platform for COVID-19 research

J. Chan, H. Chu, Hin Chu, 2021, EBioMedicine.

Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids

J. Chan, H. Chu, D. Pei, 2022, Signal Transduction and Targeted Therapy.

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Dong Yang, Lei Wen, Cun Li, 2019, Nature Communications.

Superhydrophobicity preventing surface contamination as a novel strategy against COVID-19

H. Chu, Pingan Zhu, Liqiu Wang, 2021, Journal of colloid and interface science.

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Liyuan Liu, Yicheng Guo, K. To, 2021, Nature.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

J. Chan, Zhiwei Chen, K. Yuen, 2021, bioRxiv.

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Jian-Piao Cai, Lin-Lei Chen, J. Chan, 2020, Pharmacological Research.

Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters

K. To, J. Chan, Honglin Chen, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Ronald A. Li, S. Chanda, R. Sun, 2021, Nature.

Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study

O. Tsang, K. To, D. Lung, 2020, The Lancet Microbe.

Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinase

K. Yuen, H. Chu, K. Kok, 2020, Journal of medical virology.

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

K. To, K. Yuen, H. Chu, 2020, Nature Communications.

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

K. To, Jian-Piao Cai, J. Chan, 2020, Viruses.

Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern.

Ke Zhang, H. Chu, D. Jin, 2016, AIDS research and human retroviruses.

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection

Jian-Piao Cai, J. Chan, K. Yuen, 2021, Emerging microbes & infections.

Infection of bat and human intestinal organoids by SARS-CoV-2

K. To, C. Yip, Jian-Piao Cai, 2020, Nature Medicine.

A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters

K. To, Jian-Piao Cai, J. Chan, 2021, Emerging microbes & infections.

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice

K. Yuen, Jie Zhou, H. Chu, 2017, Front. Immunol..

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

Chuan Qin, Yanfeng Yao, Cun Li, 2015, The Journal of infectious diseases.

Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids

You-Qiang Song, Jian-Piao Cai, K. Yuen, 2022, Signal transduction and targeted therapy.

Human airway organoids model SARS-CoV-2 high infectiousness and evasion of interferon response

C. Yip, Jian-Piao Cai, J. Chan, 2020 .

Emerging SARS-CoV-2 variants expand species tropism to murines

K. To, Jian-Piao Cai, W. Chan, 2021, EBioMedicine.

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation

K. To, Jian-Piao Cai, J. Chan, 2021, EMBO molecular medicine.

Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus

Jian-Piao Cai, K. Yuen, Jie Zhou, 2021, Stem cell reports.

Differentiated human airway organoids to assess infectivity of emerging influenza virus

K. To, J. Chan, Honglin Chen, 2018, Proceedings of the National Academy of Sciences.

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

Dong Yang, Yuxin Hou, Yue Chai, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

Liyuan Liu, J. Chan, K. Yuen, 2022, Nature.

Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex

H. Chu, L. Lapierre, J. Goldenring, 2013, PLoS pathogens.

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

M. Obeidat, Y. Bossé, K. Hao, 2015, The Journal of infectious diseases.

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs

Jian-Piao Cai, J. Chan, K. Yuen, 2022, Emerging microbes & infections.

Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets

J. Chan, K. Yuen, H. Chu, 2021, Computational and structural biotechnology journal.

In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn

Jian-Piao Cai, Cuiting Luo, J. Chan, 2021, Viruses.

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

D. Ho, K. To, J. Chan, 2021, bioRxiv.

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection

Man, Yeung, Zhang, 2021 .

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

Jian-Piao Cai, J. Chan, Honglin Chen, 2015, The Journal of infectious diseases.

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

K. To, Cuiting Luo, J. Chan, 2022, Cellular & Molecular Immunology.

Long SARS-CoV-2 nucleocapsid sequences in blood monocytes collected soon after hospital admission

Kwok-Hung Chan, Kaiming Tang, K. To, 2020, bioRxiv.

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2

Chuan Qin, Yanfeng Yao, Kwok-Hung Chan, 2016, Nature Microbiology.

A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.

Jie Zhou, Ke Zhang, H. Chu, 2016, The Journal of antimicrobial chemotherapy.

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase

Jie Zhou, Ke Zhang, H. Chu, 2016, Scientific Reports.

Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain

Jie Zhou, H. Chu, Shuofeng Yuan, 2015, Antimicrobial Agents and Chemotherapy.

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

K. To, Jian-Piao Cai, W. Chan, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Liyuan Liu, Yicheng Guo, K. To, 2021, Nature.

Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.

H. Chu, P. Spearman, Jeong-Joong Yoon, 2012, Cell host & microbe.

Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

J. Yue, H. Chu, Guoliang Zhang, 2021, Signal Transduction and Targeted Therapy.

Infection of bat and human intestinal organoids by SARS-CoV-2

O. Tsang, K. To, C. Yip, 2020, Nature Medicine.

Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity

Jian-Piao Cai, J. Chan, K. Yuen, 2021, EBioMedicine.

Air and environmental sampling for SARS-CoV-2 around hospitalized patients with coronavirus disease 2019 (COVID-19)

K. To, C. Yip, Kwok-Hung Chan, 2020, Infection Control & Hospital Epidemiology.

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

K. To, Jian-Piao Cai, J. Chan, 2020, Emerging microbes & infections.

Title Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H 1 N 1 Influenza Virus Play Detrimental Roles in H 1 N 1-Infected Mice

K. Yuen, Jie Zhou, H. Chu, 2017 .

A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.

H. Chu, D. Jin, B. Zheng, 2015, The Journal of antimicrobial chemotherapy.

Animal models in SARS-CoV-2 research

J. Chan, K. Yuen, H. Chu, 2022, Nature Methods.

Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19

K. To, Jian-Piao Cai, Lin-Lei Chen, 2020, bioRxiv.

Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.

H. Chu, P. Spearman, Jaang-Jiun Wang, 2009, Current topics in microbiology and immunology.

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

J. Chan, Zhiwei Chen, K. Yuen, 2022, Science Translational Medicine.

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

K. To, Kwok-Hung Chan, J. Chan, 2020, Emerging microbes & infections.

The Intracellular Virus-Containing Compartments in Primary Human Macrophages Are Largely Inaccessible to Antibodies and Small Molecules

H. Chu, P. Spearman, Jeong-Joong Yoon, 2012, PloS one.

Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin and DC SIGN positive compartments that are accessible to neutralizing antibodies

Erica L Johnson, H. Chu, P. Spearman, 2014, BMC Infectious Diseases.

SARS-CoV-2 exploits host DGAT and ADRP for efficient replication

K. To, Cuiting Luo, J. Chan, 2021, Cell Discovery.

SARS-CoV-2 exploits host DGAT and ADRP for efficient replication

K. To, Jian-Piao Cai, Cuiting Luo, 2021, Cell discovery.

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

K. To, Jian-Piao Cai, J. Chan, 2020, Science Advances.

Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

K. To, J. Chan, K. Yuen, 2022, Emerging microbes & infections.

Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice

K. To, Jian-Piao Cai, Lin-Lei Chen, 2023, Viruses.

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

J. Chan, K. Yuen, Lu Lu, 2022, Cell Research.

Factors affecting stability and infectivity of SARS-CoV-2

K. To, Kwok-Hung Chan, V. Cheng, 2020, Journal of Hospital Infection.

Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Jian-Piao Cai, Cuiting Luo, J. Chan, 2022, Nature Communications.

Superhydrophobicity prevents surface contamination of COVID-19

H. Chu, Pingan Zhu, Liqiu Wang, 2021, Journal of Colloid and Interface Science.

Identification and characterization of GLDC as host susceptibility gene to severe influenza

K. To, J. Chan, K. Yuen, 2018, EMBO molecular medicine.

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells

C. Yip, J. Chan, K. Yuen, 2019, International journal of molecular sciences.

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer

Jian-Piao Cai, J. Chan, K. Yuen, 2020, Journal of Infection.

Liquid repellency enabled antipathogen coatings

J. Chan, Nan Huang, H. Chu, 2021, Materials Today Bio.

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis

J. Chan, K. Yuen, Jie Zhou, 2015, Virology Journal.

Probable Animal-to-Human Transmission of SARS-CoV-2 Delta Variant AY.127 Causing a Pet Shop-Related COVID-19 Outbreak in Hong Kong

O. Tsang, K. To, A. Tam, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Discovery and high prevalence of Phasi Charoen-like virus in field-captured Aedes aegypti in South China.

Jinquan Cheng, H. Chu, Renli Zhang, 2018, Virology.

Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters

S. Chanda, R. Sun, K. To, 2020, Research square.

H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses

K. To, K. Yuen, H. Chu, 2019, Cell Death & Disease.

Phosphorylation of the nucleocapsid protein of Hantaan virus by casein kinase II

H. Chu, Jeong-Joong Yoon, Manbok Kim, 2015, Journal of Microbiology.

Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants

K. To, I. Hung, K. Yuen, 2022, bioRxiv.

Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters

D. Lung, Jian-Piao Cai, Honglin Chen, 2023, Emerging microbes & infections.

Berbamine inhibits the infection of SARS-CoV-2 and flaviviruses by compromising TPRMLs-mediated endolysosomal trafficking of viral receptors

J. Chan, J. Yue, H. Chu, 2020 .

Title Amino acid substitutions V 63 I or A 37 S / I 61 T / V 63 I / V 100 A in the PA N-terminal domain increase the virulence of H 7 N 7 influenza A virus

Wenjun Song, Ke Zhang, H. Chu, 2016 .

Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants

Gang Li, K. To, Jian-Piao Cai, 2023, Proceedings of the National Academy of Sciences of the United States of America.

A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Yifei Wang, H. Chu, J. Nan, 2023, Signal Transduction and Targeted Therapy.

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase.

Jie Zhou, Ke Zhang, H. Chu, 2016, Antiviral research.

In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor

Jian-Piao Cai, Cuiting Luo, J. Chan, 2021, International journal of biological sciences.

PAN substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities.

H. Chu, Cun Li, Shuofeng Yuan, 2017, The Journal of general virology.

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

C. Yip, J. Chan, K. Yuen, 2019, International journal of molecular sciences.

Engineered Intranasal Virus Trap Provides Effective Protection Against SARS‐CoV‐2 Infection in Hamsters

H. Chu, Bao-Zhong Zhang, Chuyuan Zhang, 2023, Advanced Functional Materials.

COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses

Jian-Piao Cai, K. Yuen, H. Chu, 2023, eBioMedicine.

Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response

I. Hung, H. Chu, H. Shuai, 2023, Nature communications.

Absence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model

K. To, D. Lung, Jian-Piao Cai, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Rational design of a booster vaccine against COVID-19 based on antigenic distance.

K. To, Lin-Lei Chen, I. Hung, 2023, Cell host & microbe.

The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5

K. To, Jian-Piao Cai, Lin-Lei Chen, 2023, EBioMedicine.

Comparative analysis of SARS‐CoV‐2 Omicron BA.2.12.1 and BA.5.2 variants

J. Chan, H. Chu, Shuofeng Yuan, 2022, Journal of medical virology.

Altered host protease determinants for SARS-CoV-2 Omicron

Jian-Piao Cai, J. Chan, K. Yuen, 2023, Science advances.

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

M. Obeidat, Y. Bossé, K. Hao, 2015, The Journal of infectious diseases.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

Cuiting Luo, Rui Qiao, H. Chu, 2023, bioRxiv.