C. Brandsma

H. Frijlink, D. Slebos, H. Kerstjens, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Differential roles for lysyl oxidase (like), family members in chronic obstructive pulmonary disease; from gene and protein expression to function

P. Sharma, W. Timens, C. Brandsma, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD

D. Postma, G. Koppelman, W. Boersma, 2020, Scientific Reports.

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

M. Kobor, P. Nair, A. Knox, 2018, Clinical Epigenetics.

Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD

M. Obeidat, Y. Bossé, K. Hao, 2019, European Respiratory Journal.

The Translation from Risk Allele to Biological Function in Chronic Obstructive Pulmonary Disease. What's in It for FAM13A?

W. Timens, C. Brandsma, 2016, American journal of respiratory and critical care medicine.

Mouse Protocadherin-1 Gene Expression Is Regulated by Cigarette Smoke Exposure In Vivo

I. Sayers, G. Koppelman, M. Nawijn, 2014, PloS one.

Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17+ Cells in Asthmatic Airways

D. Postma, N. T. ten Hacken, W. Timens, 2016, PloS one.

University of Groningen Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17 ( + ) Cells in Asthmatic

Luinge, D. Postma, W. Timens, 2016 .

RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

S. Phipps, W. Timens, C. Brandsma, 2020, Allergy.

Lymphoid follicles in (very) severe COPD: beneficial or harmful?

W. Timens, C. Brandsma, K. Bracke, 2009, European Respiratory Journal.

Dynamic Reciprocity: The Role of the Extracellular Matrix Microenvironment in Amplifying and Sustaining Pathological Lung Fibrosis

C. Brandsma, I. Heijink, J. Burgess, 2018, Molecular and Translational Medicine.

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

D. Postma, W. Timens, C. Brandsma, 2016, European Respiratory Journal.

Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper‐responsiveness

Y. Bossé, D. Postma, D. Nickle, 2015, Allergy.

Link between increased cellular senescence and extracellular matrix changes in COPD.

W. Timens, C. Brandsma, I. Heijink, 2020, American journal of physiology. Lung cellular and molecular physiology.

miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly

R. Bals, C. Herr, C. Beisswenger, 2022, International journal of molecular sciences.

Serum periostin does not reflect type 2-driven inflammation in COPD

M. Nawijn, H. Kerstjens, W. Timens, 2018, Respiratory Research.

The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête.

Y. Prakash, C. Brandsma, J. Burgess, 2021, Physiology.

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins

W. Timens, C. Brandsma, I. Heijink, 2020, Thorax.

A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages

Y. Bossé, K. Hao, P. Olinga, 2017, Scientific Reports.

University of Groningen Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1 Brandsma,

D. Postma, V. Guryev, R. Bischoff, 2020 .

The search for autoantibodies against elastin, collagen and decorin in COPD

D. Postma, H. Kerstjens, W. Timens, 2011, European Respiratory Journal.

heme oxygenase expression in the lung

H. Frijlink, D. Slebos, H. Kerstjens, 2007 .

Fibulin-5 as a potential therapeutic target in COPD

D. Postma, W. Timens, C. Brandsma, 2016, Expert opinion on therapeutic targets.

Changes in DNA methylation after corticosteroids treatment in COPD patients

W. Timens, C. Brandsma, M. Berge, 2020 .

Longitudinal effects of smoking cessation on DNA methylation in bronchial biopsies of COPD and asymptomatic smokers

N. T. ten Hacken, W. Timens, W. Kooistra, 2019, Molecular pathology and funct. genomics.

A genome-wide association study of chronic obstructive pulmonary disease in Hispanics.

Qi Yan, Wei Chen, Edwin K Silverman, 2015, Annals of the American Thoracic Society.

MiR‐31‐5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease

N. T. ten Hacken, W. Timens, C. Brandsma, 2020, Allergy.

Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways

Fabian J Theis, B. Ponder, J. Vonk, 2021, Allergy.

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

Y. Sio, F. Chew, E. Burchard, 2022, Clinical and translational allergy.

Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction

Joshua D. Campbell, Y. Bossé, K. Hao, 2014, Thorax.

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction

T. Spector, L. Wain, N. Shrine, 2014, PLoS genetics.

Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma.

G. Maksym, F. Chu, C. Brandsma, 2019, American journal of respiratory and critical care medicine.

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Benjamin B. Sun, Blair H. Smith, M. Jarvelin, 2019, Nature Genetics.

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

M. Schuliga, D. Knight, C. Brandsma, 2022, bioRxiv.

Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice.

D. Postma, H. Kerstjens, F. Cassee, 2008, Inhalation toxicology.

Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD.

D. Postma, B. Rutgers, W. Timens, 2013, American journal of physiology. Lung cellular and molecular physiology.

Genome‐wide association study on the FEV1/FVC ratio in never‐smokers identifies HHIP and FAM13A

Cleo C. van Diemen, A. Hofman, Y. Bossé, 2017, The Journal of allergy and clinical immunology.

A cellular census of human lungs identifies novel cell states in health and in asthma

Fabian J Theis, S. Teichmann, L. Simon, 2019, Nature Medicine.

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD

D. Postma, S. Lam, G. Koppelman, 2019, European Respiratory Journal.

Identification of Drug Candidates to Suppress Cigarette Smoke‐induced Inflammation via Connectivity Map Analyses

M. Obeidat, Y. Bossé, J. Hassell, 2017, American journal of respiratory cell and molecular biology.

Genetic regulation of gene expression of MIF family members in lung tissue

M. Obeidat, D. Nickle, W. Timens, 2020, Scientific Reports.

The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD

M. Obeidat, Y. Bossé, D. Nickle, 2018, Scientific Reports.

A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD

Y. Bossé, K. Hao, D. Postma, 2014, Thorax.

Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

Fabian J Theis, M. Nawijn, V. Guryev, 2021, ERJ Open Research.

MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation.

G. Joos, C. Brandsma, I. Heijink, 2021, American journal of physiology. Lung cellular and molecular physiology.

Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD

W. Timens, C. Brandsma, I. Heijink, 2019, European Respiratory Journal.

Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution

Joshua D. Campbell, Gang Liu, M. Lenburg, 2018, Science Advances.

Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD

Dirkje S Postma, D. Postma, C. Brandsma, 2016, European Respiratory Journal.

High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD

K. Steiling, W. Timens, C. Brandsma, 2022, Scientific Reports.

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

M. Obeidat, Y. Bossé, K. Hao, 2015, The Journal of infectious diseases.

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

G. Brusselle, W. Timens, C. Brandsma, 2019, The Journal of pathology.

Differential switching to IgG and IgA in active smoking COPD patients and healthy controls

D. Postma, H. Kerstjens, W. Timens, 2012, European Respiratory Journal.

Lung tissue gene-expression signature for the ageing lung in COPD

Y. Bossé, D. Postma, D. Nickle, 2017, Thorax.

miR-638 regulates gene expression networks associated with emphysematous lung destruction

Avrum Spira, Dirkje S Postma, Joshua D. Campbell, 2013, Genome Medicine.

Marked TGF-β-regulated miRNA expression changes in both COPD and control lung fibroblasts

K. Kok, A. van den Berg, J. Kluiver, 2019, Scientific Reports.

Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease

Y. Bossé, D. Postma, D. Nickle, 2017, Respiratory Research.

Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?

D. Postma, D. Slebos, H. Kerstjens, 2008, Respiratory research.

D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling

Bin Liu, M. Smit, Shanshan Song, 2021, EBioMedicine.

Impact of acute exposure to cigarette smoke on airway gene expression.

D. Postma, N. T. ten Hacken, M. Lenburg, 2018, Physiological genomics.

Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier

N. T. ten Hacken, W. Timens, C. Brandsma, 2022, Respirology.

A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract

H. Boezen, C. Brandsma, I. Heijink, 2021, Frontiers in Physiology.

microRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD

D. Postma, A. Spira, W. Timens, 2018, European Respiratory Journal.

A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK

Avrum Spira, Julie E. Zeskind, Dirkje S Postma, 2012, Genome Medicine.

BET proteins are associated with the induction of small airway fibrosis in COPD

I. Adcock, C. Brandsma, B. Oliver, 2021, Thorax.

Identification of asthma-associated microRNAs in bronchial biopsies

W. Timens, C. Brandsma, I. Heijink, 2021, European Respiratory Journal.

Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population

Y. Bossé, K. Hao, D. Postma, 2019, BMC Pulmonary Medicine.

Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease

M. Obeidat, Y. Bossé, K. Hao, 2017, EBioMedicine.

Unravelling the complexity of COPD by microRNAs: it's a small world after all

D. Postma, W. Timens, C. Brandsma, 2015, European Respiratory Journal.

CALL FOR PAPERS Biomarkers in Lung Diseases: From Pathogenesis to Prediction to New Therapies Noncanonical WNT-5B signaling induces inﬂammatory responses in human lung ﬁbroblasts

C. Brandsma, R. Gosens, M. Menzen, 2022 .

Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses.

Y. Bossé, D. Postma, H. Kauczor, 2015, American journal of respiratory and critical care medicine.

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

W. Timens, M. Königshoff, C. Brandsma, 2017, European Respiratory Review.

Cigarette smoke-induced emphysema: A role for the B cell?

D. Postma, H. Kerstjens, W. Timens, 2006, American journal of respiratory and critical care medicine.

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma

G. Maksym, W. Timens, C. Brandsma, 2020, Scientific Reports.

Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms.

D. Nickle, J. Vonk, R. Vermeulen, 2019, Environment international.

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

M. Schuliga, D. Knight, C. Brandsma, 2021, Cells.

Correction: Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

Y. Bossé, K. Hao, D. Postma, 2012, PLoS Genetics.

Increased levels of (class switched) memory B cells in peripheral blood of current smokers

D. Postma, H. Kerstjens, W. Timens, 2009, Respiratory research.

Molecular signature of smoking in human lung tissues.

Dirkje S Postma, Wim Timens, Philippe Joubert, 2012, Cancer research.

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression

D. Postma, W. Boersma, N. T. ten Hacken, 2017, Respiratory Research.

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma

G. Maksym, W. Timens, C. Brandsma, 2020, Scientific Reports.

Effects of cigarette smoke extract on human airway smooth muscle cells in COPD

D. Postma, I. Adcock, Ling Chen, 2014, European Respiratory Journal.

Current Smoking is Associated with Decreased Expression of miR-335-5p in Parenchymal Lung Fibroblasts

K. Kok, A. van den Berg, J. Kluiver, 2019, International journal of molecular sciences.

Klaas, K. Kok, V. Guryev, 2019, Scientific Reports.

Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1

D. Postma, V. Guryev, R. Bischoff, 2020, Thorax.

Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice

D. Postma, H. Kerstjens, W. Timens, 2010, BMC pulmonary medicine.

Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms

Benjamin M. Smith, M. Obeidat, Y. Bossé, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD

Y. Bossé, D. Postma, T. Beaty, 2014, European Respiratory Journal.

Role of BAFF in pulmonary autoantibody responses induced by chronic cigarette smoke exposure in mice

Y. Bossé, K. Hao, Rongchang Chen, 2016, Physiological reports.

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts

D. Postma, M. Lenburg, A. Spira, 2017, PloS one.

Proteogenomics and Multi-omics Data Integration for Personalized Medicine

Victor Guryev, Rainer Bischoff, Frank Suits, 2019, Handbook of Biomarkers and Precision Medicine.

miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD

D. Postma, W. Timens, C. Brandsma, 2017, European Respiratory Journal.

Non-canonical WNT-5 B signalling induces inflammatory responses in human lung 1 fibroblasts

C. Brandsma, R. Gosens, M. Menzen, 2016 .

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis

Y. Bossé, D. Postma, D. Nickle, 2016, Thorax.

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

M. Obeidat, Y. Bossé, K. Hao, 2015, The Journal of infectious diseases.

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Lorna M. Lopez, C. Gieger, I. Deary, 2016 .

The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD

M. Obeidat, Y. Bossé, D. Nickle, 2018, Scientific Reports.

Farming exposure and asthma phenotypes

W. Timens, C. Brandsma, D. Heederik, 2015 .

Nitrogen Dioxide Exposure Attenuates Cigarette Smoke-Induced Cytokine Production in Mice

D. Postma, H. Kerstjens, F. Cassee, 2008, Inhalation toxicology.

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts

Joshua D. Campbell, D. Postma, M. Lenburg, 2017, PloS one.

Osteoprotegerin is elevated in pulmonary fibrosis and associates with IPF progression

M. Kool, P. Olinga, M. Kreuter, 2020, bioRxiv.

E-cigarette vapour induces cellular senescence in primary lung fibroblasts and may contribute to lung pathology

W. Timens, C. Brandsma, I. Heijink, 2023, bioRxiv.

Shifted T-cell polarisation after agricultural dust exposure in mice and men

W. Timens, C. Brandsma, E. Telenga, 2014, Thorax.

Shifted T-cell polarisation after agricultural dust exposure in mice and men

W. Timens, C. Brandsma, E. Telenga, 2014 .

Age-associated Differences in the Human Lung Extracellular 1 Matrix

J. Vonk, P. Horvatovich, G. Marko‐Varga, 2022 .

Role of RANKL in Alveolar Epithelial Cell Regeneration: Potential Novel Contributor to Lung Tissue Repair

W. Timens, C. Brandsma, R. Cool, 2023, bioRxiv.

Molecular signature of smoking in human lung tissues.

Y. Bossé, D. Postma, D. Sin, 2012, Cancer research.

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts

Joshua D. Campbell, D. Postma, M. Lenburg, 2017, PloS one.

University of Groningen Identification of transforming growth factorbeta-lregulated microRNAs and the microRNAtargetomes in primary lung fibroblasts

A. Spira, J. Kluiver, W. Timens, 2017 .

Collagen type XIV is proportionally lower in the lung tissue of patients with IPF

M. Nawijn, C. Brandsma, I. Heijink, 2023, Scientific reports.

The ageing extracellular matrix of the lung

C. Brandsma, P. Boekema, Pieter Boekema, 2017 .

Online Data

Y. Bossé, M. Lenburg, A. Spira, 2017 .

Novel views on endotyping asthma, its remission, and COPD

G. Koppelman, M. Nawijn, M. Efremova, 2022 .

The pharmacogenomics of inhaled corticosteroids and lung function decline in COPD

M. Obeidat, K. Hao, T. Beaty, 2019, European Respiratory Journal.

airway and parenchymal fibroblasts in severe COPD 2

D. Postma, B. Rutgers, W. Timens, 2013 .

MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast–Epithelium Crosstalk

W. Timens, C. Brandsma, I. Heijink, 2022, Cells.