H. Hisamichi

发表

Discovery of ASP5878: Synthesis and structure-activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity.

Ikumi Kuriwaki, M. Kameda, Kazuhiko Iikubo, 2022, Bioorganic & medicinal chemistry.

Identification of a key element for hydrogen‐bonding patterns between protein kinases and their inhibitors

H. Hisamichi, S. Kuromitsu, S. Fujita, 2008, Proteins.

Cycloadditions in syntheses. Part 41. Chiral spirocyclic 5-arylmethylene-1,3-dioxane-4,6-diones as novel synthons for enantiomerically pure 2-arylcyclopropane-1,1-dicarboxylates

H. Hisamichi, T. Furuya, Masayuki Sato, 1989 .

Structure-activity relationships of cephalosporins having a (dimethylisoxazolidinio)vinyl moiety at their 3-position.

H. Hisamichi, R. Hara, K. Sakamoto, 1996, The Journal of antibiotics.

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives.

Masaya Orita, Atsushi Ichikawa, Ryo Naito, 2005, Bioorganic & medicinal chemistry.

Synthesis and biological activity of new cephem compounds with a 3-(2-butenyl)- and a 3-(1,3-butadienyl)group at their 3-position.

H. Hisamichi, R. Hara, H. Itahana, 1996, The Journal of antibiotics.

Studies on beta-lactam antibiotics. IV. An improved synthesis of 3-(isothiazolylthiomethyl)cephalosporins and its application to new derivatives.

H. Hisamichi, R. Hara, N. Nagano, 1994, The Journal of antibiotics.

Synthetic studies on selective type 4 phosphodiesterase (PDE 4) inhibitors. 1. Structure-activity relationships and pharmacological evaluation of 1,8-naphthyridin-2(1H)-one derivatives.

H. Hisamichi, M. Iwata, K. Takayama, 2002, Chemical & pharmaceutical bulletin.

YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors

H. Hisamichi, S. Kuromitsu, M. Shibasaki, 2006, Clinical Cancer Research.

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.

Ikumi Kuriwaki, M. Kameda, Kazuhiko Iikubo, 2021, Bioorganic & medicinal chemistry.

Cycloaddition reactions of a 3-(1,3-butadienyl)cephalosporin and antibacterial activity of new cephem derivatives.

H. Hisamichi, R. Hara, H. Itahana, 1996, The Journal of antibiotics.