O. Kranenburg

C. Mummery, A. Zantema, A. van der Eb, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Gi‐mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine‐phosphorylated Grb2 SH3 binding protein, but not Src nor Shc

P. Hordijk, I. Verlaan, O. Kranenburg, 1997, The EMBO journal.

Lysophosphatidic acid: G-protein signalling and cellular responses.

O. Kranenburg, W. Moolenaar, F. Postma, 1997, Current opinion in cell biology.

Hypoxia After Liver Surgery Imposes an Aggressive Cancer Stem Cell Phenotype on Residual Tumor Cells

I. B. Borel Rinkes, S. Fátrai, O. Kranenburg, 2014, Annals of surgery.

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

P. V. van Diest, F. Vesuna, V. Raman, 2015, Oncotarget.

Voluntary exercise influences metastatic organotropism in a murine colorectal cancer model

A. May, O. Kranenburg, D. Raats, 2021, JCSM Rapid Communications.

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

I. B. Borel Rinkes, R. Lindeboom, M. Vermeulen, 2022, Cancer research.

A potential role for CCN2/CTGF in aggressive colorectal cancer

R. Goldschmeding, O. Kranenburg, I. Ubink, 2016, Journal of Cell Communication and Signaling.

Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin: protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial

J. Burger, R. Mathijssen, I. de Hingh, 2019, BMJ Open.

Associations of non-pedunculated T1 colorectal adenocarcinoma outcome with consensus molecular subtypes, immunoscore, and microsatellite status: a multicenter case-cohort study

J. Tuynman, F. Vleggaar, P. Siersema, 2020, Modern Pathology.

KRAS Promotes Apoptosis of Human Colorectal Tumor Cells by ReovirusT3D and Oxaliplatin but not by Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand

S. Shirasawa, T. Sasazuki, O. Kranenburg, 2006 .

KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand.

I. B. Borel Rinkes, S. Shirasawa, T. Sasazuki, 2006, Cancer research.

Lymphangiogenic Gene Expression Is Associated With Lymph Node Recurrence and Poor Prognosis After Partial Hepatectomy for Colorectal Liver Metastasis

I. B. Borel Rinkes, O. Kranenburg, Susanne J van Schelven, 2017, Annals of surgery.

Recurrence Location After Resection of Colorectal Liver Metastases Influences Prognosis

I. B. Borel Rinkes, O. Kranenburg, I. Molenaar, 2014, Journal of Gastrointestinal Surgery.

Effects of tirapazamine on experimental colorectal liver metastases after radiofrequency ablation

I. B. Borel Rinkes, O. Kranenburg, A. Minchinton, 2012, The British journal of surgery.

Diacylglycerol Kinase θ Binds to and Is Negatively Regulated by Active RhoA*

W. V. van Blitterswijk, O. Kranenburg, W. Moolenaar, 1999, The Journal of Biological Chemistry.

Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch

A. Zantema, A. van der Eb, O. Kranenburg, 1995, FEBS letters.

Prognostic value of microvessel density in stage II and III colon cancer patients: a retrospective cohort study

G. Meijer, H. Stockmann, E. Belt, 2019, BMC Gastroenterology.

Ageing and Hepatic Steatosis Exacerbate Ischemia/Reperfusion-Accelerated Outgrowth of Colorectal Micrometastases

I. B. Borel Rinkes, O. Kranenburg, R. Hillegersberg, 2008, Annals of Surgical Oncology.

Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model

P. V. van Diest, I. B. Borel Rinkes, E. Voest, 2005, Hepatology.

External Validation of Two Established Clinical Risk Scores Predicting Outcome after Local Treatment of Colorectal Liver Metastases in a Nationwide Cohort

C. Punt, M. Koopman, O. Kranenburg, 2022, Cancers.

Specialized nutrition improves muscle function and physical activity without affecting chemotherapy efficacy in C26 tumour‐bearing mice

A. May, O. Kranenburg, S. Elias, 2021, Journal of cachexia, sarcopenia and muscle.

KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer

J. Laoukili, O. Kranenburg, Emre Küçükköse, 2022, Cell Death & Disease.

Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms

O. Werz, J. Laoukili, A. Koeberle, 2019, Redox biology.

Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy

J. Laoukili, S. Poghosyan, O. Kranenburg, 2022, Cancers.

Radiofrequency ablation of colorectal liver metastases induces an inflammatory response in distant hepatic metastases but not in local accelerated outgrowth

P. V. van Diest, O. Kranenburg, I. Molenaar, 2010, Journal of surgical oncology.

Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting

P. Coffer, O. Kranenburg, Sonia Aristin Revilla, 2022, Frontiers in Immunology.

Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

O. Kranenburg, W. Moolenaar, 2001, Oncogene.

Regulating c-Ras function cholesterol depletion affects caveolin association, GTP loading, and signaling

I. Verlaan, O. Kranenburg, W. Moolenaar, 2001, Current Biology.

Glycation induces formation of amyloid cross-beta structure in albumin.

P. D. de Groot, E. Voest, O. Kranenburg, 2003, Journal of Biological Chemistry.

Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability

I. B. Borel Rinkes, J. Laoukili, O. Kranenburg, 2017, Oncotarget.

Dynamic Visualization of TGF-β/SMAD3 Transcriptional Responses in Single Living Cells

J. van Rheenen, M. Hornsveld, Miao-Ping Chien, 2022, Cancers.

Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer

M. G. Koerkamp, F. Holstege, M. D. de Wit, 2013, British Journal of Cancer.

Consensus molecular subtype 4 (CMS4)-targeted therapy in primary colon cancer: A proof-of-concept study

I. B. Borel Rinkes, M. Koopman, T. Schwartz, 2022, Frontiers in Oncology.

Detection of Experimental Colorectal Peritoneal Metastases by a Novel PDGFRβ-Targeting Nanobody

I. B. Borel Rinkes, K. Luoto, O. Kranenburg, 2022, Cancers.

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Maria C. Lecca, Kristiaan J. Lenos, D. M. Miedema, 2022, Nature Communications.

Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC)

M. Lahaye, J. Burger, I. de Hingh, 2019, BMJ Open.

Unusual site of pseudomyxoma peritonei recurrence after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report of intraluminal disease manifestation in the small bowel

A. Witkamp, O. Kranenburg, L. Brosens, 2022, World Journal of Surgical Oncology.

Gi-mediated tyrosine phosphorylation of Grb2 (growth-factor-receptor-bound protein 2)-bound dynamin-II by lysophosphatidic acid.

I. Verlaan, O. Kranenburg, W. Moolenaar, 1999, The Biochemical journal.

Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue

E. Cuppen, O. Kranenburg, A. van Hoeck, 2022, Nature Communications.

Prometastatic NOTCH Signaling in Colon Cancer.

O. Kranenburg, 2015, Cancer discovery.

Mice lacking functional CD95-ligand display reduced proliferation of the intestinal epithelium without gross homeostatic alterations

I. B. Borel Rinkes, I. Nijman, O. Kranenburg, 2016, Medical Molecular Morphology.

NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

O. Kranenburg, D. Raats, G. Knoll, 2020, Cell Death & Disease.

Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.

A. Houweling, A. van der Eb, O. Kranenburg, 1996, Human gene therapy.

NS-398, a selective cyclooxygenase-2 inhibitor, reduces experimental bladder carcinoma outgrowth by inhibiting tumor cell proliferation.

I. B. Borel Rinkes, O. Kranenburg, N. Smakman, 2005, Urology.

A strategy for genetic modification of the spike-encoding segment of human reovirus T3D for reovirus targeting

O. Kranenburg, R. Hoeben, D. V. D. Wollenberg, 2008, Gene Therapy.

In vitro chemotherapy-associated muscle toxicity is attenuated with nutritional support, while treatment efficacy is retained

A. May, O. Kranenburg, B. Dorresteijn, 2022, Oncotarget.

Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile.

A. Zantema, A. van der Eb, O. Kranenburg, 1995, Oncogene.

Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.

H. van Dam, A. Zantema, A. van der Eb, 1993, Oncogene.

Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy

I. B. Borel Rinkes, G. Kops, O. Kranenburg, 2019, The British journal of surgery.

BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis.

I. B. Borel Rinkes, M. Koopman, J. Laoukili, 2022, Cell reports.

Detection of tumor‐derived cell‐free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid

G. Meijer, C. Punt, M. Lahaye, 2021, The journal of pathology. Clinical research.

Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA.

O. Kranenburg, W. Moolenaar, L. Oomen, 1997, Journal of cell science.

Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system.

P. Carmeliet, E. Voest, O. Kranenburg, 2003, Molecular cancer research : MCR.

Mouse Models of Colorectal Cancer and Liver Metastases

I. B. Borel Rinkes, O. Kranenburg, I. B. Rinkes, 2005, Digestive Surgery.

p116Rip Is A Novel Filamentous Actin-binding Protein*

J. Calafat, O. Kranenburg, W. Moolenaar, 2003, Journal of Biological Chemistry.

Organoid models of gastrointestinal cancers in basic and translational research

Jun Yu, O. Kranenburg, Haipeng Xiao, 2020, Nature Reviews Gastroenterology & Hepatology.

Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle

M. Noteborn, A. Zantema, O. Kranenburg, 1991, Journal of virology.

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Kat S. Moore, Hayley E. Francies, E. Cuppen, 2019, Proceedings of the National Academy of Sciences.

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.

Alexander van Oudenaarden, Hans Clevers, Johan H van Es, 2019, Cancer discovery.

Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

J. Mullenders, S. Boj, M. Koopman, 2021, npj Precision Oncology.

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

D. Zwijnenburg, L. Vermeulen, J. Koster, 2016, Oncogene.

Characterization of p190RhoGEF, A RhoA-specific Guanine Nucleotide Exchange Factor That Interacts with Microtubules*

M. Ahmadian, O. Kranenburg, W. Moolenaar, 2001, The Journal of Biological Chemistry.

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

A. Zantema, A. Eb, O. Kranenburg, 1996, The EMBO journal.

The value of miRNA in diagnosing thyroid cancer: a systematic review.

O. Kranenburg, G. Valk, I. B. Rinkes, 2012, Cancer biomarkers : section A of Disease markers.

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

R. Fodde, A. Sacchetti, O. Sansom, 2021, eLife.

Phenotypic plasticity and partial EMT underlie local invasion and distant metastasis in colon cancer

R. Fodde, A. Sacchetti, O. Sansom, 2020, bioRxiv.

Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

I. B. Borel Rinkes, C. Punt, S. Boj, 2022, Journal for ImmunoTherapy of Cancer.

Comparative Proteomics of Colon Cancer Stem Cells and Differentiated Tumor Cells Identifies BIRC6 as a Potential Therapeutic Target*

H. Clevers, R. Vries, S. Piersma, 2011, Molecular & Cellular Proteomics.

The secretome of colon cancer stem cells contains drug-metabolizing enzymes.

I. B. Borel Rinkes, S. Piersma, W. V. van Houdt, 2013, Journal of proteomics.

Surgical implantation of an abdominal imaging window for intravital microscopy

Jacco van Rheenen, O. Kranenburg, J. Rheenen, 2013, Nature Protocols.

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

A. van Oudenaarden, H. Clevers, D. Spierings, 2019, Nature Genetics.

Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer

I. B. Borel Rinkes, E. Santo, J. Laoukili, 2016, Gut.

Control of colorectal metastasis formation by K-Ras.

I. B. Borel Rinkes, E. Voest, O. Kranenburg, 2005, Biochimica et biophysica acta.

Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition

W. V. van Houdt, O. Kranenburg, I. B. Rinkes, 2010, Cellular oncology : the official journal of the International Society for Cellular Oncology.

Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles

P. Diest, O. Kranenburg, W. V. Houdt, 2008, Cancer Gene Therapy.

Dual effect of KrasD12 knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy

R. Offringa, O. Kranenburg, I. B. Rinkes, 2005, Oncogene.

Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.

I. B. Borel Rinkes, J. Medema, W. V. van Houdt, 2010, Gastroenterology.

Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.

P. V. van Diest, I. B. Borel Rinkes, O. Kranenburg, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

Stimulation of angiogenesis by Ras proteins.

E. Voest, O. Kranenburg, M. Gebbink, 2004, Biochimica et biophysica acta.

Wip1 confers G2 checkpoint recovery competence by counteracting p53‐dependent transcriptional repression

R. Medema, W. Bruinsma, A. Brás, 2009, The EMBO journal.

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.

H. Clevers, J. Korving, H. Begthel, 2021, Cell stem cell.

Induction of polyploidy in adenovirus E1-transformed cells by the mitotic inhibitor colcemid.

A. Zantema, A. van der Eb, O. Kranenburg, 1996, Virus research.

Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction.

A. Hall, O. Kranenburg, D. Drechsel, 1999, Molecular biology of the cell.

A review of the sensitivity of metastatic colorectal cancer patients with deficient mismatch repair to standard-of-care chemotherapy and monoclonal antibodies, with recommendations for future research.

M. Koopman, A. May, O. Kranenburg, 2021, Cancer treatment reviews.

Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry

F. Markowetz, I. Nagtegaal, P. Kuppen, 2016, Clinical Cancer Research.

RNF43 mutations facilitate mucinous colorectal cancer metastasis via formation of a tumour-intrinsic niche

I. Jordens, H. Snippert, S. Tejpar, 2022, bioRxiv.

Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity

J. Koster, J. Laoukili, A. Huitema, 2022, British Journal of Cancer.

ALDH1A1 expression is associated with poor differentiation, ‘right-sidedness’ and poor survival in human colorectal cancer

I. B. Borel Rinkes, O. Kranenburg, Lizet M. van der Waals, 2018, PloS one.

Increased Levels of Oxidative Damage in Liver Metastases Compared with Corresponding Primary Colorectal Tumors: Association with Molecular Subtype and Prior Treatment.

P. V. van Diest, I. B. Borel Rinkes, J. Laoukili, 2018, The American journal of pathology.

Macrophages induce “budding” in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions

D. Zwijnenburg, I. B. Borel Rinkes, J. Koster, 2018, Oncotarget.

Histopathological and molecular classification of colorectal cancer and corresponding peritoneal metastases

I. B. Borel Rinkes, A. Aalbers, O. Kranenburg, 2018, The British journal of surgery.

Neoadjuvant chemotherapy affects molecular classification of colorectal tumors

I. B. Borel Rinkes, L. Vermeulen, J. Medema, 2017, Oncogenesis.

Imatinib treatment of poor prognosis mesenchymal-type primary colon cancer: a proof-of-concept study in the preoperative window period (ImPACCT)

I. B. Borel Rinkes, M. Koopman, R. Mathijssen, 2017, BMC Cancer.

A Novel Diagnostic Tool for Selecting Patients With Mesenchymal-Type Colon Cancer Reveals Intratumor Subtype Heterogeneity.

P. V. van Diest, I. B. Borel Rinkes, O. Kranenburg, 2017, Journal of the National Cancer Institute.

CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

J. Laoukili, O. Kranenburg, D. Raats, 2017, Cell Death & Disease.

Accelerated Perinecrotic Outgrowth of Colorectal Liver Metastases Following Radiofrequency Ablation is a Hypoxia-Driven Phenomenon

P. V. van Diest, I. B. Borel Rinkes, E. Voest, 2009, Annals of surgery.

Tumor Seeding During Colonoscopy as a Possible Cause for Metachronous Colorectal Cancer.

F. Vleggaar, P. Siersema, R. Schiffelers, 2019, Gastroenterology.

Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.

I. B. Borel Rinkes, H. Clevers, R. Vries, 2011, Gastroenterology.

Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes

M. Maurice, O. Kranenburg, H. Nojima, 2014, Open Biology.

Oncogenic KRAS desensitizes colorectal tumor cells to epidermal growth factor receptor inhibition and activation.

P. V. van Diest, I. B. Borel Rinkes, W. V. van Houdt, 2010, Neoplasia.

Ritsma Pre-Micrometastasis Stage During Liver Metastasis Intravital Microscopy Through an Abdominal Imaging Window Reveals a

T. Schumacher, O. Kranenburg, J. Rheenen, 2012 .

ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer

P. V. van Diest, M. V. van Oijen, M. Koopman, 2015, Journal of Cancer.

Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells.

I. B. Borel Rinkes, J. Koster, S. Fátrai, 2015, Gastroenterology.

PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells.

F. Holstege, C. Maas, I. B. Borel Rinkes, 2013, Neoplasia.

CD95 signaling in colorectal cancer.

I. B. Borel Rinkes, O. Kranenburg, E. Steller, 2012, Biochimica et biophysica acta.

SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

J. Koster, S. Fátrai, O. Kranenburg, 2015, Clinical Cancer Research.

Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases

P. V. van Diest, I. B. Borel Rinkes, O. Kranenburg, 2008, Cellular oncology : the official journal of the International Society for Cellular Oncology.

Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa

I. B. Borel Rinkes, J. Medema, W. V. van Houdt, 2010, British Journal of Cancer.

First-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy (oxaliplatin) for isolated unresectable colorectal peritoneal metastases: protocol of a multicentre, single-arm, phase II study (CRC-PIPAC-II)

J. Burger, I. de Hingh, M. Los, 2021, BMJ Open.

Mode of progression after radioembolization in patients with colorectal cancer liver metastases

I. B. Borel Rinkes, M. Koopman, O. Kranenburg, 2020, EJNMMI Research.

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6)

A. Zwinderman, J. Tuynman, R. Fehrmann, 2019, BMC Cancer.

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

S. Narumiya, H. Bito, F. Matsumura, 1998, The Journal of cell biology.

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase*

I. Verlaan, O. Kranenburg, W. Moolenaar, 1999, The Journal of Biological Chemistry.

Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1

A. Zantema, A. van der Eb, P. Keblusek, 1996, Journal of virology.

Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures

I. B. Borel Rinkes, J. Laoukili, O. Kranenburg, 2019, Scientific Reports.

Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19 ( + )-liver cells deficient for p 53 and

T. Roskams, A. de Bruin, O. Kranenburg, 2018 .

Modification of mammalian reoviruses for use as oncolytic agents

Rob C Hoeben, O. Kranenburg, Diana JM Van Den Wollenberg, 2009, Expert opinion on biological therapy.

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

Johannes G. Reiter, Shriya V. Nagpal, J. Lennerz, 2020, Nature Genetics.

Proteomics in studying cancer stem cell biology

W. V. van Houdt, O. Kranenburg, I. B. Rinkes, 2012, Expert review of proteomics.

A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity

P. Black, O. Kranenburg, R. Meijer, 2021, Cells.

CD95 is a key mediator of invasion and accelerated outgrowth of mouse colorectal liver metastases following radiofrequency ablation.

I. B. Borel Rinkes, O. Kranenburg, E. Steller, 2010, Journal of hepatology.

Liver lymphatic drainage patterns follow segmental anatomy in a murine model

T. Padera, S. Poghosyan, O. Kranenburg, 2020, Scientific Reports.

Sensitization to Apoptosis Underlies KrasD12-Dependent Oncolysis of Murine C26 Colorectal Carcinoma Cells by Reovirus T3D

O. Kranenburg, I. B. Rinkes, N. Smakman, 2005, Journal of Virology.

The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion

I. B. Borel Rinkes, J. van Rheenen, J. Laoukili, 2011, EMBO reports.

Synergistic killing of colorectal cancer cells by oxaliplatin and ABT-737

O. Kranenburg, E. Steller, D. Raats, 2011, Cellular Oncology.

Peritoneal Metastases From Colorectal Cancer: Defining and Addressing the Challenges

I. de Hingh, O. Kranenburg, K. van der Speeten, 2021, Frontiers in Oncology.

Glycation Induces Formation of Amyloid Cross-β Structure in Albumin*

P. D. de Groot, E. Voest, O. Kranenburg, 2003, Journal of Biological Chemistry.

Recombinant endostatin forms amyloid fibrils that bind and are cytotoxic to murine neuroblastoma cells in vitro

E. Voest, O. Kranenburg, L. Kroon-Batenburg, 2003, FEBS letters.

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

Johannes G. Reiter, Shriya V. Nagpal, J. Lennerz, 2020, Nature Genetics.

β-Amyloid (Aβ) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation

E. Voest, R. Kayed, O. Kranenburg, 2005, Molecular and Cellular Neuroscience.

Synergistic Effect of Interstitial Laser Coagulation and Doxorubicin in a Murine Tumor Recurrence Model of Solitary Colorectal Liver Metastasis

I. B. Borel Rinkes, P. Diest, O. Kranenburg, 2006, Annals of Surgical Oncology.

Doxorubicin‐induced skeletal muscle atrophy: Elucidating the underlying molecular pathways

A. May, A. Huitema, E. Wall, 2019, Acta physiologica.

Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells

A. Zantema, A. van der Eb, O. Kranenburg, 1995, The Journal of cell biology.

Epidermal growth factor receptor (EGFR) and prostaglandin-endoperoxide synthase 2 (PTGS2) are prognostic biomarkers for patients with resected colorectal cancer liver metastases

P. V. van Diest, I. B. Borel Rinkes, R. van Hillegersberg, 2014, British Journal of Cancer.

Surgery-induced tumor growth in (metastatic) colorectal cancer.

I. B. Borel Rinkes, O. Kranenburg, K. Govaert, 2017, Surgical oncology.

Perinecrotic hypoxia contributes to ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases.

P. V. van Diest, I. B. Borel Rinkes, O. Kranenburg, 2007, The American journal of pathology.

A role for CD95 signaling in ischemia/reperfusion‐induced invasion and outgrowth of colorectal micrometastases in mouse liver

I. B. Borel Rinkes, O. Kranenburg, E. Steller, 2011, Journal of surgical oncology.

GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer.

I. B. Borel Rinkes, J. Koster, R. Brigelius-Flohé, 2014, Cancer research.

Prolonged portal triad clamping during liver surgery for colorectal liver metastases is associated with decreased time to hepatic tumour recurrence.

I. B. Borel Rinkes, R. van Hillegersberg, W. V. van Houdt, 2010, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

RNF43 mutations facilitate colorectal cancer metastasis via formation of a tumour-intrinsic niche

I. Jordens, H. Snippert, S. Tejpar, 2023, bioRxiv.

Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer.

O. Kranenburg, M. Lam, S. Elias, 2023, PET clinics.

Tissue-Type Plasminogen Activator Is a Multiligand Cross-β Structure Receptor

E. Voest, O. Kranenburg, L. Kroon-Batenburg, 2002, Current Biology.

Tissue-type plasminogen activator is a multiligand cross-beta structure receptor.

E. Voest, O. Kranenburg, L. Kroon-Batenburg, 2002, Current biology : CB.

Long-Lived Human Lymphatic Endothelial Cells to Study Lymphatic Biology and Lymphatic Vessel/Tumor Coculture in a 3D Microfluidic Model.

P. Vulto, J. Laoukili, S. Poghosyan, 2021, ACS biomaterials science & engineering.

Differential regulation of the Wilms' tumor gene, WT1, during differentiation of embryonal carcinoma and embryonic stem cells.

A. Jochemsen, A. van der Eb, O. Kranenburg, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Anatomic versus Metabolic Tumor Response Assessment after Radioembolization Treatment.

D. Sze, M. A. van den Bosch, I. B. Borel Rinkes, 2017, Journal of vascular and interventional radiology : JVIR.

Tissue clearing and immunostaining to visualize the spatial organization of vasculature and tumor cells in mouse liver

I. B. Borel Rinkes, S. Poghosyan, O. Kranenburg, 2023, Frontiers in Oncology.

Identification of a Novel, Putative Rho-specific GDP/GTP Exchange Factor and a RhoA-binding Protein: Control of Neuronal Morphology

O. Kranenburg, W. Moolenaar, M. Gebbink, 1997, The Journal of cell biology.

A. Zwinderman, J. Tuynman, R. Fehrmann, 2019, BMC Cancer.

Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification.

Bas B L Penning de Vries, H. Clevers, R. de Bree, 2023, Med.

Validation of bioluminescence imaging of colorectal liver metastases in the mouse.

I. B. Borel Rinkes, O. Kranenburg, A. Martens, 2004, The Journal of surgical research.

NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

O. Kranenburg, D. Raats, G. Knoll, 2020, Cell Death & Disease.

Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases: A Phase 2 Randomized Clinical Trial.

J. Tuynman, C. Punt, M. Lahaye, 2021, JAMA surgery.

Imatinib treatment of poor prognosis mesenchymal-type primary colon cancer: a proof-of-concept study in the preoperative window period (ImPACCT)

I. B. Borel Rinkes, M. Koopman, O. Kranenburg, 2017, BMC Cancer.

Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era

C. Punt, H. Verheul, M. Koopman, 2020, British Journal of Cancer.

Colorectal liver metastases that survive radioembolization display features of aggressive tumor behavior.

I. B. Borel Rinkes, O. Kranenburg, A. Braat, 2023, HPB : the official journal of the International Hepato Pancreato Biliary Association.

Circulating CD95-ligand as a potential prognostic marker for recurrence in patients with synchronous colorectal liver metastases.

R. van Hillegersberg, E. Voest, W. V. van Houdt, 2011, Anticancer research.

The death receptor CD 95 activates the cofilin pathway to stimulate tumor cell invasion

J. Laoukili, O. Kranenburg, J. Rheenen, 2011 .

Circulating CD 95-ligand as a Potential Prognostic Marker for Recurrence in Patients with Synchronous Colorectal Liver Metastases

E. Voest, O. Kranenburg, A. Gunning, 2011 .

Liver lymphatic drainage patterns follow segmental anatomy.

I. B. Borel Rinkes, T. Padera, S. Poghosyan, 2022, British Journal of Surgery.

Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF

I. B. Borel Rinkes, R. Medema, R. Kerbel, 2010, Cancer biology & therapy.

Paired image- and FACS-based toxicity assays for high content screening of spheroid-type tumor cell cultures

I. B. Borel Rinkes, D. Egan, O. Kranenburg, 2015, FEBS open bio.

Abstract 4294: Differentiated colorectal cancer cells protect tumor-initiating cells from irinotecan

H. Clevers, R. Vries, O. Kranenburg, 2010 .

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

R. Fodde, H. Snippert, J. Laoukili, 2023, Frontiers in Immunology.

How CD95 stimulates invasion

I. B. Borel Rinkes, O. Kranenburg, E. Steller, 2011, Cell cycle.

Amyloid-β-stimulated plasminogen activation by tissue-type plasminogen activator results in processing of neuroendocrine factors

A. Heck, E. Voest, O. Kranenburg, 2005, Neuroscience.

Comprehensive evaluation of structural variation detection algorithms for whole genome sequencing

Y. Kamatani, Y. Momozawa, C. Terao, 2019, Genome Biology.

Selective portal clamping to minimize hepatic ischaemia–reperfusion damage and avoid accelerated outgrowth of experimental colorectal liver metastases

I. B. Borel Rinkes, R. van Hillegersberg, O. Kranenburg, 2006, The British journal of surgery.

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

P. V. van Diest, F. Vesuna, V. Raman, 2015, Oncotarget.

Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes

M. Maurice, O. Kranenburg, H. Nojima, 2014, Open biology.

Predicting early extrahepatic recurrence after local treatment of colorectal liver metastases

I. B. Borel Rinkes, C. Punt, M. Koopman, 2023, The British journal of surgery.

Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb

T. Roskams, A. de Bruin, O. Kranenburg, 2016, Oncotarget.

Dose finding study for unilobar radioembolization using holmium-166 microspheres to improve resectability in patients with HCC: the RALLY protocol

I. B. Borel Rinkes, J. Ijzermans, O. V. van Delden, 2023, BMC Cancer.

Proteomics in studying cancer stem cell biology

W. V. van Houdt, O. Kranenburg, J. Knol, 2012, Expert review of proteomics.

Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.

I. B. Borel Rinkes, H. Clevers, R. Vries, 2011, Gastroenterology.

SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

J. Koster, S. Fátrai, O. Kranenburg, 2015, Clinical Cancer Research.

CD95 signaling in colorectal cancer.

I. B. Borel Rinkes, O. Kranenburg, E. Steller, 2012, Biochimica et biophysica acta.

The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion

I. B. Borel Rinkes, J. van Rheenen, J. Laoukili, 2011, EMBO reports.

CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

J. Laoukili, O. Kranenburg, Susanne J van Schelven, 2017, Cell Death & Disease.

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

A. van Oudenaarden, H. Clevers, D. Spierings, 2019, Nature Genetics.

Iron‐responsive element of Divalent metal transporter 1 (Dmt1) controls Notch‐mediated cell fates

D. Zwijnenburg, M. Vooijs, A. Groot, 2023, The FEBS journal.

BRAF V600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-speciﬁc metastasis by stimulating glutathione synthesis

M. Koopman, J. Laoukili, O. Kranenburg, 2022 .

Abstract 5388: High throughput toxicity assay for three-dimensional cell cultures

D. Egan, O. Kranenburg, K. Trumpi, 2014 .

Mechanical regulation of cell fate transitions underlying colorectal cancer metastasis formation

J. van Rheenen, O. Kranenburg, M. Gloerich, 2023, bioRxiv.

Surgical outcomes of major hepatectomy following “radiation lobectomy” for hepatic malignancies and insufficiently functional future liver remnant: initial experience

O. Kranenburg, J. Hagendoorn, M. Lam, 2020, The British journal of surgery.