V. Flemington

发表

Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells

M. A. King, I. Ganley, V. Flemington, 2016, Oncogene.

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models

Clay W Scott, Ronald S. Reiserer, Clayton M. Britt, 2022, PLoS biology.

Identification and optimization of a novel series of selective PIP5K inhibitors.

D. M. Andrews, N. Divecha, R. Rowlinson, 2021, Bioorganic & medicinal chemistry.

Development of isotope-enriched phosphatidylinositol-4- and 5-phosphate cellular mass spectrometry probes

V. Flemington, A. Saunders, S. Conway, 2020, Chemical science.

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

S. Cook, J. Dry, Paul D. Smith, 2019, Nature Communications.

Challenges and Opportunities in Cancer Drug Resistance.

Paul D. Smith, S. Fawell, V. Flemington, 2020, Chemical reviews.

Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of non-small cell lung cancer (NSCLC).

J. Breed, M. Anderton, Lyman J. L. Feron, 2019, Journal of medicinal chemistry.

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.

J. Debreczeni, Lyman J. L. Feron, Michael Tonge, 2017, Journal of medicinal chemistry.

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.

Karen Roberts, Michael James, Philip Hopcroft, 2015, Journal of medicinal chemistry.

AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

M. Garnett, O. Delpuech, Paul D. Smith, 2020, Molecular Cancer Therapeutics.

Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.

M. Waring, D. M. Andrews, R. Rowlinson, 2014, Chemical Communications.