D. Avizonis

发表

High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum

M. McClelland, Xue-Ru Wu, M. Pollak, 2016, Molecular Cancer Therapeutics.

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.

M. Tyers, J. Coulombe-Huntington, I. Topisirovic, 2020, Molecular cell.

Metabolomics Analyses of Cancer Cells in Controlled Microenvironments.

D. Avizonis, S. Gravel, J. St-Pierre, 2016, Methods in molecular biology.

Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells

Alexander V. Zhdanov, P. Baranov, D. Andreev, 2022, FEBS open bio.

Software Tools for NMR Metabolomics

J. German, C. Slupsky, D. Avizonis, 2011 .

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.

Edward T Chouchani, N. Danial, L. Walensky, 2021, Cell reports.

Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN

J. Milbrandt, Jean J. Zhao, R. Segal, 2021, The Journal of cell biology.

Kinetic and thermodynamic characterization of DNA duplex–hairpin interconversion for two DNA decamers: d(CAACGGGTTG) and d(CAACCCGTTG)

D. Avizonis, D. Kearns, 1995, Biopolymers.

Autophagy-dependent glutaminolysis drives superior IL21 production in HIV-1-specific CD4 T cells

J. van Grevenynghe, J. Routy, D. Avizonis, 2021, Autophagy.

Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids.

N. Rattray, I. Topisirovic, D. Avizonis, 2020, Cell reports.

Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.

M. Hollingsworth, R. Friedman, J. Wilkinson, 2022, Molecular cell.

Title High Sensitivity of an HaRAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with Â 240-Fold Higher Drug Concentration in Urine than Serum Permalink

Xiaolin, M. Pollak, Zhongbo Liu, 2016 .

Assignment of hyperfine-shifted resonances in yeast ferricytochrome c isozyme 2 using the proton pre-steady-state nuclear Overhauser effect.

D. Avizonis, J. Satterlee, S. Moench, 1988, Biochimica et Biophysica Acta.

Stable Isotope Tracer Analysis in Isolated Mitochondria from Mammalian Systems

D. Avizonis, J. St-Pierre, Sylvia Andrzejewski, 2014, Metabolites.

Electronic Referencing in Quantitative NMR

D. Argyropoulos, D. Avizonis, 2010 .

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.

Alexey Sergushichev, Emma E. Vincent, Maxim N. Artyomov, 2015, Molecular cell.

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.

Takla Griss, B. Faubert, B. Viollet, 2013, Cell metabolism.

Solid phase synthesis of 5-hydroxymethyluracil containing DNA

V. Hsu, D. Avizonis, M. Conte, 1992 .

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

N. Sonenberg, T. Alain, A. Pause, 2013, Cell metabolism.

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.

Gary D Bader, A. Shamas-Din, M. Minden, 2017, Blood.

Structural characterization of d(CAACCCGTTG) and d(CAACGGGTTG) mini-hairpin loops by heteronuclear NMR: the effects of purines versus pyrimidines in DNA hairpins.

D. Avizonis, D. Kearns, 1995, Nucleic acids research.

PGC-1α supports glutamine metabolism in breast cancer

B. Faubert, Russell G. Jones, U. Akavia, 2013, Cancer & metabolism.

PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply.

W. Muller, D. Avizonis, J. St-Pierre, 2012, Cancer research.

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α

Takla Griss, E. E. Vincent, B. Faubert, 2014, Proceedings of the National Academy of Sciences.

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

J. Ursini-Siegel, C. Chabot, C. Kleinman, 2021, Nature Communications.

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

J. Pelletier, O. Larsson, M. Pollak, 2019, Nature Communications.

Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling

E. Ma, Russell G. Jones, D. Roy, 2020, Scientific Reports.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides

C. Greenwood, J. Ursini-Siegel, M. Ohh, 2017, bioRxiv.

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer

G. Mills, Takla Griss, Russell G. Jones, 2013, Cancer & metabolism.

Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation

Russell G. Jones, S. Ficarro, J. Marto, 2020, Nature Metabolism.

Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation

Russell G. Jones, S. Ficarro, J. Marto, 2020, Nature Metabolism.

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.

J. Rabinowitz, A. Berghuis, P. Gros, 2020, Cell reports.

Alterations in Cellular Energy Metabolism Associated with the Antiproliferative Effects of the ATM Inhibitor KU-55933 and with Metformin

M. Pollak, D. Avizonis, J. Pierre, 2012, PloS one.

Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment

Russell G. Jones, M. Minden, N. Johnson, 2019, bioRxiv.

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro.

R. Tjian, A. Näär, J. T. Kadonaga, 1998, Genes & development.

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome

Russell G. Jones, B. Freedman, R. Flavell, 2014, The Journal of experimental medicine.

Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.

A. Roulston, Gäelle Bridon, D. Avizonis, 2014, Cancer research.

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

C. Greenwood, E. Ma, Russell G. Jones, 2018, Cell metabolism.

Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition

W. Foulkes, W. Miller, Jie Su, 2020, Molecular Cancer Therapeutics.

The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring GC/MS

D. Avizonis, O. Mamer, J. St-Pierre, 2013, Metabolomics.

Deletion of the gene encoding G0/G1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice

S. Kersten, M. Kelliher, M. Tremblay, 2014, Diabetologia.

PGC-1α supports glutamine metabolism in breast cancer

B. Faubert, Russell G. Jones, U. Akavia, 2013, Cancer & Metabolism.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

T. Pawson, J. Ursini-Siegel, M. Pollak, 2018, Cancer research.

Activation of Sarm1 produces cADPR to increase intra-axonal calcium and promote axon degeneration in CIPN

J. Milbrandt, Jean J. Zhao, R. Segal, 2021, bioRxiv.

A novel method for quantification of cefazolin local tissue concentration in blood, fat, synovium, and bone marrow using liquid chromatography - mass spectrometry.

D. Avizonis, J. Montreuil, A. Hart, 2023, Journal of pharmaceutical and biomedical analysis.

PARP activation and enhanced NAD consumption pemetrexed in non-small cell lung cancer cells is mediated by Synergy between the NAMPT inhibitor GMX 1777 ( 8 ) and

A. Roulston, Gäelle Bridon, D. Avizonis, 2014 .

Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss

W. Foulkes, D. Huntsman, G. Morin, 2023, Nature communications.

Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids.

N. Rattray, I. Topisirovic, D. Avizonis, 2022, Cell reports.

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.

Takla Griss, B. Faubert, B. Viollet, 2013, Cell metabolism.

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

N. Sonenberg, T. Alain, A. Pause, 2013, Cell metabolism.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides

C. Greenwood, M. Ohh, O. Larsson, 2017, bioRxiv.

Metabolomics Analyses of Cancer Cells in Controlled Microenvironments.

D. Avizonis, J. St-Pierre, Simon-Pierre Gravel, 2016, Methods in molecular biology.

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro.

R. Tjian, A. Näär, J. T. Kadonaga, 1998, Genes & development.

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

I. Topisirovic, D. Avizonis, David J. Papadopoli, 2023, bioRxiv.

High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum

Xue-Ru Wu, M. Pollak, Zhongbo Liu, 2016, Molecular Cancer Therapeutics.

p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress

C. Kleinman, S. Hébert, D. Avizonis, 2024, Redox biology.

Targeting fatty acid oxidation enhances response to HER2-targeted therapy

D. Avizonis, Harvey W. Smith, C. Lavoie, 2024, Nature communications.

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer

G. Mills, Takla Griss, Russell G. Jones, 2013, Cancer & Metabolism.