X. Zi

发表

High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum

M. McClelland, Xue-Ru Wu, M. Pollak, 2016, Molecular Cancer Therapeutics.

Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines

X. Zi, R. Eskander, N. Bhatia, 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Flavokawain B, a kava chalcone, induces apoptosis via up‐regulation of death‐receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth

Zhongbo Liu, Xuesen Li, X. Zi, 2010, International journal of cancer.

Capillary endothelia from two ADPKD patients are polyploidy.

S. Nauli, Wissam AbouAlaiwi, X. Zi, 2016, Annals of clinical cytology and pathology.

Flavokawains in Cancer Prevention and Treatment: Potentials and Challenges

X. Zi, A. Simoneau, D. Jandial, 2012 .

Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo.

Dongjun Fu, Ting Zhu, Yan-Bing Zhang, 2020, European journal of medicinal chemistry.

Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression: Synergy between TGF-β and IGF Signaling

Z. Jia, D. Mercola, Qiang Zhang, 2014, BioMed research international.

KAVA Chalcone, Flavokawain A, Inhibits Urothelial Tumorigenesis in the UPII-SV40T Transgenic Mouse Model

Xue-Ru Wu, Zhongbo Liu, Xuesen Li, 2013, Cancer Prevention Research.

Lycopene enhances docetaxel's effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels.

M. Lilly, X. Zi, A. Simoneau, 2011, Neoplasia.

Title Lycopene Enhances Docetaxel ' s Effect in Castration-Resistant Prostate Cancer Associated with Insulin-like Growth Factor I Receptor Levels 1 Permalink

M. Lilly, X. Zi, A. Simoneau, 2011 .

WIF 1 , a Wnt pathway inhibitor , regulates SKP 2 and c-myc expression leading to G 1 arrest and growth inhibition of human invasive urinary bladder cancer cells

F. Jurnak, Shunqiang Li, R. Holcombe, 2009 .

WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells

F. Jurnak, Shunqiang Li, R. Holcombe, 2009, Molecular Cancer Therapeutics.

A phase II study of docetaxel plus lycopene in metastatic castrate resistant prostate cancer.

E. Uchio, X. Zi, J. Fruehauf, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Dietary feeding of flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice

Zhongbo Liu, Xuesen Li, X. Zi, 2014, Toxicology reports.

Molecular targeted approaches to cancer therapy and prevention using chalcones.

Yan-Bing Zhang, Christopher A. Blair, X. Zi, 2014, Current cancer drug targets.

Prostate cancer immunotherapy: a review of recent advancements with novel treatment methods and efficacy.

E. Uchio, X. Zi, B. Wang, 2022, American journal of clinical and experimental urology.

Bioactive Suture

P. Parikh, C. McLaren, G. Yoo, 2004, Clinical Cancer Research.

Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway

Chunli Wu, Zhongbo Liu, N. Yokoyama, 2017, Journal of biomedical research.

Triazole-dithiocarbamate based, selective LSD1 inactivators inhibit gastric cancer cell growth, invasion and migration

D. Mobley, Wen-en Zhao, X. Zi, 2014 .

Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma

Jinghang Zhang, Hongling Zhao, E. Schwartz, 2020, Translational oncology.

Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen

Xin Li, Ruiwen Zhang, Wei Wang, 2017, Front. Pharmacol..

Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD1

Xuesen Li, E. Uchio, X. Zi, 2021, Journal of translational genetics and genomics.

cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

David S. Yee, Zhongbo Liu, Xuesen Li, 2010 .

Expression and prognostic utility of PD-L1 in patients with squamous cell carcinoma of the bladder.

Y. Lotan, R. Youssef, X. Zi, 2019, Urologic oncology.

Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is and caused

Yu Qin, Yu Ke, Lin Yuan, 2017 .

Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species

Yu Ke, X. Zi, Hong-min Liu, 2016, Oncotarget.

Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy.

Victor Pham, Dongjun Fu, X. Zi, 2019, Molecular carcinogenesis.

Dkk-3 , a SecretedWnt Antagonist , Suppresses Tumorigenic Potential and PulmonaryMetastasis in Osteosarcoma

X. Zi, Peter McQueen, T. Ji, 2015 .

Dkk-3, a Secreted Wnt Antagonist, Suppresses Tumorigenic Potential and Pulmonary Metastasis in Osteosarcoma

X. Zi, Peter McQueen, T. Ji, 2013, Sarcoma.

Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer

Victor Pham, E. Uchio, X. Zi, 2022, Frontiers in Oncology.

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Victor Pham, Chunli Wu, E. Uchio, 2017, Current Pharmacology Reports.

Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.

D. Mobley, Wen-en Zhao, X. Zi, 2013, Journal of medicinal chemistry.

The Effect of Gartanin, a Naturally Occurring Xanthone in Mangosteen Juice, on the mTOR Pathway, Autophagy, Apoptosis, and the Growth of Human Urinary Bladder Cancer Cell Lines

Zhongbo Liu, Xuesen Li, X. Zi, 2013, Nutrition and cancer.

Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization.

Victor Pham, Dongjun Fu, Li-Rong Zhang, 2018, European journal of medicinal chemistry.

Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.

Dongjun Fu, Yan-Bing Zhang, Sai-Yang Zhang, 2017, European journal of medicinal chemistry.

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.

Dongjun Fu, Yan-Bing Zhang, Sai-Yang Zhang, 2017, European journal of medicinal chemistry.

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

Y. Lu, M. Pollak, X. Zi, 2001, Journal of the National Cancer Institute.

Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.

X. Zi, A. Simoneau, 2005, Cancer research.

Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy

Zhongbo Liu, Xuesen Li, X. Zi, 2012, Molecular carcinogenesis.

Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins.

R. Agarwal, D. Feyes, X. Zi, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism

Xue-Ru Wu, Zhongbo Liu, E. Uchio, 2023, Molecules.

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

David S. Yee, Zhongbo Liu, Xuesen Li, 2010, Molecular Cancer.

Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling.

X. Zi, F. Lin, Yi Guo, 2008, Cancer research.

Wnt signaling in castration-resistant prostate cancer: implications for therapy.

D. Mercola, N. Yokoyama, X. Zi, 2014, American journal of clinical and experimental urology.

Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice

Zhongbo Liu, E. Uchio, X. Zi, 2022, Pharmaceutics.

Kava Components Down-Regulate Expression of AR and AR Splice Variants and Reduce Growth in Patient-Derived Prostate Cancer Xenografts in Mice

M. Lilly, Zhongbo Liu, Christopher A. Blair, 2012, PloS one.

Potential molecular targeting of splice variants for cancer treatment.

Christopher A. Blair, X. Zi, 2011, Indian journal of experimental biology.

The Wnt signaling pathway: implications for therapy in osteosarcoma

X. Zi, Peter D McQueen, Yi Guo, 2011, Expert review of anticancer therapy.

Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin.

R. Agarwal, X. Zi, 1999, Biochemical and biophysical research communications.

Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma

Z. Jia, D. Mercola, Chung Lee, 2018 .

Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms

Xin Li, Ruiwen Zhang, Jianwei Zhou, 2018, Carcinogenesis.

Overexpression of ErbB 2 receptor inhibits IGF-I-induced Shc – MAPK signaling pathway in breast cancer cells q , qq

X. Zi, Yunhua Zhao, Yuhong Lu, 2003 .

Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness.

R. Holcombe, X. Zi, A. Simoneau, 2005, Cancer research.

Cellular Invasiveness Prostate Cancer PC-3 Cells Suppresses Tumor Growth and Secreted Wnt Antagonist , in Human Androgen-Independent Expression of Frzb / Secreted Frizzled-Related Protein 3 , a

R. Holcombe, X. Zi, A. Simoneau, 2005 .

Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

Victor Pham, Dongjun Fu, Xuesen Li, 2019, Cell Communication and Signaling.

Title Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp 2 degradation

Victor Pham, Dongjun Fu, Xuesen Li, 2019 .

Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention.

D. Mercola, P. Sassone-Corsi, Yan-Bing Zhang, 2013, Current cancer drug targets.

Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention.

R. Agarwal, X. Zi, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer.

B. Monk, R. Holcombe, X. Zi, 2012, Gynecologic oncology.

Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway.

Yu Ke, Wen-en Zhao, X. Zi, 2015, Toxicology and applied pharmacology.

Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth

Chunli Wu, X. Zi, Lixia Chen, 2016, Scientific Reports.

Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model

D. Mercola, M. Lilly, N. Yokoyama, 2015, Oncotarget.

Dominant Negative LRP5 Decreases Tumorigenicity and Metastasis of Osteosarcoma in an Animal Model

X. Zi, Yi Guo, B. Hoang, 2008, Clinical orthopaedics and related research.

When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?

D. Mercola, N. Yokoyama, E. Uchio, 2015, Current Pharmacology Reports.

Effect of Antioxidant-rich Foods and Supplements on Cancer Risk

X. Zi, A. Simoneau, 2013 .

Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis

P. Cohen, Shuo Lin, M. Pollak, 2007, Oncogene.

A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells.

R. Agarwal, H. Kung, X. Zi, 1998, Cancer research.

Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells.

Yu Ke, X. Zi, Xiao-Jing Shi, 2013, Current cancer drug targets.

New withanolides with TRAIL-sensitizing effect from Physalis pubescens L.

X. Zi, Jian Huang, Lixia Chen, 2016, RSC advances.

A Novel Ferroptosis Related Gene Signature for Prognosis Prediction in Patients With Colon Cancer

X. Zi, Yanqiao Zhang, Qian Zhang, 2021, Frontiers in Oncology.

Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma

D. Zheng, Jinghang Zhang, X. Zi, 2018, Scientific Reports.

Molecular mechanisms underlying IGF‐I‐induced attenuation of the growth‐inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

M. Pollak, X. Zi, Yuhong Lu, 2004, International journal of cancer.

Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells.

R. Agarwal, X. Zi, R P Singh, 2000, Carcinogenesis.

Impairment of erbB 1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU 145 cells

R. Agarwal, R. Singh, X. Zi, 2000 .

Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF alpha.

R. Agarwal, H. Mukhtar, X. Zi, 1997, Biochemical and biophysical research communications.

Effects of the Kava Chalcone Flavokawain A Differ in Bladder Cancer Cells with Wild-type versus Mutant p53

X. Zi, A. Simoneau, Yaxiong Tang, 2008, Cancer Prevention Research.

Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.

M. Pollak, X. Zi, Michael Pollak, 2004, Biochemical and biophysical research communications.

A new brominated chalcone derivative suppresses the growth of gastric cancer cells in vitro and in vivo involving ROS mediated up-regulation of DR5 and 4 expression and apoptosis.

Haiyang Yu, Yan-Bing Zhang, Cheng-yun Jin, 2016, Toxicology and applied pharmacology.

The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma

D. Zheng, Hongling Zhao, E. Schwartz, 2021, Annals of the New York Academy of Sciences.

Nutraceuticals in Human Urinary Bladder Cancer Prevention and Treatment

Christopher A. Blair, X. Zi, 2012 .

Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma

X. Zi, T. Ji, R. Eskander, 2015, Molecular Cancer.

Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma

X. Zi, Yi Guo, B. Hoang, 2010, Molecular Cancer Therapeutics.

Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos‐2 cells

R. Holcombe, X. Zi, R. Gorlick, 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation

Xue-Ru Wu, J. Meeks, E. Uchio, 2023, Biomolecules.

Effect of perineoplasm perinephric adipose tissues on migration of clear cell renal cell carcinoma cells: a potential role of WNT signaling

N. Yokoyama, Christopher A. Blair, X. Zi, 2016, Oncotarget.

A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells

Yan-Bing Zhang, Cheng-yun Jin, X. Zi, 2017, Scientific Reports.

Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells.

R. Agarwal, M. Pollak, X. Zi, 2000, Cancer research.

Androgen-independent Prostate Cancer Cells Protein 3 Expression and Inhibits Proliferation of Silibinin UpRegulates Insulin-like Growth Factor-Binding Updated

R. Agarwal, M. Pollak, X. Zi, 2000 .

Advances in Brief Silibinin UpRegulates Insulin-like Growth Factor-Binding Protein 3 Expression and Inhibits Proliferation of Androgen-independent Prostate Cancer Cells 1

R. Agarwal, M. Pollak, X. Zi, 2000 .

A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells

Yan-Bing Zhang, Cheng-yun Jin, X. Zi, 2017, Scientific Reports.

Abstract 1255: Delta-tocopherol induced endoplasmic reticulum stress causes autophagic degradation of ER and cell death in bladder cancer models

Chung S. Yang, Christopher A. Blair, X. Zi, 2018, Prevention Research.

Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line

X. Zi, R. Eskander, T. Sakai, 2012, The journal of obstetrics and gynaecology research.

Bladder Cancer Chemopreventive Agents: Current Knowledge and Concepts.

X. Zi, K. Spradling, Y. Wu, 2016, Mini reviews in medicinal chemistry.

Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis

X. Zi, T. Ji, R. Eskander, 2013, Molecular Cancer.

Comprehensive analysis of cuproptosis-related genes on bladder cancer prognosis, tumor microenvironment invasion, and drug sensitivity

X. Zi, Xueli Yuan, Jinqiao Li, 2023, Frontiers in Oncology.

Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments for bladder augmentation: in vivo, long term, and functional pilot study.

G. Hidas, Zhongbo Liu, X. Zi, 2015, Journal of pediatric urology.

Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin

Chunli Wu, X. Zi, B. Hoang, 2017, Molecules.

Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

Victor Pham, Dongjun Fu, Xuesen Li, 2019, Cell Communication and Signaling.

The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ras Model

Xue-Ru Wu, Zhongbo Liu, E. Uchio, 2023, Cancers.

(1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one

Victor Pham, Dongjun Fu, X. Zi, 2018, Molbank.

Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma

D. Zheng, Hongling Zhao, E. Schwartz, 2023, bioRxiv.

CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer

G. Wilding, I. Roninson, A. Chumanevich, 2023, bioRxiv.