Jiansheng Wu

发表

Oncogenic ERBB3 mutations in human cancers.

Somasekar Seshagiri, Jeremy Stinson, Charles Eigenbrot, 2013, Cancer cell.

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

S. Kummerfeld, V. Dixit, Jinfeng Liu, 2017, Proceedings of the National Academy of Sciences.

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

I. Mellman, Daniel J. Anderson, M. J. C. Ludlam, 2012, Proceedings of the National Academy of Sciences.

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Karl H. Clodfelter, P. Bauer, N. Kley, 2013, Bioorganic & medicinal chemistry letters.

Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine.

C. Ly, S. Sideris, S. Malek, 2011, Journal of medicinal chemistry.

Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.

C. Ly, S. Sideris, S. Malek, 2012, Journal of medicinal chemistry.

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

S. Kummerfeld, G. Salvesen, S. Warming, 2015, Nature.

Critical role of activation induced cytidine deaminase in Experimental Autoimmune Encephalomyelitis

J. DeVoss, A. Zarrin, S. Warming, 2012, Autoimmunity.

The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development

Jennie R. Lill, J. Zha, Jiansheng Wu, 2008, Molecular and Cellular Biology.

Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

P. Carter, S. Hymowitz, Jianping Yin, 2019, mAbs.

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

Somasekar Seshagiri, Paula Katavolos, Omar Abdel-Wahab, 2012, Science.

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

B. Peters, Z. Kan, S. Seshagiri, 2009, Cancer cell.

Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers

Somasekar Seshagiri, Thomas D. Wu, Jeremy Stinson, 2012, Proceedings of the National Academy of Sciences.

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.

K. Bowman, Jiansheng Wu, R. Firestein, 2016, ACS medicinal chemistry letters.

The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.

Adam R. Johnson, Jianwen A. Feng, Lawren C. Wu, 2012, Structure.

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

M. Amiot, D. Lawrence, P. Walter, 2018, Proceedings of the National Academy of Sciences.

Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.

Adam R. Johnson, C. Eigenbrot, A. Estevez, 2016, ACS chemical biology.

Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy

Joshua C. Chang, S. Durinck, Z. Modrušan, 2019, Scientific Reports.

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.

Philippe Bergeron, Kevin R Clark, James R Kiefer, 2016, ACS medicinal chemistry letters.

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

Jessica L. Larson, K. Scearce-Levie, A. Jubb, 2013, The Journal of experimental medicine.

Increased Targeting of Donor Switch Region and IgE in Sγ1-Deficient B Cells

A. Zarrin, V. Dixit, S. Heldens, 2010, The Journal of Immunology.

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

D. Sampath, K. Bair, Weiru Wang, 2014, PloS one.

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

BinQing Wei, Y. Franke, E. Day, 2019, Structure.