T. Ryckmans

发表

Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study.

Ian J. Brown, P. Elliott, J. Stamler, 2012, Analytical methods : advancing methods and applications.

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.

P. Fish, T. Ryckmans, S. Phillips, 2009, Bioorganic & medicinal chemistry letters.

Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure–Activity Relationship Study of C-Glycosidic LecB Inhibitors

R. Hartmann, A. Imberty, T. Ryckmans, 2019, Journal of medicinal chemistry.

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa.

R. Hartmann, A. Imberty, T. Brunner, 2017, Journal of the American Chemical Society.

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.

T. Ryckmans, P. Cox, Linda Kitching, 2011, Bioorganic & medicinal chemistry letters.

Modulation of the vasopressin system for the treatment of CNS diseases.

T. Ryckmans, 2010, Current opinion in drug discovery & development.

Dual NK1 Antagonists—Serotonin Reuptake Inhibitors as Potential Antidepressants. Part 2. SAR and Activity of Benzyloxyphenethyl Piperazine Derivatives.

R. Grimée, Y. Lamberty, T. Ryckmans, 2003 .

First Dual NK1 Antagonists—Serotonin Reuptake Inhibitors: Synthesis and SAR of a New Class of Potential Antidepressants.

Y. Lamberty, T. Ryckmans, O. Berton, 2002 .

Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.

P. Fish, T. Ryckmans, N. Barta, 2008, Bioorganic & medicinal chemistry letters.

Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists

T. Ryckmans, J. Bryans, T. Peakman, 2011 .

Enantioselective synthesis of (R)- and (S)-N-Boc-morpholine-2-carboxylic acids by enzyme-catalyzed kinetic resolution: application to the synthesis of reboxetine analogs

Malcolm C. Mackenny, P. Fish, T. Ryckmans, 2009 .

First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants.

Thomas Ryckmans, Patrick Pasau, Y. Lamberty, 2002, Bioorganic & Medicinal Chemistry Letters.

A concise total synthesis of the lichen macrolide (+)-aspicilin.

T. Ryckmans, I. Markó, C. Dubost, 2006, Organic letters.

Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.

P. Fish, T. Ryckmans, A. Stobie, 2009, Bioorganic & medicinal chemistry letters.

5-Aminopyrazoles from enolisable ketones and 1-cyano-1-alkylhydrazines.

T. Ryckmans, B. Tinant, H. Viehe, 1997 .

Benzimidazolo-diazepines From 1,3-dienes and Arenediazocyanides Through a 1,3,4-tri-aza-cope Rearrangement

T. Ryckmans, H. Viehe, Daniel Rousselle, 1992 .

Discovery of orally bioavailable NK1 receptor antagonists.

T. Taverne, T. Ryckmans, L. Goossens, 2003, Bioorganic & medicinal chemistry letters.

Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.

R. Grimée, Y. Lamberty, T. Ryckmans, 2002, Bioorganic & medicinal chemistry letters.

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.

Kiyoyuki Omoto, Angus Nedderman, Sharan K Bagal, 2016, Journal of medicinal chemistry.

Identification of novel scaffolds targeting Mycobacterium tuberculosis

T. Ryckmans, P. Sander, P. Selchow, 2019, Journal of Molecular Medicine.

TAK1 Inhibition in the DFG‐Out Conformation

Peter G. Dodd, P. Cohen, W. P. Hoorn, 2013, Chemical biology & drug design.

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.

Malcolm C. Mackenny, P. Fish, T. Ryckmans, 2008, Bioorganic & medicinal chemistry letters.

Chapter 6 Advances in Vasopressin Receptor Agonists and Antagonists

T. Ryckmans, 2009 .

Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.

Dafydd R Owen, Thomas Ryckmans, M. Edwards, 2009, Bioorganic & medicinal chemistry letters.

[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.

P. Fish, T. Ryckmans, A. Stobie, 2008, Bioorganic & medicinal chemistry letters.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.

Brian E Marron, Neil A Castle, Rubben Torella, 2017, Bioorganic & medicinal chemistry letters.

The discovery of a potent series of carboxamide TRPA1 antagonists

J. Warmus, T. Ryckmans, P. Cox, 2016 .

SAR mining and its application to the design of TRPA1 antagonists

Sarah Elizabeth Skerratt, James Edward John Mills, Alan Daniel Brown, 2012 .

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.

Malcolm C. Mackenny, P. Fish, T. Ryckmans, 2008, Bioorganic & medicinal chemistry letters.