S. Kochhar

发表

Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption.

Jeremiah Stamler, Elaine Holmes, Jeremy K Nicholson, 2010, The American journal of clinical nutrition.

Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy.

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2007, Journal of proteome research.

Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning 1H NMR spectroscopy.

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2007, Journal of proteome research.

Rapid and noninvasive metabonomic characterization of inflammatory bowel disease.

I. Wilson, E. Holmes, F. Shanahan, 2007, Journal of proteome research.

Nutritional metabonomics: applications and perspectives.

Z. Ramadan, S. Kochhar, L. Fay, 2007, Journal of proteome research.

A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week.

Stephen J. Bruce, R. Bibiloni, S. Moco, 2013, The Journal of nutrition.

Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry.

Stephen J. Bruce, S. Kochhar, S. Rezzi, 2009, Analytical chemistry.

A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2007, Molecular systems biology.

Metabonomic investigations of aging and caloric restriction in a life-long dog study.

Elaine Holmes, Jeremy K Nicholson, Dennis Lawler, 2007, Journal of proteome research.

Exploring the sequence‐structure protein landscape in the glycosyltransferase family

Ziding Zhang, M. Grigorov, S. Kochhar, 2003, Protein science : a publication of the Protein Society.

Isotopomics: a top-down systems biology approach for understanding dynamic metabolism in rats using [1,2-(13)C(2)] acetate.

Z. Ramadan, A. Fuerholz, C. Poussin, 2010, Analytical chemistry.

Summary recommendations for standardization and reporting of metabolic analyses

Nigel W. Hardy, Jake T. M. Pearce, Stephen J. Bruce, 2005, Nature Biotechnology.

Global metabolic profiling analysis on human urine by UPLC-TOFMS: issues and method validation in nutritional metabolomics.

Stephen J. Bruce, Z. Ramadan, S. Kochhar, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Nutritional metabonomics: an approach to promote personalized health and wellness.

S. Kochhar, F. Martin, S. Rezzi, 2011, Chimia.

Automated SPE-RP-HPLC fractionation of biofluids combined to off-line NMR spectroscopy for biomarker identification in metabonomics.

S. Kochhar, F. Martin, S. Rezzi, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Chemometric strategies to assess metabonomic imprinting of food habits in epidemiological studies

T. Sørensen, K. Kyvik, A. Ross, 2010 .

Self-modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs.

J. Lindon, J. Nicholson, S. Richards, 2008, Analytical chemistry.

Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways.

C. Chou, J. Nicholson, C. Boulangé, 2013, Journal of proteome research.

Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry.

D. Barron, G. Williamson, S. Kochhar, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The role of liquid chromatography and flow injection analyses coupled to isotope ratio mass spectrometry for studying human in vivo glucose metabolism.

T. Stellingwerff, S. Kochhar, S. Rezzi, 2011, Rapid communications in mass spectrometry : RCM.

Metabolomic Applications to Decipher Gut Microbial Metabolic Influence in Health and Disease

S. Kochhar, F. Martin, S. Rezzi, 2012, Front. Physio..

Validation of a FFQ for estimating whole-grain cereal food intake

N. Pineau, A. Ross, S. Kochhar, 2009, British Journal of Nutrition.

Prediction of fat oxidation capacity using 1H-NMR and LC-MS lipid metabolomic data combined with phenotypic data

A. Astrup, Z. Ramadan, T. Pers, 2008 .

Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818

J. Nicholson, E. Holmes, O. Cloarec, 2012, Gut.

Panorganismal gut microbiome-host metabolic crosstalk.

R. Bibiloni, J. Lindon, J. Nicholson, 2009, Journal of proteome research.

Natural Carbon Isotope Abundance of Plasma Metabolites and Liver Tissue Differs between Diabetic and Non-Diabetic Zucker Diabetic Fatty Rats

A. Ross, S. Kochhar, E. Pouteau, 2013, PloS one.

Metabolomics in nutrition

S. Moco, A. Ross, S. Kochhar, 2013 .

Promoting Gut Health with Probiotic Metabolomics

S. Kochhar, F. Martin, S. Rezzi, 2011 .

Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model.

G. Kollias, D. Haller, M. Klingenspor, 2011, Journal of proteome research.

Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma.

D. Barron, G. Williamson, S. Kochhar, 2010, The Journal of nutrition.

A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial.

J. Kirwan, A. Ross, S. Kochhar, 2018, Metabolism: clinical and experimental.

Paracatalytic self-inactivation of fructose-1,6-bisphosphate aldolase. Structure of the crosslink formed at the active site.

P. Christen, S. Kochhar, R. Hollenstein, 1993, European journal of biochemistry.

Metabolite Profiling Reveals that Dark Chocolate May Beneficially Modulate the Stress-related Metabolism in Humans

S. Kochhar, F. Martin, S. Rezzi, 2010 .

A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects

Stephen J. Bruce, R. Bibiloni, A. Ross, 2011, British Journal of Nutrition.

Stability and robustness of human metabolic phenotypes in response to sequential food challenges.

J. Lindon, J. Nicholson, E. Holmes, 2012, Journal of proteome research.

Study of Antioxidant Enzymes Activity during Organogenesis and In Vitro Propagation of Asiatic Hybrid Lily

S. Kochhar, V. Pandey, P. Misra, 2013, Journal of Plant Biochemistry and Biotechnology.

Comparison of Electrospray Ionization and Atmospheric Chemical Ionization Coupled with the Liquid Chromatography-Tandem Mass Spectrometry for the Analysis of Cholesteryl Esters

S. Kochhar, S. Shim, Hae-Rim Lee, 2015, International journal of analytical chemistry.

Mechanism of racemization of amino acids by aspartate aminotransferase.

P. Christen, S. Kochhar, Philipp Christen, 1992, European journal of biochemistry.

An NMR- and MS-based metabonomic investigation of saliva metabolic changes in feline odontoclastic resorptive lesions (FORL)-diseased cats

Z. Ramadan, D. Jacobs, S. Kochhar, 2007, Metabolomics.

Reply to L Zheng et al

S. Jebb, C. Seal, I. Brownlee, 2012 .

Lycopene bioavailability and metabolism in humans: an accelerator mass spectrometry study.

H. Synal, K. Wertz, S. Tannenbaum, 2011, The American journal of clinical nutrition.

Rapid and sensitive analysis of alkylresorcinols from cereal grains and products using HPLC-Coularray-based electrochemical detection.

A. Ross, S. Kochhar, 2009, Journal of agricultural and food chemistry.

Amino acid analysis by high-performance liquid chromatography after derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide.

P. Christen, S. Kochhar, 1989, Analytical biochemistry.

An active center tryptophan residue in liquefying α- amylase from Bacillusamyloliquefaciens

S. Kochhar, R. D. Dua, R. Dua, 1985 .

Cloning and overexpression of the Lactobacillus bulgaricus NAD(+)-dependent D-lactate dehydrogenase gene in Escherichia coli:purification and characterization of the recombinant enzyme.

S. Kochhar, H. Hottinger, N. Chuard, 1992, Biochemical and biophysical research communications.

No genetic footprints of the fat mass and obesity associated (FTO) gene in human plasma 1H CPMG NMR metabolic profiles

R. Bro, L. Christiansen, T. Sørensen, 2014, Metabolomics.

A Whole-Grain Diet Reduces Cardiovascular Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial.

S. Navaneethan, J. Kirwan, A. Ross, 2016, The Journal of nutrition.

Chemical modification of liquefying α-amylase: Role of tyrosine residues at its active center

S. Kochhar, R. D. Dua, R. Dua, 1985 .

Quality control despite mistranslation caused by an ambiguous genetic code

J. Sabina, R. Larossa, D. Söll, 2008, Proceedings of the National Academy of Sciences.

The enantiomeric error frequency of aspartate aminotransferase.

P. Christen, S. Kochhar, 1988, European journal of biochemistry.

Active site studies on Bacillus amyloliquefaciens α-amylase (I)

S. Kochhar, R. D. Dua, 1985, Molecular and Cellular Biochemistry.

Probiotic Modulation of Symbiotic Gut Microbial–host Metabolic Interactions in a Humanized Microbiome Mouse Model

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2022 .

Evolutionary relationship of NAD(+)-dependent D-lactate dehydrogenase: comparison of primary structure of 2-hydroxy acid dehydrogenases.

S. Kochhar, H. Hottinger, P. Hunziker, 1992, Biochemical and biophysical research communications.

A metabolic system-wide characterisation of the pig: a model for human physiology.

J. Lindon, J. Nicholson, E. Holmes, 2011, Molecular bioSystems.

Characterization of peptides formed during fermentation of cocoa bean.

S. Kochhar, B. Keely, D. Goodall, 2001, Journal of agricultural and food chemistry.

Primary structure of the abundant seed albumin of Theobroma cacao by mass spectrometry.

S. Kochhar, M. Juillerat, K. Gartenmann, 2000, Journal of agricultural and food chemistry.

Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.

Victor S Lamzin, Keith S Wilson, Sunil Kochhar, 2002, Journal of molecular biology.

Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation.

A. Smilde, S. Bijlsma, I. Macdonald, 2006, Analytical chemistry.

Roles of his205, his296, his303 and Asp259 in catalysis by NAD+-specific D-lactate dehydrogenase.

V S Lamzin, V. Lamzin, S. Kochhar, 2000, European journal of biochemistry.

Glutamate 264 modulates the pH dependence of the NAD(+)-dependent D-lactate dehydrogenase.

S. Kochhar, H. Hottinger, N. Chuard, 1992, The Journal of biological chemistry.

Primary structure, physicochemical properties, and chemical modification of NAD(+)-dependent D-lactate dehydrogenase. Evidence for the presence of Arg-235, His-303, Tyr-101, and Trp-19 at or near the active site.

S. Kochhar, H. Hottinger, P. Hunziker, 1992, The Journal of biological chemistry.

Magic angle spinning NMR and 1H-31P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies.

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2008, Analytical chemistry.

Cloning and overexpression of Lactobacillus helveticus D-lactate dehydrogenase gene in Escherichia coli.

T. Atkinson, S. Kochhar, H. Hottinger, 1992, European journal of biochemistry.

Metabonomics and Gut Microbiota in Nutrition and Disease

S. Kochhar, F. Martin, 2015, Molecular and Integrative Toxicology.

A Serpin from the Gut Bacterium Bifidobacterium longum Inhibits Eukaryotic Elastase-like Serine Proteases*

M. Affolter, D. Ivanov, S. Kochhar, 2006, Journal of Biological Chemistry.

Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2006, Journal of proteome research.

Biomarkers of Nutrient Bioactivity and Efficacy: A Route Toward Personalized Nutrition

I. Silva-Zolezzi, I. Rubio-Aliaga, S. Kochhar, 2012, Journal of clinical gastroenterology.

Lysine-induced premature transcription termination in the lysC operon of Bacillus subtilis.

S. Kochhar, H. Paulus, Henry Paulus, 1996, Microbiology.

Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation.

Z. Ramadan, J. Malagelada, Javier Santos, 2008, Gastroenterology.

Assessing the performance of statistical validation tools for megavariate metabolomics data

Age K. Smilde, Eduard P. P. A. Derks, Ivana Bobeldijk, 2006, Metabolomics.

Introduction to Metabonomics in Systems Biology Research

S. Kochhar, F. Martin, 2015 .

Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics.

Doris M Jacobs, Sunil Kochhar, Z. Ramadan, 2006, Analytical biochemistry.

Metabolic profiling using principal component analysis, discriminant partial least squares, and genetic algorithms.

Z. Ramadan, M. Grigorov, S. Kochhar, 2006, Talanta.

A plasma global metabolic profiling approach applied to an exercise study monitoring the effects of glucose, galactose and fructose drinks during post-exercise recovery.

Stephen J. Bruce, C. Boesch, E. Scheurer, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Amino acid analysis by high-performance liquid chromatography after derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (Marfey's reagent).

P. Christen, S. Kochhar, B. Mouratou, 2000, Methods in molecular biology.

Amino Acid Analysis by Precolumn Derivatization with 1-Fluoro-2,4-Dinitrophenyl-5-I-Alanine Amide (Marfey’s Reagent)

P. Christen, S. Kochhar, 2009 .

Colonization-Induced Host-Gut Microbial Metabolic Interaction

E. Want, L. Krause, P. van Bladeren, 2011, mBio.

Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity.

J. Lindon, J. Nicholson, E. Holmes, 2009, Journal of proteome research.

Everyday Eating Experiences of Chocolate and Non-Chocolate Snacks Impact Postprandial Anxiety, Energy and Emotional States

N. Antille, S. Kochhar, F. Martin, 2012, Nutrients.

Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis.

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2005, Journal of proteome research.

The Effect of Chocolate on Human and Gut Microbial Metabolic Interactions: Emphasis on Human Health and Nutritional Status

S. Kochhar, F. Martin, S. Rezzi, 2013 .

Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects.

Sebastiano Collino, Serge Rezzi, Sunil Kochhar, 2009, Journal of proteome research.

Metabolic phenotype modulation by caloric restriction in a lifelong dog study.

J. Nicholson, S. Richards, E. Holmes, 2013, Journal of proteome research.

Assay for aliphatic amino acid decarboxylases by high-performance liquid chromatography.

P. Christen, S. Kochhar, P. Mehta, 1989, Analytical biochemistry.

Short-chain peptide analysis by high-performance liquid chromatography coupled to electrospray ionization mass spectrometer after derivatization with 9-fluorenylmethyl chloroformate.

S. Kochhar, K. Gartenmann, 1999, Journal of agricultural and food chemistry.

Dietary modulation of gut functional ecology studied by fecal metabonomics.

J. Nicholson, S. Kochhar, F. Martin, 2010, Journal of proteome research.

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes

Elaine Holmes, Jeremy K Nicholson, Serge Rezzi, 2008, Molecular systems biology.

Focus on Plant Molecular Biology-2 BIOTECHNOLOGICAL APPROACHES TO IMPROVE NITROGEN USE EFFICIENCY IN PLANTS

P. K. Jaiwal, R. Singh, R. Pathak, 2022 .

Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals.

Z. Ramadan, P. van Bladeren, J. Lindon, 2007, Journal of proteome research.

An active-site carboxyl group in liquefying α-amylase: specific chemical modification

S. Kochhar, R. Dua, 1984 .

An active-site carboxyl group in liquefying alpha-amylase: specific chemical modification.

S. Kochhar, R. Dua, 1984, Bioscience Reports.

Experimental metabonomic model of dietary variation and stress interactions.

Elaine Holmes, John C Lindon, Jeremy K Nicholson, 2006, Journal of proteome research.

Gut microbiota modulate the metabolism of brown adipose tissue in mice.

J. Nicholson, E. Holmes, M. Dumas, 2012, Journal of proteome research.

Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model

Z. Ramadan, P. van Bladeren, J. Lindon, 2008, Molecular systems biology.

The stereospecific labilization of the C-4' pro-S hydrogen of pyridoxamine 5'-phosphate is abolished in (Lys258----Ala) aspartate aminotransferase.

P. Christen, J. Kirsch, S. Kochhar, 1987, The Journal of biological chemistry.

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains

R. Weindruch, T. Prolla, S. Kochhar, 2013, Metabolites.

Design of Virtual Libraries of Umami-Tasting Molecules

Martin G. Grigorov, Hedwig Schlichtherle-Cerny, Michael Affolter, 2003, J. Chem. Inf. Comput. Sci..

Precision of GE Lunar iDXA for the measurement of total and regional body composition in nonobese adults.

S. Kochhar, F. Martin, L. Fay, 2012, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

Metabolic assessment of gradual development of moderate experimental colitis in IL-10 deficient mice.

Dirk Haller, Serge Rezzi, Leticia Quintanilla-Fend, 2009, Journal of proteome research.

Metabotyping of biofluids reveals stress-based differences in gut permeability in healthy individuals.

J. Malagelada, Javier Santos, M. Vicario, 2009, Journal of proteome research.

Validation on high variance metabolic profiles: Taste stratification in a free living population

Stephen J. Bruce, N. Martin, J. Coutre, 2010 .

2-Furoylglycine as a Candidate Biomarker of Coffee Consumption.

J. Nicholson, E. Holmes, P. Schmitt‐Kopplin, 2015, Journal of agricultural and food chemistry.

Monitoring Healthy Metabolic Trajectories with Nutritional Metabonomics

S. Kochhar, F. Martin, S. Rezzi, 2009, Nutrients.

Defining personal nutrition and metabolic health through metabonomics.

S. Kochhar, F. Martin, S. Rezzi, 2007, Ernst Schering Foundation symposium proceedings.

Acute experimental stress evokes a differential gender‐determined increase in human intestinal macromolecular permeability

J. Malagelada, F. Azpiroz, Javier Santos, 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Alignment using variable penalty dynamic time warping.

Serge Rezzi, Stephen J. Bruce, Stephen Bruce, 2009, Analytical chemistry.

Descriptor‐based protein remote homology identification

Ziding Zhang, Sunil Kochhar, Ziding Zhang, 2005, Protein science : a publication of the Protein Society.

Specific dietary preferences are linked to differing gut microbial metabolic activity in response to dark chocolate intake.

K. Redeuil, S. Moco, S. Kochhar, 2012, Journal of proteome research.

Studies on the Mechanism of Action of Aspartate Aminotransferase (AspAT) by Cryoenzymological and Isotope Techniques

P. Christen, S. Kochhar, H. Gehring, 1987 .

Plasma alkylresorcinols as a biomarker of whole-grain food consumption in a large population: results from the WHOLEheart Intervention Study.

S. Jebb, C. Seal, I. Brownlee, 2012, The American journal of clinical nutrition.

Simultaneous measurement of 13C- and 15N-isotopic enrichments of threonine by mass spectrometry.

Z. Ramadan, D. Breuillé, M. Faure, 2009, Rapid communications in mass spectrometry : RCM.

Chemometric strategy for modeling metabolic biological space along the gastrointestinal tract and assessing microbial influences.

Serge Rezzi, Ivan Montoliu, Sunil Kochhar, 2010, Analytical chemistry.

Gut microbiota modulate the metabolism of brown adipose tissue in mice.

J. Nicholson, E. Holmes, M. Dumas, 2012, Journal of proteome research.

Dietary modulation of gut functional ecology studied by fecal metabonomics.

J. Nicholson, S. Kochhar, F. Martin, 2010, Journal of Proteome Research.

Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling.

H. Daniel, M. Affolter, M. Kussmann, 2011, Journal of proteome research.

A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial.

J. Kirwan, A. Ross, S. Kochhar, 2018, Metabolism: clinical and experimental.

Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

T. Lundstedt, Z. Ramadan, P. van Bladeren, 2008, Molecular systems biology.

A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week.

Stephen J. Bruce, R. Bibiloni, S. Moco, 2013, The Journal of nutrition.

Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry.

Stephen J. Bruce, S. Kochhar, S. Rezzi, 2009, Analytical chemistry.

Assessing the performance of statistical validation tools for megavariate metabolomics data

A. Smilde, S. Bijlsma, E. Verheij, 2006, Metabolomics.

A Whole-Grain-Rich Diet Reduces Urinary Excretion of Markers of Protein Catabolism and Gut Microbiota Metabolism in Healthy

R. Bibiloni, S. Moco, S. Kochhar, 2013 .

Isolation and characterization of 2S cocoa seed albumin storage polypeptide and the corresponding cDNA.

S. Kochhar, J. McCarthy, K. Gartenmann, 2001, Journal of agricultural and food chemistry.