J. Wilkinson

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The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going?

Eleni Zengini, C. Finan, J. Wilkinson, 2016, The Journal of Rheumatology.

Decoding the genomic basis of osteoarthritis

E. Zeggini, C. Lelliott, J. Choudhary, 2019, bioRxiv.

Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment

I. Holen, W. Gregory, P. Heath, 2019, Clinical Cancer Research.

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions

I. Holen, J. Wilkinson, P. Avgoustou, 2015, Clinical & Experimental Metastasis.

Estimating an Individual’s Probability of Revision Surgery After Knee Replacement: A Comparison of Modeling Approaches Using a National Data Set

V. Kadirkamanathan, E. McCloskey, A. Blom, 2018, American journal of epidemiology.

Estimating an Individual’s Probability of Revision Surgery After Knee Replacement: A Comparison of Modeling Approaches Using a National Data Set

V. Kadirkamanathan, E. McCloskey, A. Blom, 2018, American journal of epidemiology.

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

E. Zeggini, U. Thorsteinsdóttir, K. Stefánsson, 2017, Human molecular genetics.

The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis

E. Zeggini, J. Wilkinson, J. M. Wilkinson, 2020, Calcified Tissue International.

Quantifying the Characteristics of the Acetabulum and Proximal Femur using a Semi-automated Hip Morphology Software Programme (SHIPS)

M. Doherty, J. Wilkinson, Lang Yang, 2013, Hip international : the journal of clinical and experimental research on hip pathology and therapy.

Assessment of Osteoporosis at Autopsy: Mechanical Methods Compared to Radiological and Histological Techniques

E. Patterson, J. Wilkinson, D. Cotton, 1991, Medicine, science, and the law.

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

Tom R. Gaunt, E. Zeggini, I. Tachmazidou, 2019, Nature Genetics.

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

Tom R. Gaunt, E. Zeggini, I. Tachmazidou, 2018, bioRxiv.

arcOGEN Consortium (2019). Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nature Genetics , 51 (2), 230-236.

Tom R. Gaunt, E. Zeggini, I. Tachmazidou, 2018 .

Direct plain radiographic methods versus EBRA-Digital for measuring implant migration after total hip arthroplasty.

I. Stockley, J. Wilkinson, N. Phillips, 2002, The Journal of arthroplasty.

Bone remodelling around a cemented polyethylene cup. A longitudinal densitometry study.

R. Eastell, I. Stockley, J. Wilkinson, 2006, The Journal of bone and joint surgery. British volume.

Precision of periprosthetic bone mineral density measurements using Hologic Windows versus DOS-based analysis software.

R. Eastell, I. Stockley, J. Wilkinson, 2006, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

Particle-Induced Osteolysis Is Mediated by TIRAP/Mal in Vitro and in Vivo: Dependence on Adherent Pathogen-Associated Molecular Patterns.

E. Kiss-Toth, J. Wilkinson, J. Gebhart, 2016, The Journal of bone and joint surgery. American volume.

Variation in the secreted frizzled‐related protein‐3 gene and risk of Osteolysis and heterotopic ossification after total hip arthroplasty

R. Eastell, Anthony G. Wilson, L. Southam, 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

High-spatial-resolution bone densitometry with dual-energy X-ray absorptiometric region-free analysis.

Alejandro F. Frangi, Alejandro F Frangi, J. Pozo, 2015, Radiology.

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

I. Holen, R. Clarke, J. Wilkinson, 2019, Breast Cancer Research.

Revision and 90-day mortality following hip arthroplasty in patients with inflammatory arthritis and ankylosing spondylitis enrolled in the National Joint Registry for England and Wales

A. Blom, J. Wilkinson, A. Macgregor, 2021, Hip international : the journal of clinical and experimental research on hip pathology and therapy.

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

E. Zeggini, G. Ritchie, J. Choudhary, 2016, Scientific Reports.

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene

A. Uitterlinden, J. V. van Meurs, E. Zeggini, 2020, Annals of the Rheumatic Diseases.

Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

E. Zeggini, K. Hatzikotoulas, A. Wainwright, 2018, Communications Biology.

Quantitating the effect of prosthesis design on femoral remodeling using high‐resolution region‐free densitometric analysis (DXA‐RFA)

Alejandro F. Frangi, Alejandro F Frangi, J. Pozo, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Automatic Quality Control for Population Imaging: A Generic Unsupervised Approach

Alejandro F. Frangi, Alejandro F Frangi, José María Pozo, 2016, MICCAI.

Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification

E. Kiss-Toth, J. Wilkinson, Favour Felix-Ilemhenbhio, 2022, International journal of molecular sciences.

Transmission of Whole Body Vibration - Comparison of Three Vibration Platforms in Healthy Subjects.

E. McCloskey, J. Wilkinson, Lang Yang, 2020, Bone.

Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation

E. Dall’Ara, J. Wilkinson, S. Oliviero, 2020, Materials.

TITLE Integrated molecular phenotyping identifies genes and pathways disrupted in osteoarthritis

E. Zeggini, G. Ritchie, J. Choudhary, 2016 .

An analysis of 30‐day mortality after weekend versus weekday elective joint arthroplasty in England and Wales: A COHORT STUDY USING THE NATIONAL JOINT REGISTRY DATASET

A. Blom, J. Wilkinson, L. Hunt, 2017, The bone & joint journal.

Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health.

A. Gartland, J. Wilkinson, Karan M. Shah, 2011, Bone.

Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty.

R. Eastell, I. Stockley, E. Kiss-Toth, 2008, Arthritis and rheumatism.

Cannabinoids: novel therapies for arthritis?

C. L. Le Maitre, J. Wilkinson, S. Dunn, 2012, Future medicinal chemistry.

Quantitating Age‐Related BMD Textural Variation from DXA Region‐Free‐Analysis: A Study of Hip Fracture Prediction in Three Cohorts

Alejandro F Frangi, Alejandro F. Frangi, R. Eastell, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification

K. Hatzikotoulas, E. Kiss-Toth, A. Gartland, 2022, International journal of molecular sciences.

The use of bisphosphonates to meet orthopaedic challenges.

J. Wilkinson, J. Wilkinson, 2020, Bone.

Accuracy of joint aspiration for the preoperative diagnosis of infection in total hip arthroplasty.

I. Stockley, J. Wilkinson, P. Norman, 2006, The Journal of arthroplasty.

Statistical Shape and Appearance Models in Osteoporosis

Timothy F. Cootes, Alejandro F Frangi, Alejandro F. Frangi, 2014, Current Osteoporosis Reports.

Understanding the tissue effects of tribo‐corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells

A. Gartland, J. Wilkinson, P. Quinn, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

E. Dall’Ara, J. Wilkinson, J. Rochester, 2020, Scientific Reports.

Influence of Femoral Component Design on Proximal Femoral Bone Mass After Total Hip Replacement: A Randomized Controlled Trial.

P. Beaulé, J. Wilkinson, G. Grammatopoulos, 2020, The Journal of bone and joint surgery. American volume.

Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro‐inflammatory stimuli

R. Eastell, E. Kiss-Toth, J. Wilkinson, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro

A. Gartland, J. Wilkinson, Karan M. Shah, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Pathways to understanding the genomic aetiology of osteoarthritis

E. Zeggini, L. Southam, J. Wilkinson, 2017, Human molecular genetics.

Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

E. Zeggini, K. Hatzikotoulas, A. Wainwright, 2018, Communications Biology.

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

Kari Stefansson, Sophie Hackinger, Eleftheria Zeggini, 2018, Nature Genetics.

The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?

E. Zeggini, I. Tachmazidou, K. Hatzikotoulas, 2019, Clinical orthopaedics and related research.

Risk Factors for Aseptic Loosening Following Total Hip Arthroplasty

J. Wilkinson, S. Macinnes, A. Gordon, 2012 .

Auditory and Visual Health after Ten Years of Exposure to Metal-on-Metal Hip Prostheses: A Cross-Sectional Study Follow Up

S. Hickman, J. Wilkinson, J. Ray, 2014, PloS one.

Metal-on-Metal Hip Prostheses and Systemic Health: A Cross-Sectional Association Study 8 Years after Implantation

M. Paley, A. Morton, I. Stockley, 2013, PloS one.

Effects of chronic cobalt and chromium exposure after metal‐on‐metal hip resurfacing: An epigenome‐wide association pilot study

E. Zeggini, A. Gartland, J. Wilkinson, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Effect of mixing technique on the properties of acrylic bone-cement: a comparison of syringe and bowl mixing systems.

I. Stockley, J. Wilkinson, A. Miles, 2000, The Journal of arthroplasty.

The genetic and epigenetic contributions to the development of nutritional rickets

J. Wilkinson, A. Adebajo, I. Ogunmwonyi, 2022, Frontiers in Endocrinology.

Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies

A. Hofman, A. Uitterlinden, T. Spector, 2014, Arthritis & rheumatology.

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

A. Hofman, A. Uitterlinden, T. Spector, 2013, Annals of the rheumatic diseases.

Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis

E. Zeggini, N. W. Rayner, Yolande F M Ramos, 2016, Annals of the rheumatic diseases.

Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies

C. L. Le Maitre, J. Wilkinson, S. Dunn, 2016, Cannabis and cannabinoid research.

A Spatio-Temporal Ageing Atlas of the Proximal Femur

Alejandro F Frangi, Alejandro F. Frangi, Eugene McCloskey, 2020, IEEE Transactions on Medical Imaging.

Spatio-Temporal Atlas of Bone Mineral Density Ageing

Alejandro F. Frangi, Alejandro F Frangi, José María Pozo, 2018, MICCAI.

Use of high resolution dual‐energy x‐ray absorptiometry‐region free analysis (DXA‐RFA) to detect local periprosthetic bone remodeling events

Alejandro F Frangi, J. Pozo, J. Wilkinson, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

high-s patial- r esolution Bone Densitometry with Dual- energy X-ray absorptiometric r egion-

Alejandro F Frangi, J. Pozo, J. Wilkinson, 2015 .

High-spatial-resolution bone densitometry with dual-energy X-ray absorptiometric region-free analysis.

Alejandro F Frangi, J. Pozo, J. Wilkinson, 2015, Radiology.

THU0004 The Role of Histone Deacetylases in Rheumatoid Arthritis Fibroblasts-Like Synoviocytes

J. Wilkinson, M. Muthana, S. Aynsley, 2013 .

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Bjarni V. Halldórsson, A. Hofman, A. Uitterlinden, 2010, Annals of the rheumatic diseases.

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

Simon C. Potter, Bjarni V. Halldórsson, A. Hofman, 2010, Annals of the rheumatic diseases.

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.

A. Hofman, T. Spector, J. V. van Meurs, 2010, Osteoarthritis and cartilage.

Aetiology of Hip Dysplasia: Genetic and Environmental Factors

J. Wilkinson, G. Grammatopoulos, S. Thiagarajah, 2020 .

The Genetic Epidemiology of Developmental Dysplasia of the Hip: A Genome-Wide Association Study Harnessing National Clinical Audit Data

E. Zeggini, K. Hatzikotoulas, D. Eastwood, 2017, bioRxiv.

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

Tom R. Gaunt, E. Zeggini, I. Tachmazidou, 2018, bioRxiv.

A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

E. Dall’Ara, J. Wilkinson, J. Rochester, 2020, Scientific Reports.

Personalized estimation of one-year mortality risk after elective hip or knee arthroplasty for osteoarthritis

V. Kadirkamanathan, E. McCloskey, O. Furnes, 2020, Bone & joint research.

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes.

C. L. Le Maitre, J. Wilkinson, S. Dunn, 2014, Osteoarthritis and cartilage.

Effect of denosumab on osteolytic lesion activity after total hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial

R. Eastell, J. Wilkinson, N. Hoggard, 2021 .

Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry: A UK cohort study

M. Whitehouse, A. Blom, A. Beswick, 2021, PLoS medicine.

Disposable versus reusable laparoscopic cholecystectomy instruments - an audit of costs

J. Wilkinson, K. Hosie, M. Hargrave, 1995 .

Good outcome of total hip replacement in patients with cerebral palsy

A. Blom, J. Wilkinson, L. Hunt, 2016, Acta orthopaedica.

Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo‐Controlled Trial

G. Murray, S. Ralston, A. Duckworth, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Long-term outcome of a cementless, hemispherical, press-fit acetabular component: survivorship analysis and dose-response relationship to linear polyethylene wear.

I. Stockley, J. Wilkinson, A. Hamer, 2010, The Journal of bone and joint surgery. British volume.

Use of kernel-based Bayesian models to predict late osteolysis after hip replacement

V. Kadirkamanathan, V. Kadirkamanathan, J. Wilkinson, 2013, Journal of The Royal Society Interface.

Accurate Bone Segmentation in 2D Radiographs Using Fully Automatic Shape Model Matching Based On Regression-Voting

Timothy F. Cootes, Claudia Lindner, J. Mark Wilkinson, 2013, MICCAI.

A Comparison of the Surgical Practice of Potential Revision Outlier Joint Replacement Surgeons With Non-outliers: A Case Control Study From the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man.

Y. Ben-Shlomo, M. Whitehouse, A. Blom, 2020, The Journal of arthroplasty.

Effect of sliding-taper compared with composite-beam cemented femoral prosthesis loading regime on proximal femoral bone remodeling: a randomized clinical trial.

I. Stockley, J. Wilkinson, R. Kerry, 2013, The Journal of bone and joint surgery. American volume.

Pelvic periprosthetic bone mineral density measurement around cemented vs cementless acetabular prostheses.

J. Wilkinson, R. Jayasuriya, Raveen L. Jayasuriya, 2014, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

JointCalc: A web-based personalised patient decision support tool for joint replacement

Visakan Kadirkamanathan, Parham Aram, J. Mark Wilkinson, 2020, Int. J. Medical Informatics.

Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis

E. Zeggini, L. Southam, R. Brooks, 2021, Annals of the Rheumatic Diseases.

EBRA-Digital release 2003 versus 1998: A comparison of instrument repeatability for measuring implant migration and wear

I. Stockley, J. Wilkinson, A. Hamer, 2005 .

EBRA-Digital release 2003 versus 1998: A comparison of instrument repeatability for measuring implant migration and wear.

I. Stockley, J. Wilkinson, A. Hamer, 2005, Hip international : the journal of clinical and experimental research on hip pathology and therapy.

Improved phenotype definitions of OA in genetic association studies highlight a structural role for a common variant in LRCH1

E. Zeggini, L. Southam, A. Day-Williams, 2015 .

Quantifying Pelvic Periprosthetic Bone Remodeling Using Dual-Energy X-Ray Absorptiometry Region-Free Analysis

Alejandro F Frangi, J. Pozo, J. Wilkinson, 2017, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

Osteocyte physiology and response to fluid shear stress are impaired following exposure to cobalt and chromium: Implications for bone health following joint replacement

A. Gartland, J. Wilkinson, N. Mani, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty.

R. Eastell, I. Stockley, J. Wilkinson, 2005, The Journal of bone and joint surgery. American volume.

The Uptake of New Knee Replacement Implants in the UK: Analysis of the National Joint Registry for England and Wales.

M. Whitehouse, A. Blom, C. Penfold, 2019, The Journal of arthroplasty.

Understanding the uptake of new hip replacement implants in the UK: a cohort study using data from the National Joint Registry for England and Wales

M. Whitehouse, A. Blom, A. Sayers, 2019, BMJ Open.

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions

I. Holen, J. Wilkinson, P. Avgoustou, 2015, Clinical & Experimental Metastasis.

Homogeneity in prediction of survival probabilities for subcategories of hipprosthesis data: the Nordic Arthroplasty Register Association, 2000–2013

J. Kärrholm, O. Furnes, H. Malchau, 2019, Clinical Epidemiology.

CLEP_A_199227 519..524

J. Kärrholm, O. Furnes, H. Malchau, 2019 .

A novel variant in GLIS3 is associated with osteoarthritis

E. Zeggini, N. W. Rayner, I. Tachmazidou, 2018, Annals of the rheumatic diseases.

Fully Automatic Segmentation of the Proximal Femur Using Random Forest Regression Voting

Timothy F. Cootes, Claudia Lindner, J. Mark Wilkinson, 2013, IEEE Transactions on Medical Imaging.

Accurate Fully Automatic Femur Segmentation in Pelvic Radiographs Using Regression Voting

Timothy F. Cootes, Claudia Lindner, J. Mark Wilkinson, 2012, MICCAI.

Development of a fully automatic shape model matching (FASMM) system to derive statistical shape models from radiographs: application to the accurate capture and global representation of proximal femur shape.

C Lindner, S Thiagarajah, J M Wilkinson, 2013, Osteoarthritis and cartilage.

International variation in distribution of ASA class in patients undergoing total hip arthroplasty and its influence on mortality: data from an international consortium of arthroplasty registries

A. Silman, O. Furnes, C. Combescure, 2021, Acta orthopaedica.

Rates of hip and knee joint replacement amongst different ethnic groups in England: an analysis of National Joint Registry data.

P. Dieppe, Y. Ben-Shlomo, A. Blom, 2017, Osteoarthritis and cartilage.

Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis.

J. Wilkinson, M. Muthana, M. Akil, 2015, Human molecular genetics.

A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation

T. Quertermous, E. Kiss-Toth, J. Wilkinson, 2013, PloS one.

Reply to letter by Gallo and Petrek commenting on interleukin-1 receptor antagonist and interleukin-6 polymorphisms and post-total hip arthroplasty osteolysis.

R. Eastell, I. Stockley, E. Kiss-Toth, 2009, Arthritis and rheumatism.

Estimating patient-specific mortality after joint replacement: algorithm development and validation using national audit datasets

Visakan Kadirkamanathan, Parham Aram, Lea Trela-Larsen, 2019, Osteoarthritis and Cartilage.

An evaluation of survival modelling approaches for personalised risk prediction after hip replacement for osteoarthritis

V. Kadirkamanathan, E. McCloskey, A. Blom, 2018 .

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

I. Holen, R. Clarke, J. Wilkinson, 2019, Breast Cancer Research.

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

Tom R. Gaunt, E. Zeggini, I. Tachmazidou, 2019, Nature Genetics.

Pain following colonoscopy: elimination with carbon dioxide.

G. Norman, G. Stevenson, J. Wilkinson, 1992, Gastrointestinal endoscopy.

Systemic toxicity related to metal hip prostheses

R. Ferner, J. Wilkinson, J. Wilkinson, 2014, Clinical toxicology.

Distinct Concentration-Dependent Molecular Pathways Regulate Bone Cell Responses to Cobalt and Chromium Exposure from Joint Replacement Prostheses

M. Dunning, A. Gartland, J. Wilkinson, 2021, International journal of molecular sciences.

Regenerative medicine will make orthopaedic implants obsolete in our time Orthopaedic Research Society first annual meeting debate, San Diego, March 21st, 2017

J. Wilkinson, J. Jacobs, B. Johnstone, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

The risk of cardiac failure following metal-on-metal hip arthroplasty

N. Chaturvedi, J. Moon, C. Manisty, 2018, The bone & joint journal.

Middle cerebral artery blood velocity, embolisation, and neurological outcome during carotid endarterectomy: a prospective comparison of the Javid and the Pruitt-Inahara shunts.

J. Wilkinson, J. M. Wilkinson, J. Beard, 1997, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.