T. Hirasawa

发表

Systems metabolic engineering: the creation of microbial cell factories by rational metabolic design and evolution.

H. Shimizu, C. Furusawa, Takaaki Horinouchi, 2013, Advances in biochemical engineering/biotechnology.

Production of Glutamate and Glutamate-Related Amino Acids: Molecular Mechanism Analysis and Metabolic Engineering

Takashi Hirasawa, Hiroshi Shimizu, H. Shimizu, 2006 .

13C‐metabolic flux analysis for batch culture of Escherichia coli and its pyk and pgi gene knockout mutants based on mass isotopomer distribution of intracellular metabolites

Nobuyoshi Ishii, M. Tomita, K. Nakahigashi, 2010, Biotechnology progress.

Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae.

Chikara Furusawa, Katsunori Yoshikawa, Takashi Hirasawa, 2009, FEMS yeast research.

Transcriptome analysis of parallel-evolved Escherichia coli strains under ethanol stress

Naoaki Ono, Chikara Furusawa, Tetsuya Yomo, 2010, BMC Genomics.

Comparative analysis of transcriptional responses to saline stress in the laboratory and brewing strains of Saccharomyces cerevisiae with DNA microarray

H. Shimizu, S. Shioya, K. Nagahisa, 2006, Applied Microbiology and Biotechnology.

Direct measurement of isotopomer of intracellular metabolites using capillary electrophoresis time-of-flight mass spectrometry for efficient metabolic flux analysis.

Masaru Tomita, Tomoyoshi Soga, Takashi Hirasawa, 2007, Journal of chromatography. A.

Integrated metabolic flux and omics analysis of Synechocystis sp. PCC 6803 under mixotrophic and photoheterotrophic conditions.

H. Shimizu, C. Furusawa, F. Matsuda, 2014, Plant & cell physiology.

Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli

Chikara Furusawa, Katsunori Yoshikawa, Takashi Hirasawa, 2014, Microbial Cell Factories.

Investigating the effects of perturbations to pgi and eno gene expression on central carbon metabolism in Escherichia coli using 13 C metabolic flux analysis

Chikara Furusawa, Hirotada Mori, Takashi Hirasawa, 2012, Microbial Cell Factories.

Phenotypic convergence in bacterial adaptive evolution to ethanol stress

H. Shimizu, C. Furusawa, N. Ono, 2014, BMC Evolutionary Biology.

Omics‐Integrated Approach for Metabolic State Analysis of Microbial Processes

H. Shimizu, C. Furusawa, F. Matsuda, 2017 .

Comprehensive phenotypic analysis of single‐gene deletion and overexpression strains of Saccharomyces cerevisiae

Chikara Furusawa, Katsunori Yoshikawa, Takashi Hirasawa, 2011, Yeast.

Saccharomyces cerevisiae and DNA microarray analyses: what did we learn from it for a better understanding and exploitation of yeast biotechnology?

H. Shimizu, C. Furusawa, T. Hirasawa, 2010, Applied Microbiology and Biotechnology.

Metabolic engineering of Saccharomyces cerevisiae to improve succinic acid production based on metabolic profiling

Takashi Hirasawa, Hiroshi Shimizu, H. Shimizu, 2014, Bioscience, biotechnology, and biochemistry.

Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis

H. Shimizu, S. Ishikawa, N. Ogasawara, 2015, Bioscience, biotechnology, and biochemistry.

Integrated transcriptomic and metabolomic analysis of the central metabolism of Synechocystis sp. PCC 6803 under different trophic conditions.

H. Shimizu, C. Furusawa, T. Hirasawa, 2013, Biotechnology journal.

Adaptation of Saccharomyces cerevisiae Cells to High Ethanol Concentration and Changes in Fatty Acid Composition of Membrane and Cell Size

H. Shimizu, K. Nagahisa, C. Furusawa, 2008, PloS one.

13 C-metabolic flux analysis in heterologous cellulase production by Bacillus subtilis genome-reduced strain.

H. Shimizu, N. Ogasawara, K. Ozaki, 2014, Journal of biotechnology.

l-Cysteine production by metabolically engineered Corynebacterium glutamicum

T. Hirasawa, M. Kondoh, Mariko Kondoh, 2019, Applied Microbiology and Biotechnology.

Differential importance of trehalose accumulation in Saccharomyces cerevisiae in response to various environmental stresses.

H. Shimizu, T. Hirasawa, S. Mahmud, 2010, Journal of bioscience and bioengineering.

Recombineering to homogeneity: extension of multiplex recombineering to large‐scale genome editing

Nanette R. Boyle, H. Shimizu, C. Furusawa, 2013, Biotechnology journal.

Characterization of a Corynebacterium glutamicum dnaB mutant that shows temperature-sensitive growth and mini-cell formation

T. Hirasawa, M. Wachi, M. Uchida, 2014, Archives of Microbiology.

DNA microarray analysis onSaccharomyces cerevisiae under high carbon dioxide concentration in fermentation process

H. Shimizu, S. Shioya, K. Nagahisa, 2005 .

kdsA mutations affect FtsZ-ring formation in Escherichia coli K-12.

T. Hirasawa, K. Nagai, H. Teraoka, 2002, Microbiology.

Constitutive expression of the global regulator AbrB restores the growth defect of a genome-reduced Bacillus subtilis strain and improves its metabolite production

H. Shimizu, S. Ishikawa, N. Ogasawara, 2022, DNA research : an international journal for rapid publication of reports on genes and genomes.

Improvement of L-Lactate Production by CYB2 Gene Disruption in a Recombinant Saccharomyces cerevisiae Strain under Low pH Condition

Chikara Furusawa, Katsunori Yoshikawa, Takashi Hirasawa, 2008, Bioscience, biotechnology, and biochemistry.

Identification of target genes conferring ethanol stress tolerance to Saccharomyces cerevisiae based on DNA microarray data analysis.

Yoshio Katakura, Suteaki Shioya, Chikara Furusawa, 2007, Journal of biotechnology.

Multiple High-Throughput Analyses Monitor the Response of E. coli to Perturbations

Pei Yee Ho, H. Mori, Nobuyoshi Ishii, 2007, Science.

Effect of trehalose accumulation on response to saline stress in Saccharomyces cerevisiae

H. Shimizu, K. Nagahisa, T. Hirasawa, 2009, Yeast.

Proteomic analysis of responses to osmotic stress in laboratory and sake-brewing strains of Saccharomyces cerevisiae

H. Shimizu, S. Shioya, K. Nagahisa, 2009 .

Genome-wide expression analysis of Saccharomyces pastorianus orthologous genes using oligonucleotide microarrays.

H. Shimizu, C. Furusawa, Takaaki Horinouchi, 2010, Journal of bioscience and bioengineering.

Metabolic pathway recruiting through genomic data analysis for industrial application of Saccharomyces cerevisiae

H. Shimizu, S. Shioya, K. Nagahisa, 2007 .

INVERSE METABOLIC ENGINEERING BY INTEGRATION OF MULTIPLE OMICS ANALYSES

H. Shimizu, S. Shioya, K. Nagahisa, 2007 .

Utilization of Saccharomyces cerevisiae recombinant strain incapable of both ethanol and glycerol biosynthesis for anaerobic bioproduction

H. Shimizu, C. Furusawa, T. Hirasawa, 2013, Applied Microbiology and Biotechnology.

Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae.

H. Shimizu, C. Furusawa, T. Hirasawa, 2012, Journal of bioscience and bioengineering.

Adaptive Laboratory Evolution of Microorganisms: Methodology and Application for Bioproduction

T. Hirasawa, Tomoya Maeda, 2022, Microorganisms.

Design of Superior Cell Factories Based on Systems Wide Omics Analysis

Hiroshi Shimizu, Chikara Furusawa, Katsunori Yoshikawa, 2012 .

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB.

H. Shimizu, C. Furusawa, T. Hirasawa, 2014, The Journal of general and applied microbiology.

Dynamic change in promoter activation during lysine biosynthesis in Escherichia coli cells.

Chikara Furusawa, Tetsuya Yomo, Takashi Hirasawa, 2008, Molecular bioSystems.

A Corynebacterium glutamicum rnhA recG Double Mutant Showing Lysozyme- sensitivity, Temperature-sensitive Growth, and UV-Sensitivity

Y. Kumagai, T. Hirasawa, K. Nagai, 2003, Bioscience, biotechnology, and biochemistry.

fcsA29 mutation is an allele of polA gene of Escherichia coli.

K. Nagano, T. Hirasawa, F. Takaku, 1999, Bioscience, biotechnology, and biochemistry.

Double Mutant Showing Lysozyme-sensitivity , Temperature-sensitiye Growth , and UV-Sensitivity

Y. Kumagai, T. Hirasawa, Masaaki WAcHii, 2017 .

Understanding the mechanism of heat stress tolerance caused by high trehalose accumulation in Saccharomyces cerevisiae using DNA microarray.

H. Shimizu, C. Furusawa, T. Hirasawa, 2012, Journal of bioscience and bioengineering.

Investigating the effectiveness of DNA microarray analysis for identifying the genes involved in l-lactate production by Saccharomyces cerevisiae

Chikara Furusawa, Katsunori Yoshikawa, Takashi Hirasawa, 2009, Applied Microbiology and Biotechnology.

Analysis of adaptation to high ethanol concentration in Saccharomyces cerevisiae using DNA microarray

H. Shimizu, K. Nagahisa, C. Furusawa, 2009, Bioprocess and biosystems engineering.

Comparison of transcriptional responses to osmotic stresses induced by NaCl and sorbitol additions in Saccharomyces cerevisiae using DNA microarray.

H. Shimizu, S. Shioya, K. Nagahisa, 2006, Journal of bioscience and bioengineering.

Effect of odhA overexpression and odhA antisense RNA expression on Tween-40-triggered glutamate production by Corynebacterium glutamicum

Chikara Furusawa, Takashi Hirasawa, Keisuke Nagahisa, 2009, Applied Microbiology and Biotechnology.

Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum

Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu, 2009, Microbial cell factories.

Improving protein secretion of a transglutaminase-secreting Corynebacterium glutamicum recombinant strain on the basis of 13C metabolic flux analysis.

H. Shimizu, C. Furusawa, T. Hirasawa, 2011, Journal of bioscience and bioengineering.

Induction of glutamic acid production by copper in Corynebacterium glutamicum

T. Hirasawa, Shunsuke Ogata, 2021, Applied Microbiology and Biotechnology.

Integrated Analysis of the Transcriptome and Metabolome of Corynebacterium glutamicum during Penicillin-Induced Glutamic Acid Production.

C. Furusawa, T. Hirasawa, K. Yoshikawa, 2018, Biotechnology journal.

Recent advances in amino acid production by microbial cells.

Takashi Hirasawa, Hiroshi Shimizu, H. Shimizu, 2016, Current opinion in biotechnology.

Investigation of phosphorylation status of OdhI protein during penicillin- and Tween 40-triggered glutamate overproduction by Corynebacterium glutamicum

H. Shimizu, C. Furusawa, T. Hirasawa, 2011, Applied Microbiology and Biotechnology.

L-Glutamate production by lysozyme-sensitive Corynebacterium glutamicum ltsA mutant strains

T. Hirasawa, K. Nagai, M. Wachi, 2001, BMC biotechnology.

A Mutation in the Corynebacterium glutamicum ltsA Gene Causes Susceptibility to Lysozyme, Temperature-Sensitive Growth, and l-Glutamate Production

T. Hirasawa, M. Wachi, K. Nagai, 2000, Journal of bacteriology.

Requirement of de novo synthesis of the OdhI protein in penicillin-induced glutamate production by Corynebacterium glutamicum

Takashi Hirasawa, Keisuke Nagahisa, Hiroshi Shimizu, 2010, Applied Microbiology and Biotechnology.

Reconstruction and verification of a genome-scale metabolic model for Synechocystis sp. PCC6803

Chikara Furusawa, Katsunori Yoshikawa, Takashi Hirasawa, 2011, Applied Microbiology and Biotechnology.

Glutamate Fermentation-2: Mechanism of L-Glutamate Overproduction in Corynebacterium glutamicum.

T. Hirasawa, M. Wachi, 2016, Advances in biochemical engineering/biotechnology.

Glutamic Acid Fermentation: Discovery of Glutamic Acid‐Producing Microorganisms, Analysis of the Production Mechanism, Metabolic Engineering, and Industrial Production Process

H. Shimizu, T. Hirasawa, 2016 .

17. Glutamic Acid

H. Shimizu, T. Hirasawa, 2014 .

Molecular mechanisms and metabolic engineering of glutamate overproduction in Corynebacterium glutamicum.

H. Shimizu, C. Furusawa, T. Hirasawa, 2012, Sub-cellular biochemistry.

Ergothioneine production by Corynebacterium glutamicum harboring heterologous biosynthesis pathways.

Y. Satoh, T. Hirasawa, T. Dairi, 2022, Journal of bioscience and bioengineering.

Metabolic flux balance analysis of an industrially useful microorganism Corynebacerium glutamicum by a genome-scale reconstructed model

Hiroshi Shimizu, Chikara Furusawa, Takashi Hirasawa, 2008, BIONETICS.

Distinct roles of two anaplerotic pathways in glutamate production induced by biotin limitation in Corynebacterium glutamicum.

Takashi Hirasawa, Keisuke Nagahisa, Hiroki Sato, 2008, Journal of bioscience and bioengineering.

l-Cysteine production by metabolically engineered Corynebacterium glutamicum

T. Hirasawa, Mariko Kondoh, 2019, Applied Microbiology and Biotechnology.

Extracting the hidden features in saline osmotic tolerance in Saccharomyces cerevisiae from DNA microarray data using the self-organizing map: biosynthesis of amino acids

Yoshio Katakura, Suteaki Shioya, Chikara Furusawa, 2007, Applied Microbiology and Biotechnology.

Potential of a Saccharomyces cerevisiae recombinant strain lacking ethanol and glycerol biosynthesis pathways in efficient anaerobic bioproduction

H. Shimizu, T. Hirasawa, Yoshihiro Ida, 2014, Bioengineered.

Genome-wide identification of the targets for genetic manipulation to improve L-lactate production by Saccharomyces cerevisiae by using a single-gene deletion strain collection.

H. Shimizu, C. Furusawa, T. Hirasawa, 2013, Journal of biotechnology.

Enhanced L-cysteine production by overexpressing potential L-cysteine exporter genes in an L-cysteine-producing recombinant strain of Corynebacterium glutamicum

T. Hirasawa, Mariko Kondoh, Mayumi Kishino, 2019, Bioscience, biotechnology and biochemistry.

Growth promotion in Corynebacterium glutamicum by overexpression of the NCgl2986 gene encoding a protein homologous to peptidoglycan amidases.

T. Hirasawa, N. Iwai, M. Wachi, 2020, The Journal of general and applied microbiology.

Requirement of the LtsA Protein for Formation of the Mycolic Acid-Containing Layer on the Cell Surface of Corynebacterium glutamicum

Y. Kumagai, T. Hirasawa, M. Wachi, 2021, Microorganisms.

Genome-wide identification of the targets for genetic manipulation to improve L-lactate production by Saccharomyces cerevisiae by using a single-gene deletion strain collection.

H. Shimizu, C. Furusawa, T. Hirasawa, 2013, Journal of biotechnology.

Relationship between noise characteristics in protein expressions and regulatory structures of amino acid biosynthesis pathways.

H. Shimizu, C. Furusawa, T. Hirasawa, 2010, IET systems biology.

Effect of malic enzyme on ethanol production by Synechocystis sp. PCC 6803.

H. Shimizu, T. Hirasawa, Katsunori Yoshikawa, 2015, Journal of bioscience and bioengineering.

Analysis of Responses of Complex Bionetworks to Changes in Environmental Conditions

Hiroshi Shimizu, Suteaki Shioya, Takashi Hirasawa, 2004, BioADIT.