Z. Shriver

发表

Glycomics: a pathway to a class of new and improved therapeutics

Zachary Shriver, Ram Sasisekharan, Z. Shriver, 2004, Nature Reviews Drug Discovery.

Sialylneolacto-N-tetraose c (LSTc)-bearing Liposomal Decoys Capture Influenza A Virus*

H. Ploegh, D. Fygenson, Z. Shriver, 2013, The Journal of Biological Chemistry.

LSTc-bearing decoys capture influenza virus 1

H. Ploegh, D. Fygenson, Z. Shriver, 2013 .

Glycan Receptor Binding of the Influenza A Virus H7N9 Hemagglutinin

Nathan W. Stebbins, V. Sasisekharan, Z. Shriver, 2013, Cell.

Glycosylation at Asn91 of H1N1 haemagglutinin affects binding to glycan receptors

Rahul Raman, Karthik Viswanathan, Zachary Shriver, 2012, The Biochemical journal.

Harnessing glycomics technologies: Integrating structure with function for glycan characterization

Z. Shriver, R. Sasisekharan, R. Raman, 2012, Electrophoresis.

Glycosylation at Asn[supscript 91] of H1N1 haemagglutinin affects binding to glycan receptors

Z. Shriver, R. Sasisekharan, R. Raman, 2012 .

Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin

A. Srinivasan, T. Tumpey, Z. Shriver, 2010, PloS one.

Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans.

Z. Shriver, R. Sasisekharan, G. Venkataraman, 2002, Seminars in thrombosis and hemostasis.

Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice

Rahul Raman, Hui Zeng, Karthik Viswanathan, 2009, Science.

Amino acid interaction networks provide a new lens for therapeutic antibody discovery and anti-viral drug optimization.

Z. Shriver, K. Viswanathan, G. Babcock, 2015, Current opinion in virology.

Addendum: Chinese hamster ovary cells can produce galactose-α-1, 3-galactose antigens on proteins

Z. Shriver, R. Sasisekharan, R. Raman, 2011, Nature Biotechnology.

Methods for Structural Analysis of Heparin and Heparan Sulfate

Z. Shriver, I. Capila, G. Venkataraman, 2005 .

Outbreak of adverse reactions associated with contaminated heparin.

Robert Langer, Steven Kozlowski, Arjun Srinivasan, 2008, The New England journal of medicine.

The Tainted Heparin Story: An Update

Z. Shriver, R. Sasisekharan, G. Torri, 2009, Thrombosis and Haemostasis.

From crisis to opportunity: A perspective on the heparin crisis

Z. Shriver, R. Sasisekharan, 2009, Thrombosis and Haemostasis.

Heparin and heparan sulfate: analyzing structure and microheterogeneity.

Z. Shriver, R. Sasisekharan, I. Capila, 2012, Handbook of experimental pharmacology.

Quantitative assessment of FGF regulation by cell surface heparan sulfates.

Z. Shriver, R. Sasisekharan, G. Venkataraman, 2004, Biochemical and biophysical research communications.

Direct isolation and sequencing of specific protein-binding glycosaminoglycans

Z. Shriver, R. Sasisekharan, G. Venkataraman, 2001, Nature Medicine.

Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans.

J. C. Davis, Z. Shriver, R. Sasisekharan, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates.

E. Ooi, H. Tan, Z. Shriver, 2017, Antiviral research.

Heparan Sulfate d-Glucosaminyl 3-O-Sulfotransferase-3A SulfatesN-Unsubstituted Glucosamine Residues*

K. Yoshida, J. Liu, Z. Shriver, 1999, The Journal of Biological Chemistry.

Characterization of a Heparan Sulfate Octasaccharide That Binds to Herpes Simplex Virus Type 1 Glycoprotein D*

R. Eisenberg, G. Cohen, R. Linhardt, 2002, The Journal of Biological Chemistry.

Clinical and virological responses to a broad-spectrum human monoclonal antibody in an influenza virus challenge study.

Z. Shriver, Kristy J. Szretter, Patrick F. Smith, 2020, Antiviral research.

Assessment of the quality and structural integrity of a complex glycoprotein mixture following extraction from the formulated biopharmaceutical drug product.

Z. Shriver, Yan Yin, I. Capila, 2011, Journal of pharmaceutical and biomedical analysis.

Sequencing complex polysaccharides.

Z. Shriver, R. Sasisekharan, R. Raman, 1999, Science.

Profiling the glycoforms of the intact alpha subunit of recombinant human chorionic gonadotropin by high-resolution capillary electrophoresis-mass spectrometry.

T. Rejtar, D. Thakur, B. Karger, 2009, Analytical chemistry.

Structural elucidation of the tetrasaccharide pool in enoxaparin sodium

J. Lansing, Z. Shriver, I. Capila, 2012, Analytical and Bioanalytical Chemistry.

Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin.

K. Biemann, R. Linhardt, Z. Shriver, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Mass spectrometric evidence for the enzymatic mechanism of the depolymerization of heparin-like glycosaminoglycans by heparinase II.

K. Biemann, Z. Shriver, R. Sasisekharan, 1998, Proceedings of the National Academy of Sciences of the United States of America.

6-O-Sulfotransferase-1 Represents a Critical Enzyme in the Anticoagulant Heparan Sulfate Biosynthetic Pathway*

D. Beeler, Jian Liu, Z. Shriver, 2001, The Journal of Biological Chemistry.

Glycomics‐based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay

Udayanath Aich, Z. Shriver, R. Sasisekharan, 2011, The FEBS journal.

Overexpression of Merlin in B16F10 mouse melanoma cells reduces their metastatic activity: role of the cell surface heparan sulfate glycosaminoglycans.

Z. Galcheva-gargova, Z. Shriver, G. Venkataraman, 1992, International journal of oncology.

A broadly neutralizing human monoclonal antibody is effective against H7N9

Vidya Subramanian, H. Yen, G. Wogan, 2015, Proceedings of the National Academy of Sciences.

S-methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase.

Stephen Naylor, K. Veverka, Z. Shriver, 1995, Biochemical pharmacology.

Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.

D. Fygenson, Z. Shriver, D. Knipe, 2015, Antiviral research.

Expression in Escherichia coli, purification and kinetic characterization of human heparan sulfate 3-O-sulfotransferase-1.

Jian Liu, Z. Shriver, R. Sasisekharan, 2002, Biochemical and biophysical research communications.

Rational design of low-molecular weight heparins with improved in vivo activity

R. Langer, Z. Shriver, R. Sasisekharan, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route.

R. Langer, Shiladitya Sengupta, Z. Shriver, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An integrated approach using orthogonal analytical techniques to characterize heparan sulfate structure

J. Pradines, V. Farutin, Z. Shriver, 2016, Glycoconjugate Journal.

Heparinase II from Flavobacterium heparinum

Z. Shriver, R. Sasisekharan, K. Pojasek, 1998, The Journal of Biological Chemistry.

Histidine 295 and histidine 510 are crucial for the enzymatic degradation of heparan sulfate by heparinase III.

Z. Shriver, R. Sasisekharan, Y. Hu, 2000, Biochemistry.

Biologically Active Decorin Is a Monomer in Solution*

R. Iozzo, S. Goldoni, Z. Shriver, 2004, Journal of Biological Chemistry.

Capillary Electrophoretic Analysis of Isolated Sulfated Polysaccharides to Characterize Pharmaceutical Products.

Z. Shriver, R. Sasisekharan, 2021, Methods in molecular biology.

Capillary electrophoretic analysis of isolated sulfated polysaccharides to characterize pharmaceutical products.

Z. Shriver, R. Sasisekharan, 2015, Methods in molecular biology.

Antibody–Bactericidal Macrocyclic Peptide Conjugates To Target Gram‐Negative Bacteria

Andrew M Wollacott, Kenneth D. Johnson, A. Wollacott, 2018, Chembiochem : a European journal of chemical biology.

Biochemical Investigations and Mapping of the Calcium-binding Sites of Heparinase I from Flavobacterium heparinum *

Z. Shriver, R. Sasisekharan, Dongfang Liu, 1999, The Journal of Biological Chemistry.

Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1.

Z. Shriver, R. Sasisekharan, G. Venkataraman, 2003, The Biochemical journal.

Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution.

E. Yates, G. Sassaki, Z. Shriver, 2013, Biochemistry.

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

Robert Langer, Robert J Linhardt, Benito Casu, 2008, Nature Biotechnology.

USP compendial methods for analysis of heparin: chromatographic determination of molecular weight distributions for heparin sodium

Z. Shriver, B. Mulloy, F. Jameison, 2014, Analytical and Bioanalytical Chemistry.

Molecular cloning of the heparin/heparan sulfate delta 4,5 unsaturated glycuronidase from Flavobacterium heparinum, its recombinant expression in Escherichia coli, and biochemical determination of its unique substrate specificity.

T. Kiziltepe, Z. Shriver, R. Sasisekharan, 2002, Biochemistry.

Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum.

P. Kiley, Z. Shriver, R. Sasisekharan, 2001, Biochemical and biophysical research communications.

The Calcium-binding Sites of Heparinase I fromFlavobacterium heparinum Are Essential for Enzymatic Activity*

Z. Shriver, R. Sasisekharan, G. Venkataraman, 1999, The Journal of Biological Chemistry.

Roles of heparan-sulphate glycosaminoglycans in cancer

Zachary Shriver, Ram Sasisekharan, Ganesh Venkataraman, 2002, Nature Reviews Cancer.

Insights into the Human Glycan Receptor Conformation of 1918 Pandemic Hemagglutinin–Glycan Complexes Derived from Nuclear Magnetic Resonance and Molecular Dynamics Studies

E. Yates, Z. Shriver, R. Sasisekharan, 2014, Biochemistry.

Crystal Structure of Fibroblast Growth Factor 9 Reveals Regions Implicated in Dimerization and Autoinhibition*

M. Mohammadi, A. V. Eliseenkova, O. Ibrahimi, 2001, The Journal of Biological Chemistry.

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

C. L. Chu, Z. Galcheva-gargova, Z. Shriver, 2011, PloS one.

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: A new approach to prevent and treat bacterial infections

A. Wollacott, Z. Shriver, B. Pentelute, 2022, bioRxiv.

Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions

Douglas A Lauffenburger, Zachary Shriver, Melody K Morris, 2011, Biotechnology journal.

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

Zachary Shriver, Kenneth D. Johnson, Scott J. Miller, 2018, Synthesis.

Characterization of an Antibody Recognizing the Conserved Inner Core of Pseudomonas aeruginosa Lipopolysaccharides.

B. Ramakrishnan, A. Wollacott, Z. Shriver, 2020, Biochemistry.

Contaminated heparin associated with adverse clinical events and activation of the contact system.

R. Langer, J. Woodcock, G. D. Dal Pan, 2008, The New England journal of medicine.

HSulf-1 and HSulf-2 Are Potent Inhibitors of Myeloma Tumor Growth in Vivo*

R. Sanderson, Z. Shriver, R. Sasisekharan, 2005, Journal of Biological Chemistry.

Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.

V. Sasisekharan, Z. Shriver, R. Sasisekharan, 2014, Trends in microbiology.

Simultaneous structure-activity determination of disulfiram photolysis products by on-line continuous-flow liquid secondary ion mass spectrometry and enzyme inhibition assay.

L. Benson, Stephen Naylor, K. Veverka, 1995, Journal of chromatography. A.

Integrated Approach for Characterization of Highly Heterogeneous Drugs

Zachary Shriver, Ram Sasisekharan, Rahul Raman, 2019, The Science and Regulations of Naturally Derived Complex Drugs.

Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis

Z. Shriver, R. Sasisekharan, G. Venkataraman, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The Heparin/Heparan Sulfate 2-O-Sulfatase from Flavobacterium heparinum

Z. Shriver, R. Sasisekharan, G. Venkataraman, 2003, The Journal of Biological Chemistry.

Extending human IgG half-life using structure-guided design

Andrew M Wollacott, B. Ramakrishnan, A. Wollacott, 2018, mAbs.

A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.

Vlado Dančík, Rahul Raman, Karthik Viswanathan, 2016, Trends in microbiology.

VIS832, a novel CD138-targeting monoclonal antibody, potently induces killing of human multiple myeloma and further synergizes with IMiDs or bortezomib in vitro and in vivo

B. Ramakrishnan, N. Munshi, A. Wollacott, 2020, Blood Cancer Journal.

Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks

Andrew M Wollacott, A. Wollacott, M. F. Boni, 2016, EBioMedicine.

The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.

B. Barlogie, J. Shaughnessy, L. Suva, 2007, Blood.

Cell surface glypicans are low-affinity endostatin receptors.

D. Mukhopadhyay, L. Cantley, R. Kalluri, 2001, Molecular cell.

Context-specific target definition in influenza a virus hemagglutinin-glycan receptor interactions.

Z. Shriver, R. Sasisekharan, R. Raman, 2009, Chemistry & biology.

Modular glycosphere assays for high-throughput functional characterization of influenza viruses

Rahul Raman, Karthik Viswanathan, Zachary Shriver, 2013, BMC Biotechnology.

A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.

Andrew M Wollacott, B. Ramakrishnan, A. Wollacott, 2019, Kidney international.

Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study

Z. Shriver, S. Smits, Patrick F. Smith, 2019, EBioMedicine.

Orthogonal analytical approaches to detect potential contaminants in heparin

R. Langer, Zhenqing Zhang, R. Linhardt, 2009, Proceedings of the National Academy of Sciences.

Competitive inhibition of heparinase by persulfonated glycosaminoglycans: a tool to detect heparin contamination.

Udayanath Aich, Z. Shriver, R. Sasisekharan, 2011, Analytical chemistry.

Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

E. Ooi, H. Tan, Z. Shriver, 2018, PLoS neglected tropical diseases.

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

Hamid Tissire, Karthik Viswanathan, Zachary Shriver, 2015, Cell.

The Heparin/Heparan Sulfate 2-O-Sulfatase from Flavobacterium heparinum

Z. Shriver, R. Sasisekharan, R. Raman, 2003, The Journal of Biological Chemistry.

Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site.

K. Biemann, R. Linhardt, J. Turnbull, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Probing Fibroblast Growth Factor Dimerization and Role of Heparin-like Glycosaminoglycans in Modulating Dimerization and Signaling*

L. Varticovski, Z. Shriver, R. Sasisekharan, 2001, The Journal of Biological Chemistry.

Oligomeric self-association of basic fibroblast growth factor in the absence of heparin-like glycosaminoglycans.

Z. Shriver, R. Sasisekharan, G. Venkataraman, 1999, The Biochemical journal.

Distinct heparan sulfate glycosaminoglycans are responsible for mediating fibroblast growth factor‐2 biological activity through different fibroblast growth factor receptors

Z. Shriver, R. Sasisekharan, G. Venkataraman, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The US regulatory and pharmacopeia response to the global heparin contamination crisis

Roger L. Williams, J. Woodcock, D. Keire, 2016, Nature Biotechnology.

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

Z. Shriver, R. Sasisekharan, R. Raman, 2010, Nature Biotechnology.

A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in Ferrets

T. Tumpey, Z. Shriver, R. Sasisekharan, 2011, PloS one.

Antibody-Based Strategies to Prevent and Treat Influenza

Z. Shriver, R. Sasisekharan, J. Trevejo, 2015, Front. Immunol..

Emerging views of heparan sulfate glycosaminoglycan structure/activity relationships modulating dynamic biological functions.

Zachary Shriver, Ram Sasisekharan, Dongfang Liu, 2002, Trends in cardiovascular medicine.

Heparin/Heparan Sulfate 6-O-Sulfatase from Flavobacterium heparinum

Z. Shriver, R. Sasisekharan, R. Raman, 2009, The Journal of Biological Chemistry.

Extrapolating from sequence—the 2009 H1N1 'swine' influenza virus

Rahul Raman, Zachary Shriver, Ram Sasisekharan, 2009, Nature Biotechnology.

myeloma therapy The syndecan-1 heparan sulfate proteoglycan is a viable target for

B. Barlogie, L. Suva, J. Epstein, 2013 .

Electrospun polyvinylpyrrolidone fibers with high concentrations of ferromagnetic and superparamagnetic nanoparticles.

Udayanath Aich, R. Linhardt, J. Dordick, 2011, ACS applied materials & interfaces.

Structural prediction of antibody‐APRIL complexes by computational docking constrained by antigen saturation mutagenesis library data

Andrew M Wollacott, Luke N Robinson, Boopathy Ramakrishnan, 2019, Journal of molecular recognition : JMR.

Heparin sensing: blue-chip binding.

Z. Shriver, R. Sasisekharan, 2013, Nature chemistry.

Thermodynamics of Inter- and Intramolecular Hydrogen Bonding in (Diphosphine)platinum(II) Diolate Complexes and Its Role in Carbohydrate Complexation Regioselectivity.

Z. Shriver, M. A. Andrews, G. K. Cook, 1997, Inorganic chemistry.

Outbreak of adverse reactions associated with contaminated heparin.

R. Langer, M. Arduino, Z. Shriver, 2008, The New England journal of medicine.