D. Harder

发表

Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue.

R. Roman, D. Harder, A. Lange, 1997, Journal of vascular research.

Role of astrocytes in cerebrovascular regulation.

R. Koehler, D. Harder, D. Gebremedhin, 2006, Journal of applied physiology.

Astrocytes and the regulation of cerebral blood flow

R. Koehler, R. Roman, D. Harder, 2009, Trends in Neurosciences.

Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites.

R J Roman, R. Roman, N. Alkayed, 1998, Stroke.

Spontaneous Flow Oscillations in the Cerebral Cortex during Acute Changes in Mean Arterial Pressure

R J Roman, A. Hudetz, A. Hudetz, 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.

R. Koehler, J. Falck, R. Roman, 2008, American journal of physiology. Heart and circulatory physiology.

Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells

E. Jacobs, D. Harder, D. Gebremedhin, 1995, Pflügers Archiv.

Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release.

D. Harder, D. Munzenmaier, 2000, American journal of physiology. Heart and circulatory physiology.

Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current.

W. Campbell, D. Harder, A. Lange, 1999, The American journal of physiology.

Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels.

R. Roman, J. Falck, W. Campbell, 1994, The American journal of physiology.

Effect of 20-HETE Inhibition on Infarct Volume and Cerebral Blood Flow after Transient Middle Cerebral Artery Occlusion

R. Koehler, R. Roman, D. Harder, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Beneficial Effects of a new 20-HETE Synthesis Inhibitor, TS-011, on Hemorrhagic and Ischemic Stroke

S. Okuyama, D. Harder, N. Miyata, 2005 .

Beneficial Effects of a New 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, TS-011 [N-(3-Chloro-4-morpholin-4-yl) Phenyl-N′-hydroxyimido Formamide], on Hemorrhagic and Ischemic Stroke

S. Okuyama, R. Roman, D. Harder, 2005, Journal of Pharmacology and Experimental Therapeutics.

Effects of a 20-HETE antagonist and agonists on cerebral vascular tone.

J. Falck, R. Roman, K. Takeuchi, 2004, European journal of pharmacology.

Contribution of 5-Hydroxytryptamine 1 B Receptors and 20-Hydroxyeiscosatetraenoic Acid to Fall in Cerebral Blood Flow After Subarachnoid Hemorrhage

R. Roman, D. Harder, Ming Yu, 2003 .

Contribution of 5-Hydroxytryptamine1B Receptors and 20-Hydroxyeiscosatetraenoic Acid to Fall in Cerebral Blood Flow After Subarachnoid Hemorrhage

R. Roman, D. Harder, Ming Yu, 2003, Stroke.

Endothelium-dependent modulation of endothelin-induced vasoconstriction and membrane depolarization in cat cerebral arteries.

D. Harder, G. Rubanyi, K. Kauser, 1990, The Journal of pharmacology and experimental therapeutics.

Pressure Releases a Transferable Endothelial Contractile Factor in Cat Cerebral Arteries

D. Harder, C. Sánchez-Ferrer, G. Rubanyi, 1989, Circulation research.

Effect of a New Inhibitor of the Synthesis of 20-HETE on Cerebral Ischemia Reperfusion Injury

S. Okuyama, S. Nakaike, R. Roman, 2006, Stroke.

Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes

Yubo Fan, D. Harder, J. Gershan, 2019, npj Precision Oncology.

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

E. Jacobs, P. Pratt, J. Falck, 2007, Prostaglandins & other lipid mediators.

20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat.

M. L. Schulte, A. Hudetz, R. Roman, 2002, American journal of physiology. Heart and circulatory physiology.

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow.

A. Hudetz, A. Hudetz, R. Roman, 1996, The American journal of physiology.

Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo

D. Harder, J. Gershan, K. Rarick, 2013, PloS one.

Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.

R. Koehler, J. Falck, D. Harder, 2012, American journal of physiology. Heart and circulatory physiology.

Epoxyeicosatrienoic acid‐dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation

R. Koehler, S. Hwang, J. Falck, 2008, American journal of physiology. Heart and circulatory physiology.

Hypoxia-induced activation in small isolated pulmonary arteries from the cat.

C. Dawson, D. Harder, J. Madden, 1985, Journal of applied physiology.

Astrocytic responses to high glucose impairs barrier formation in cerebral microvessel endothelial cells.

D. Harder, O. Palygin, A. Staruschenko, 2022, American journal of physiology. Regulatory, integrative and comparative physiology.

Attenuation of neonatal ischemic brain damage using a 20‐HETE synthesis inhibitor

R. Koehler, D. Crafa, L. Martin, 2012, Journal of neurochemistry.

Cardiac glycoside stimulation of inward Ca++ current in vascular smooth muscle of canine coronary artery.

R. Berne, D. Harder, N. Sperelakis, 1979, The Journal of pharmacology and experimental therapeutics.

Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage.

J. Cusick, R. Roman, L. Hacein-Bey, 2006, AJNR. American journal of neuroradiology.

Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE.

R. Roman, K. Takeuchi, D. Harder, 2005, American journal of physiology. Heart and circulatory physiology.

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat.

D. Harder, L. Tseng, Hsiang-En Wu, 2007, European journal of pharmacology.

Epoxyeicosatetrinoic acids released by astrocytes: function in cerebral angiogenesis

D. Harder, Chenyang Zhang, 2002 .

Mechanoreception by the endothelium: mediators and mechanisms of pressure- and flow-induced vascular responses.

D. Harder, G. Rubanyi, A. Johns, 1990, Blood vessels.

Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism.

Amadou K. S. Camara, D. Harder, D. Stowe, 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Estrogen receptors and effects of estrogen on membrane electrical properties of coronary vascular smooth muscle

D. Harder, P. Coulson, 1979, Journal of cellular physiology.

Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles.

J. Falck, R. Roman, J. Falck, 1998, Circulation research.

The protective effect of astrocyte-derived 14,15-EET on H2O2- induced cell injury in Astrocyte-dopaminergic neuronal cell line co-culture

J. Falck, D. Harder, P. Sarkar, 2014 .

The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture

J. Falck, D. Harder, P. Sarkar, 2012, Neuroscience.

Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes

D. Harder, K. Nithipatikom, V. Prasad, 2008, Neurochemistry International.

Renal And Cardiovascular Actions Of 20‐Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids

R. Roman, D. Harder, K. Maier, 2000, Clinical and experimental pharmacology & physiology.

Hypoxic induction of Ca2+-dependent action potentials in small pulmonary arteries of the cat.

C. Dawson, D. Harder, J. Madden, 1985, Journal of applied physiology.

Pressure‐Dependent Membrane Depolarization in Cat Middle Cerebral Artery

D. Harder, 1984, Circulation research.

Vascular muscle cell depolarization and activation in renal arteries on elevation of transmural pressure.

R. Gilbert, D. Harder, J. Lombard, 1987, The American journal of physiology.

Degenerin/Epithelial Na+ Channel Proteins: Components of a Vascular Mechanosensor

H. Drummond, D. Harder, D. Gebremedhin, 2004, Hypertension.

Membrane ATPase mechanism of K+-return relaxation in arterial muscles of stroke-prone SHR and WKY.

D. Harder, K. Hermsmeyer, 1986, The American journal of physiology.

Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature.

A. Tryba, D. Harder, D. Lourim, 2014, American journal of physiology. Cell physiology.

Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol.

R. Roman, D. Harder, J. Narayanan, 1994, The American journal of physiology.

Bioassay of an Endothelium-Derived Hyperpolarizing Factor from Bovine Coronary Arteries: Role of a Cytochrome P450 Metabolite

P. Pratt, W. Campbell, D. Harder, 1998, Journal of Vascular Research.

Transduction of physical force by the vascular wall Role of phospholipase C and cytochrome P450 metabolites of arachidonic acid.

R. Roman, D. Harder, D. Gebremedhin, 1995, Trends in cardiovascular medicine.

Mechanisms of pressure-induced myogenic activation of cerebral and renal arteries: role of the endothelium.

R. Roman, D. Harder, J. Lombard, 1989, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow.

D. Harder, D. Gebremedhin, J. Narayanan, 2011, American journal of physiology. Heart and circulatory physiology.

Cerebrovascular alterations in protein kinase C-mediated constriction in stroke-prone rats.

D. Harder, J. Smeda, S. King, 1999, Stroke.

Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats.

R. Roman, D. Harder, D. Gebremedhin, 2014, American journal of physiology. Heart and circulatory physiology.

Title Page: 1 Enhanced large conductance K + channel (BK) activity contributes to the impaired myogenic response in the 2

C. J. Zablocki, R. Roman, D. Harder, 2014 .

Mechanism of cGMP contribution to the vasodilator response to NO in rat middle cerebral arteries.

R. Roman, D. Harder, K. Maier, 2002, American journal of physiology. Heart and circulatory physiology.

Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle.

J. Falck, R. Roman, D. Harder, 1992, The American journal of physiology.

Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium.

D. Harder, 1987, Circulation research.

Cellular and ionic signal transduction mechanisms for the mechanical activation of renal arterial vascular smooth muscle.

R. Roman, D. Harder, 1993, Journal of the American Society of Nephrology : JASN.

Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity.

E. Jacobs, J. Falck, R. Roman, 1996, The American journal of physiology.

Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen–Glucose Deprivation in Cortical Neurons

R. Koehler, J. Falck, R. Roman, 2017, Cellular and Molecular Neurobiology.

Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.

R. Busse, E. Jacobs, B. Fisslthaler, 2003, American journal of physiology. Heart and circulatory physiology.

Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.

H. Jacob, L. Juncos, R. Roman, 2013, American journal of physiology. Heart and circulatory physiology.

Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteries.

D. Harder, J. Lombard, Yanping Liu, 2002, American journal of physiology. Heart and circulatory physiology.

20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.

B. Masters, J. Falck, R. Roman, 1993, Circulation research.

Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure.

D. Harder, J. Osborn, J. Lombard, 1990, The American journal of physiology.

20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.

E. Jacobs, J. Falck, R. Roman, 1996, The American journal of physiology.

Mechanism of Action of EDRF on Pressurized Arteries: Effect on K+ Conductance

D. Harder, G. Rubanyi, K. Kauser, 1989, Circulation research.

Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa)

D. Weihrauch, D. Harder, Nicole L Lohr, 2021, PloS one.

Enhanced myogenic depolarization in hypertensive cerebral arterial muscle.

D. Harder, J. Lombard, J. Smeda, 1985, Circulation research.

Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid.

J. Falck, W. Campbell, K. Nithipatikom, 2001, Analytical biochemistry.

Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.

P. Ortiz de Montellano, B. Masters, R. Roman, 1991, Circulation research.

Coexistence of two types of Ca(2+)-activated K+ channels in rat renal arterioles.

E. Jacobs, R. Roman, D. Harder, 1996, The American journal of physiology.

Neuroprotection and P450 2C11 Upregulation After Experimental Transient Ischemic Attack

R. Traystman, N. Alkayed, P. Hurn, 2002, Stroke.

Traystman and Patricia D. Hurn Neuroprotection and P450 2c11 Upregulation after Experimental Transient Ischemic Neuroprotection and P450 2c11 Upregulation after Experimental Transient Ischemic Attack

R. Traystman, P. Hurn, D. Harder, 2022 .

Neuroprotection and P 450 2 C 11 Upregulation After Experimental Transient Ischemic Attack

R. Traystman, N. Alkayed, P. Hurn, 2002 .

Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution.

D. Harder, A. Camara, D. Stowe, 2007, American journal of physiology. Heart and circulatory physiology.

Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH.

R. Roman, K. Takeuchi, D. Harder, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Cardiovascular-Kidney Interactions in Health and Disease Hemoglobin , NO , and 20-HETE interactions in mediating cerebral vasoconstriction following

R. Roman, K. Takeuchi, D. Harder, 2005 .

An angiographic method for in vivo study of arteries of the circle of Willis in small animals.

A. Clough, C. Dawson, D. Harder, 1992, The American journal of physiology.

Prologue: EDHF--what is it?

W. Campbell, D. Harder, 2001, American journal of physiology. Heart and circulatory physiology.

Cannabinoid CB 1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca 2 1 channel current

W. Campbell, D. Harder, A. Lange, 1999 .

The Effect of Superoxide Anion on Autoregulation of Cerebral Blood Flow

R. Roman, D. Harder, K. Yamaura, 2005, Stroke.

Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats

R. Roman, D. Harder, J. Imig, 2015, PloS one.

Metabolites of Arachidonic Acid in the Regulation of Tone Endothelium-Derived Hyperpolarizing Factors and Vascular Cytochrome P450

W. Campbell, D. Harder, 2013 .

Identifying endothelium-derived hyperpolarizing factor: recent approaches to assay the role of epoxyeicosatrienoic acids.

D. Harder, K. Maier, M. Medhora, 2001, Japanese journal of pharmacology.

Effect of Reduced Oxygen Availability upon Myogenic Depolarization and Contraction of Cat Middle Cerebral Artery

D. Harder, J. Lombard, J. Smeda, 1986, Circulation research.

Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries.

J. Falck, R. Roman, D. Harder, 1998, American journal of physiology. Renal physiology.

Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.

J. Falck, R. Roman, D. Stec, 1996, The American journal of physiology.

Myogenic activation of canine small renal arteries after nonchemical removal of the endothelium.

D. Harder, J. Lombard, Y. Liu, 1994, The American journal of physiology.

Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.

E. Jacobs, J. Falck, R. Roman, 2000, American journal of physiology. Lung cellular and molecular physiology.

Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review).

D. Harder, M. Medhora, 1998, International journal of molecular medicine.

Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures.

J. Falck, R. Roman, D. Harder, 2012, American journal of physiology. Heart and circulatory physiology.

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen‐glucose deprivation

R. Koehler, A. Sapirstein, B. Hammock, 2017, Journal of neurochemistry.

Response of Venous Membrane Potentials to Calcium Blockade in Spontaneous Hypertension

D. Harder, J. Lombard, S. Contney, 1983, Hypertension.

Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles.

J. Falck, R. Roman, D. Harder, 1999, Hypertension.

Transmembrane potential and amino acid transport in rat hepatocytes in primary monolaver culture

D. Harder, R. Wondergem, Robert Wondergem, 1980, Journal of cellular physiology.

Action potentials induced in guinea pig arterial smooth muscle by tetraethylammonium.

D. Harder, N. Sperelakis, 1979, The American journal of physiology.

Vascular Smooth Muscle Membrane Potential and a Ouabain-Like Humoral Factor in One-Kidney, One-Clip Hypertension in Rats

D. Harder, H. Bryant, M. Pamnani, 1982 .

3 – Membrane Electrical Activation of Arterial Smooth Muscle

D. Harder, 1982 .

Sympathetic supraspinal control of venous membrane potential in spontaneous hypertension in vivo.

D. Harder, S. Contney, J. Mccubbin, 1982, The American journal of physiology.

Electrical and Mechanical Responses to Endothelin in Small Arteries of the Dog Kidney

D. Harder, J. Lombard, K. Kauser, 1994 .

Enhanced Vascular Tone in the Renal Vasculature of Spontaneously Hypertensive Rats

R. Roman, D. Harder, D. Gebremedhin, 1990, Hypertension.

Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog.

D. Harder, P. Dernbach, A. Waters, 1987, The Journal of clinical investigation.

Possible Cellular MechanismforCerebral Vasospasm after Experimental Subarachnoid HemorrhageintheDog

D. Harder, 1987 .

Ca-induced Ca release: lessons regarding cell models.

D. Harder, 2004, American journal of physiology. Heart and circulatory physiology.

20-Hydroxyeicosatetraenoic Acid-induced Vasoconstriction and Inhibition of Potassium Current in Cerebral Vascular Smooth Muscle Is Dependent on Activation of Protein Kinase C*

D. Harder, A. Lange, D. Gebremedhin, 1997, The Journal of Biological Chemistry.

Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats.

R. Roman, D. Harder, D. Gebremedhin, 1993, Journal of vascular research.

Differential Effects of Adenosine and Nitroglycerin on the Action Potentials of Large and Small Coronary Arteries

R. Berne, D. Harder, N. Sperelakis, 1979, Circulation research.

Influence of Physical and Environmental Factors on Ion Channels in Arterial Muscle

R. Roman, D. Harder, D. Gebremedhin, 1993 .

Pressure-dependent contraction of rat juxtamedullary afferent arterioles.

R. Roman, D. Harder, C. Sánchez-Ferrer, 1989, Circulation research.

A method for the isolation of cells from arteries of various sizes

D. Harder, J. Madden, M. Subramanian, 1991 .

Cgmp-Dependent Calcium Desensitization Contributes to Vasodilator Response to Nitric Oxide in Rat Middle Cerebral Arteries

R. Roman, Chengwen Sun, D. Harder, 2000 .

Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation.

J. Falck, R. Roman, D. Harder, 1999, The American journal of physiology.

Cytochrome P-450 ω-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation.

J. Falck, R. Roman, D. Harder, 1999, American journal of physiology. Heart and circulatory physiology.

Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs.

E. Jacobs, R. Roman, D. Harder, 1998, American journal of respiratory cell and molecular biology.

Interaction of Mechanisms Involving Epoxyeicosatrienoic Acids, Adenosine Receptors, and Metabotropic Glutamate Receptors in Neurovascular Coupling in Rat Whisker Barrel Cortex

R. Koehler, J. Falck, D. Harder, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Regulation of the cerebral circulation by cytochrome P450 epoxygenase activity

R. Koehler, R. Traystman, J. Carhuapoma, 2002 .

Altered membrane properties of cerebral vascular smooth muscle following subarachnoid hemorrhage: an electrophysiological study. I. Changes in resting membrane potential (Em) and effect on the electrogenic pump potential contribution to Em.

D. Harder, A. Waters, 1985, Stroke.

Electrical activation of arterial muscle.

D. Harder, A. Waters, 1984, International review of cytology.

In vivo membrane potentials of smooth muscle cells in the caudal artery of the rat.

D. Harder, H. Bryant, M. Pamnani, 1985, The American journal of physiology.

Electrical stimulation of the endothelial surface of pressurized cat middle cerebral artery results in TTX-sensitive vasoconstriction.

D. Harder, J. Madden, 1987, Circulation research.

Leukotriene B4 ω-side chain hydroxylation by CYP4F5 and CYP4F6

R. Roman, D. Harder, K. Maier, 2003 .

Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries.

J. Falck, R. Roman, D. Harder, 1998, The American journal of physiology.

Membrane Electrical Mechanism of Basilar Artery Constriction and Pial Artery Dilation by Norepinephrine

P. Abel, D. Harder, K. Hermsmeyer, 1981, Circulation research.

Comparison of electrical properties of middle cerebral and mesenteric artery in cat.

D. Harder, 1980, The American journal of physiology.

Response of Large and Small Coronary Arteries to Adenosine, Nitroglycerin, Cardiac Glycosides, and Calcium Antagonists

R. Berne, D. Harder, N. Sperelakis, 1980 .

A cellular mechanism for myogenic regulation of cat cerebral arteries

D. Harder, 2006, Annals of Biomedical Engineering.

Membrane potential measurements during rat liver regeneration

D. Harder, R. Wondergem, 1980, Journal of cellular physiology.

Sodium‐Potassium Pump Activity in Reduced Renal‐Mass Hypertension

D. Harder, J. Buggy, H. Bryant, 1983, Hypertension.

Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6.

R. Roman, D. Harder, K. Maier, 2003, Archives of biochemistry and biophysics.

The Role of Astrocytes in Tumor Growth and Progression

D. Harder, R. Ramchandran, Emily I Gronseth, 2018 .

Electromechanical coupling in feline basilar artery in response to serotonin.

D. Harder, A. Waters, 1983, European Journal of Pharmacology.

Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors.

P. Pratt, W. Campbell, D. Harder, 1996, Circulation research.

Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.

D. Harder, J. Bylund, Chenyang Zhang, 2002, Biochemical and biophysical research communications.

Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries.

J. Falck, R. Roman, D. Harder, 2000, American journal of physiology. Heart and circulatory physiology.

Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.

A. Hudetz, A. Hudetz, R. Roman, 1999, Stroke.

Zinc-Finger Nuclease Knockout of Dual-Specificity Protein Phosphatase-5 Enhances the Myogenic Response and Autoregulation of Cerebral Blood Flow in FHH.1BN Rats

H. Jacob, R. Roman, D. Harder, 2014, PloS one.

Bepridil Blockade of Ca2+-Dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery

D. Harder, N. Sperelakis, 1981, Journal of cardiovascular pharmacology.

Identification of a putative microvascular oxygen sensor.

R. Roman, D. Harder, A. Lange, 1996, Circulation research.

Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats.

J. Falck, R. Roman, D. Harder, 2008, American journal of physiology. Heart and circulatory physiology.

Recommendations of the National Heart, Lung, and Blood Institute Working Group on Cerebrovascular Biology and Disease

J. Simard, M. Moskowitz, C. Iadecola, 2006, Stroke.

Antiangiogenic Effect of Inhibitors of Cytochrome P450 on Rats with Glioblastoma Multiforme

D. Harder, D. Gebremedhin, Danica Jakovčević, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Cytochrome P450 eicosanoids and cerebral vascular function

D. Harder, A. Simpkins, J. Imig, 2011, Expert Reviews in Molecular Medicine.

Effect of morphine on electrophysiological properties of circular and longitudinal muscles.

R. Gilbert, S. Sarna, D. Harder, 1987, The American journal of physiology.

Distribution of excitatory junction potential amplitude in cat cerebral arteries: Examination of its quantal nature and modulation by opiates

J. Kalbfleisch, D. Harder, J. Madden, 1987, Journal of cellular physiology.

Membrane electrical properties of vascular smooth muscle from the guinea pig superior mesenteric artery

D. Harder, N. Sperelakis, 1978, Pflügers Archiv.

Membrane activation of smooth muscle from rabbit basilar artery by dopamine

D. Harder, 1981, Pflügers Archiv.

Active vascular smooth muscle tone and venous membrane potentials during hemorrhage.

D. Harder, J. Lombard, W. Stekiel, 1980, The American journal of physiology.

Effect of methylprednisolone on small vein responses to hemorrhage and norepinephrine.

D. Harder, J. Lombard, W. Stekiel, 1982, European journal of pharmacology.

Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone.

R. Roman, W. Campbell, D. Harder, 1995, Journal of Vascular Research.

Cellular actions of halothane on cat cerebral arterial muscle.

J. Kampine, D. Harder, J. Madden, 1985, Stroke.

Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia.

R. Koehler, D. Harder, D. Gebremedhin, 2015, Journal of applied physiology.

Cerebral Capillary Endothelial Cell Mitogenesis and Morphogenesis Induced by Astrocytic Epoxyeicosatrienoic Acid

D. Harder, Chenyang Zhang, 2002, Stroke.

Norepinephrine effect on in situ venous membrane potential in spontaneously hypertensive rats.

D. Harder, S. Contney, W. Stekiel, 1981, The American journal of physiology.

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response.

D. Harder, B. Kalyanaraman, Simmy Thomas, 2007, Free radical biology & medicine.

A membrane electrical mechanism for hypoxic vasoconstriction of small pulmonary arteries from cat.

C. Dawson, D. Harder, J. Madden, 1985, Chest.

Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone.

W. Campbell, D. Harder, William B. Campbell, 1999, Circulation research.

Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion.

R. Koehler, R. Roman, D. Harder, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain

D. Harder, J. Narayanan, P. Sarkar, 2011, Neuroscience.

Antinociception Produced by 14,15-Epoxyeicosatrienoic Acid Is Mediated by the Activation of β-Endorphin and Met-Enkephalin in the Rat Ventrolateral Periaqueductal Gray

P. Pratt, J. Falck, D. Harder, 2008, Journal of Pharmacology and Experimental Therapeutics.

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors.

R. Koehler, R. Traystman, J. Carhuapoma, 2002, American journal of physiology. Heart and circulatory physiology.

Production of 20-HETE and its role in autoregulation of cerebral blood flow.

A. Hudetz, A. Hudetz, J. Falck, 2000, Circulation research.

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.

K. Chandy, Takashi Saito, H. Miura, 2008, The Journal of clinical investigation.

Integration of the Medical College of Wisconsin Physician Scientist Pathway and Summer Research Programs to Increase Medical Student Research Skills

D. Harder, D. Brousseau, 2013 .

Increased blood pressure in mice lacking cytochrome P450 2J5

K. Korach, D. Zeldin, J. F. Couse, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cytochrome P450 2C is an EDHF synthase in coronary arteries

R. Busse, M. Potente, B. Fisslthaler, 1999, Nature.

Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450.

J. Falck, R. Roman, J. Falck, 1993, Hypertension.

Role of a Changing Membrane Potential (Em) and Matching Blood Flow with Neuronal Activity

D. Harder, D. Gebremedhin, M. Terashvili, 2012 .

Cytochrome P450 2C9‐derived epoxyeicosatrienoic acids induce angiogenesis via cross‐talk with the epidermal growth factor receptor

R. Busse, B. Fisslthaler, I. Fleming, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Membrane mechanisms in arterial hypertension.

D. Harder, K. Hermsmeyer, 1983, Hypertension.

Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes.

J. Falck, D. Harder, M. Bienengraeber, 2014, American journal of physiology. Heart and circulatory physiology.

Altered splenic catecholamine concentrations during experimental allergic encephalomyelitis

D. Harder, D. Roerig, U. Wesselmann, 1987, Pharmacology Biochemistry and Behavior.

Reactive oxygen species cerebral autoregulation in health and disease.

P. Pratt, D. Harder, D. Gebremedhin, 2006, Pediatric clinics of North America.

Early effects of experimental diabetes on central catecholamine concentrations

D. Harder, D. Roerig, U. Wesselmann, 1988, Brain Research Bulletin.

Heterogeneity of membrane properties in vascular muscle cells from various vascular beds.

D. Harder, 1983, Federation proceedings.

Altered membrane electrical properties of smooth muscle cells from small cerebral arteries of hypertensive rats.

D. Harder, W. Halpern, L. Brann, 1983, Blood vessels.

Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells

D. Weihrauch, D. Harder, D. Gebremedhin, 2016, PloS one.

Role of the vascular endothelium in regulating the response of small arteries of the dog kidney to transmural pressure elevation and reduced PO2.

D. Harder, J. Lombard, H. Eskinder, 1990, Circulation research.

The effect of alkaline pH and transmural pressure on arterial constriction and membrane potential of hypertensive cerebral arteries

D. Harder, J. Lombard, J. Smeda, 1987, Pflügers Archiv.

Cellular mechanism of force development in cat middle cerebral artery by reducedPCO2

D. Harder, J. Madden, 1985, Pflügers Archiv.

Effect of H+ and elevated PCO2on membrane electrical properties of rat cerebral arteries

D. Harder, 1982, Pflügers Archiv.

Metabotropic Glutamate Receptor Activation Enhances the Activities of Two Types of Ca2+-Activated K+Channels in Rat Hippocampal Astrocytes

R. Koehler, D. Harder, D. Gebremedhin, 2003, The Journal of Neuroscience.

transfusion of cell-free polymeric hemoglobin response to decreased hematocrit after exchange Role of 20-HETE in the pial arteriolar constrictor

R. Koehler, S. Hwang, J. Falck, 2015 .

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes.

R. Roman, N. Alkayed, D. Harder, 1996, Stroke.

Increased sensitivity of cat cerebral arteries to serotonin upon elevation of transmural pressure

D. Harder, 1988, Pflügers Archiv.

Role of astrocytes in matching blood flow to neuronal activity.

D. Harder, Danica Jakovčević, David R Harder, 2007, Current topics in developmental biology.

Cellular mechanisms of opiate receptor stimulation in cat middle cerebral artery.

D. Harder, D R Harder, J. Madden, 1984, European journal of pharmacology.

Effects of 12-HETE on isolated dog renal arcuate arteries.

R. Roman, D. Harder, Y. H. Ma, 1991, The American journal of physiology.

Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats.

N. Alkayed, D. Harder, E. Birks, 1997, Stroke.

Dependency of Cortical Functional Hyperemia to Forepaw Stimulation on Epoxygenase and Nitric Oxide Synthase Activities in Rats

R. Koehler, N. Alkayed, D. Harder, 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

High glucose conditioned neonatal astrocytes results in impaired mitogenic activity in cerebral microvessel endothelial cells in co-culture

D. Harder, K. Rarick, Qiuli Liu, 2019, Heliyon.

Regulation of Cerebral Blood Flow: Response to Cytochrome P450 Lipid Metabolites.

D. Harder, D. Gebremedhin, K. Rarick, 2018, Comprehensive Physiology.

Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells.

D. Harder, D. Gebremedhin, K. Yamaura, 2008, American journal of physiology. Heart and circulatory physiology.

Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats.

D. Harder, A. Zou, N. Rusch, 1994, Hypertension.

Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+-activated K+ channel current in cultured rat hippocampal astrocytes

E. Jacobs, D. Harder, D. Gebremedhin, 2006, Neuroscience.

Reactive Oxygen Species Modulate Astrocyte and Capillary Endothelial Cell Functions in the Regulation of Cerebral Blood Flow

D. Harder, D. Gebremedhin, Nadi T. Wickramasekera, 2014 .

Mechanisms regulating cerebral blood flow as therapeutic targets.

P. Pratt, D. Harder, M. Medhora, 2004, Current opinion in investigational drugs.

Astrocytes function in matching blood flow to metabolic activity.

D. Harder, D. Gebremedhin, Chenyang Zhang, 2002, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate.

R. Koehler, R. Traystman, F. Northington, 2000, American journal of physiology. Heart and circulatory physiology.

Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20‐HETE which enhances L‐type Ca2+ current

D. Harder, A. Lange, D. Gebremedhin, 1998, The Journal of physiology.

Redox Signaling via Oxidative Inactivation of PTEN Modulates Pressure-Dependent Myogenic Tone in Rat Middle Cerebral Arteries

H. Miura, D. Harder, D. Gebremedhin, 2013, PloS one.

Regulation of the Cerebral Circulation Role of astrocytes in cerebrovascular regulation

R. Koehler, D. Harder, D. Gebremedhin, 2005 .

Modulation of vascular tone in renal microcirculation by erythrocytes: role of EDRF.

R. Roman, D. Harder, D. Gebremedhin, 1993, The American journal of physiology.

Hypoxia increases the activity of Ca2+-sensitive K+ channels in cat cerebral arterial muscle cell membranes

D. Harder, D. Gebremedhin, A. Greene, 1994, Pflügers Archiv.

Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids.

D. Harder, M. Medhora, J. Narayanan, 2001, Trends in cardiovascular medicine.

Distensibility of small arteries of the dog lung.

D A Rickaby, C A Dawson, J H Linehan, 1991, Journal of applied physiology.

Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes.

R. Roman, D. Harder, D. Gebremedhin, 2000, Acta physiologica Scandinavica.

Adenosine Can Mediate its Actions through Generation of Reactive Oxygen Species

D. Harder, D. Gebremedhin, D. Lourim, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Action potential generation in reaggregates of rat aortic smooth muscle cells in primary culture.

D. Harder, N. Sperelakis, 1979, Blood vessels.

Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes.

R. Roman, D. Harder, D. Gebremedhin, 2016, Prostaglandins & other lipid mediators.

Endogenous events modulating myogenic regulation of cerebrovascular function.

D. Harder, D. Gebremedhin, Sandeep Gopalakrishnan, 2014, Current vascular pharmacology.

Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries.

D. Harder, D. Gebremedhin, R. Ramchandran, 2013, Journal of applied physiology.

A common pathway for regulation of nutritive blood flow to the brain: arterial muscle membrane potential and cytochrome P450 metabolites.

R. Roman, D. Harder, A. Lange, 1998, Acta physiologica Scandinavica.

Characterization of an outward K+ current in freshly dispersed cerebral arterial muscle cells

D. Harder, N. Rusch, P. Bonnet, 1991, Pflügers Archiv.

Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes.

J. Falck, D. Harder, M. Bienengraeber, 2014, American journal of physiology. Heart and circulatory physiology.

Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.

R. Koehler, J. Falck, R. Roman, 2008, American journal of physiology. Heart and circulatory physiology.

Effect of high glucose condition on glucose metabolism in primary astrocytes

D. Harder, K. Rarick, Susan S. Cohen, 2020, Brain Research.

Membrane Electrical Effects of Histamine on Vascular Smooth Muscle of Canine Coronary Artery

D. Harder, 1980, Circulation research.