J. Kunisawa

Koji Kariya-city Aichi-pref. Tanaka, J. Kunisawa, T. Nakanishi, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Host- and Microbe-Dependent Dietary Lipid Metabolism in the Control of Allergy, Inflammation, and Immunity

T. Nagatake, A. Saika, J. Kunisawa, 2019, Front. Nutr..

Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL‐expressing plasmacytoid dendritic cells in mice

H. Kiyono, T. Tomonaga, M. Arita, 2020, Allergy.

Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases

H. Kiyono, K. Hosomi, J. Kunisawa, 2019, Gut microbes.

ω3 fatty acid metabolite, 12‐hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α

T. Tomonaga, M. Arita, J. Adachi, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.

H. Kiyono, J. Kunisawa, 2005, Cellular and molecular life sciences : CMLS.

Intestinal epithelial barrier and mucosal immunity

H. Kiyono, J. Kunisawa, J. Kunisawa, 2005, Cellular and Molecular Life Sciences.

Enzymatically polymerised polyphenols prepared from various precursors potentiate antigen-specific immune responses in both mucosal and systemic compartments in mice.

H. Kiyono, J. Kunisawa, N. Ohno, 2021, PloS one.

Immunological Function of Sphingosine 1-Phosphate in the Intestine

H. Kiyono, J. Kunisawa, 2012, Nutrients.

Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis.

H. Kiyono, J. Kunisawa, 2011, Cell host & microbe.

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

H. Kiyono, K. Takeda, J. Kunisawa, 2012, The Journal of Immunology.

Regulatory T Cells in the Colon + Foxp3Dietary Folic Acid Promotes Survival of

H. Kiyono, K. Takeda, J. Kunisawa, 2022 .

Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium.

H. Kiyono, J. Kunisawa, T. Nochi, 2004, Clinical immunology.

Influence of Dietary Components and Commensal Bacteria on the Control of Mucosal Immunity

J. Kunisawa, Hidehiko Suzuki, 2020 .

The Specific Roles of Vitamins in the Regulation of Immunosurveillance and Maintenance of Immunologic Homeostasis in the Gut

K. Hosomi, J. Kunisawa, Koji Hosomi, 2017, Immune network.

Vitamin B9 and ATP in the control and development of intestinal inflammation

J. Kunisawa, 2015 .

Sphingosine 1-Phosphate-Mediated Trafficking of Pathogenic Th2 and Mast Cells for the Control of Food Allergy

H. Kiyono, J. Kunisawa, Gohda, 2007 .

Sphingosine 1-Phosphate-Mediated Trafficking of Pathogenic Th2 and Mast Cells for the Control of Food Allergy1

H. Kiyono, J. Kunisawa, Y. Kurashima, 2007, The Journal of Immunology.

for the Control of Food Allergy Cells Trafficking of Pathogenic Th2 and Mast Sphingosine 1-Phosphate-Mediated

H. Kiyono, J. Kunisawa, Gohda, 2007 .

Mucosal SIgA Enhancement: Development of Safe and Effective Mucosal Adjuvants and Mucosal Antigen Delivery Vehicles

J. Mcghee, H. Kiyono, J. Kunisawa, 2007 .

The Gut Microbiome as a Promising Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma

K. Mizuguchi, Y. Maniwa, T. Itoh, 2020 .

Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition

H. Kiyono, K. Ueda, M. Arita, 2013, Proceedings of the National Academy of Sciences.

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

K. Mizuguchi, Yi-an Chen, Y. Yonejima, 2022, Nature Communications.

The Airway Antigen Sampling System: Respiratory M Cells as an Alternative Gateway for Inhaled Antigens

S. Fukuyama, H. Kiyono, Shintaro Sato, 2011, The Journal of Immunology.

Colonization by Streptococcus pneumoniae Prevents Invasive Disease and Nasal Nanogel-Based PspA Intranasal Vaccine

H. Kiyono, Shintaro Sato, Masafumi Yamamoto, 2013 .

Sphingosine 1-Phosphate Regulates the Egress of IgA Plasmablasts from Peyer’s Patches for Intestinal IgA Responses1

H. Kiyono, J. Kunisawa, Y. Kurashima, 2008, The Journal of Immunology.

Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.

H. Kiyono, J. Kunisawa, Y. Kurashima, 2007, Blood.

Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium

H. Kiyono, J. Kunisawa, Y. Kurashima, 2007, The Journal of experimental medicine.

Sphingosine 1-phosphate dependence in the regulation of lymphocyte traffi cking to the gut epithelium

H. Kiyono, J. Kunisawa, Y. Kurashima, 2007 .

Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine

H. Kiyono, K. Fukase, T. Nagatake, 2021, Frontiers in Pharmacology.

Lymphoid Tissues Associated with Gastrointestinal (GI) Mucosa

H. Kiyono, T. Nagatake, J. Kunisawa, 2019, Lymph Node Metastasis in Gastrointestinal Cancer.

Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.

H. Kiyono, J. Kunisawa, Y. Kurashima, 2008, Blood.

Clostridium perfringens enterotoxin-based protein engineering for the vaccine design and delivery system.

K. Hosomi, J. Kunisawa, Huangwenxian Lan, 2019, Vaccine.

Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice

H. Kiyono, J. Kunisawa, Y. Aramaki, 2017, BMC Research Notes.

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

C. Coban, K. Ishii, S. Ziegler, 2016, Immunity.

Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses

H. Kiyono, J. Kunisawa, 2012, Front. Immun..

Regulation of Intestinal IgA Responses by Dietary Palmitic Acid and Its Metabolism

H. Kiyono, M. Arita, J. Aoki, 2014, The Journal of Immunology.

Dietary Palmitic Acid and Its Metabolism Regulation of Intestinal IgA Responses by

H. Kiyono, M. Arita, J. Aoki, 2014 .

Stool pattern is associated with prevalence of tumorigenic bacteria of the microbiota and plasma and fecal fatty acids in healthy Japanese adults

K. Wakabayashi, N. Kubota, T. Kubota, 2020 .

Gut Bacteria

Y. Benno, T. Hennet, H. Kiyono, 2009, Mucosal Immunology.

Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts

K. Mizuguchi, Yi-an Chen, T. Nakagata, 2020, BMC microbiology.

Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

S. Akira, C. Sasakawa, S. Fukuyama, 2009, The Journal of experimental medicine.

Metabolic changes during B cell differentiation for the production of intestinal IgA antibody

J. Kunisawa, 2016, Cellular and Molecular Life Sciences.

Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity

K. Ishii, H. Kiyono, Shintaro Sato, 2018, Mucosal Immunology.

Gateway for Inhaled Antigens Respiratory M Cells as an Alternative The Airway Antigen Sampling System:

S. Fukuyama, H. Kiyono, Shintaro Sato, 2011 .

Negative regulation of DSS-induced experimental colitis by PILRα.

H. Kiyono, J. Kunisawa, T. Suenaga, 2015, International immunology.

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.

C. Ziegler, Nitin Kumar, H. Kiyono, 2016, Immunity.

A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo

H. Kiyono, J. Kunisawa, I. Ishikawa, 2012, PloS one.

Development of Adjuvant-Free Bivalent Food Poisoning Vaccine by Augmenting the Antigenicity of Clostridium perfringens Enterotoxin

K. Hosomi, J. Kunisawa, M. Kondoh, 2018, Front. Immunol..

Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus

H. Kiyono, Y. Yoshioka, Y. Tsutsumi, 2010, Journal of Virology.

Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Inﬂuenza Virus (cid:1)

H. Kiyono, Y. Yoshioka, Y. Tsutsumi, 2010 .

Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy

H. Kiyono, J. Kunisawa, 2016, Front. Nutr..

Diversity of energy metabolism in immune responses regulated by micro-organisms and dietary nutrition

K. Hosomi, J. Kunisawa, Koji Hosomi, 2020, International immunology.

A novel vaccine delivery system using immunopotentiating fusogenic liposomes.

Koji Kariya-city Aichi-pref. Tanaka, Y. Tsutsumi, T. Mayumi, 1999, Biochemical and biophysical research communications.

Title Central Role of Core Binding Factor β 2 in Mucosa-Associated LymphoidTissue Organogenesis in Mouse

S. Fukuyama, H. Kiyono, Shintaro Sato, 2018 .

Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse

S. Fukuyama, H. Kiyono, Shintaro Sato, 2015, PloS one.

Polymeric Caffeic Acid Acts as a Nasal Vaccine Formulation against Streptococcus pneumoniae Infections in Mice

J. Kunisawa, Y. Adachi, Y. Negishi, 2021, Pharmaceutics.

Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids

K. Mizuguchi, Yi-an Chen, T. Kubota, 2022, Nutrients.

Polymeric Caffeic Acid Is a Safer Mucosal Adjuvant That Augments Antigen-Specific Mucosal and Systemic Immune Responses in Mice.

H. Kiyono, J. Kunisawa, N. Ohno, 2018, Molecular pharmaceutics.

Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan

H. Ikematsu, K. Hotta, T. Matsuda, 2021, Cancer science.

[Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine].

H. Kiyono, J. Kunisawa, M. Gohda, 2007, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Mechanisms underlying enhanced IgA production in Peyer's patch cells by membrane vesicles derived from Lactobacillus sakei.

T. Nagatake, A. Saika, Ayu Matsunaga, 2021, Bioscience, biotechnology, and biochemistry.

Sendai Virus Fusion Protein-Mediates Simultaneous Induction of MHC Class I/II-Dependent Mucosal and Systemic Immune Responses Via the Nasopharyngeal-Associated Lymphoreticular Tissue Immune System1

H. Kiyono, S. Nakagawa, T. Mayumi, 2001, The Journal of Immunology.

Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants.

K. Hosomi, J. Kunisawa, Zilai Liu, 2022, Vaccine.

Salt‐inducible kinase 3 deficiency exacerbates lipopolysaccharide‐induced endotoxin shock accompanied by increased levels of pro‐inflammatory molecules in mice

T. Ohkawara, T. Nagatake, J. Kunisawa, 2015, Immunology.

Oriental Medicine-Initiated Examination of Mucosal Immune System for the Development of Mucosal Immunotherapy

J. Kunisawa, 2013 .

Herbal medicine-initiated approaches for the elucidation of immunological network in the intestine (Symposium in the 29th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)

H. Kiyono, J. Kunisawa, M. Kamioka, 2013 .

Lack of antigen‐specific immune responses in anti‐IL‐7 receptor α chain antibody‐treated Peyer's patch‐null mice following intestinal immunization with microencapsulated antigen

H. Kiyono, Y. Tsutsumi, S. Nakagawa, 2002, European journal of immunology.

BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses

K. Ishii, Tomoaki Koga, T. Nagatake, 2019, Mucosal Immunology.

Critical Role of Dendritic Cells in T Cell Retention in the Interfollicular Region of Peyer’s Patches

H. Kiyono, Shintaro Sato, J. Kunisawa, 2013, The Journal of Immunology.

Gut-associated lymphoid tissues for the development of oral vaccines.

H. Kiyono, J. Kunisawa, Y. Kurashima, 2012, Advanced drug delivery reviews.

IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893

J. Kunisawa, Y. Katakura, Shino Yamasaki-Yashiki, 2018, Bioscience of microbiota, food and health.

Complexation hydrogels as potential carriers in oral vaccine delivery systems

N. Peppas, N. Kamei, M. Takeda-Morishita, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Identification of Human Gut Microbiome Associated with Enterolignan Production

K. Mizuguchi, Yi-an Chen, T. Nakagata, 2022, Microorganisms.

Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048

J. Kunisawa, Kenji Yamamoto, Yasuki Higashimura, 2018, Bioscience, biotechnology, and biochemistry.

Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia.

H. Kiyono, A. Abe, Shintaro Sato, 2019, International immunology.

Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses.

H. Kiyono, T. Mayumi, J. Kunisawa, 2000, Vaccine.

A macromolecular delivery vehicle for protein-based vaccines: Acid-degradable protein-loaded microgels

Jean M. J. Fréchet, Jun Kunisawa, N. Shastri, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Vitamin-Mediated Regulation of Intestinal Immunity

H. Kiyono, J. Kunisawa, 2013, Front. Immunol..

Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults

T. Kubota, H. Murakami, Harumi Ohno, 2021, BMC Microbiology.

Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha

T. Nagatake, Prabha Tiwari, Eri Node, 2023, Frontiers in Molecular Biosciences.

Vaginal Memory T Cells Induced by Intranasal Vaccination Are Critical for Protective T Cell Recruitment and Prevention of Genital HSV-2 Disease

H. Kiyono, Shintaro Sato, Y. Kawaguchi, 2014, Journal of Virology.

Transcription factor Spi-B–dependent and –independent pathways for the development of Peyer’s patch M cells

H. Kiyono, Shintaro Sato, H. Okura, 2012, Mucosal Immunology.

Intestinal villous M cells: an antigen entry site in the mucosal epithelium.

C. Sasakawa, H. Kiyono, Masafumi Yamamoto, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense

J. Renauld, H. Kiyono, Shintaro Sato, 2022, Proceedings of the National Academy of Sciences.

Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

T. Kaisho, H. Kiyono, J. Kunisawa, 2020, Mucosal Immunology.

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

B. Becher, M. Sakamoto, Y. Benno, 2014, Science.

IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake

H. Kiyono, Toshiro Sato, N. Tachibana, 2017, The Journal of experimental medicine.

All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen‐processing pathway

N. Shastri, T. Serwold, J. Kunisawa, 2005, Immunological reviews.

Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota

K. Mizuguchi, Y. Miki, Kei Yamamoto, 2022, JCI insight.

Impact of the intestinal environment on the immune responses to vaccination.

J. Kunisawa, Koji Hosomi, 2020, Vaccine.

Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine

H. Kiyono, K. Fukase, T. Nagatake, 2020, Vaccines.

Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

T. Kaisho, H. Kiyono, J. Kunisawa, 2020, Mucosal Immunology.

Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine

K. Honda, H. Kiyono, K. Takeda, 2013, The Journal of Immunology.

ATP in the Small Intestine Responses through Regulation of Luminal Diphosphohydrolase 7 Controls Th 17 Cell Ecto-Nucleoside Triphosphate

K. Honda, H. Kiyono, K. Takeda, 2012 .

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

H. Kiyono, M. Setou, K. Yagi, 2018, Scientific Reports.

Potential Roles of CCR5+ CCR6+ Dendritic Cells Induced by Nasal Ovalbumin plus Flt3 Ligand Expressing Adenovirus for Mucosal IgA Responses

J. Mcghee, H. Kiyono, Masato Yamamoto, 2013, PloS one.

Immunological commonalities and distinctions between airway and digestive immunity.

H. Kiyono, J. Kunisawa, T. Nochi, 2008, Trends in immunology.

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

M. Hattori, J. Kunisawa, K. Hase, 2019, bioRxiv.

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.

O. Ohara, H. Kiyono, Satoshi Tanaka, 2012, Blood.

Lipopolysaccharide Derived From the Lymphoid-Resident Commensal Bacteria Alcaligenes faecalis Functions as an Effective Nasal Adjuvant to Augment IgA Antibody and Th17 Cell Responses

H. Kiyono, K. Fukase, T. Nagatake, 2021, Frontiers in Immunology.

Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice

S. Akira, H. Kiyono, K. Takeda, 2013, Nature Communications.

Immune regulation and monitoring at the epithelial surface of the intestine.

H. Kiyono, J. Kunisawa, 2013, Drug discovery today.

Aberrant Interaction of the Gut Immune System with Environmental Factors in the Development of Food Allergies

H. Kiyono, J. Kunisawa, 2010, Current allergy and asthma reports.

Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches

T. Honda, K. Kabashima, J. Kunisawa, 2023, Immunological reviews.

Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

M. Sakamoto, Y. Benno, C. Sasakawa, 2010, Proceedings of the National Academy of Sciences.

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

F. Bushman, D. Weiner, H. Kiyono, 2012, Science.

Role of Lactobacillus pentosus Strain b240 and the Toll-Like Receptor 2 Axis in Peyer's Patch Dendritic Cell-Mediated Immunoglobulin A Enhancement

H. Kiyono, Yuji Suzuki, J. Kunisawa, 2014, PloS one.

HIV Mucosal Vaccine: Nasal Immunization with gp160-Encapsulated Hemagglutinating Virus of Japan-Liposome Induces Antigen-Specific CTLs and Neutralizing Antibody Responses1

H. Kiyono, Y. Sawa, J. Kunisawa, 2003, The Journal of Immunology.

Peyer’s Patches and Mesenteric Lymph Nodes Cooperatively Promote Enteropathy in a Mouse Model of Food Allergy

H. Kiyono, Masafumi Yamamoto, O. Igarashi, 2014, PloS one.

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

T. Iwanaga, O. Ohara, M. Kubo, 2019, Scientific Reports.

Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine

Hiroshi Kiyono, Jun Kunisawa, H. Kiyono, 2007, Immunological reviews.

TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells.

K. Ishii, H. Kiyono, K. Fukase, 2023, International immunopharmacology.

Role of interleukin-6 in antigen-specific mucosal immunoglobulin A induction by cationic liposomes

H. Kiyono, J. Kunisawa, Y. Negishi, 2021, International Immunopharmacology.

Intranasal administration of cationic liposomes enhanced granulocyte–macrophage colony-stimulating factor expression and this expression is dispensable for mucosal adjuvant activity

H. Kiyono, J. Kunisawa, Y. Aramaki, 2018, BMC Research Notes.

Acid-degradable particles for protein-based vaccines: enhanced survival rate for tumor-challenged mice using ovalbumin model.

Young Jik Kwon, Jun Kunisawa, Lana Lau, 2004, Bioconjugate chemistry.

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

K. Mizuguchi, K. Ishii, S. Akira, 2014, Nature Communications.

Role of Interleukin-6 in the Antigen-Specific Mucosal Immunoglobulin A Responses Induced by CpG Oligodeoxynucleotide-Loaded Cationic Liposomes

H. Kiyono, J. Kunisawa, Y. Negishi, 2022, Membranes.

Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice

H. Kiyono, J. Kunisawa, Y. Aramaki, 2017, BMC Research Notes.

Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1.

H. Kiyono, M. Suematsu, M. Setou, 2015, Cell reports.

Biochemical detection system for intermediates of endogenous antigen and elucidation of the role of molecular chaperones.

J. Kunisawa, 2023, Cellular immunology.

Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway.

N. Shastri, J. Kunisawa, 2006, Immunity.

The group II chaperonin TRiC protects proteolytic intermediates from degradation in the MHC class I antigen processing pathway.

Jun Kunisawa, N. Shastri, J. Kunisawa, 2003, Molecular cell.

Classification of the Occurrence of Dyslipidemia Based on Gut Bacteria Related to Barley Intake

K. Mizuguchi, Z. Yamagata, H. Murakami, 2022, Frontiers in Nutrition.

Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements

Dieter M. Tourlousse, Ken Kasahara, J. Nakayama, 2022, Microbiology spectrum.

[The development of mucosal vaccine using bacterial function for targeting mucosal tissues].

H. Kiyono, K. Yagi, J. Kunisawa, 2014, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine

H. Kiyono, K. Yagi, J. Kunisawa, 2015, PloS one.

[The cutting edge of epithelium-targeted drug development].

J. Kunisawa, M. Kondoh, 2014, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system.

S. Fukuyama, H. Kiyono, J. Kunisawa, 2005, Current molecular medicine.

Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice

K. Ishii, M. Kawano, T. Nagatake, 2018, International immunology.

9 – Analysis of Intestinal T Cell Populations and Cytokine Productions

H. Kiyono, J. Kunisawa, 2010 .

Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation.

H. Kiyono, J. Kunisawa, M. Kweon, 2007, Clinical immunology.

Erratum to “Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4+ CD45RBhigh T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation” [Clin. Immunol. 123 (2007) 30–39]

H. Kiyono, J. Kunisawa, M. Kweon, 2007 .

Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

H. Kiyono, K. Fukase, T. Nagatake, 2020, Microorganisms.

High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells

F. Ginhoux, T. Nomura, T. Dainichi, 2017, Scientific Reports.

The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.

S. Akira, M. Kubo, H. Kiyono, 2014, Immunity.

Pharmacotherapy by intracellular delivery of drugs using fusogenic liposomes: application to vaccine development.

S. Nakagawa, T. Mayumi, J. Kunisawa, 2001, Advanced drug delivery reviews.

12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

T. Tomonaga, J. Adachi, T. Nagatake, 2021, Scientific Reports.

Future Prospects for Food Research in the Post-Microbiome Era.

J. Kunisawa, 2022, Journal of nutritional science and vitaminology.

17(S),18(R)‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression

T. Nagatake, S. Kishino, Prabha Tiwari, 2019, FASEB bioAdvances.

Emerging roles of metabolites of ω3 and ω6 essential fatty acids in the control of intestinal inflammation

T. Nagatake, J. Kunisawa, 2019, International immunology.

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues

Ichigaku Takigawa, T. Nagatake, J. Kunisawa, 2018, Cell reports.

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

Makoto Arita, Takahiro Hayasaka, Mitsutoshi Setou, 2015, Scientific Reports.

Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study

K. Mizuguchi, Z. Yamagata, H. Murakami, 2021, BMC Nutrition.

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

H. Kiyono, T. Tomonaga, J. Adachi, 2019, Allergy.

Relationship between Human Gut Microbiota and Nutrition Intake in Hypertensive Discordant Monozygotic Twins

K. Mizuguchi, J. Kunisawa, Jonguk Park, 2021 .

The mucosal immune system for secretory IgA responses and mucosal vaccine development

H. Kiyono, J. Kunisawa, T. Nochi, 2010 .

The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma

K. Mizuguchi, Y. Maniwa, T. Itoh, 2022, AntiCancer Research.

Effects of Malted Rice Amazake on Constipation Symptoms and Gut Microbiota in Children and Adults with Severe Motor and Intellectual Disabilities: A Pilot Study

K. Mizuguchi, J. Kunisawa, Jonguk Park, 2021, Nutrients.

Categorization of the Ocular Microbiome in Japanese Stevens–Johnson Syndrome Patients With Severe Ocular Complications

K. Mizuguchi, C. Sotozono, J. Kunisawa, 2021, Frontiers in Cellular and Infection Microbiology.

Relationship between Nutrient Intake and Human Gut Microbiota in Monozygotic Twins

K. Mizuguchi, J. Kunisawa, Y. Iwatani, 2021, Medicina.

MANTA, an integrative database and analysis platform that relates microbiome and phenotypic data

Kenji Mizuguchi, Yi-An Chen, Attayeb Mohsen, 2020, PloS one.

Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing.

K. Mizuguchi, J. Kunisawa, Jonguk Park, 2019, Journal of oral biosciences.

Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to a cholera toxin-based nasal vaccine

M. Setou, T. Nagatake, J. Kunisawa, 2020, International immunology.

Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV.

H. Kiyono, J. Kunisawa, T. Miura, 2002, Virology.

Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4

T. Nagatake, Eri Node, A. Saika, 2023, Frontiers in Immunology.

Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy

S. Akira, M. Kubo, H. Kiyono, 2020, Mucosal Immunology.

Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A

H. Kiyono, K. Kabayama, K. Fukase, 2021, Angewandte Chemie.

Development of mucosal vaccine based on DDS

J. Kunisawa, Koji Hosomi, 2022, Drug Delivery System.

Enzymatically synthesized exopolysaccharide of a probiotic strain Leuconostoc mesenteroides NTM048 shows adjuvant activity to promote IgA antibody responses

J. Kunisawa, Kenji Yamamoto, Yusuke Tomabechi, 2021, Gut microbes.

Altered gut microbiota and its association with inflammation in patients with chronic thromboembolic pulmonary hypertension: a single-center observational study in Japan

K. Mizuguchi, H. Nanri, J. Kunisawa, 2022, BMC Pulmonary Medicine.

Characteristic Gut Bacteria in High Barley Consuming Japanese Individuals without Hypertension

K. Mizuguchi, Z. Yamagata, H. Murakami, 2023, Microorganisms.

Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity

K. Mizuguchi, T. Nagatake, H. Murakami, 2017, Scientific Reports.

Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults

N. Kubota, T. Kubota, H. Murakami, 2021, BMC microbiology.

[Applicable strategies for the mucosal immune system in the regulation of allergic diseases].

H. Kiyono, J. Kunisawa, Y. Kurashima, 2008, Arerugi = [Allergy].

Intranasal administration of sodium nitroprusside augments antigen-specific mucosal and systemic antibody production in mice

J. Kunisawa, Y. Negishi, H. Yamazaki, 2023, International immunopharmacology.

Antigen-Specific CTLs and Neutralizing Virus of Japan-Liposome Induces with gp 160-Encapsulated Hemagglutinating HIV Mucosal Vaccine : Nasal Immunization

H. Kiyono, Y. Sawa, J. Kunisawa, 2002 .

Anti-allergic property of dietary phytoestrogen secoisolariciresinol diglucoside through microbial and β-glucuronidase-mediated metabolism.

T. Nagatake, Kento Sawane, J. Kunisawa, 2022, The Journal of nutritional biochemistry.

Nutritional components regulate the gut immune system and its association with intestinal immune disease development

H. Kiyono, J. Kunisawa, Aayam Lamichhane, 2013, Journal of gastroenterology and hepatology.

Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells

Y. Fuse, T. Nagatake, J. Kunisawa, 2023, Scientific Reports.

Vitamin-mediated immune regulation in the development of inflammatory diseases.

J. Kunisawa, Hidehiko Suzuki, 2015, Endocrine, metabolic & immune disorders drug targets.

The Anti-obesity and Anti-inflammatory Effects of “LICONINE ™ ”, an Extract of Glycyrrhiza Uralensis, on Diet-induced Obese Mice and 3T3-L1 Mouse Adipocytes

J. Kunisawa, L. Juneja, Michiyo Abe, 2017 .

Role of salivary microbiome in IL‐10 production and efficacy of sublingual immunotherapy

S. Fujieda, J. Kunisawa, E. Noguchi, 2021, Allergy.

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

H. Kiyono, M. Setou, K. Yagi, 2018, Scientific Reports.

Gut microbiome, metabolome, and allergic diseases.

So‐ichiro Hirata, J. Kunisawa, 2017, Allergology international : official journal of the Japanese Society of Allergology.

BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses

K. Ishii, Tomoaki Koga, T. Nagatake, 2019, Mucosal Immunology.

Negative regulation of DSS-induced experimental colitis by PILRα.

H. Kiyono, J. Kunisawa, T. Suenaga, 2015, International immunology.

Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.

H. Kiyono, J. Kunisawa, Y. Kurashima, 2008, Blood.

Lentinula Edodes Mycelia extract regulates the function of antigen-presenting cells to activate immune cells and prevent tumor-induced deterioration of immune function

T. Nagatake, J. Kunisawa, Y. Matsui, 2023, BMC Complementary Medicine and Therapies.

“LICONINE®”, an Extract of Glycyrrhiza Uralensis, Normalizes the Fecal Microbiota Disturbance in Diet-induced Obese Mice

J. Kunisawa, L. Juneja, Michiyo Abe, 2018, Journal of Food and Nutrition Research.

Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium

H. Kiyono, J. Kunisawa, Y. Kurashima, 2007, The Journal of experimental medicine.