A. Hessell

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Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane

Jamie K. Scott, Jason E. Donald, D. Burton, 2012, Journal of Virology.

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

D. Burton, E. Saphire, M. Fusco, 2008, Nature.

Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

N. Haigwood, O. Schwartz, A. Hessell, 2022, Nature Communications.

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2007, Nature.

Animal models in HIV-1 protection and therapy

N. Haigwood, A. Hessell, 2015, Current opinion in HIV and AIDS.

Chapter 8 – FcγRs Across Species

A. Hessell, B. Moldt, 2013 .

Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

O. Schwartz, A. Hessell, M. Ackerman, 2021, mBio.

Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques

N. Haigwood, A. Hessell, Tong-Tong Wu, 2017, PloS one.

Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIVSF162P3-Infected Infant Rhesus Macaques

N. Haigwood, D. Burton, A. Legasse, 2013, Journal of Virology.

Title Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIV SF 162 P 3-Infected Infant Rhesus Macaques Permalink

D. Burton, A. Legasse, M. Axthelm, 2013 .

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

N. Haigwood, J. Mascola, M. Axthelm, 2020, Nature Communications.

Antibodies Tip the Balance Towards an HIV Cure.

N. Haigwood, A. Hessell, 2019, Trends in immunology.

Simplifying the synthesis of SIgA: combination of dIgA and rhSC using affinity chromatography.

D. Burton, A. Hessell, Karen Saye-Francisco, 2014, Methods.

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

John P. Moore, D. Burton, B. Keele, 2011, Proceedings of the National Academy of Sciences.

Potent Inhibition of HIV‐1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis

C. Barbas, D. Burton, A. Hessell, 2010, Chembiochem : a European journal of chemical biology.

Inhibition of HIV-1 Infectivity and Epithelial Cell Transfer by Human Monoclonal IgG and IgA Antibodies Carrying the b12 V Region1

D. Burton, A. Hessell, N. Mantis, 2007, The Journal of Immunology.

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge.

Lindsay N. Carpp, N. Haigwood, J. Mascola, 2019, Cell host & microbe.

Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay.

D. Burton, P. Parren, P. Jahrling, 2002, Virology.

Virus Control in Vaccinated Rhesus Macaques Is Associated with Neutralizing and Capturing Antibodies against the SHIV Challenge Virus but Not with V1V2 Vaccine–Induced Anti-V2 Antibodies Alone

N. Haigwood, M. Gorny, D. Montefiori, 2021, The Journal of Immunology.

Induction of neutralizing antibodies in rhesus macaques using V3 mimotope peptides.

N. Haigwood, S. Zolla-Pazner, M. Gorny, 2016, Vaccine.

Differential induction of anti-V3 crown antibodies with cradle- and ladle-binding modes in response to HIV-1 envelope vaccination.

N. Haigwood, S. Zolla-Pazner, M. Gorny, 2017, Vaccine.

Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Speciﬁc Human Monoclonal Antibodies

N. Haigwood, M. Piepenbrink, A. Hessell, 2015 .

Neutralizing Antibodies and Control of HIV: Moves and Countermoves

N. Haigwood, A. Hessell, 2012, Current HIV/AIDS Reports.

IL-33 enhances the kinetics and quality of the antibody response to a DNA and protein-based HIV-1 Env vaccine.

N. Haigwood, J. Thakar, M. Piepenbrink, 2019, Vaccine.

CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques

N. Haigwood, A. Hessell, J. Rangel-Moreno, 2021, Frontiers in Immunology.

Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses.

N. Haigwood, S. Zolla-Pazner, M. Totrov, 2019, Cell reports.

Efficacy of silk fibroin biomaterial vehicle for in vivo mucosal delivery of Griffithsin and protection against HIV and SHIV infection ex vivo

P. Ziprin, C. Herrera, A. Hessell, 2020, Journal of the International AIDS Society.

Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.

D. Burton, K. Nicolaou, A. Hessell, 2011, Bioorganic & medicinal chemistry.

IgA Antibodies Carrying the b12 V Regionand Cell Transfer by Human Monoclonal IgG Inhibition of HIV-1 Infectivity and Epithelial

D. Burton, A. Hessell, N. Mantis, 2007 .

Cloning and functional testing of rhesus macaque (Macaca mulatta) IL‐9 and IL‐33

N. Haigwood, A. Hessell, J. Kobie, 2020, Journal of medical primatology.

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in newborn macaques

N. Haigwood, J. Mascola, B. Graham, 2016, Nature Medicine.

Envelope Variants Circulating as Initial Neutralization Breadth Developed in Two HIV-Infected Subjects Stimulate Multiclade Neutralizing Antibodies in Rabbits

N. Haigwood, S. Kalams, H. Robins, 2014, Journal of Virology.

Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic

N. Haigwood, A. Hessell, David A. Spencer, 2021, Frontiers in Public Health.

Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.

Dafna M. Abelson, D. Burton, E. Saphire, 2009, Acta crystallographica. Section D, Biological crystallography.

Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia

D. Burton, P. Parren, H. Whittle, 2000, AIDS.

Use of broadly neutralizing antibodies for HIV‐1 prevention

N. Haigwood, J. Mascola, A. Pegu, 2017, Immunological reviews.

Macaque Long-Term Nonprogressors Resist Superinfection with Multiple CD8+ T Cell Escape Variants of Simian Immunodeficiency Virus

D. Burton, T. Friedrich, E. Rakasz, 2010, Journal of Virology.

Passive and active antibody studies in primates to inform HIV vaccines

N. Haigwood, A. Hessell, Delphine C. Malherbe, 2018, Expert review of vaccines.

Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens

N. Haigwood, L. Stamatatos, D. Montefiori, 2016, The Journal of Immunology.

Emergence of Broadly Neutralizing Antibodies and Viral Coevolution in Two Subjects during the Early Stages of Infection with Human Immunodeficiency Virus Type 1

N. Haigwood, L. Stamatatos, S. Kalams, 2014, Journal of Virology.

Neutralizing Antibodies in Rabbits HIV-Infected Subjects Stimulate Multiclade Neutralization Breadth Developed in Two Envelope Variants Circulating as Initial

N. Haigwood, S. Kalams, H. Robins, 2014 .

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2009, Science.

Polyfunctional Tier 2–Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor

N. Haigwood, D. Sather, A. Hessell, 2021, The Journal of Immunology.

Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Specific Human Monoclonal Antibodies.

N. Haigwood, M. Piepenbrink, A. Hessell, 2015, Monoclonal antibodies in immunodiagnosis and immunotherapy.

Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L

D. Burton, D. Watkins, W. Koff, 2009, Journal of Virology.

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

Pascal Poignard, Dennis R Burton, D. Burton, 2009, Nature Medicine.

Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers

D. Burton, D. Watkins, W. Koff, 2009, PLoS pathogens.

Fc receptor but not complement binding is important in antibody protection against HIV

D. Burton, P. Parren, P. Marx, 2007, Nature.

An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10

J. Binley, D. Burton, I. Wilson, 2007, Journal of Virology.

Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In Vitro

C. Cheng‐Mayer, John P. Moore, D. Burton, 2001, Journal of Virology.

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

S. Zolla-Pazner, Daniel W. Heindel, J. Prévost, 2021, bioRxiv.

Reduced Cell-Associated DNA and Improved Viral Control in Macaques following Passive Transfer of a Single Anti-V2 Monoclonal Antibody and Repeated Simian/Human Immunodeficiency Virus Challenges

N. Haigwood, S. Zolla-Pazner, A. Hessell, 2018, Journal of Virology.

Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development

N. Haigwood, H. Robins, D. Sather, 2020, Frontiers in Immunology.

A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced FcγRIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques

S. Iida, D. Burton, P. Parren, 2012, Journal of Virology.

1 Monoclonal Antibody b 12 Has Enhanced Fc ? RIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques Permalink

P. Parren, D. Watkins, J. Schmitz, 2012 .

Macaques Vaccinated with Simian Immunodeficiency Virus SIVmac239Δnef Delay Acquisition and Control Replication after Repeated Low-Dose Heterologous SIV Challenge

D. Burton, D. Watkins, W. Koff, 2010, Journal of Virology.

Effector Function Activities of a Panel of Mutants of a Broadly Neutralizing Antibody against Human Immunodeficiency Virus Type 1

P. Parren, A. Hessell, J. V. D. van de Winkel, 2001, Journal of Virology.

Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques

N. Haigwood, A. Hessell, S. Dorta-Estremera, 2019, Journal of Virology.

The MHC Class II Cofactor HLA-DM Interacts with Ig in B Cells

Wei Jiang, A. Hessell, A. Madec, 2014, The Journal of Immunology.

A Panel of IgG1 b12 Variants with Selectively Diminished or Enhanced Affinity for Fcγ Receptors To Define the Role of Effector Functions in Protection against HIV

D. Burton, J. Harvey, D. Dunlop, 2011, Journal of Virology.

Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge

N. Haigwood, H. Robins, M. Axthelm, 2021, Frontiers in Immunology.

Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates

N. Haigwood, A. Hessell, A. Crowley, 2023, mBio.

An HIV Vaccine Targeting the V2 Region of the HIV Envelope Induces a Highly Durable Polyfunctional Fc-Mediated Antibody Response in Rhesus Macaques

N. Haigwood, S. Zolla-Pazner, M. Totrov, 2020, Journal of Virology.

Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans

M. Piepenbrink, J. Liesveld, A. Hessell, 2020, Cell reports medicine.

A Recombinant Human Monoclonal Antibody to Human Metapneumovirus Fusion Protein That Neutralizes Virus In Vitro and Is Effective Therapeutically In Vivo

D. Burton, J. Crowe, D. Wright, 2007, Journal of Virology.

Design, synthesis, and biological evaluation of a biyouyanagin compound library

D. Burton, K. Nicolaou, D. Nomura, 2011, Proceedings of the National Academy of Sciences.

Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines

N. Haigwood, S. Zolla-Pazner, L. Morris, 2021, Nature communications.

Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines

N. Haigwood, S. Zolla-Pazner, L. Morris, 2022, Nature Communications.

Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir

D. Matthies, Rick Huang, M. Pazgier, 2023, bioRxiv.

A large repertoire of B cell lineages targeting one cluster of epitopes in a vaccinated rhesus macaque.

N. Haigwood, M. Gorny, X. Kong, 2021, Vaccine.

Emergence of monoclonal antibody b12-resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure.

E. Bunnik, H. Schuitemaker, N. Nanlohy, 2010, The Journal of general virology.

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

N. Haigwood, J. Mascola, M. Axthelm, 2020, Nature Communications.

Symbiotic Nitrogen Fixation in the Fungus Gardens of Leaf-Cutter Ants

David M. Stevenson, Paul J. Weimer, Cameron R. Currie, 2009, Science.

Emergence of Broadly Neutralizing Antibodies and Viral Coevolution in Two Subjects during the Early Stages of Infection with Human Immunodeficiency Virus Type 1

N. Haigwood, L. Stamatatos, S. Kalams, 2014, Journal of Virology.

Animal models in HIV-1 protection and therapy

N. Haigwood, A. Hessell, 2015, Current opinion in HIV and AIDS.

Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir

D. Matthies, M. Pazgier, W. Tolbert, 2023, Nature communications.

Sex- and species-associated differences in complement-mediated immunity in humans and rhesus macaques

A. Hessell, T. Bruel, Benjamin S. Goldberg, 2024, mBio.

Sex and species associated differences in Complement-mediated immunity in Humans and Rhesus macaques

A. Hessell, T. Bruel, Benjamin S. Goldberg, 2023, bioRxiv.

Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Design, synthesis, and biological evaluation of a biyouyanagin compound library

B. Cravatt, A. Hessell, D. Sarlah, 2011 .

Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.

D. Burton, K. Nicolaou, A. Hessell, 2011, Bioorganic & medicinal chemistry.

Immune perturbation following SHIV infection is greater in newborn macaques than in infants.

N. Haigwood, Eisa Mahyari, A. Hessell, 2024, JCI insight.

Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates

L. Weinberger, N. Haigwood, J. Burnett, 2024, Science.