M. Zwick

发表

The Conserved Positive Charge in the Transmembrane Domain of HIV Gp41 Contributes to Its Intrinsic Preference for Trimerization

P. Dawson, T. Reichart, D. Leaman, 2019 .

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding.

S. Sligar, P. Dawson, T. Reichart, 2016, Angewandte Chemie.

Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization

D. Leaman, M. Zwick, A. Kim, 2014, PLoS pathogens.

Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41

Paul W. H. I. Parren, Erica Ollmann Saphire, Dennis R. Burton, 2001, Journal of Virology.

Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies

Renate Kunert, Bette Korber, Christos J. Petropoulos, 2004, Journal of Virology.

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41.

Renate Kunert, Robyn L Stanfield, Ian A Wilson, 2005, Immunity.

Structure-Function Analysis of the Epitope for 4E10, a Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody

D. Burton, I. Wilson, P. Dawson, 2006, Journal of Virology.

Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity

D. Burton, M. Zwick, E. Scherer, 2007, AIDS.

4E10-Resistant HIV-1 Isolated from Four Subjects with Rare Membrane-Proximal External Region Polymorphisms

J. Mullins, G. Aldrovandi, F. Bibollet-Ruche, 2010, PloS one.

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

R. Wyatt, Richard Wilson, M. Zwick, 2017, Journal of Virology.

Crystal Structure of a Neutralizing Human IgG Against HIV-1: A Template for Vaccine Design

Garrett M. Morris, Robyn L. Stanfield, Paul W. H. I. Parren, 2001, Science.

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2007, Nature.

Tyrosine Sulfation of Human Antibodies Contributes to Recognition of the CCR5 Binding Region of HIV-1 gp120

Christoph Grundner, Peter D. Kwong, Wenhui Li, 2003, Cell.

A welcome burst of human antibodies

D. Burton, M. Zwick, Johannes S. Gach, 2008, Nature Biotechnology.

A Low-Molecular-Weight Entry Inhibitor of both CCR5- and CXCR4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp41

S. Butler, D. Leaman, M. Zwick, 2010, Journal of Virology.

A Low-Molecular-Weight Entry Inhibitor of both CCR 5-and CXCR 4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp 41

S. Butler, D. Leaman, M. Zwick, 2010 .

A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

J. Binley, P. Poignard, M. Zwick, 2013, PloS one.

Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

T. Wrin, D. Leaman, M. Zwick, 2013, PloS one.

Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.

D. Burton, P. Parren, R. Dwek, 2003, Advances in experimental medicine and biology.

Identification and Characterization of a Peptide That Specifically Binds the Human, Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody b12

Jamie K. Scott, C. Barbas, D. Burton, 2001, Journal of Virology.

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

Chaim A. Schramm, Kenneth H. Zhou, J. Yates, 2020, Cell reports.

Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells

B. Finlay, F. Portillo, M. Zwick, 1996, Molecular microbiology.

Phage-displayed peptide libraries.

M. Zwick, J. Scott, J. Shen, 1998, Current opinion in biotechnology.

Dense Array of Spikes on HIV-1 Virion Particles

R. Wyatt, A. Olson, D. Leaman, 2017, Journal of Virology.

2010-3-23 4 E 10-Resistant HIV-1 Isolated from Four Subjects with Rare Membrane-Proximal External Region Polymorphisms

J. Mullins, G. Aldrovandi, F. Bibollet-Ruche, 2010 .

Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies.

N. Greenspan, E. Toone, B. M. Pinto, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Homodimeric peptides displayed by the major coat protein of filamentous phage.

M. Zwick, J. Scott, J. Shen, 2000, Journal of molecular biology.

Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells.

B. Finlay, M. Zwick, K. Leung, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The conserved positive charge in the transmembrane domain of HIV gp41 contributes to its trimerization

P. Dawson, T. Reichart, D. Leaman, 2020 .

Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding

H. Tagare, J. Lifson, P. Uchil, 2022, bioRxiv.

HIV-1 neutralization: mechanisms and relevance to vaccine design.

D. Burton, M. Zwick, 2007, Current HIV research.

Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition

Ping Zhu, Renate Kunert, Pauline M. Rudd, 2003, Science.

Synthesis and analysis of the membrane proximal external region epitopes of HIV‐1

P. Dawson, M. Zwick, Johannes S. Gach, 2010, Journal of peptide science : an official publication of the European Peptide Society.

Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

Christoph Grundner, Christos J. Petropoulos, Terri Wrin, 2003, Journal of Virology.

Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage.

D. Burton, M. Zwick, A. Labrijn, 2007, Protein engineering, design & selection : PEDS.

Filamentous phage as an immunogenic carrier to elicit focused antibody responses against a synthetic peptide.

M. Zwick, J. Scott, N. V. van Houten, 2006, Vaccine.

A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12

Paul W. H. I. Parren, Dennis R. Burton, D. Burton, 2003, Journal of Virology.

Molecular Features of the Broadly Neutralizing Immunoglobulin G1 b12 Required for Recognition of Human Immunodeficiency Virus Type 1 gp120

Jamie K. Scott, D. Burton, P. Parren, 2003, Journal of Virology.

The maltose-binding protein as a scaffold for monovalent display of peptides derived from phage libraries.

C. Barbas, L. Bonnycastle, M. Zwick, 1998, Analytical biochemistry.

Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing response.

M. Luscher, K. MacDonald, M. Zwick, 2005, Vaccine.

An MPER antibody neutralizes HIV-1 using germline features shared among donors

D. Burton, I. Wilson, A. Ward, 2019, Nature Communications.

Functional Optimization of Broadly Neutralizing HIV-1 Antibody 10E8 by Promotion of Membrane Interactions

D. Leaman, M. Zwick, E. Rujas, 2018, Journal of Virology.

Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules.

D. Leaman, M. Zwick, Johannes S. Gach, 2011, Current topics in medicinal chemistry.

Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region

J. Mascola, R. Wyatt, G. Nabel, 2009, Journal of Virology.

Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice

Klaus N. Lovendahl, Kelly K. Lee, D. Leaman, 2022, Cell.

Access of antibody molecules to th conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary HIV-1

J. Sodroski, J. Binley, R. Wyatt, 2009 .

Functional Stability of Unliganded Envelope Glycoprotein Spikes among Isolates of Human Immunodeficiency Virus Type 1 (HIV-1)

D. Burton, D. Leaman, M. Zwick, 2011, PloS one.

A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite

I. Wilson, Jiang Zhu, K. Hong, 2020, Science Advances.

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

D. Burton, D. Watkins, T. Friedrich, 2008, The Journal of experimental medicine.

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

John P. Moore, D. Burton, I. Wilson, 2015, Nature Communications.

A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein

D. Burton, P. Parren, Susan Tang, 2011, PloS one.

In-Solution Virus Capture Assay Helps Deconstruct Heterogeneous Antibody Recognition of Human Immunodeficiency Virus Type 1

D. Leaman, M. Zwick, Heather L. Kinkead, 2010, Journal of Virology.

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

D. Burton, A. McMichael, D. Leaman, 2010, Proceedings of the National Academy of Sciences.

An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10

J. Binley, D. Burton, I. Wilson, 2007, Journal of Virology.

Simian Immunodeficiency Virus Engrafted with Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Epitopes: Replication, Neutralization, and Survey of HIV-1-Positive Plasma

D. Richman, D. Burton, T. Greenough, 2006, Journal of Virology.

Nature of Nonfunctional Envelope Proteins on the Surface of Human Immunodeficiency Virus Type 1

J. Binley, D. Burton, L. Morris, 2006, Journal of Virology.

The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploring.

M. Zwick, 2005, AIDS.

Anti-Human Immunodeficiency Virus Type 1 (HIV-1) Antibodies 2F5 and 4E10 Require Surprisingly Few Crucial Residues in the Membrane-Proximal External Region of Glycoprotein gp41 To Neutralize HIV-1

H. Katinger, D. Burton, M. Zwick, 2005, Journal of Virology.

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

J. Mascola, R. Wyatt, R. Bailer, 2019, Immunity.

Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.

Jamie K. Scott, Erica Ollmann Saphire, Ian A Wilson, 2007, Journal of molecular biology.

Cryo-ET of HIV reveals Env positioning on Gag lattice and structural variation among Env trimers

Klaus N. Lovendahl, Kelly K. Lee, D. Leaman, 2021 .

Dhanier Ft Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp 41

J. Binley, H. Katinger, John P. Moore, 2009 .

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Wayne C Koff, Chung-Yi Wu, Chi-Huey Wong, 2014, Immunity.

Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope.

I. Wilson, J. Julien, R. Stanfield, 2011, Journal of molecular biology.

Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10

D. Burton, W. Schief, D. Nemazee, 2013, The Journal of Immunology.

A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-knob-in-hole-reversed immunoadhesin

B. Torbett, D. Rawlings, R. James, 2023, Molecular therapy. Methods & clinical development.

Identiﬁcation and Characterization of a New Cross-Reactive Human Immunodeﬁciency Virus Type 1-Neutralizing Human Monoclonal Antibody

Dennis R. Burton, Xiaodong Xiao, Peter Bouma, 2022 .

Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes

A. Ward, J. H. Lee, D. Leaman, 2015, Journal of Virology.

A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

D. Burton, I. Wilson, P. Dawson, 2009, Journal of Virology.

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

Ian A Wilson, Dennis R Burton, Michael Zwick, 2007, Journal of molecular biology.

The Long Third Complementarity-Determining Region of the Heavy Chain Is Important in the Activity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5

H. Katinger, D. Burton, P. Parren, 2004, Journal of Virology.

Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning.

D. Dimitrov, P. Prabakaran, R. Lal, 2004, Journal of molecular biology.

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

Chaim A. Schramm, Kenneth H. Zhou, J. Yates, 2019, bioRxiv.

A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

Dennis R. Burton, Pascal Poignard, D. Burton, 2010, PLoS pathogens.

Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

E. Reinherz, G. Wagner, Jia-huai Wang, 2009, Proceedings of the National Academy of Sciences.

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.

R. Wyatt, S. Sharma, D. Nemazee, 2016, Cell reports.

Membrane Env Liposomes Facilitate Immunization with Multivalent Full-Length HIV Spikes

D. Leaman, M. Zwick, Armando Stano, 2021, Journal of virology.

Membrane Env liposomes for immunization with HIV spikes

D. Leaman, M. Zwick, Armando Stano, 2020, bioRxiv.

Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution

D. Leaman, M. Zwick, 2013, PLoS pathogens.

Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at Its Apex

D. Leaman, M. Zwick, A. Kim, 2017, Journal of Virology.

Neutralization Synergy of Human Immunodeficiency Virus Type 1 Primary Isolates by Cocktails of Broadly Neutralizing Antibodies

H. Katinger, D. Burton, P. Parren, 2001, Journal of Virology.

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

J. Julien, C. Eggeling, D. Leaman, 2021, iScience.

Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments

J. Julien, C. Eggeling, C. Domene, 2020, Cell reports.

Combinatorial Phage Antibody Libraries

D. Burton, M. Zwick, R. Williamson, 2006 .

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

D. Richman, D. Burton, C. Bewley, 2008, Virology.

Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization.

J. Hoxie, J. Binley, P. Moore, 2008, Virology.

gp41: HIV's shy protein

D. Burton, E. Saphire, M. Zwick, 2004, Nature Medicine.

Neutralizing HIV Antibody 4E10 Cells in Knock-In Mice Expressing Broadly Immune Tolerance Negatively Regulates B

D. Burton, W. Schief, M. Zwick, 2013 .

Intracellular replication of Salmonella within epithelial cells is associated with filamentous structures containing lysosomal membrane glycoproteins.

B. Finlay, M. Zwick, K. Leung, 1993, Infectious agents and disease.