A. Labrijn

发表

Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41

Paul W. H. I. Parren, Erica Ollmann Saphire, Dennis R. Burton, 2001, Journal of Virology.

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

P. Parren, A. Heck, A. Labrijn, 2013, mAbs.

When binding is enough: nonactivating antibody formats.

A. Labrijn, R. Aalberse, J. Schuurman, 2008, Current opinion in immunology.

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3–CH3 Interaction Strength

P. Parren, I. Lasters, A. Heck, 2011, The Journal of Immunology.

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.

P. Parren, A. Heck, P. Gros, 2016, Molecular cell.

Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope.

D. Burton, D. Dimitrov, X. Ji, 2004, Biochemistry.

Quantitative analysis of the interaction strength and dynamics of human IgG4 half molecules by native mass spectrometry.

P. Parren, I. Lasters, A. Heck, 2011, Structure.

Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors

A. Labrijn, K. Kemper, T. van Hall, 2021, Cancers.

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

P. Parren, M. Chiu, Sandeep Somani, 2017, Scientific Reports.

CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory

S. Verploegen, A. Labrijn, M. Houtkamp, 2018, Molecular Cancer Therapeutics.

Molecular Basis of Assem bly and Activation of Complement Component C 1 in Complex with Immunoglobulin G 1 and Antigen Graphical

P. Parren, A. Heck, P. Gros, 2016 .

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.

D. Seshasayee, Lawren C. Wu, L. Diehl, 2007, The Journal of clinical investigation.

Controlled Fab-arm exchange for the generation of stable bispecific IgG1

P. Parren, A. Labrijn, J. Schuurman, 2014, Nature Protocols.

Fab-arm exchange

P. Parren, A. Labrijn, J. Schuurman, 2012, mAbs.

Anticorps monoclonaux anti-cd32b

P. Parren, A. Labrijn, J. G. Winkel, 2008 .

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

M. Chiu, A. Labrijn, W. Atkins, 2017, The Journal of Biological Chemistry.

Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

Christoph Grundner, Christos J. Petropoulos, Terri Wrin, 2003, Journal of Virology.

Neutralizing antibodies to the HIV-1 envelope glycoproteins

C. Broder, J. Binley, D. Burton, 2004 .

Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage.

D. Burton, M. Zwick, A. Labrijn, 2007, Protein engineering, design & selection : PEDS.

Bispecific antibodies: a mechanistic review of the pipeline

P. Parren, J. Reichert, A. Labrijn, 2019, Nature Reviews Drug Discovery.

A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12

Paul W. H. I. Parren, Dennis R. Burton, D. Burton, 2003, Journal of Virology.

Production of stable bispecific IgG1 by controlled Fab-arm exchange

P. Parren, A. Labrijn, P. V. van Berkel, 2013, mAbs.

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

Michael J. Gramer, Paul W. H. I. Parren, P. Parren, 2013, Proceedings of the National Academy of Sciences.

Neutralizing Epitopes of HIV-1 R ev ie w s Neutralizing Epitopes of HIV-1

P. Parren, A. Labrijn, 2003 .

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

P. Parren, B. '. ’t Hart, A. Labrijn, 2017, Scientific Reports.

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

P. Parren, A. Labrijn, J. Schuurman, 2017, Analytical chemistry.

Dhanier Ft Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp 41

J. Binley, H. Katinger, John P. Moore, 2009 .

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

P. Parren, S. Verploegen, A. Labrijn, 2020, EBioMedicine.

FcγR Binding and ADCC Activity of Human IgG Allotypes

G. Vidarsson, A. Labrijn, M. Wuhrer, 2020, Frontiers in Immunology.

Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity

H. Ditzel, P. Parren, A. Labrijn, 2022, Journal for ImmunoTherapy of Cancer.

Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning.

D. Dimitrov, P. Prabakaran, R. Lal, 2004, Journal of molecular biology.

UvA-DARE ( Digital Academic Repository ) Neutralizing antibodies to the HIV-1 envelope glycoproteins

C. Broder, J. Binley, D. Burton, 2009 .

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

P. Parren, C. Polman, A. Labrijn, 2009, Nature Biotechnology.

Hitting Ebola, to the power of two

P. Parren, A. Labrijn, 2016, Science.

Fc-Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer.

P. Parren, A. Labrijn, T. Rispens, 2013, Molecular immunology.

Opening the door to innovation

P. Parren, A. Labrijn, J. Schuurman, 2014, mAbs.

Novel strategy for the selection of human recombinant Fab fragments to membrane proteins from a phage-display library.

H. Schuitemaker, C. Hack, A. Labrijn, 2002, Journal of immunological methods.

CH3 - Affecting the Noncovalent CH3 CH3 Domain Enable Fab-Arm Exchange by Species-Specific Determinants in the IgG

P. Parren, I. Lasters, A. Heck, 2011 .

Bispecific antibodies: a mechanistic review of the pipeline

Janice M Reichert, P. Parren, J. Reichert, 2019, Nature Reviews Drug Discovery.

Mutation of the TGN1412 anti‐CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super‐agonist activity

A. Labrijn, S. Esparon, P. Hogarth, 2023, Immunology and cell biology.

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

P. Parren, B. '. ’t Hart, A. Labrijn, 2017, Scientific Reports.

Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41

J. Binley, H. Katinger, John P. Moore, 2001, Journal of Virology.

In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope

D R Burton, H J Ditzel, J. Binley, 1996, Journal of virology.

Impact of structural modifications of IgG antibodies on effector functions

G. Vidarsson, A. Labrijn, Thijs L. J. van Osch, 2024, Frontiers in immunology.