I. Marenholz

发表

C. Heizmann, R. Lovering, I. Marenholz, 2006, Biochimica et biophysica acta.

S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation.

C. Heizmann, P. Erne, A. Domenighetti, 2008, General physiology and biophysics.

Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.

T. Keil, S. Lau, U. Wahn, 2006, The Journal of allergy and clinical immunology.

Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Manuel A. R. Ferreira, M. Jarvelin, C. Gieger, 2015, Nature Genetics.

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Manuel A. R. Ferreira, J. Witte, C. Gieger, 2017, Nature Genetics.

Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks

Manuel A. R. Ferreira, Cameron D. Palmer, M. Jarvelin, 2017, Nature Genetics.

S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses.

C. Heizmann, B. Schäfer, P. Erne, 2006, Biochimica et biophysica acta.

Genome‐wide association study of body mass index in 23 000 individuals with and without asthma

D. Strachan, W. McArdle, M. Farrall, 2013, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Age-of-onset information helps identify 76 genetic variants associated with allergic disease

Manuel A. R. Ferreira, J. Witte, G. Abecasis, 2020, PLoS genetics.

S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature).

C. Heizmann, I. Marenholz, G. Fritz, 2004, Biochemical and biophysical research communications.

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy

M. Nöthen, C. Schmidt, B. Niggemann, 2017, Nature Communications.

SMARCAD1 Haploinsufficiency Underlies Huriez Syndrome and Associated Skin Cancer Susceptibility.

N. Hübner, Young-Ae Lee, J. Esparza-Gordillo, 2018, The Journal of investigative dermatology.

Human epidermal differentiation complex in a single 2.5 Mbp long continuum of overlapping DNA cloned in bacteria integrating physical and transcript maps.

G. Mirza, J. Ragoussis, D. Nižetić, 1999, The Journal of investigative dermatology.

A common variant on chromosome 11q13 is associated with atopic dermatitis

S. Heath, T. Illig, U. Wahn, 2009, Nature Genetics.

Meta-analysis identifies seven susceptibility loci involved in the atopic march

Manuel A. R. Ferreira, C. Gieger, D. Postma, 2015, Nature Communications.

Lack of association of the G protein-coupled receptor for asthma susceptibility gene with atopic dermatitis.

U. Wahn, Young-Ae Lee, C. Söderhäll, 2005, The Journal of allergy and clinical immunology.

Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema.

Young-Ae Lee, J. Esparza-Gordillo, M. Macek, 2011, The Journal of investigative dermatology.

Association of Filaggrin loss‐of‐function‐mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population

U. Wahn, Young-Ae Lee, I. Marenholz, 2009, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Hongmei, Laurent F. Thomas, M. Jarvelin, 2022, medRxiv.

Genetic analysis of the epidermal differentiation complex (EDC) on human chromosome 1q21: chromosomal orientation, new markers, and a 6-Mb YAC contig.

I. Marenholz, I. Ragoussis, D. Mischke, 1996, Genomics.

Phenotype consensus is required to enable large‐scale genetic consortium studies of food allergy

G. Koppelman, J. Hui, Young-Ae Lee, 2020, Allergy.

Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21.

C. Heizmann, B. Schäfer, I. Marenholz, 1996, Cell calcium.

4th Pediatric Allergy and Asthma Meeting (PAAM)

Manuel A. R. Ferreira, C. Gieger, D. Postma, 2016, Clinical and Translational Allergy.

Food allergy and gastrointestinal disease Filaggrin loss-of-functionmutations are associated with persistence of egg andmilk allergy

B. Niggemann, T. Keil, S. Lau, 2022 .

Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex.

J. Ragoussis, C. Heizmann, I. Marenholz, 1999, Genomics.

Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21

J. Ragoussis, D. Nižetić, O. Myklebost, 2002, Oncogene.

Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.

I. Marenholz, C. Backendorf, D. Mischke, 2001, Genome research.

Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ("epidermal differentiation complex") on human chromosome 1q21.

I. Marenholz, D. Mischke, A. Ziegler, 1996, The Journal of investigative dermatology.

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.

C. Gieger, M. Waldenberger, A. Peters, 2019, The Journal of allergy and clinical immunology.

Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

David M. Evans, M. Jarvelin, C. Gieger, 2015, Nature Genetics.

Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex.

D. Nižetić, N. Mirancea, D. Hohl, 2005, The Journal of investigative dermatology.

Eleven loci with new reproducible genetic associations with allergic disease risk

D. Hinds, J. Vonk, G. Koppelman, 2019, The Journal of allergy and clinical immunology.

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA‐DRB1

A Motyer, Damjan Vukcevic, A. Motyer, 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

Catherine L. Worth, M. Jarvelin, C. Gieger, 2021, Nature Communications.

Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

James T. Elder, C. Gieger, M. Nöthen, 2015, American journal of human genetics.

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Yusuke Nakamura, Sen Yang, Andre Franke, 2013, Nature Genetics.

Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family.

I. Petersen, K. Schlüns, C. Heizmann, 2002, Genomics.

Multi-ancestry association study identifies new asthma risk loci that co-localize with 1 immune cell enhancer marks 2

Sina A. Gharib, Cameron D. Palmer, L. Liang, 2017 .

A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.

L. Liang, G. Abecasis, T. Keil, 2013, The Journal of allergy and clinical immunology.

An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium

S. Lau, Young-Ae Lee, A. Thiel, 2022, Clinical and translational allergy.

Evaluation of food allergy candidate loci in the Genetics of Food Allergy study.

M. Nöthen, C. Schmidt, B. Niggemann, 2018, The Journal of allergy and clinical immunology.

Variants in a Novel Epidermal Collagen Gene (COL29A1) Are Associated with Atopic Dermatitis

U. Wahn, Young-Ae Lee, H. Schulz, 2007, PLoS biology.

Genetics (AAGC) (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.

Weidinger, M. Jarvelin, C. Gieger, 2015 .

S100A16, a ubiquitously expressed EF-hand protein which is up-regulated in tumors.

C. Heizmann, I. Marenholz, 2004, Biochemical and biophysical research communications.

Genome-wide approaches to the etiology of eczema.

Young-Ae Lee, J. Esparza-Gordillo, I. Marenholz, 2010, Current opinion in allergy and clinical immunology.

Maternal Filaggrin Mutations Increase the Risk of Atopic Dermatitis in Children: An Effect Independent of Mutation Inheritance

B. Niggemann, T. Keil, S. Lau, 2015, PLoS genetics.

Genomic organization and mapping of the human and mouse neuronal β2-nicotinic acetylcholine receptor genes

R. Elliott, D. Hamer, I. Marenholz, 1999, Mammalian Genome.

Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains.

I. Marenholz, D. Mischke, B. Schutte, 2000, Gene.

An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma.

Thomas Keil, Klaus Rohde, T. Keil, 2009, The Journal of allergy and clinical immunology.

Shared genetic determinants between eczema and other immune-related diseases

Young-Ae Lee, J. Esparza-Gordillo, I. Marenholz, 2013, Current opinion in allergy and clinical immunology.

The genetics of the skin barrier in eczema and other allergic disorders

Young-Ae Lee, J. Esparza-Gordillo, I. Marenholz, 2015, Current opinion in allergy and clinical immunology.

The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever.

S. Lau, Young-Ae Lee, J. Esparza-Gordillo, 2011, Human molecular genetics.

Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

T. Ahluwalia, K. Bønnelykke, H. Bisgaard, 2019, Allergy.

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.

J. Witte, M. Nöthen, G. Koppelman, 2018, The Journal of allergy and clinical immunology.

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy

M. Nöthen, C. Schmidt, B. Niggemann, 2017, Nature Communications.

A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema.

U. Wahn, Young-Ae Lee, J. Esparza-Gordillo, 2007, The Journal of allergy and clinical immunology.

Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.

B. Niggemann, T. Keil, S. Lau, 2022, The Journal of allergy and clinical immunology.

A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.

C. Gieger, A. Kretschmer, M. Waldenberger, 2015, The Journal of allergy and clinical immunology.

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure☆

D. Postma, A. Ramasamy, D. Strachan, 2014, The Journal of allergy and clinical immunology.

New insights from genetic studies of eczema

Young-Ae Lee, I. Marenholz, Aleix Arnau-Soler, 2023, Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V.

Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis

H. Holzhütter, Young-Ae Lee, J. Esparza-Gordillo, 2012, BMC Medical Genetics.

Protein-coding variants contribute to the risk of atopic dermatitis and skin- 1 specific gene expression 2

M. Waldenberger, K. Strauch, T. Ahluwalia, 2019 .

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

James T. Elder, M. Nöthen, Yusuke Nakamura, 2013, Nature Genetics.

The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever.

S. Lau, Young-Ae Lee, J. Esparza-Gordillo, 2011, Human molecular genetics.

Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial

I. Marenholz, B. Kalb, Lara Meixner, 2024, Trials.