Yang Feng

发表

Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain.

D. Dimitrov, Zhongyu Zhu, Wei-zao Chen, 2008, Journal of molecular biology.

A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin

Wei Li, D. Dimitrov, X. Ji, 2017, Cell Host & Microbe.

CD22-CAR T Cells Induce Remissions in CD19-CAR Naïve and Resistant B-ALL

Yang Feng, Boro Dropulic, Marianna Sabatino, 2017, Nature Medicine.

Discovery of novel candidate therapeutics and diagnostics based on engineered human antibody domains.

D. Dimitrov, P. Prabakaran, T. Ying, 2014, Current drug discovery technologies.

Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1

Wei Li, D. Dimitrov, M. Dyba, 2016, mAbs.

Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn

D. Dimitrov, P. Prabakaran, T. Ying, 2015, mAbs.

Design, expression and characterization of a soluble single-chain functional human neonatal Fc receptor.

D. Dimitrov, Yang Feng, R. Gong, 2011, Protein expression and purification.

Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar

Yang Feng, Ponraj Prabakaran, Simona Colantonio, 2014, mAbs.

Identification and characterization of a novel agonistic anti-DR4 human monoclonal antibody

D. Dimitrov, Zhongyu Zhu, Yang Feng, 2010, mAbs.

Scaling-up and production of therapeutic antibodies for preclinical studies.

D. Dimitrov, Yang Feng, 2009, Methods in molecular biology.

Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor.

D. Dimitrov, Zhongyu Zhu, Yang Feng, 2011, Biochemical and biophysical research communications.

DDEDEDDDDD EDDEDDDDED DEEEEEEEEE EPVKEAPGKR KKEMAKQKAA PEAKKQKVEG . 301 TEPTTAFNLF VGNLNFNKSA PELKTGISDV FAKNDLAVVD VRIGMTRKFG YVDFESAEDL . 361 EKALELTGLK VFGNEIKLEK PKGKDSKKER DARTLLAKNL PYKVTQDELK EVFEDAAEIR . 421 LVSKDGKSKG IAYIEFKTEA DAEKTFEEKQ GTEIDGRSIS LYYTGEKGQN QDYRGGKNST

D. Dimitrov, Zhongyu Zhu, Yang Feng, 2011 .

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells

D. Dimitrov, T. Ying, Liying Ma, 2017, Scientific Reports.

Soluble Monomeric IgG1 Fc*

D. Dimitrov, T. Ying, Wei-zao Chen, 2012, The Journal of Biological Chemistry.

Potent Neutralization of Hendra and Nipah Viruses by Human Monoclonal Antibodies

Lin-Fa Wang, Yang Feng, C. Broder, 2006, Journal of Virology.

Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.

J. Khan, Jun S. Wei, M. Marra, 2017, Cancer cell.

Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens

D. Dimitrov, P. Prabakaran, Wei-zao Chen, 2011, Biochemical and Biophysical Research Communications.

Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics

D. Dimitrov, Zhongyu Zhu, Wei-zao Chen, 2012, Molecular Cancer Therapeutics.

A large human domain antibody library combining heavy and light chain CDR3 diversity.

D. Dimitrov, Zhongyu Zhu, Wei-zao Chen, 2010, Molecular immunology.

Exceptionally Potent Cross-Reactive Neutralization of Nipah and Hendra Viruses by a Human Monoclonal Antibody

C. Broder, D. Dimitrov, Zhongyu Zhu, 2008, The Journal of infectious diseases.

Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity

D. Dimitrov, Zhongyu Zhu, Qi Zhao, 2011, Molecular Cancer Therapeutics.

Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

D. Dimitrov, M. Stetler-Stevenson, T. Fry, 2019, Clinical Cancer Research.

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

D. Dimitrov, T. Zhou, Lingshu Wang, 2015, Nature Communications.

Targeting of Bone-Derived Insulin-Like Growth Factor-II by a Human Neutralizing Antibody Suppresses the Growth of Prostate Cancer Cells in a Human Bone Environment

D. Dimitrov, A. Ochiai, K. Nagai, 2010, Clinical Cancer Research.

Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody*

Yang Feng, Ponraj Prabakaran, Xiaodong Xiao, 2006, Journal of Biological Chemistry.

Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies

D. Dimitrov, R. Baric, K. Subbarao, 2007, Proceedings of the National Academy of Sciences.

Oligomerization of the SARS-CoV S glycoprotein: dimerization of the N-terminus and trimerization of the ectodomain

D. Dimitrov, Yang Feng, Xiaodong Xiao, 2004, Biochemical and Biophysical Research Communications.

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

D. Dimitrov, P. Prabakaran, Zhongyu Zhu, 2014, Biomedicines.

Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling

D. Dimitrov, S. Lamberts, J. Frystyk, 2013, Molecular and Cellular Endocrinology.

Study of the Relationship Between Serum Amino Acid Metabolism and Lymph Node Metastasis in Patients with Colorectal Cancer

Yanping Wang, Yang Feng, D. Xue, 2020, OncoTargets and therapy.

A large library based on a novel (CH2) scaffold: identification of HIV-1 inhibitors.

D. Dimitrov, R. Ishima, Yang Feng, 2009, Biochemical and biophysical research communications.

Fusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies.

D. Dimitrov, Zhongyu Zhu, Wei-zao Chen, 2012, Biochemical and biophysical research communications.

MYELOID NEOPLASIA Targeting of folate receptor b on acute myeloid leukemia blasts with chimeric antigen receptor – expressing T cells

P. Low, D. Dimitrov, D. Powell, 2015 .

Cancer cell survival depends on collagen uptake into tumor-associated stroma

D. Dimitrov, S. Seaman, C. Szot, 2022, Nature Communications.

Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains

D. Dimitrov, P. Prabakaran, T. Ying, 2013, Journal of Virology.

Specific targeting to B cells by lipid-based nanoparticles conjugated with a novel CD22-ScFv.

D. Dimitrov, H. Garg, R. Blumenthal, 2010, Experimental and molecular pathology.

Shortened Engineered Human Antibody CH2 Domains

D. Dimitrov, Qi Zhao, Yanping Wang, 2011, The Journal of Biological Chemistry.

A new bispecific antibody targeting non-overlapping epitopes on IGF2: design, in vitro characterization and pharmacokinetics in macaques.

D. Dimitrov, Wei-zao Chen, Qi Zhao, 2014, Experimental and molecular pathology.

Engineered Soluble Monomeric IgG1 CH3 Domain

D. Dimitrov, T. Ying, Wei-zao Chen, 2013, The Journal of Biological Chemistry.

Pharmacokinetics of engineered human monomeric and dimeric CH2 domains

D. Dimitrov, Yang Feng, D. Bramhill, 2012, mAbs.

Monomeric IgG1 Fc molecules displaying unique Fc receptor interactions that are exploitable to treat inflammation-mediated diseases

D. Dimitrov, T. Ying, Wei-zao Chen, 2014, mAbs.

CD22-CAR T Cells Induce Remissions in CD19-CAR Naïve and Resistant B-ALL

D. Dimitrov, M. Sabatino, R. Orentas, 2017, Nature medicine.

Assessment of folate receptor-β expression in human neoplastic tissues

P. Low, D. Dimitrov, D. Visscher, 2015, Oncotarget.

Engineered Single Human CD4 Domains as Potent HIV-1 Inhibitors and Components of Vaccine Immunogens

D. Dimitrov, Zhongyu Zhu, Wei-zao Chen, 2011, Journal of Virology.

Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies

D. Dimitrov, K. Yuen, P. Prabakaran, 2014, Journal of Virology.

Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers

D. Dimitrov, Zhongyu Zhu, Wei-zao Chen, 2008, Proceedings of the National Academy of Sciences.

Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes

D. Dimitrov, J. Maris, Zhongyu Zhu, 2016, mAbs.

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.

Yang Feng, Michel Sadelain, Prasad S Adusumilli, 2016, The Journal of clinical investigation.

M2-Type Macrophages Induce Tregs Generation by Activating the TGF-β/Smad Signalling Pathway to Promote Colorectal Cancer Development

Xiaoyu Song, Yanping Wang, Yang Feng, 2021, OncoTargets and therapy.

Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22

D. Dimitrov, J. Julien, Yang Feng, 2021, The Journal of biological chemistry.

High affinity FRβ-specific CAR T cells eradicate AML and normal yeloid lineage without HSC toxicity

D. Dimitrov, D. Powell, Yang Feng, 2016, Leukemia.

Antibody Aggregation: Insights from Sequence and Structure

Yang Feng, Wei Li, Ponraj Prabakaran, 2016, Antibodies.

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.

D. Dimitrov, S. Seaman, C. Szot, 2017, Cancer cell.

Characterization of a chimeric monoclonal antibody against the insulin-like growth factor-I receptor

D. Dimitrov, Yanping Wang, Yang Feng, 2009, mAbs.

Tumor stroma‐targeted antibody‐drug conjugate triggers localized anticancer drug release

D. Dimitrov, S. Seaman, C. Szot, 2018, The Journal of clinical investigation.

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

P. Low, C. Ruppert, D. Dimitrov, 2019, Arthritis Research & Therapy.

Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations

D. Dimitrov, P. Prabakaran, Maria G. Singarayan, 2012, Immunogenetics.

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

D. Dimitrov, N. Longo, P. Prabakaran, 2009, Biochemical and Biophysical Research Communications.

Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.

P. Low, D. Dimitrov, D. Powell, 2015, Blood.

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells

D. Dimitrov, T. Ying, Liying Ma, 2017, Scientific Reports.

Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Wei Li, D. Dimitrov, Zhongyu Zhu, 2017, Front. Immunol..

N-terminal truncation of an isolated human IgG1 CH2 domain significantly increases its stability and aggregation resistance.

D. Dimitrov, P. Prabakaran, T. Ying, 2013, Molecular pharmaceutics.

Engineered Human Antibody Constant Domains with Increased Stability*

T. Veenstra, D. Dimitrov, P. Prabakaran, 2009, Journal of Biological Chemistry.

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations.

D. Dimitrov, H. Gendelman, J. McMillan, 2015, Biomaterials.

A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity

Mitchell Ho, I. Pastan, D. Dimitrov, 2009, Molecular Cancer Therapeutics.

A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity

P. Low, D. Dimitrov, Zhongyu Zhu, 2011, Arthritis research & therapy.

Anti-CD 276-drug conjugates display potent anti-tumor and anti-metastatic activity d Pyrrolobenzodiazepine dimers are optimal warheads for targeting tumor

D. Dimitrov, S. Seaman, C. Szot, 2022 .

A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma

Yang Feng, Chunyu Yang, Jinhao Liu, 2021, World Journal of Surgical Oncology.

Folate receptor‐β constitutes a marker for human proinflammatory monocytes

D. Dimitrov, R. Amato, Yang Feng, 2014, Journal of leukocyte biology.

Antibody-based therapeutics against components of the IGF system

D. Dimitrov, Yang Feng, 2012, Oncoimmunology.

Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function

Yang Feng, Xiaodong Xiao, D. Dimitrov, 2006, Molecular Cancer Therapeutics.

A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

Wei Li, D. Dimitrov, V. Puri, 2019, PLoS pathogens.

Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing

D. Dimitrov, P. Prabakaran, Zhongyu Zhu, 2012, Front. Microbio..

Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies

D. Dimitrov, Wei-zao Chen, Yang Feng, 2009, Viruses.

Title Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins : Implications for evasion of immune responses and design of vaccine

D. Dimitrov, N. Longo, P. Prabakaran, 2009 .

Structure of an isolated unglycosylated antibody CH2 domain

D. Dimitrov, J. Gan, P. Prabakaran, 2008, Acta crystallographica. Section D, Biological crystallography.

Monoclonal antibodies against components of the IGF system for cancer treatment.

D. Dimitrov, Yang Feng, 2008, Current opinion in drug discovery & development.

Characterization of human IgG repertoires in an acute HIV-1 infection.

D. Dimitrov, P. Prabakaran, Zhongyu Zhu, 2012, Experimental and molecular pathology.

CD22-CAR T Cells Induce Remissions in CD19-CAR Naïve and Resistant B-ALL

D. Dimitrov, M. Sabatino, R. Orentas, 2017, Nature Medicine.

Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.

P. Low, D. Dimitrov, Yang Feng, 2015, Blood.

Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.

J. Khan, Jun S. Wei, M. Marra, 2017, Cancer cell.

Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations

D. Dimitrov, P. Prabakaran, Maria G. Singarayan, 2011, Immunogenetics.

A large human domain antibody library combining heavy and light chain CDR3 diversity.

D. Dimitrov, Zhongyu Zhu, Wei-zao Chen, 2010, Molecular immunology.

Germline-like predecessors of antibodies Implications for evasion of immune responses and design of vaccine immunogens

D. Dimitrov, N. Longo, P. Prabakaran, 2009 .

Assessment of folate receptor-β expression in human neoplastic tissues

P. Low, D. Dimitrov, D. Visscher, 2015, Oncotarget.

Antibody-Guided Nanoparticles

D. Dimitrov, P. Prabakaran, Yang Feng, 2008 .