Sharad K Sharma

发表

Influence of molecular size on tissue distribution of antibody fragments

Zhe Li, B. Krippendorff, Sharad K Sharma, 2016, mAbs.

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1

D. Fairlie, Sharad K Sharma, David P Fairlie, 2017, The Journal of Immunology.

Resveratrol as an adjunct therapy in cyclophosphamide‐treated MCF‐7 cells and breast tumor explants

Neetu Singh, V. Garg, Rashmi Chaturvedi, 2011, Cancer science.

Haemophilus influenzae Lipoprotein P6 of Nontypeable Dual Orientation of the Outer Membrane

Sharad K Sharma, L. K. Wright, M. Khan, 2014 .

Preclinical Development of MGC018, a Duocarmycin-based Antibody–drug Conjugate Targeting B7-H3 for Solid Cancer

Y. Li, P. Moore, Sharad K Sharma, 2017, Molecular Cancer Therapeutics.

Deficiencies in the CD4+ T-Helper Cell Arm of the Immune System of Neonates and Young Children.

M. Pichichero, Sharad K Sharma, 2013, Pediatric allergy, immunology, and pulmonology.

PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans.

M. Pichichero, Sharad K Sharma, L. Filkins, 2012, Microbes and infection.

Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis.

D. Pandey, Sharad K Sharma, M. Bhonde, 2022, European journal of pharmacology.

Predicting toxicities in humans by nonclinical safety testing: an update with particular reference to anticancer compounds.

Sharad K Sharma, V. Ahuja, Sanjay Bokan, 2017, Drug discovery today.

Synergistic Activities of MET/RON Inhibitor BMS-777607 and mTOR Inhibitor AZD8055 to Polyploid Cells Derived from Pancreatic Cancer and Cancer Stem Cells

Ruiwen Zhang, Ming-Hai Wang, Sharad K Sharma, 2013, Molecular Cancer Therapeutics.

Discovery of Potent, Selective and State-Dependent NaV1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure-Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides.

Sneha S. Joshi, P. Gupta, M. Bock, 2020, Journal of medicinal chemistry.

Reduced serum IgG responses to pneumococcal antigens in otitis-prone children may be due to poor memory B-cell generation.

M. Pichichero, Sharad K Sharma, J. Casey, 2012, The Journal of infectious diseases.

Host lung immunity is severely compromised during tropical pulmonary eosinophilia: role of lung eosinophils and macrophages

Sharad K Sharma, Pankaj Sharma, M. Srivastava, 2016, Journal of leukocyte biology.

Quantitative Evaluation of the Effect of Antigen Expression Level on Antibody–Drug Conjugate Exposure in Solid Tumor

Zhe Li, Sharad K Sharma, D. Shah, 2021, The AAPS Journal.

BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression

D. Wiederschain, F. Nestle, Sharad K Sharma, 2022, Journal for ImmunoTherapy of Cancer.

Cellular Immune Response in Young Children Accounts for Recurrent Acute Otitis Media

M. Pichichero, Sharad K Sharma, 2013, Current Allergy and Asthma Reports.

Increased sensitivity to antigen in high avidity CD8+ T cells results from augmented membrane proximal T‐cell receptor signal transduction

Sharad K Sharma, M. Alexander-Miller, 2011, Immunology.

Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization.

H. Goyal, Sharad K Sharma, Rakesh Kumar, 2020, Bioorganic & medicinal chemistry.

Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents

Ruiwen Zhang, Ming-Hai Wang, Sharad K Sharma, 2013, Molecular Cancer Therapeutics.

Prophylactic potential of liposomized integral membrane protein of Plasmodium yoelii nigeriensis against blood stage infection in BALB/c mice.

O. Mohammad, Sharad K Sharma, V. Dwivedi, 2007, Vaccine.

Pulmonary Alveolar Macrophages Contribute to the Premetastatic Niche by Suppressing Antitumor T Cell Responses in the Lungs

Sharad K Sharma, M. Markiewski, Navin K Chintala, 2015, The Journal of Immunology.

Complement C 5 a receptor facilitates cancer metastasis by altering T cell responses in the metastatic niche

W. Gorczyca, D. Fairlie, Sharad K Sharma, 2014 .

Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo

Sharad K Sharma, S. Chandra, K. Vinod, 2010, Toxicology mechanisms and methods.

Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi

Sharad K Sharma, P. Bajpai, S. Shakya, 2008, Parasitology Research.

Escheriosome entrapped soluble blood stage antigens impart protective immunity against a multi-drug resistant isolate of Plasmodium yoelii nigeriensis in BALB/c mice.

O. Mohammad, Sharad K Sharma, P. Bajpai, 2006, Vaccine.

Non PC liposome entrapped promastigote antigens elicit parasite specific CD8+ and CD4+ T-cell immune response and protect hamsters against visceral leishmaniasis.

O. Mohammad, Shazia Khan, Sharad K Sharma, 2006, Vaccine.

An orally available non-nucleotide STING agonist with antitumor activity

Andrew M Haidle, J. Cumming, I. Kariv, 2020, Science.

Prevention of BMS‐777607‐induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

Ruiwen Zhang, Jianwei Zhou, Ming-Hai Wang, 2014, Molecular oncology.

Drug safety testing paradigm, current progress and future challenges: an overview

Sharad K Sharma, Varun Ahuja, Sharad Sharma, 2014, Journal of applied toxicology : JAT.

CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens.

A. Almudevar, M. Pichichero, T. Mosmann, 2013, Vaccine.

Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1

G. Parks, Sharad K Sharma, M. Alexander-Miller, 2010, Journal of leukocyte biology.

Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models.

H. Goyal, Sharad K Sharma, P. Bernstein, 2020, Journal of medicinal chemistry.

Integration of bioanalytical measurements using PK-PD modeling and simulation: implications for antibody-drug conjugate development.

Sharad Sharma, Antari Khot, Dhaval K Shah, 2015, Bioanalysis.

Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition.

M. Pichichero, Sharad K Sharma, J. Casey, 2011, The Journal of infectious diseases.

Altering T-Cell Responses in the Metastatic Niche Complement C 5 a Receptor Facilitates Cancer Metastasis

W. Gorczyca, D. Fairlie, Sharad K Sharma, 2014 .

Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate.

Sharad K Sharma, A. Das, H. Kumar, 2019, Journal of medicinal chemistry.

Quantitative characterization of in vitro bystander effect of antibody-drug conjugates

Aman P. Singh, Sharad K Sharma, D. Shah, 2016, Journal of Pharmacokinetics and Pharmacodynamics.

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis.

Sharad K Sharma, M. Markiewski, Navin K Chintala, 2016, Journal of visualized experiments : JoVE.

Discovery of novel, potent, brain-permeable and orally efficacious positive allosteric modulator of alpha 7 nicotinic acetylcholine receptor [4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide], structure activity relationship and preclinical characterization.

Sharad K Sharma, Girish D. Hatnapure, G. Jana, 2019, Journal of medicinal chemistry.

Erratum to: Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer

Ruiwen Zhang, Jianwei Zhou, Ming-Hai Wang, 2016, Journal of Experimental & Clinical Cancer Research.

Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer

Ruiwen Zhang, Jianwei Zhou, Ming-Hai Wang, 2016, Journal of Experimental & Clinical Cancer Research.

Use of liposomized tetracycline in elimination of Wolbachia endobacterium of human lymphatic filariid Brugia malayi in a rodent model

Sharad K Sharma, S. Vedi, M. Owais, 2005, Journal of drug targeting.

A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART® Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Characterization As CD123 x CD3 and CD19 x CD3 DART Molecules

P. Moore, Sharad K Sharma, Ling Huang, 2018, Blood.

Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells

Zhe Li, Sharad K Sharma, D. Shah, 2020, Drug Metabolism and Disposition.

Erratum to: Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer

Ruiwen Zhang, Jianwei Zhou, Ming-Hai Wang, 2016, Journal of experimental & clinical cancer research : CR.

Liposome Based Vaccines: Prophylactic Measure Against Infectious Diseases

Sharad K Sharma, 2005 .

Application of bacterial reverse mutation assay for detection of non-genotoxic carcinogens

Sharad K Sharma, Sharad Sharma, Rewan Kanode, 2017, Toxicology mechanisms and methods.

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITIES- PREDICTION AND EXPERIMENTAL VALIDATION FOR SOME PYRIDINE CONTAINING HYDROXYTRIAZENES

Sharad K Sharma, D. Jo, Ashok Patidar, 2015 .

CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens.

A. Almudevar, M. Pichichero, T. Mosmann, 2013, Vaccine.