K. Sharpless

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Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

M. G. Finn, Hartmuth C. Kolb, K. Barry Sharpless, 2001, Angewandte Chemie.

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.

Luke G Green, K. Sharpless, V. Rostovtsev, 2002, Angewandte Chemie.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

M. Finn, H. Kolb, K. Sharpless, 2001 .

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.

P. Taylor, P. Carlier, M. Finn, 2002, Angewandte Chemie.

The growing impact of click chemistry on drug discovery.

H. Kolb, K. Sharpless, K. B. Sharpless, 2003, Drug discovery today.

A Potent and Highly Selective Inhibitor of Human α-1,3-Fucosyltransferase via Click Chemistry

Chi‐Huey Wong, K. Sharpless, V. Fokin, 2003 .

"On water": unique reactivity of organic compounds in aqueous suspension.

M. Finn, H. Kolb, K. Sharpless, 2005, Angewandte Chemie.

Iterative in situ click chemistry creates antibody-like protein-capture agents.

Jason E Hein, Arundhati Nag, James R Heath, 2009, Angewandte Chemie.

Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1.

J. Heath, Su Seong Lee, K. Sharpless, 2011, Journal of the American Chemical Society.

In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

Chi-Huey Wong, Benoit Colasson, Chi‐Huey Wong, 2004, Angewandte Chemie.

High stereo- and regioselectivities in the transition metal catalyzed epoxidations of olefinic alcohols by tert-butyl hydroperoxide

K. Sharpless, R. Michaelson, K. B. Sharpless, 1973 .

Mechanism of the molybdenum and vanadium catalyzed epoxidation of olefins by alkyl hydroperoxides

K. Sharpless, A. O. Chong, K. B. Sharpless, 1977 .

Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B

K. Sharpless, V. Fokin, S. Tucker, 2013 .

Catalytic asymmetric epoxidation and kinetic resolution: modified procedures including in situ derivatization

K. Sharpless, R. M. Hanson, J. M. Klunder, 1987 .

SuFEx Chemistry of Thionyl Tetrafluoride (SOF4 ) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates.

K. Sharpless, J. Moses, Suhua Li, 2018, Angewandte Chemie.

Multivalent, bifunctional dendrimers prepared by click chemistry.

C. Hawker, M. Finn, K. Sharpless, 2005, Chemical communications.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

M. G. Finn, Hartmuth C. Kolb, K. Barry Sharpless, 2001 .

New Ligands and Improved Enantioselectivities for the Asymmetric Dihydroxylation of Olefins

K. Sharpless, H. Becker, M. Taniguchi, 1995 .

Antiviral Stilbene 1,2-Diamines Prevent Initiation of Hepatitis C Virus RNA Replication at the Outset of Infection

F. Chisari, K. Sharpless, V. Fokin, 2011, Journal of Virology.

Comparing two models for the selectivity in the asymmetric dihydroxylation reaction (AD)

H. Kolb, K. Sharpless, H. Becker, 1994 .

Experimental and Theoretical Kinetic Isotope Effects for Asymmetric Dihydroxylation. Evidence Supporting a Rate-Limiting “(3 + 2)” Cycloaddition

K. Houk, K. Sharpless, D. Singleton, 1997 .

Chromyl chloride oxidations of olefins. Possible role of organometallic intermediates in the oxidations of olefins by oxo transition metal species

K. Sharpless, J. Bäckvall, K. B. Sharpless, 1977 .

Asymmetric epoxidation provides shortest routes to four chiral epoxy alcohols which are key intermediates in syntheses of methymycin, erythromycin, leukotriene C-1, and disparlure

K. Sharpless, T. Katsuki, K. B. Sharpless, 1981 .

Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry.

Younan Xia, T. Carell, P. Gölitz, 2014, Angewandte Chemie.

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

D. Wolan, K. Sharpless, Stefano Forli, 2019, Proceedings of the National Academy of Sciences.

Large-scale and highly enantioselective synthesis of the taxol C-13 side chain through asymmetric dihydroxylation

H. Kolb, K. Sharpless, K. B. Sharpless, 1994 .

Asymmetric synthesis of both enantiomers of tomoxetine and fluoxetine. Selective reduction of 2,3-epoxycinnamyl alcohol with Red-Al

K. Sharpless, K. B. Sharpless, Y. Gao, 1988 .

Kinetic resolution of racemic .beta.-hydroxy amines by enantioselective N-oxide formation

K. Sharpless, S. Miyano, K. B. Sharpless, 1983 .

.alpha.-Hydroxy ketones in high enantiomeric purity from asymmetric dihydroxylation of enol ethers

K. Sharpless, K. B. Sharpless, T. Hashiyama, 1992 .

Olefin synthesis. Rate enhancement of the elimination of alkyl aryl selenoxides by electron-withdrawing substituents

K. Sharpless, M. W. Young, K. B. Sharpless, 1975 .

Bromine-Catalyzed Aziridination of Olefins. A Rare Example of Atom-Transfer Redox Catalysis by a Main Group Element

K. Sharpless, J. U. Jeong, K. B. Sharpless, 1998 .

Polytriazoles as copper(I)-stabilizing ligands in catalysis.

K. Sharpless, V. Fokin, K. B. Sharpless, 2004, Organic letters.

Catalytic Asymmetric Dihydroxylation

M. VanNieuwenhze, H. Kolb, K. Sharpless, 1994 .

Copper‐Catalyzed Synthesis of N‐Sulfonyl‐1,2,3‐triazoles: Controlling Selectivity.

K. Sharpless, V. Fokin, Sukbok Chang, 2007 .

Asymmetric dihydroxylation via ligand-accelerated catalysis

K. Sharpless, E. Jacobsen, K. B. Sharpless, 1988 .

Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization.

A. Olson, K. Sharpless, V. Fokin, 2006, Journal of medicinal chemistry.

Diols via Catalytic Dihydroxylation

K. Sharpless, M. Beller, 2003 .

Chain-Growth Sulfur(VI) Fluoride Exchange Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates

K. Sharpless, Peng Wu, J. Bae, 2021, ACS central science.

Chain-Growth SuFEx Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates

K. Sharpless, Peng Wu, J. Bae, 2021 .

Kinetic resolution of racemic allylic alcohols by enantioselective epoxidation. A route to substances of absolute enantiomeric purity

V. Martín, K. Sharpless, Yasuhiro Yamada, 1981 .

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores From 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs.

D. Wolan, K. Sharpless, J. Moses, 2020, Angewandte Chemie.

Inhibitors of HIV-1 protease by using in situ click chemistry.

William Lindstrom, Arthur J Olson, John H Elder, 2006, Angewandte Chemie.

In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor.

S. Ōmura, K. Sharpless, T. Sunazuka, 2016, Chemical & pharmaceutical bulletin.

Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry

S. Ōmura, K. Sharpless, K. Shiomi, 2009, The Journal of Antibiotics.

Probing gorge dimensions of cholinesterases by freeze-frame click chemistry.

P. Taylor, K. Sharpless, D. Fournier, 2008, Chemico-biological interactions.

Copper-catalyzed synthesis of N-sulfonyl-1,2,3-triazoles: controlling selectivity.

K. Sharpless, V. Fokin, Sukbok Chang, 2007, Angewandte Chemie.

Efficient synthesis of 2-substituted-1,2,3-triazoles.

K. Sharpless, V. Fokin, K. B. Sharpless, 2008, Organic letters.

Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4 )-Derived Connective Hubs for Bioconjugation to DNA and Proteins.

Chu Wang, Peng Wu, F. Liu, 2019, Angewandte Chemie.

Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines

K. Sharpless, B. Gao, Jiajia Dong, 2021, Angewandte Chemie.

Chain-Growth SuFEx Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates

K. Sharpless, Peng Wu, J. Bae, 2021 .

Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines.

K. Sharpless, B. Gao, Jiajia Dong, 2021, Angewandte Chemie.

SuFEx-enabled high-throughput medicinal chemistry.

V. Nizet, D. Wolan, K. Sharpless, 2019, Journal of the American Chemical Society.

Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation.

K. Sharpless, Jiajia Dong, K. B. Sharpless, 2016, The Journal of organic chemistry.

Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub.

K. Sharpless, J. Moses, Suhua Li, 2017, Angewandte Chemie.

SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts.

Bin Wu, Gerui Ren, Qing-feng Xu, 2017, Angewandte Chemie.

Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates.

K. Sharpless, J. Moses, Suhua Li, 2016, Chemistry.

Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy.

Wentao Chen, J. Kelly, K. Sharpless, 2016, Angewandte Chemie.

A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry.

K. Sharpless, Peng Wu, Hua-Li Qin, 2016, Angewandte Chemie.

Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides.

K. Sharpless, Gao-Feng Zha, Peng Wu, 2017, Angewandte Chemie.

Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates.

Jian‐mei Lu, K. Sharpless, Yi Liu, 2017, Nature chemistry.

Click chemistry in materials synthesis. III. Metal‐adhesive polymers from Cu(I)‐catalyzed azide–alkyne cycloaddition

D. Díaz, M. Finn, K. Sharpless, 2007 .

Click chemistry in materials synthesis. 1. Adhesive polymers from copper‐catalyzed azide‐alkyne cycloaddition

Philipp Holzer, D. Díaz, M. Finn, 2004 .

Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates.

F. Himo, K. Sharpless, V. Rostovtsev, 2004, Journal of the American Chemical Society.

SuFExable polymers with helical structures derived from thionyl tetrafluoride

F. Zhou, Jian‐mei Lu, K. Sharpless, 2019, Nature Chemistry.

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.

K. Sharpless, David J. D. Wilson, B. Parker, 2018, Angewandte Chemie.

Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks

K. Sharpless, V. Fokin, R. Epple, 2002 .

Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity.

S. Ōmura, Y. Yamaguchi, K. Sharpless, 2007, Bioorganic & medicinal chemistry letters.

Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms

K. Sharpless, H. Zuilhof, S. Pujari, 2018, Chemistry.

Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.

P. Taylor, M. Katalinić, K. Sharpless, 2019, Chemistry.

A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an "F-SO2 +" Donor of Unprecedented Reactivity, Selectivity, and Scope.

K. Sharpless, Jiajia Dong, Tiancheng Ma, 2018, Angewandte Chemie.

Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE.

K. Sharpless, J. Moses, S. Silverman, 2017, Chemistry.

Applications of Aziridinium Ions. Selective Syntheses of β-Aryl-α,β-diamino Esters

K. Sharpless, K. B. Sharpless, Tsung-Hsun Chuang and, 1999 .

Synthesis of vicinal diamines from cyclic sulfates

K. Sharpless, P. Richardson, L. Nelson, 1995 .

Highly Efficient Epoxidation of Olefins Using Aqueous H2O2 and Catalytic Methyltrioxorhenium/Pyridine: Pyridine-Mediated Ligand Acceleration

K. Sharpless, J. Rudolph, K. Reddy, 1997 .

Comparison of amine additives most effective in the new methyltrioxorhenium-catalyzed epoxidation process

K. Sharpless, H. Adolfsson, K. B. Sharpless, 1999 .

Primary amides. A general nitrogen source for catalytic asymmetric aminohydroxylation of olefins.

K. Sharpless, M. Bartsch, K. B. Sharpless, 2000, Organic letters.

A Highly Efficient Aminohydroxylation Process

K. Sharpless, A. Rubin, K. B. Sharpless, 1997 .

Applications of Aziridinium Ions: Selective Syntheses of Pyrazolidin-3-ones and Pyrazolo[1,2-a]pyrazoles

K. Sharpless, K. B. Sharpless, T. Chuang, 2000 .

CATALYTIC AMINOHYDROXYLATION USING ADENINE-DERIVATIVES AS THE NITROGEN SOURCE

D. Jerina, K. Sharpless, K. Dress, 1998 .

Tert-butylsulfonamide. A new nitrogen source for catalytic aminohydroxylation and aziridination of olefins.

K. Sharpless, H. Liu, K. B. Sharpless, 1999, Organic letters.

Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles as nitrogen sources.

K. Sharpless, K. Dress, H. Liu, 1999, Angewandte Chemie.

THE OSMIUM-CATALYZED AMINOHYDROXYLATION OF BAYLIS-HILLMAN OLEFINS

K. Sharpless, W. Pringle, K. B. Sharpless, 1999 .

A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanides.

K. Sharpless, K. B. Sharpless, Z. Demko, 2002, Angewandte Chemie.

Preparation of 5-substituted 1H-tetrazoles from nitriles in water.

K. Sharpless, K. B. Sharpless, Z. Demko, 2001, The Journal of organic chemistry.

A short route to a moshe'rs acid precursor via catalytic asymmetric dihydroxylation (AD)

K. Sharpless, K. B. Sharpless, Y. Bennani, 1994 .

Lower valent tungsten halides. New class of reagents for deoxygenation of organic molecules

K. Sharpless, K. B. Sharpless, M. Umbreit, 1972 .

Direct deoxygenation of vicinal diols with tungsten(IV). A new olefin synthesis

K. Sharpless, K. B. Sharpless, T. Flood, 1972 .

In situ click chemistry: a powerful means for lead discovery

K. Sharpless, K Barry Sharpless, Roman Manetsch, 2006, Expert opinion on drug discovery.

Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition.

Qian Wang, M. Finn, K. Sharpless, 2003, Journal of the American Chemical Society.

Synthesis of All Four Isomers of Disparlure Using Osmium-Catalyzed Asymmetric Dihydroxylation.

E. Keinan, K. Sharpless, S. Sinha, 1992 .

The asymmetric epoxidation of tert-butyl substituted allylic alcohols

K. Sharpless, K. B. Sharpless, M. J. Schweiter, 1985 .

Total Synthesis of the L-Hexoses

K. Sharpless, S. Masamune, S. Ko, 1983, Science.

Addition Reactions with Formation of Carbon–Oxygen Bonds: (ii) Asymmetric Methods of Epoxidation

K. Sharpless, Roy A. Johnson, K. B. Sharpless, 1991 .

8 – On the Mechanism of Asymmetric Epoxidation with Titanium—Tartrate Catalysts

M. Finn, K. Sharpless, K. B. Sharpless, 1985 .

Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes.

Craig J Hawker, Peng Wu, Arnulf Scheel, 2004, Angewandte Chemie.

Anhydrous tert-butyl hydroperoxide in toluene: the preferred reagent for applications requiring dry TBHP

K. Sharpless, K. B. Sharpless, B. E. Rossiter, 1983 .

Mechanistic studies on the Cu-catalyzed three-component reactions of sulfonyl azides, 1-alkynes and amines, alcohols, or water: dichotomy via a common pathway.

K. Sharpless, V. Fokin, Sukbok Chang, 2008, The Journal of organic chemistry.

Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification

Zoran Radić, Palmer Taylor, K. Barry Sharpless, 2014, Journal of medicinal chemistry.

New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases*

P. Taylor, M. Katalinić, K. Sharpless, 2011, The Journal of Biological Chemistry.

Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases*

P. Taylor, K. Sharpless, V. Fokin, 2012, The Journal of Biological Chemistry.

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase

P. Taylor, M. Katalinić, K. Sharpless, 2019, Toxicology and applied pharmacology.

Ligand‐Accelerated Catalysis

D. J. Berrisford, C. Bolm, K. Sharpless, 1995 .

The Osmium-Catalyzed Asymmetric Dihydroxylation: A New Ligand Class and a Process Improvement

Jens Hartung, K. Barry Sharpless, Kouhei Morikawa, 1992 .

New ligands double the scope of the catalytic asymmetric dihydroxylation of olefins

W. Amberg, T. Ukita, K. Sharpless, 1991 .

Selective transformations of threo-2,3-dihydroxy esters

K. Sharpless, K. B. Sharpless, P. Fleming, 1991 .

In situ opening of epoxy alcohols: a convenient alternative to the isolation of unstable epoxy alcohols

K. Sharpless, S. Ko, K. B. Sharpless, 1986 .

Nucleophilic opening of 2,3-epoxy acids and amides mediated by titanium isopropoxide. Highly enhanced C-3 selectivity

K. Sharpless, K. B. Sharpless, J. Chong, 1985 .

Two new asymmetric epoxidation catalysts. Unusual stoichiometry and inverse enantiofacial selection

M. Finn, K. Sharpless, Roy A. Johnson, 1984 .

Preclusion of the “second cycle” in the osmium-catalyzed asymmetric dihydroxylation of olefins leads to a superior process

K. Sharpless, K. B. Sharpless, Y. Ogino, 1990 .

Documenting the scope of the catalytic asymmetric dihydroxylation

K. Sharpless, B. Lohray, J. Wai, 1989 .

Rapid 'sar' via click chemistry : An alkyne-bearing spiramycin is fused with diverse azides to yield new triazole-antibacterial candidates

S. Ōmura, Y. Yamaguchi, K. Sharpless, 2006 .

Why is tetrazole formation by addition of azide to organic nitriles catalyzed by zinc(II) salts?

F. Himo, K. Sharpless, Louis Noodleman, 2003, Journal of the American Chemical Society.

An Expedient Route to the Tetrazole Analogues of α-Amino Acids

K. Sharpless, K. B. Sharpless, Z. Demko, 2002 .

An intramolecular [2 + 3] cycloaddition route to fused 5-heterosubstituted tetrazoles.

K. Sharpless, K. B. Sharpless, Z. Demko, 2001, Organic letters.

Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.

P. Taylor, K. Sharpless, Z. Kovarik, 2019, Toxicology letters.

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

I. Wilson, J. Kelly, E. Powers, 2013, Journal of the American Chemical Society.

Palladium-catalyzed, ligand-free Suzuki reaction in water using aryl fluorosulfates.

K. Sharpless, B. Jiang, P. Xing, 2015, Organic letters.

The first practical method for asymmetric epoxidation

K. Sharpless, T. Katsuki, K. B. Sharpless, 1980 .

In situ click chemistry: enzyme inhibitors made to their own specifications.

Zoran Radić, Palmer Taylor, P. Taylor, 2004, Journal of the American Chemical Society.

Using Sulfuramidimidoyl Fluorides that Undergo Sulfur(VI) Fluoride Exchange for Inverse Drug Discovery

J. Kelly, B. Hammock, C. Morisseau, 2020, Nature Chemistry.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

M. Finn, H. Kolb, K. Sharpless, 2001 .

Selenium dioxide oxidation of endocyclic olefins. Evidence for a dissociation-recombination pathway

M. Warpehoski, K. Sharpless, K. B. Sharpless, 1982 .

Allylic oxidation of olefins by catalytic and stoichiometric selenium dioxide with tert-butyl hydroperoxide

K. Sharpless, K. B. Sharpless, M. Umbreit, 1977 .

Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor

S. Ōmura, S. Hirono, H. Nakano, 2013, Proceedings of the National Academy of Sciences.

A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry.

Chi-Huey Wong, Shih-Jung Huang, Chi‐Huey Wong, 2003, Journal of the American Chemical Society.

Synthetic applications of arylselenenic and arylseleninic acids. Conversion of olefins to allylic alcohols and epoxides

K. Sharpless, K. B. Sharpless, T. Hori, 1978 .

Stereoselective epoxidation of acyclic allylic alcohols. A correction of our previous work.

K. Sharpless, K. B. Sharpless, T. Verhoeven, 1979 .

Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.

K. Sharpless, Guang Yang, Louis Noodleman, 2021, Journal of the American Chemical Society.

A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.

I. Wilson, J. Kelly, Yvonne S. Eisele, 2015, Journal of the American Chemical Society.

Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited.

K. Sharpless, V. Fokin, K. B. Sharpless, 2004, Organic letters.

Polytriazoles as Copper(I)‐Stabilizing Ligands in Catalysis.

K. Barry Sharpless, Valery V. Fokin, K. Sharpless, 2004 .

Regioselective azide opening of 2,3-epoxy alcohols by [Ti(O-i-Pr)2(N3)2]: synthesis of .alpha.-amino acids

P. Carlier, K. Sharpless, K. B. Sharpless, 1988 .

Osmium‐Catalyzed Vicinal Oxyamination of Olefins by Chloramine‐T: cis‐2‐(p‐Toluenesulfonamido)Cyclohexanol and 2‐Methyl‐3‐(p‐Toluenesulfonamido)‐2‐Pentanol

K. Sharpless, K. B. Sharpless, E. Herranz, 2003 .

Improvements in the osmium-catalyzed oxyamination of olefins by chloramine-T

K. Sharpless, K. B. Sharpless, E. Herranz, 1978 .

Stereospecific vicinal oxyamination of olefins by alkylimidoosmium compounds

K. Sharpless, L. Truesdale, K. B. Sharpless, 1978 .

Osmium-catalyzed vicinal oxyamination of olefins by N-chloro-N-argentocarbamates

K. Sharpless, K. B. Sharpless, S. Biller, 1978 .

Synthesis of dioxobis(tert-alkylimido)osmium(VIII) and oxotris(tert-alkylimido)osmium(VIII) complexes. Stereospecific vicinal diamination of olefins

K. Sharpless, K. Oshima, A. O. Chong, 1977 .

New reaction. Stereospecific vicinal oxyamination of olefins by alkyl imido osmium compounds

K. Sharpless, L. Truesdale, K. B. Sharpless, 1975 .

A simple method for the preparation of N-sulfonylsulfilimines from sulfides.

K. Sharpless, A. Marzinzik, K. B. Sharpless, 2001, The Journal of organic chemistry.

Asymmetric dihydroxylation of aryl allyl ethers

K. Sharpless, K. B. Sharpless, Z.‐M. Wang, 1993 .

A greatly improved procedure for ruthenium tetroxide catalyzed oxidations of organic compounds

V. Martín, K. Sharpless, P. Carlsen, 1981 .

A general approach to γ-lactones via osmium-catalyzed asymmetric dihydroxylation. Synthesis of (−)- and (+)-muricatacin.

E. Keinan, K. Sharpless, S. Sinha, 1992 .

Catalytic Asymmetric Dihydroxylation.

M. VanNieuwenhze, K. Sharpless, K. B. Sharpless, 2010 .

In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.

Zoran Radić, Palmer Taylor, P. Taylor, 2005, Journal of the American Chemical Society.

Modular click chemistry libraries for functional screens using a diazotizing reagent

K. Sharpless, Jiajia Dong, Genyi Meng, 2019, Nature.

Ruthenium-catalyzed cycloaddition of alkynes and organic azides.

Ian D. Williams, K. Sharpless, V. Fokin, 2006, Journal of the American Chemical Society.

Stereo and regioselective openings of chiral 2,3-epoxy alcohols. Versatile routes to optically pure natural products and drugs. Unusual kinetic resolutions

V. Martín, K. Sharpless, C. Behrens, 1983 .

Osmium catalyzed vicinal hydroxylation of olefins by tert-butyl hydroperoxide under alkaline conditions

K. Sharpless, K. B. Sharpless, Kageyasu Akashi, 1976 .

Asymmetric dihydroxylation (AD) of N,N-dialkyl and N-methoxy-N-methyl α,β- and β,γ-unsaturated amides

K. Sharpless, K. B. Sharpless, Y. Bennani, 1993 .

Sulfur fluoride exchange

K. Sharpless, H. Zuilhof, J. Moses, 2023, Nature Reviews Methods Primers.

High-performing polysulfate dielectrics for electrostatic energy storage under harsh conditions.

Boyce S. Chang, R. Ritchie, Zongren Peng, 2023, Joule.

Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors

D. Wolan, K. Sharpless, Stefano Forli, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Identification of simple arylfluorosulfates as potent agents against resistant bacteria

K. Sharpless, Xiangxiang Zhao, Jiajia Dong, 2021, Proceedings of the National Academy of Sciences.

Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

D. Wolan, B. Cravatt, K. Sharpless, 2020, bioRxiv.

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

D. Wolan, K. Sharpless, Stefano Forli, 2019 .

SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.

Peng Wu, Gencheng Li, K. Sharpless, 2018, Journal of the American Chemical Society.

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

B. Cravatt, Wentao Chen, J. Kelly, 2018, Journal of the American Chemical Society.

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.

I. Wilson, B. Cravatt, Wentao Chen, 2016, Journal of the American Chemical Society.

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

M. G. Finn, K. Barry Sharpless, Larissa B. Krasnova, 2014 .

SuFEx-based synthesis of polysulfates.

K. Sharpless, V. Fokin, J. Oakdale, 2014, Angewandte Chemie.

Heterogeneous catalytic asymmetric dihydroxylation: Use of a polymer-bound alkaloid

K. Sharpless, B. Kim, K. B. Sharpless, 1990 .

Asymmetric epoxidation of allyl alcohol: efficient routes to homochiral .beta.-adrenergic blocking agents

K. Sharpless, J. M. Klunder, S. Ko, 1986 .

Role of Architecture and Molecular Weight in the Formation of Tailor-Made Ultrathin Multilayers Using Dendritic Macromolecules and Click Chemistry

C. Hawker, K. Sharpless, V. Fokin, 2007 .

A New Approach to Osmium‐Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins

K. Sharpless, V. Fokin, R. Epple, 2002 .

Catalytic asymmetric synthesis of new halogenated chiral synthons

K. Sharpless, K. B. Sharpless, K. Vanhessche, 1997 .

A practical route to enantiopure 1,2-aminoalcohols

K. Sharpless, K. B. Sharpless, Han‐Ting Chang, 1996 .

Asymmetric dihydroxylation affords enantiomerically pure C12 building blocks from traps, traps, cis-1,5,9-cyclododecatriene

K. Sharpless, K. B. Sharpless, U. Hugger, 1995 .

Coelacanths and catalysis

K. Sharpless, K. B. Sharpless, 1994 .

[18F]SuFEx Click Chemistry Enabled Ultrafast Late-stage Radiosynthesis

Nan Wang, K. Sharpless, Peng Wu, 2020 .

Mechanism of epoxidation of olefins by covalent peroxides of molybdenum(VI)

K. Sharpless, D. Williams, K. B. Sharpless, 1972 .

Short and practical syntheses of(R)-(−)-carnitine and (R)-(−)-γ-amino-β-hydroxybutyric acid (GABOB)

H. Kolb, K. Sharpless, K. B. Sharpless, 1993 .

Titanium isopropoxide-mediated nucleophilic openings of 2,3-epoxy alcohols. A mild procedure for regioselective ring-opening

K. Sharpless, K. B. Sharpless, M. Caron, 1985 .

Ti(O-i-Pr)4-mediated nucleophilic openings of 2,3-epoxy alcohols. A mild procedure for regioselective ring-opening

K. Sharpless, K. B. Sharpless, M. Caron, 1985 .

Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.

F. Gillin, L. Eckmann, P. Hruz, 2009, Journal of medicinal chemistry.

Selenium dioxide oxidation of olefins. Evidence for the intermediacy of allylseleninic acids

K. Sharpless, K. B. Sharpless, R. Lauer, 1972 .

Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis

L. Eckmann, T. Lauwaet, K. Sharpless, 2020, PLoS neglected tropical diseases.

Homogeneous Selective Oxidation

K. Sharpless, J. Lyons, J. Halpern, 1977 .

Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia

L. Eckmann, K. Sharpless, V. Fokin, 2017, Antimicrobial Agents and Chemotherapy.

Mild procedure for the conversion of epoxides to allylic alcohols. First organoselenium reagent

K. Sharpless, K. B. Sharpless, R. Lauer, 1973 .

Reactions of selenoxides: Thermal -elimination and H218O exchange.

K. Sharpless, M. W. Young, K. B. Sharpless, 1973 .

Mechanisms of tetrazole formation by addition of azide to nitriles.

F. Himo, K. Sharpless, Louis Noodleman, 2002, Journal of the American Chemical Society.

Searching for new reactivity (Nobel lecture).

K. Sharpless, K. B. Sharpless, 2002, Angewandte Chemie.

Procedure for the catalytic asymmetric epoxidation of allylic alcohols in the presence of molecular sieves

K. Sharpless, R. M. Hanson, K. B. Sharpless, 1986 .

Electrophilic and nucleophilic organoselenium reagents. New routes to .alpha.,.beta.-unsaturated carbonyl compounds

K. Sharpless, K. B. Sharpless, A. Y. Teranishi, 1973 .

From Styrenes to Enantiopure α-Arylglycines in Two Steps

K. Sharpless, K. Reddy, K. B. Sharpless, 1998 .

Mechanism of the titanium-promoted deoxygenative coupling of allyl and benzyl alcohols to hydrocarbons

K. Sharpless, B. Åkermark, K. B. Sharpless, 1969 .

Asymmetric induction in the reaction of osmium tetroxide with olefins

K. Sharpless, S. Hentges, K. B. Sharpless, 1980 .

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation.

Zoran Radić, Palmer Taylor, Pascale Marchot, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Catalytic Asymmetric Aminohydroxylation (AA) of Olefins

Guigen Li, K. Sharpless, K. B. Sharpless, 1996 .

Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging*

P. Taylor, K. Sharpless, V. Fokin, 2011, The Journal of Biological Chemistry.

Identification of a new endogenous metabolite and the characterization of its protein interactions through an immobilization approach.

G. Siuzdak, S. Trauger, E. Kalisiak, 2009, Journal of the American Chemical Society.

On "The origin of high enantioselectivity in the dihydroxylation of olefins using osmium tetraoxide and cinchona alkaloid catalysts"

H. Kwong, P. Andersson, H. Kolb, 1993 .

Chiral hydroxamic acids as ligands in the vanadium catalyzed asymmetric epoxidation of allylic alcohols by tert-butyl hydroperoxide

R. Palermo, K. Sharpless, R. Michaelson, 1977 .

Conversion of allylic phenylselenides to the rearranged allylic chlorides by N-chlorosuccinimide. Mechanism of selenium-catalyzed allylic chlorination of .beta.-pinene

K. Sharpless, K. B. Sharpless, T. Hori, 1979 .

A simple life—finding function and making connections

K. Barry Sharpless, K. Sharpless, 2019, C&EN Global Enterprise.

Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group.

K. Sharpless, T. A. Spencer, K. B. Sharpless, 1970, The Journal of biological chemistry.

Bis(trimethylsilyl) Peroxide Extends the Range of Oxorhenium Catalysts for Olefin Epoxidation

A. Yudin, K. Sharpless, K. B. Sharpless, 1997 .

Toward an understanding of the high enantioselectivity in the osmium-catalyzed asymmetric dihydroxylation. 4. Electronic effects in amine-accelerated osmylations

H. Kwong, H. Kolb, K. Sharpless, 1997 .

The first d0 metallooxaziridines. Amination of olefins [1]

J. Ibers, K. Sharpless, L. S. Liebeskind, 1978 .

Mechanism of asymmetric epoxidation. 1. Kinetics

M. Finn, K. Sharpless, K. B. Sharpless, 1991 .

Mechanism of asymmetric epoxidation. 2. Catalyst structure

M. Finn, K. Sharpless, K. B. Sharpless, 1991 .

Automated Docking with Protein Flexibility in the Design of Femtomolar "Click Chemistry" Inhibitors of Acetylcholinesterase

Arthur J. Olson, Garrett M. Morris, Palmer Taylor, 2013, J. Chem. Inf. Model..

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

Steven M. Johnson, J. Sacchettini, K. Chiang, 2005, Journal of medicinal chemistry.

Selective asymmetric dihydroxylation of polyenes

Heinrich Becker, K. Barry Sharpless, K. Sharpless, 1995 .

Selective asymmetric dihydroxylation (AD) of dienes

K. Sharpless, K. B. Sharpless, G. Crispino, 1992 .

Preparation of 5‐Substituted 1H‐Tetrazoles from Nitriles in Water.

K. Sharpless, K. B. Sharpless, Z. Demko, 2002 .

GENERAL METHOD FOR DETERMINING ABSOLUTE CONFIGURATION OF ACYCLIC ALLYLIC ALCOHOLS

K. Nakanishi, V. Martín, K. Sharpless, 1982 .

Asymmetric epoxidation of homoallylic alcohols. Synthesis of (-)-γ-amino-β(R)-hydroxybutyric acid (GABOB)

K. Sharpless, K. B. Sharpless, B. E. Rossiter, 1984 .

SELENIUM DIOXIDE OXIDATION OF D-LIMONENE, A REINVESTIGATION

K. Sharpless, K. B. Sharpless, H. P. Jensen, 1975 .

Selenium dioxide oxidation of d-limonene. Reinvestigation

K. Sharpless, H. P. Jensen, 1975 .

Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1.

Su Seong Lee, K. Sharpless, Jaehong Lim, 2011, Journal of the American Chemical Society.

A Sulfilimine Bond Identified in Collagen IV

T. Veenstra, C. Sanders, T. Conrads, 2009, Science.

Facile thermal rearrangements of allyl selenides and diselenides. [1,3] and [2,3] Shifts

K. Sharpless, K. B. Sharpless, R. Lauer, 1972 .

Mechanism of the molybdenum and vanadium catalyzed epoxidation of olefins by alkyl hydroperoxides

K. Sharpless, A. O. Chong, K. B. Sharpless, 1977 .

A simplified procedure for the stereospecific transformation of 1,2-diols into epoxides

H. Kolb, K. Sharpless, K. B. Sharpless, 1992 .

Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE.

K. Sharpless, J. Moses, S. Silverman, 2017, Chemistry.

Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

F. Gillin, L. Eckmann, D. Berg, 2013, Proceedings of the National Academy of Sciences.

A SIMPLE AND EFFICIENT METHOD FOR THE PREPARATION OF PYRIDINE N-OXIDES

A. Yudin, K. Sharpless, C. Copéret, 1998 .

Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. Kinetics

P. Andersson, H. Kolb, K. Sharpless, 1994 .

Arenesulfonate derivatives of homochiral glycidol: versatile chiral building blocks for organic synthesis

K. Sharpless, J. M. Klunder, K. B. Sharpless, 1989 .

Osmium-catalyzed vicinal oxyamination of olefins by Chloramine-T

K. Sharpless, K. Oshima, A. O. Chong, 1976 .

Asymmetric Synthesis of γ-Hydroxy α,β-Unsaturated Amides via an AD-elimination Process; Synthesis of (+)-Coriolic Acid

K. Sharpless, K. B. Sharpless, Y. Bennani, 1993 .

Selenium dioxide oxidations of olefins. Trapping of the allylic seleninic acid intermediate as a seleninolactone

A. Vasella, K. Sharpless, D. Arigoni, 1973 .

Asymmetric dihydroxylation of primary allylic halides and a concise synthesis of (−)-diepoxybutane

K. Sharpless, K. B. Sharpless, K. Vanhessche, 1994 .

Improved enantioselectivity in asymmetric dihydroxylations of terminal olefins using pyrimidine ligands

H. Kolb, K. Sharpless, Kyu‐Sung Jeong, 1993 .

Titanium isopropoxide mediated formation of 2,3-epithio alcohols from 2,3-epoxy alcohols

K. Sharpless, Yun Gao, K. B. Sharpless, 1988 .

On the mechanism of titanium-tartrate catalyzed asymmetric epoxidation

K. Sharpless, K. B. Sharpless, S. S. Woodard, 1983 .

Selenium in natural products synthesis

K. Nicolaou, N. Petasis, K. Sharpless, 1984 .

Osmium-Catalyzed Asymmetric Dihydroxylation of Cyclic Cis-Disubstituted Olefins

K. Kakiuchi, K. Sharpless, K. B. Sharpless, 1994 .

Asymmetric dihydroxylation of olefins containing sulfur: Chemoselective oxidation of CC double bonds in the presence of sulfides, 1,3-dithianes, and disulfides

K. Sharpless, P. Walsh, S. King, 1994 .