B. Costa

发表

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt.

P. Perego, D. Colombo, F. Compostella, 2015, Organic & biomolecular chemistry.

The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.

F. Da Settimo, S. Taliani, C. Martini, 2017, ACS chemical neuroscience.

TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis.

B. Cosimelli, F. Da Settimo, S. Taliani, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy

F. Da Settimo, S. Taliani, C. Martini, 2016, Scientific Reports.

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.

Riccardo Petrelli, Barbara Costa, Ettore Novellino, 2005, Journal of medicinal chemistry.

Peripheral Benzodiazepine Receptor: Characterization in Human T-Lymphoma Jurkat Cells

C. Martini, A. Lena, V. Gremigni, 2006, Molecular Pharmacology.

An update into the medicinal chemistry of translocator protein (TSPO) ligands.

F. Da Settimo, S. Taliani, C. Martini, 2020, European journal of medicinal chemistry.

Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.

C. Martini, B. Costa, F. Besnard, 2006, Bioorganic & medicinal chemistry.

Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety.

F. Coppedè, C. Martini, D. Baldwin, 2017, Journal of affective disorders.

Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.

E. Novellino, F. Da Settimo, C. Martini, 2011, European journal of medicinal chemistry.

Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells.

C. Martini, M. Breschi, S. Fogli, 2015, Anticancer research.

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.

Barbara Costa, Ettore Novellino, Luciana Marinelli, 2014, Journal of medicinal chemistry.

N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.

E. Novellino, G. Greco, G. Primofiore, 2004, Journal of medicinal chemistry.

C-nucleoside analogues of furanfurin as ligands to A1 adenosine receptors.

C. Martini, K. Varani, B. Costa, 2000, Bioorganic & medicinal chemistry.

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage

C. Martini, C. Cavallini, B. Costa, 2017, Oxidative medicine and cellular longevity.

Iminosugar Analogues of Phosphatidyl Inositol as Potential Inhibitors of Protein Kinase B (Akt)

F. Nicotra, B. Costa, L. Gioia, 2011 .

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance

F. Da Settimo, S. Taliani, C. Martini, 2014, Apoptosis.

De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein

F. Da Settimo, S. Taliani, C. Martini, 2021, International journal of molecular sciences.

Regulation of agonist binding to rat ETB receptors by cations and GTPγS

A. Lucacchini, B. Costa, L. Giusti, 2001 .

ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells.

A. Lucacchini, B. Costa, L. Giusti, 2003, Biochemical pharmacology.

Translocator protein as a promising target for novel anxiolytics.

C. Martini, B. Costa, E. Da Pozzo, 2012, Current topics in medicinal chemistry.

Peripheral type benzodiazepine receptor in human parathyroid glands: Up-regulation in adenoma

P. Miccoli, M. Castagna, A. Lucacchini, 2004, Journal of endocrinological investigation.

New N6- or N(9)-hydroxyalkyl substituted 8-azaadenines or adenines as effective A1 adenosine receptor ligands.

A. Lucacchini, B. Costa, M. Leonardi, 2003, European journal of medicinal chemistry.

Erythro- and threo-2-hydroxynonyl substituted 2-phenyladenines and 2-phenyl-8-azaadenines: ligands for A1 adenosine receptors and adenosine deaminase.

B. Costa, L. Giusti, O. Livi, 2002, Farmaco.

Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.

C. Martini, A. Lucacchini, B. Costa, 1999, Journal of medicinal chemistry.

Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents

M. Trincavelli, C. Martini, B. Costa, 2018, Stem Cell Research & Therapy.

Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.

C. Martini, B. Costa, F. Besnard, 2003, Journal of medicinal chemistry.

Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: study of the structural features for BZR recognition.

C. Martini, B. Costa, S. Selleri, 1999, Bioorganic & medicinal chemistry.

Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.

E. Novellino, B. Cosimelli, G. Greco, 2009, Journal of medicinal chemistry.

Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands.

C. Martini, A. Lucacchini, B. Costa, 2002, Farmaco.

Synthesis and preliminary pharmacological evaluation of 5-hydroxy- and 5,6-dihydroxy-1,2,3,7,12,12a-hexahydrobenzo[5,6]cyclohepta[1,2,3-ij]isoquinoline derivatives as dopamine receptor ligands.

C. Martini, A. Lucacchini, B. Costa, 2001, Bioorganic & medicinal chemistry.

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.

E. Novellino, B. Cosimelli, G. Greco, 2011, European journal of medicinal chemistry.

Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.

Barbara Costa, Claudia Martini, C. Martini, 2002, Journal of medicinal chemistry.

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.

E. Novellino, G. Greco, F. Da Settimo, 2012, Journal of medicinal chemistry.

2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.

C. Martini, B. Costa, S. Selleri, 2001, Bioorganic & medicinal chemistry.

Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation.

C. Martini, B. Costa, P. Gratteri, 2005, Bioorganic & medicinal chemistry.

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

E. Novellino, B. Cosimelli, G. Greco, 2008, Journal of medicinal chemistry.

A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.

C. Martini, B. Costa, F. Besnard, 2005, Journal of medicinal chemistry.

Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists.

C. Martini, A. Lucacchini, G. Spoto, 2005, Journal of medicinal chemistry.

Benzodiazepine receptor ligands - Part II. Synthesis and biological evaluation of pyrazolo[5,1-c][1,2,4]benzotriazine 4-oxide

C. Martini, A. Lucacchini, B. Costa, 1998 .

2,9-disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: synthesis, biochemical and molecular modelling studies.

A. Bianucci, A. Coi, B. Costa, 2005, Bioorganic & medicinal chemistry.

Sugar-based enantiomeric and conformationally constrained pyrrolo[2,1-c][1,4]-benzodiazepines as potential GABAA ligands.

F. Nicotra, B. Costa, L. Cipolla, 2011, Journal of medicinal chemistry.

AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

C. Martini, M. Breschi, S. Fogli, 2015, Anti-cancer drugs.

Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.

B. Costa, F. Peri, P. Fusi, 2009, Journal of medicinal chemistry.

5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.

K. Klotz, A. Lavecchia, C. Martini, 2008, Bioorganic & medicinal chemistry.

18-kDa TranSlocator protein association complexes in the brain: from structure to function.

C. Martini, B. Costa, E. Da Pozzo, 2020, Biochemical pharmacology.

Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.

F. Da Settimo, S. Taliani, C. Martini, 2016, ACS chemical neuroscience.

Bioisosterism, enantioselectivity, and molecular modeling of new effective N6‐ and/or N(9)‐substituted 2‐phenyl adenines and 8‐aza analogs: Different binding modes to A1 adenosine receptors

A. Coi, A. Lucacchini, B. Costa, 2001 .

Synthesis and Benzodiazepine Receptor Binding Activity of 2, 9‐Disubstituted Quinolino[2′, 3′‐5, 4](3‐pyrazolino)[3, 2‐b]purin‐4‐ones

C. Martini, A. Lucacchini, B. Costa, 2002, Archiv der Pharmazie.

Carbonic anhydrase activation profile of indole-based derivatives

F. Da Settimo, S. Taliani, C. Martini, 2021, Journal of enzyme inhibition and medicinal chemistry.

Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells.

E. Novellino, F. Da Settimo, S. Taliani, 2017, ACS chemical neuroscience.

Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation

F. Da Settimo, S. Taliani, C. Martini, 2019, International journal of molecular sciences.

Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor

Barbara Costa, Ettore Novellino, Sara Bendinelli, 2013, PloS one.

Up-regulation of A(2A) adenosine receptors by proinflammatory cytokines in rat PC12 cells.

D. Tuscano, M. Trincavelli, C. Martini, 2002, Biochemical pharmacology.

PK 11195 differentially affects cell survival in human wild‐type and 18 kDa translocator protein‐silenced ADF astrocytoma cells

C. Martini, R. Vanacore, A. Lena, 2008, Journal of cellular biochemistry.

Chemical modification of the dihydropyridines binding sites by lysine reagent, pyridoxal 5′-phosphate

C. Martini, A. Lucacchini, B. Costa, 1998, Neurochemistry International.

Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells.

C. Martini, R. Vanacore, A. Lena, 2004, Biochemical pharmacology.

Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects

M. Trincavelli, C. Martini, B. Costa, 2018, Oxidative medicine and cellular longevity.

Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets

B. Costa, F. Peri, J. Weiss, 2011, Innate immunity.

Benzodiazepine receptor ligands. III. Synthesis and biological evaluation of 2- and/or 3-substituted pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides.

C. Martini, A. Lucacchini, B. Costa, 1999, Farmaco.

Phosphatidylinositol 3‐Phosphate Mimics Based on a Sulfoquinovose Scaffold: Synthesis and Evaluation as Protein Kinase B Inhibitors

F. Nicotra, P. Perego, D. Colombo, 2014 .

TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance

F. Da Settimo, S. Taliani, C. Martini, 2015, Apoptosis.

Loss of Cannabinoid‐Stimulated Guanosine 5′‐O‐(3‐[35S]Thiotriphosphate) Binding Without Receptor Down‐Regulation in Brain Regions of Anandamide‐Tolerant Rats

T. Rubino, D. Parolaro, B. Costa, 2000, Journal of neurochemistry.

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.

C. Martini, G. Cassano, A. Lucacchini, 2009, Endocrinology.

Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO).

E. Novellino, F. Da Settimo, S. Taliani, 2017, Journal of medicinal chemistry.

Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N‐Dialkyl‐2‐arylindol‐3‐ylglyoxylamides

E. Novellino, F. Da Settimo, S. Taliani, 2017, ChemMedChem.

A(2A) adenosine receptor ligands and proinflammatory cytokines induce PC 12 cell death through apoptosis.

D. Tuscano, M. Trincavelli, C. Martini, 2003, Biochemical pharmacology.

2,3-BUTANEDIONE INACTIVATES THE [3H]NITRENDIPINE BINDING SITES, WHEREAS DIETHYLPYROCARBONATE DOES NOT

C. Martini, A. Lucacchini, B. Costa, 1996, Neurochemistry International.

Oxytocin receptor polymorphisms and adult attachment style in patients with depression

Stefano Pini, Barbara Costa, Camilla Gesi, 2009, Psychoneuroendocrinology.

TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells.

C. Martini, A. Lena, V. Gremigni, 2008, Biochimica et biophysica acta.

PIGA (N,N‐Di‐n‐butyl‐5‐chloro‐2‐(4‐chlorophenyl)indol‐3‐ylglyoxylamide), a New Mitochondrial Benzodiazepine‐Receptor Ligand, Induces Apoptosis in C6 glioma Cells

F. Da Settimo, C. Martini, R. Vanacore, 2005, Chembiochem : a European journal of chemical biology.

Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations.

E. Novellino, F. Da Settimo, S. Taliani, 2019, ACS chemical neuroscience.

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being

F. Da Settimo, S. Taliani, C. Martini, 2016, International journal of molecular sciences.

Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma

E. Novellino, F. Da Settimo, S. Taliani, 2014, Scientific Reports.

Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity

S. Taliani, C. Martini, M. Morelli, 2011, Psychoneuroendocrinology.

Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme.

E. Novellino, F. Da Settimo, S. Taliani, 2018, Journal of medicinal chemistry.

Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety: Role in complicated grief

K. Domschke, C. Martini, D. Baldwin, 2018, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Mutation analysis of oxytocin gene in individuals with adult separation anxiety

A. Mucci, P. Bucci, C. Martini, 2009, Psychiatry Research.

Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection.

S. Taliani, C. Martini, B. Costa, 2015, Biochemical Society transactions.

Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.

C. Martini, B. Costa, F. Besnard, 2002, Journal of medicinal chemistry.

Translocator protein and steroidogenesis.

C. Martini, B. Costa, E. Da Pozzo, 2018, The Biochemical journal.

Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents

C. Martini, B. Costa, M. De Leo, 2018, Stem Cell Research & Therapy.

Characterization of a cloned xenopus laevis serotonin 5-HT1A receptor expressed in the NIH-3T3 cell line.

C. Martini, B. Costa, P. Malatesta, 1999, Brain research. Molecular brain research.