Weiping Zhang

发表

A multivalent vaccine candidate targeting enterotoxigenic Escherichia coli fimbriae for broadly protecting against porcine post-weaning diarrhea

Qiangde Duan, Shengmei Pang, Wenwen Wu, 2020, Veterinary Research.

MEFA (multiepitope fusion antigen)-Novel Technology for Structural Vaccinology, Proof from Computational and Empirical Immunogenicity Characterization of an Enterotoxigenic Escherichia coli (ETEC) Adhesin MEFA

Jianhan Chen, K. Lee, Qiangde Duan, 2017, Journal of vaccines & vaccination.

Techniques for chromosomal integration and expression optimization in Escherichia coli.

Yejun Wang, Weiping Zhang, G. Zhu, 2018, Biotechnology and bioengineering.

Prevalence of virulence genes in Escherichia coli strains recently isolated from young pigs with diarrhea in the US.

Weiping Zhang, D. Francis, Mojun Zhao, 2007, Veterinary microbiology.

Progress and Challenges in Vaccine development Against Enterotoxigenic Escherichia Coli (ETEC)-Associated porcine Post- Weaning Diarrhoea (PWD)

Weiping Zhang, 2014 .

Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity

D. Sack, Weiping Zhang, Xiaosai Ruan, 2015, PloS one.

Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans

D. Sack, Weiping Zhang, 2012, Expert review of vaccines.

Current Progress in Developing Subunit Vaccines against Enterotoxigenic Escherichia coli-Associated Diarrhea

D. Sack, Weiping Zhang, 2015, Clinical and Vaccine Immunology.

Antibodies induced by enterotoxigenic Escherichia coli (ETEC) adhesin major structural subunit and minor tip adhesin subunit equivalently inhibit bacteria adherence in vitro

Qiangde Duan, Weiping Zhang, R. Nandre, 2019, PloS one.

Co-administered Tag-Less Toxoid Fusion 3xSTaN12S-mnLTR192G/L211A and CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) Induce Neutralizing Antibodies to 7 Adhesins (CFA/I, CS1-CS6) and Both Enterotoxins (LT, STa) of Enterotoxigenic Escherichia coli (ETEC)

D. Sack, Qiangde Duan, Weiping Zhang, 2018, Front. Microbiol..

Enterotoxigenic Escherichia coli Adhesin-Toxoid Multiepitope Fusion Antigen CFA/I/II/IV-3xSTaN12S-mnLTG192G/L211A-Derived Antibodies Inhibit Adherence of Seven Adhesins, Neutralize Enterotoxicity of LT and STa Toxins, and Protect Piglets against Diarrhea

D. Sack, Qiangde Duan, Weiping Zhang, 2017, Infection and Immunity.

Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model.

Qiangde Duan, Weiping Zhang, R. Nandre, 2017, Vaccine.

Enterotoxigenic Escherichia coli heat-stable toxin and heat-labile toxin toxoid fusion 3xSTaN12S-dmLT induces neutralizing anti-STa antibodies in subcutaneously immunized mice.

Qiangde Duan, Weiping Zhang, R. Nandre, 2016, FEMS microbiology letters.

Antibodies derived from an enterotoxigenic Escherichia coli (ETEC) adhesin tip MEFA (multiepitope fusion antigen) against adherence of nine ETEC adhesins: CFA/I, CS1, CS2, CS3, CS4, CS5, CS6, CS21 and EtpA.

D. Sack, Qiangde Duan, Weiping Zhang, 2016, Vaccine.

Escherichia coli Expressing EAST1 Toxin Did Not Cause an Increase of cAMP or cGMP Levels in Cells, and No Diarrhea in 5-Day Old Gnotobiotic Pigs

Weiping Zhang, S. Crupper, B. Schultz, 2012, PloS one.

Current progress in developing subunit vaccines against enterotoxigenic Escherichia coli 1

D. Sack, Weiping Zhang, 2015 .

Significance of Heat-Stable and Heat-Labile Enterotoxins in Porcine Colibacillosis in an Additive Model for Pathogenicity Studies

R. Moxley, Jessica L. Freeling, Weiping Zhang, 2006, Infection and Immunity.

The flagella of F18ab Escherichia coli is a virulence factor that contributes to infection in a IPEC-J2 cell model in vitro.

Qiangde Duan, Weiping Zhang, G. Zhu, 2012, Veterinary microbiology.

Evaluation of Multivalent Enterotoxigenic Escherichia coli Vaccine Candidate MecVax Antigen Dose-Dependent Effect in a Murine Model

Qiangde Duan, Weiping Zhang, Hyesuk Seo, 2022, Applied and environmental microbiology.

Both enzymatic and non-enzymatic properties of heat-labile enterotoxin are responsible for LT-enhanced adherence of enterotoxigenic Escherichia coli to porcine IPEC-J2 cells.

R. Moxley, R. Kaushik, Weiping Zhang, 2013, Veterinary microbiology.

Intramuscularly Administered Enterotoxigenic Escherichia coli (ETEC) Vaccine Candidate MecVax Prevented H10407 Intestinal Colonization in an Adult Rabbit Colonization Model

Weiping Zhang, Ipshita Upadhyay, Siqi Li, 2022, Microbiology spectrum.

Development of effective vaccines for enterotoxigenic Escherichia coli.

Weiping Zhang, Hyesuk Seo, 2019, The Lancet. Infectious diseases.

Immunogenicity characterization of genetically fused or chemically conjugated heat‐stable toxin toxoids of enterotoxigenic Escherichia coli in mice and pigs

Qiangde Duan, Weiping Zhang, R. Nandre, 2019, FEMS microbiology letters.

Little Heterogeneity among Genes Encoding Heat-Labile and Heat-Stable Toxins of Enterotoxigenic Escherichia coli Strains Isolated from Diarrheal Pigs

Weiping Zhang, Chengxian Zhang, Chengxian Zhang, 2009, Applied and Environmental Microbiology.

Intradermally Administered Enterotoxigenic Escherichia coli Vaccine Candidate MecVax Induces Functional Serum Immunoglobulin G Antibodies against Seven Adhesins (CFA/I and CS1 through CS6) and Both Toxins (STa and LT)

D. Sack, Weiping Zhang, Carolina García, 2021, Applied and environmental microbiology.

Significance of Enterotoxigenic Escherichia coli (ETEC) Heat-Labile Toxin (LT) Enzymatic Subunit Epitopes in LT Enterotoxicity and Immunogenicity

Qiangde Duan, Weiping Zhang, Jiachen Huang, 2018, Applied and Environmental Microbiology.

Characterization of the Binding Specificity of K88ac and K88ad Fimbriae of Enterotoxigenic Escherichia coli by Constructing K88ac/K88ad Chimeric FaeG Major Subunits

Weiping Zhang, D. Francis, Ying Fang, 2008, Infection and Immunity.

The Intriguing Interaction of Escherichia coli with the Host Environment and Innovative Strategies To Interfere with Colonization: a Summary of the 2019 E. coli and the Mucosal Immune System Meeting

Weiping Zhang, E. Dudley, A. Svennerholm, 2020, Applied and Environmental Microbiology.

Construction and immunogenicity evaluation of an epitope-based antigen against swine influenza A virus using Escherichia coli heat-labile toxin B subunit as a carrier-adjuvant.

T. Opriessnig, Weiping Zhang, K. Yoon, 2013, Veterinary microbiology.

Multiepitope Fusion Antigen: MEFA, an Epitope- and Structure-Based Vaccinology Platform for Multivalent Vaccine Development.

K. Lee, Weiping Zhang, Siqi Li, 2021, Methods in molecular biology.

Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6)

D. Sack, Weiping Zhang, A. L. Bourgeois, 2019, Human vaccines & immunotherapeutics.

A Multiepitope Fusion Antigen Elicits Neutralizing Antibodies against Enterotoxigenic Escherichia coli and Homologous Bovine Viral Diarrhea Virus In Vitro

R. Isaacson, Weiping Zhang, David E. B. Knudsen, 2013, Clinical and Vaccine Immunology.

Review of Newly Identified Functions Associated With the Heat-Labile Toxin of Enterotoxigenic Escherichia coli

Qiangde Duan, Weiping Zhang, G. Zhu, 2019, Front. Cell. Infect. Microbiol..

Engineered recombinant Escherichia coli probiotic strains integrated with F4 and F18 fimbriae cluster genes in the chromosome and their assessment of immunogenic efficacy in vivo.

Yinhua Lu, Yu Jiang, Sheng Yang, 2020, ACS synthetic biology.

Structure, Enterotoxicity, and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Stable Type I Toxin (STa) and Derivatives

Qiangde Duan, Weiping Zhang, 2016 .

Vaccines against gastroenteritis, current progress and challenges

Qiangde Duan, Weiping Zhang, Hyesuk Seo, 2020, Gut microbes.

Escherichia coli Constructs Expressing Human or Porcine Enterotoxins Induce Identical Diarrheal Diseases in a Piglet Infection Model

Weiping Zhang, D. Francis, D. Robertson, 2008, Applied and Environmental Microbiology.

Genetic Fusions of Heat-Labile Toxoid (LT) and Heat-Stable Toxin b (STb) of Porcine Enterotoxigenic Escherichia coli Elicit Protective Anti-LT and Anti-STb Antibodies

Weiping Zhang, D. Francis, 2010, Clinical and Vaccine Immunology.

Characterization of Functional B-Cell Epitopes at the Amino Terminus of Shigella Invasion Plasmid Antigen B (IpaB)

Xinfeng Han, Weiping Zhang, Ipshita Upadhyay, 2022, Applied and environmental microbiology.

Toxicity and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Labile and Heat-Stable Toxoid Fusion 3xSTaA14Q-LTS63K/R192G/L211A in a Murine Model

Weiping Zhang, David E. B. Knudsen, D. Robertson, 2013, PloS one.

Neutralizing Anti-Heat-Stable Toxin (STa) Antibodies Derived from Enterotoxigenic Escherichia coli Toxoid Fusions with STa Proteins Containing N12S, L9A/N12S, or N12S/A14T Mutations Show Little Cross-Reactivity with Guanylin or Uroguanylin

Qiangde Duan, Weiping Zhang, Nan Xiao, 2017, Applied and Environmental Microbiology.

Heat-Labile- and Heat-Stable-Toxoid Fusions (LTR192G-STaP13F) of Human Enterotoxigenic Escherichia coli Elicit Neutralizing Antitoxin Antibodies

Weiping Zhang, J. Nataro, S. Lawson, 2011, Infection and Immunity.

Coimmunization with Two Enterotoxigenic Escherichia coli (ETEC) Fimbrial Multiepitope Fusion Antigens Induces the Production of Neutralizing Antibodies against Five ETEC Fimbriae (F4, F5, F6, F18, and F41)

Qiangde Duan, Shengmei Pang, Wenwen Wu, 2020, Applied and Environmental Microbiology.

Antibodies derived from a toxoid MEFA (multiepitope fusion antigen) show neutralizing activities against heat-labile toxin (LT), heat-stable toxins (STa, STb), and Shiga toxin 2e (Stx2e) of porcine enterotoxigenic Escherichia coli (ETEC)

Qiangde Duan, Weiping Zhang, R. Nandre, 2016, Veterinary Microbiology.

A Tripartite Fusion, FaeG-FedF-LT192A2:B, of Enterotoxigenic Escherichia coli (ETEC) Elicits Antibodies That Neutralize Cholera Toxin, Inhibit Adherence of K88 (F4) and F18 Fimbriae, and Protect Pigs against K88ac/Heat-Labile Toxin Infection

Weiping Zhang, T. Casey, Xiaosai Ruan, 2011, Clinical and Vaccine Immunology.

Genetic Fusions of Heat-Labile (LT) and Heat-Stable (ST) Toxoids of Porcine Enterotoxigenic Escherichia coli Elicit Neutralizing Anti-LT and Anti-STa antibodies

Weiping Zhang, J. Nataro, D. Francis, 2009, Infection and Immunity.

Flagella from F18+Escherichia coli play a role in adhesion to pig epithelial cell lines.

Qiangde Duan, Weiping Zhang, G. Zhu, 2013, Microbial pathogenesis.

Polyvalent Protein Adhesin MEFA-II Induces Functional Antibodies against Enterotoxigenic Escherichia coli (ETEC) Adhesins CS7, CS12, CS14, CS17, and CS21 and Heat-Stable Toxin (STa)

Weiping Zhang, Ipshita Upadhyay, Siqi Li, 2023, Applied and environmental microbiology.

A multi-epitope fusion antigen candidate vaccine for Enterotoxigenic Escherichia coli is protective against strain B7A colonization in a rabbit model

D. Sack, Weiping Zhang, R. Jones, 2022, PLoS neglected tropical diseases.

Modified Heat-Stable Toxins (hSTa) of Enterotoxigenic Escherichia coli Lose Toxicity but Display Antigenicity after Being Genetically Fused to Heat-Labile Toxoid LT(R192G)

Weiping Zhang, J. Nataro, D. Robertson, 2011, Toxins.

Characterization of Heat-Stable (STa) Toxoids of Enterotoxigenic Escherichia coli Fused to Double Mutant Heat-Labile Toxin Peptide in Inducing Neutralizing Anti-STa Antibodies

Weiping Zhang, J. Nataro, J. Clements, 2014, Infection and Immunity.

Multiepitope Fusion Antigen Induces Broadly Protective Antibodies That Prevent Adherence of Escherichia coli Strains Expressing Colonization Factor Antigen I (CFA/I), CFA/II, and CFA/IV

D. Sack, Weiping Zhang, Xiaosai Ruan, 2013, Clinical and Vaccine Immunology.

Preclinical Characterization of Immunogenicity and Efficacy against Diarrhea from MecVax, a Multivalent Enterotoxigenic E. coli Vaccine Candidate

D. Sack, Qiangde Duan, Weiping Zhang, 2021, Infection and immunity.

Application of a Novel Epitope- and Structure-Based Vaccinology-Assisted Fimbria-Toxin Multiepitope Fusion Antigen of Enterotoxigenic Escherichia coli for Development of Multivalent Vaccines against Porcine Postweaning Diarrhea

R. Moxley, Weiping Zhang, T. Lu, 2020, Applied and Environmental Microbiology.

Mapping the Neutralizing Epitopes of Enterotoxigenic Escherichia coli K88 (F4) Fimbrial Adhesin and Major Subunit FaeG

R. Moxley, Weiping Zhang, T. Lu, 2019, Applied and Environmental Microbiology.

Mapping the neutralizing epitopes of F18 fimbrial adhesin subunit FedF of enterotoxigenic Escherichia coli (ETEC)

R. Moxley, Weiping Zhang, T. Lu, 2019, Veterinary Microbiology.

Oral immunization of a live attenuated Escherichia coli strain expressing a holotoxin-structured adhesin-toxoid fusion (1FaeG-FedF-LTA₂:5LTB) protected young pigs against enterotoxigenic E. coli (ETEC) infection.

Weiping Zhang, Xiaosai Ruan, 2013, Vaccine.

Avirulent K88 (F4)+ Escherichia coli strains constructed to express modified enterotoxins protect young piglets from challenge with a virulent enterotoxigenic Escherichia coli strain that expresses the same adhesion and enterotoxins.

Weiping Zhang, D. Francis, Jun Lin, 2012, Veterinary microbiology.

Mapping the neutralizing epitopes of enterotoxigenic Escherichia coli (ETEC) K88 (F4) 1 fimbrial adhesin and major subunit FaeG 2

R. Moxley, Weiping Zhang, T. Lu, 2019 .

Feasibility of avian antibodies as prophylaxis against enterotoxigenic escherichia coli colonization

Weiping Zhang, J. Nataro, Kyle D Brumfield, 2022, Frontiers in Immunology.