H. Spits

发表

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Cinque S. Soto, U. Baxa, G. Chuang, 2013, Science.

Membranes of activated CD4+ T cells expressing T cell receptor (TcR) αβ or TcR γδ induce IgE synthesis by human B cells in the presence of interleukin‐4

H. Gascan, G. Aversa, J. D. de Vries, 1992 .

A common solution to group 2 influenza virus neutralization

Gira Bhabha, Damian C. Ekiert, Andrew B. Ward, 2013, Proceedings of the National Academy of Sciences.

The biology of innate lymphoid cells

H. Spits, D. Artis, 2015, Nature.

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

B. Blom, H. Spits, F. Scheeren, 2005, Nature Immunology.

Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.

C. Buskens, W. Bemelman, B. Blom, 2015, Immunity.

NK cells and type 1 innate lymphoid cells: partners in host defense

L. Lanier, H. Spits, J. Bernink, 2016, Nature Immunology.

Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer.

A. T. Te Velde, S. V. van Deventer, H. Spits, 2002, Gastroenterology.

Stable long‐term cultures of self‐renewing B cells and their applications

H. Spits, T. Beaumont, M. Kwakkenbos, 2016, Immunological reviews.

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

René Bernards, Hergen Spits, G. Daley, 2002, Genes & development.

Functional Differences between Human NKp44− and NKp44+ RORC+ Innate Lymphoid Cells

G. Kazemier, H. Spits, J. Mjösberg, 2012, Front. Immun..

Production of IL4 by human T cells and regulation of differentiation of T-cell subsets by IL4.

H. Spits, H. Yssel, P. Schneider, 1993, Research in immunology.

Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis.

H. Spits, H. Yssel, J. Pène, 2003, Blood.

Green fluorescent protein as a selectable marker of fibronectin-facilitated retroviral gene transfer in primary human T lymphocytes.

N. Taylor, K. Pollok, M. Boyer, 1999, Human gene therapy.

Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation–Strain-Promoted (4 + 2) Cycloaddition

H. Spits, F. V. van Delft, A. Westphal, 2017, Bioconjugate chemistry.

Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice.

T. Hanke, H. Spits, T. Cupedo, 2006, Blood.

Natural killer cell clones can efficiently process and present protein antigens.

J. Haanen, J. D. de Vries, M. Roncarolo, 1991, Journal of immunology.

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones.

W. V. van Blitterswijk, J. D. de Vries, H. Spits, 1984, Journal of immunological methods.

Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development

J. Phillips, J. Cupp, M. Roncarolo, 1993 .

T cell receptor‐dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity

M. Krangel, H. Band, M. Roncarolo, 2000, European journal of immunology.

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

A. Weiss, J. Bolen, H. Spits, 1996, The EMBO journal.

Developmental origin of pre-DC2.

B. Blom, H. Spits, R. Schotte, 2002, Human immunology.

CHAPTER 2 – Dendritic cells in the thymus

H. Spits, 2001 .

Th1‐ and Th2‐like subsets of innate lymphoid cells

H. Spits, J. Mjösberg, J. Bernink, 2013, Immunological reviews.

Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2

B. Blom, H. Spits, C. Helbig, 2013, Front. Immunol..

Transcriptional control of innate lymphoid cells

H. Spits, J. Mjösberg, C. Peters, 2012, European journal of immunology.

Particle-bound enzymes in the bloodstream form of Trypanosoma brucei.

F. Opperdoes, P. Borst, H. Spits, 1977, European journal of biochemistry.

BOB.1 controls memory B-cell fate in the germinal center reaction.

M. Doorenspleet, A. Tomilin, I. Blijdorp, 2019, Journal of autoimmunity.

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

T. Huizinga, R. Toes, H. Spits, 2015, Annals of the rheumatic diseases.

Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance.

A. Tarr, J. Ball, N. Kootstra, 2019, Journal of hepatology.

cells Distinct signals control the hematopoiesis of lymphoid-related dendritic

H. Spits, K. Georgopoulos, A. Galy, 2013 .

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

Kevin Camphausen, Jacques Neefjes, Peter A. van Veelen, 2006 .

Differentiation to Control Human Plasma Cell Is Coordinated with BCL 6 Down-Regulation STAT 3-Mediated Up-Regulation of BLIMP 1

H. Spits, T. Beaumont, M. Kwakkenbos, 2008 .

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

H. Ploegh, H. Spits, N. Stam, 1986, Journal of immunology.

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

C. Figdor, R. de Waal Malefyt, R. Kastelein, 1991, The Journal of experimental medicine.

Synergy between IL-15 and Id2 Promotes the Expansion of Human NK Progenitor Cells, Which Can Be Counteracted by the E Protein HEB Required To Drive T Cell Development

B. Blom, A. Bakker, H. Spits, 2010, The Journal of Immunology.

Innate lymphoid cells in inflammation and immunity.

Hergen Spits, G. Eberl, H. Spits, 2014, Immunity.

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

W. Fokkens, R. Lutter, H. Spits, 2016, Nature Immunology.

Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.

A. T. Te Velde, H. Spits, J. Mjösberg, 2014, The Journal of investigative dermatology.

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells☆

P. Klenerman, G. Ogg, I. Panse, 2014, The Journal of allergy and clinical immunology.

Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells.

M. Rijn, M. van de Rijn, H. Spits, 1986, Science.

Melanoma cells can be eliminated by sialylated CD43 × CD3 bispecific T cell engager formats in vitro and in vivo

S. H. van der Burg, M. A. Gillissen, A. Bakker, 2020, Cancer Immunology, Immunotherapy.

Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset.

J. Cupp, H. Spits, N. Wrighton, 1991, Journal of immunology.

CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells.

F. Staal, H. Spits, E. Martínez-Cáceres, 1996, Blood.

Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus.

H. Spits, F. Vyth-Dreese, P. Res, 1999, Blood.

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors.

H. Spits, A. Venkitaraman, A. Stegmann, 1999, Immunity.

TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation.

J. V. van Dongen, B. Blom, M. Heemskerk, 1999, Blood.

IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis.

K. Karube, R. Bende, L. Smit, 2008, Blood.

Constitutively Active β-Catenin Promotes Expansion of Multipotent Hematopoietic Progenitors in Culture1

K. Garrett, Y. Baba, H. Spits, 2006, The Journal of Immunology.

Progenitors in Culture Expansion of Multipotent Hematopoietic -Catenin Promotes b Constitutively Active

K. Garrett, Y. Baba, H. Spits, 2006 .

Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming (vol 16, pg 123, 2010)

A. Radbruch, A. Bakker, H. Spits, 2010 .

Heterogeneity of type 2 innate lymphoid cells

H. Spits, J. Mjösberg, 2022, Nature Reviews Immunology.

Innate Lymphoid Cells: 10 Years On

R. Locksley, M. Colonna, F. Powrie, 2018, Cell.

Innate lymphoid cells: from helper to killer.

H. Spits, L. Krabbendam, J. Bernink, 2020, Current opinion in immunology.

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3

Marjolein J. W. de Bruijn, R. Hendriks, H. Spits, 2019, The Journal of experimental medicine.

IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

W. Fokkens, P. Hellings, S. Seys, 2019, Nature Communications.

New insights into the function, development, and plasticity of type 2 innate lymphoid cells

H. Spits, L. Krabbendam, S. Bal, 2018, Immunological reviews.

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Åsa K. Björklund, B. Blom, H. Spits, 2017, Cell reports.

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

J. D. Di Santo, N. Huntington, A. Bakker, 2011, Proceedings of the National Academy of Sciences.

Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice.

M. A. Gillissen, A. Bakker, H. Spits, 2017, Blood advances.

Human reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient

T. Schumacher, J. Haanen, H. Spits, 2008 .

CD2/LFA‐3 or LFA‐l/ICAM‐1 but not CD28/B7 interactions can augment cytotoxicity by virus‐specific CD8+ cytotoxic T lymphocytes

R. de Waal Malefyt, H. Spits, S. Verma, 1993, European journal of immunology.

that activated STAT5 is required for Hodgkin lymphomagenesis IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence

K. Karube, L. Smit, K. Ohshima, 2008 .

A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease.

D. Ruiter, H. Spits, T. D. de Witte, 2000, Blood.

A combination of anti-CD 3 and anti-CD 7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease

D. Ruiter, H. Spits, F. Preijers, 2022 .

Characterization of melanoma‐associated surface antigens involved in the adhesion and motility of human melanoma cells

C. Figdor, D. Ruiter, A. T. Te Velde, 1986, International journal of cancer.

Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria.

T. Ottenhoff, J. Haanen, H. Spits, 1990, Journal of immunology.

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

J. Neefjes, H. Spits, F. Momburg, 1992, Nature.

A New Mechanism of NK Cell Cytotoxicity Activation: The CD40–CD40 Ligand Interaction

H. Spits, E. Carbone, K. Kärre, 1997, The Journal of experimental medicine.

A new edge to immune surveillance by the neural system

H. Spits, W. Jonge, J. Bernink, 2016, Cell Research.

CD 34 + CD 38 dim Cells in the Human Thymus Can Differentiate Into T , Natural Killer , and Dendritic Cells But Are Distinct From Pluripotent Stem Cells

F. Staal, H. Spits, E. Martínez-Cáceres, 2002 .

Gastrointestinal , Hepatobiliary and Pancreatic Pathology Repopulation Efficiencies of Adult Hepatocytes , Fetal Liver Progenitor Cells , and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice

Q. Yuan, M. Manns, T. Cantz, 2010 .

Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

M. Ott, J. D. Di Santo, N. Huntington, 2010, PloS one.

Ontogeny of Human Natural Killer (NK) Cells: Fetal NK Cells Mediate Cytolytic Function and Express Cytoplasmic CD3e,~ Proteins

L. Lanier, A. Nagler, J. Phillips, 2003 .

New models of human immunity

H. Spits, 2014, Nature Biotechnology.

The modified FACS calcein AM retention assay: A high throughput flow cytometer based method to measure cytotoxicity.

M. A. Gillissen, H. Spits, G. de Jong, 2016, Journal of immunological methods.

Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity

H. Ploegh, A. Bakker, H. Spits, 2014, Proceedings of the National Academy of Sciences.

UvA-DARE ( Digital Academic Repository ) Antigen-Specific Monoclonal Antibodies Isolated from B Cells Expressing Constitutively Active STAT 5

Beaumont, H. Spits, F. Scheeren, 2011 .

Antigen-Specific Monoclonal Antibodies Isolated from B Cells Expressing Constitutively Active STAT5

H. Spits, T. Beaumont, F. Scheeren, 2011, PloS one.

Selection of a human T helper type 1-like T cell subset by mycobacteria

Elizabeth, Waal, Pieter, 1991, The Journal of experimental medicine.

Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis.

H. Spits, M. Nagasawa, X. R. Ros, 2018, Cold Spring Harbor perspectives in biology.

The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone.

B. Alarcón, H. Spits, H. Yssel, 1987, Proceedings of the National Academy of Sciences of the United States of America.

stress-induced apoptosis and regulatory T cell clones and confers resistance to oxidative Ectopic hTERT expression extends the life span of human CD4+ helper

H. Spits, H. Yssel, J. Pène, 2013 .

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

M. Manns, M. Ott, C. Rice, 2009, Cell host & microbe.

Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.

T. Schumacher, H. Spits, R. Luiten, 2012, Results in immunology.

Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells.

T. Schumacher, H. Spits, E. Hooijberg, 1999, Cellular immunology.

Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines.

J. Borst, J. D. de Vries, H. Spits, 1983, Hybridoma.

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

J. Banchereau, J. D. de Vries, H. Spits, 1988, Journal of immunology.

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

K. Arai, J. Banchereau, T. Yokota, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation.

H. Ploegh, H. Spits, K. Wagner, 2019, Methods.

Human T-Cell Biology in a Mouse Environment

H. Spits, N. Legrand, 2014 .

A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.

A. Hagenbeek, G. Storm, H. Spits, 2003, Blood.

double-mutant mice-/-c γ-/-transfer of human peripheral blood mononuclear cells in RAG 2 A new xenograft model for graft-versus-host disease by intravenous

A. Hagenbeek, G. Storm, H. Spits, 2003 .

A novel Flt3‐deficient HIS mouse model with selective enhancement of human DC development

A. Toubert, H. Spits, H. Strick-Marchand, 2016, European Journal of Immunology.

Cell Reconstitution after Bone Prior to Recovery of Thymopoiesis and Flt 3 Ligand Expands Lymphoid Progenitors

F. Staal, E. Wils, H. Spits, 2007 .

Flt3 Ligand Expands Lymphoid Progenitors Prior to Recovery of Thymopoiesis and Accelerates T Cell Reconstitution after Bone Marrow Transplantation1

F. Staal, E. Wils, H. Spits, 2007, The Journal of Immunology.

Marrow Transplantation Accelerates T Cell Reconstitution after Bone Prior to Recovery of Thymopoiesis and Flt3 Ligand Expands Lymphoid Progenitors

F. Staal, E. Wils, H. Spits, 2007 .

Peripheral T Cell Homeostasis Mice without Affecting - / - c g IL-2R - / - Rag2 Development in ''Human Immune System'' IL-7 Enhances Thymic Human T Cell

B. Blom, A. Bakker, H. Spits, 2009 .

IL-7 Enhances Thymic Human T Cell Development in “Human Immune System” Rag2−/−IL-2Rγc−/− Mice without Affecting Peripheral T Cell Homeostasis1

B. Blom, J. D. Di Santo, A. Bakker, 2009, The Journal of Immunology.

Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice

B. Blom, A. Berns, H. Spits, 1999, The Journal of experimental medicine.

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.

P. Borst, H. Spits, O. van Tellingen, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity.

J. D. de Vries, H. Spits, C. Terhorst, 1982, Journal of immunology.

Characterization of a third form of the human T cell receptor gamma/delta

J. Seidman, J. Mclean, J. Strominger, 1988, The Journal of experimental medicine.

CD40 is functionally expressed on human thymic epithelial cells.

H. Spits, A. Galy, 1992, Journal of immunology.

Accelerated thymopoiesis and improved T‐cell responses in HLA‐A2/‐DR2 transgenic BRGS‐based human immune system mice

Y. Lévy, J. D. Di Santo, O. Schwartz, 2019, European journal of immunology.

Human innate lymphoid cells.

H. Spits, M. Hazenberg, 2014, Blood.

Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse.

J. McCune, J. Krowka, J. D. de Vries, 1991, Journal of immunology.

Autonomous and extrinsic regulation of thymopoiesis inhuman immune system (HIS) mice

J. D. Di Santo, N. Huntington, A. Plet, 2011, European journal of immunology.

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell–dependent antibody responses in vivo

J. D. Di Santo, N. Huntington, A. Plet, 2011, Proceedings of the National Academy of Sciences.

stem cells natural killer, and dendritic cells but are distinct from pluripotent CD34+CD38dim cells in the human thymus can differentiate into T,

F. Staal, H. Spits, E. Martínez-Cáceres, 2011 .

Downregulation of CD1 Marks Acquisition of Functional Maturation of Human Thymocytes and Defines a Control Point in Late Stages of Human T Cell Development

B. Blom, H. Spits, T. Hori, 1997, The Journal of experimental medicine.

Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus.

M. Roncarolo, H. Spits, M. Muench, 1995, Leukemia & lymphoma.

Critical assessment of human antibody generation in humanized mouse models.

H. Spits, R. Schotte, J. Villaudy, 2014, Journal of immunological methods.

Coexpression of the human HLA-A2 or HLA-B7 heavy chain gene and human beta 2-microglobulin gene in L cells.

H. Spits, R. Maziarz, C. Terhorst, 1984, Journal of immunology.

Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes.

J. Strominger, M. Krangel, H. Spits, 1984, Journal of immunology.

Expansion of Interleukin‐22– and Granulocyte–Macrophage Colony‐Stimulating Factor–Expressing, but Not Interleukin‐17A–Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis

L. Rogge, I. Blijdorp, H. Spits, 2019, Arthritis & rheumatology.

PIM1 Reconstitutes Thymus Cellularity in Interleukin 7– and Common (cid:103) Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not CD3 (cid:103) -deﬁcient Mice

B. Blom, A. Berns, H. Spits, 1999 .

Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera

J. D. de Vries, M. Roncarolo, H. Spits, 1988, The Journal of experimental medicine.

Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen.

J. Borst, J. D. de Vries, H. Spits, 1985, Journal of immunology.

The induction of T cell-mediated cytolysis by monoclonal antibodies against the T cell receptor/CD3 complex.

H. Spits, J. Vries, H. Yssel, 1989, International reviews of immunology.

Human NaturalKillerCellCommitted Thymocytes and TheirRelationtotheT CellLineage

H. Spits, M. Sánchez, 1993 .

Recombinant interleukin 4 promotes the growth of human T cells.

K. Arai, J. Banchereau, T. Yokota, 1987, Journal of immunology.

Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies.

H. Spits, P. Capel, W. Tax, 1985, Journal of immunology.

Antigen‐specific cytotoxic T cell and antigen‐specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3

J. D. de Vries, H. Spits, J. Leeuwenberg, 1985, European journal of immunology.

The role of T cell differentiation markers in antigen-specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens.

J. Borst, J. D. de Vries, H. Spits, 1982, Journal of immunology.

CHARACTERIZATION OF A THIRD FORM OF THE HUMAN T CELL RECEPTOR y/S

J. Seidman, J. Mclean, J. Strominger, 2003 .

A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production

M. Krangel, H. Spits, H. Yssel, 1990, The Journal of experimental medicine.

A Distinct Wave of Human T Cell Receptor Y/b Lymphocytes in the Early Fetal Thymus: Evidence for Controlled Gene Rearrangement and Cytokine Production

M. Krangel, H. Spits, H. Yssel, 1990 .

Diversity and organization of human T cell receptor delta variable gene segments

M. Krangel, J. D. de Vries, H. Spits, 1989, The Journal of experimental medicine.

HLA‐DC antigens can serve as recognition elements for human cytotoxic T lymphocytes

J. Coligan, J. Borst, J. D. de Vries, 1984, European journal of immunology.

Functional and phenotypic differences between CD4+ and CD4- T cell receptor-gamma delta clones from peripheral blood.

J. D. de Vries, H. Spits, P. van Vlasselaer, 1991, Journal of immunology.

Evidence for a regulatory role of the T8 (CD8) antigen in antigen‐specific and anti‐T3‐(CD3)‐induced lytic activity of allospecific cytotoxic T lymphocyte clones

C. Melief, R. V. van Lier, H. Spits, 1986, European journal of immunology.

A cloned cytotoxic T-lymphocyte (CTL) line recognizing a subtype of HLA B27.

M. Breuning, H. Spits, J. de Vries, 1984, Human immunology.

Type 2 innate lymphoid cells–new members of the “type 2 franchise” that mediate allergic airway inflammation

H. Spits, J. Mjösberg, 2012, European journal of immunology.

Mechanisms of allergen-specific B cell tolerance in children with cow’s milk-oral immunotherapy and natural outgrowth of milk allergy

C. Akdis, K. Nadeau, S. Boyd, 2021 .

Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4.

J. Abrams, J. D. de Vries, M. Roncarolo, 1990, Journal of immunology.

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells

H. Spits, T. Cupedo, N. Crellin, 2010, The Journal of experimental medicine.

Human NKp 44 + IL-22 + cells and LTi-like cells constitute a stable RORC + lineage distinct from conventional natural killer cells

H. Spits, T. Cupedo, N. Crellin, 2010 .

In Vivo and Function of the Human Immune System Experimental Models to Study Development

H. Spits, N. Legrand, K. Weijer, 2006 .

IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines. Requirement of additional activation by phorbol myristate acetate for induction of homotypic cell adhesions.

C. Figdor, G. Lenoir, J. D. de Vries, 1989, Journal of immunology.

Modeling human lung infections in mice

H. Spits, J. Villaudy, 2019, Nature Biotechnology.

A Novel Mouse Model for Stable Engraftment of a Human Immune System and Human Hepatocytes

J. D. Di Santo, N. Huntington, H. Spits, 2015, PloS one.

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

J. D. Di Santo, N. Huntington, A. Plet, 2009, The Journal of experimental medicine.

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

J. Abrams, J. D. de Vries, H. Spits, 1988, Journal of immunology.

Early stages in human and mouse T-cell development.

H. Spits, Hergen Spits, 1994, Current opinion in immunology.

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1.

T. Mosmann, R. de Waal Malefyt, J. D. de Vries, 1990, Science.

The Loss of PTEN Allows TCR (cid:1)(cid:2) Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

Thijs J. Hagenbeek, J. Trapman, J. Nunès, 2004 .

Interplay between the TCR/CD3 Complex and CD4 or CD8 in the Activation of Cytotoxic T Lymphocytes

H. Spits, H. Yssel, J. Vries, 1989, Immunological reviews.

expansion of recent thymic emigrants bone marrow transplantation in T-cell-deficient mice by strong Interleukin-7 improves T-cell recovery after experimental T-cell-depleted

H. Spits, J. Cornelissen, E. Braakman, 2013 .

Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants.

B. van der Holt, H. Spits, B. Löwenberg, 2003, Blood.

Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

J. V. van Dongen, B. Blom, M. Heemskerk, 1999 .

In vitro-isolated human cytotoxic T-lymphocyte clones detect variations in serologically defined HLA antigens

M. Breuning, H. Spits, C. Russo, 2004, Immunogenetics.

IL-1, IL-4, and IFN-gamma differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells.

H. Spits, A. Galy, 1991, Journal of immunology.

Stimulation through CD50 (ICAM-3) induces both activation and programmed cell death of human thymocytes.

H. Spits, J. Martorell., E. Martínez-Cáceres, 1996, Tissue antigens.

A novel proangiogenic B cell subset is increased in cancer and chronic inflammation

C. Akdis, F. Castro-Giner, A. Straumann, 2020, Science Advances.

Isolation and in vitro generation of gene-manipulated human plasmacytoid and conventional dendritic cells.

J. Karrich, B. Blom, H. Spits, 2010, Methods in molecular biology.

Required To Drive T Cell Development Which Can Be Counteracted by the E Protein Expansion of Human NK Progenitor Cells , Synergy between IL-15 and Id 2 Promotes the Yasuda

B. Blom, A. Bakker, H. Spits, 2010 .

Innate lymphoid cells: The missing part of a puzzle in food allergy

S. Durham, C. Akdis, K. Nadeau, 2020, Allergy.

Development of αβ T cells in the human thymus

H. Spits, 2002, Nature Reviews Immunology.

Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes.

M. Arnaout, H. Spits, J. Pitt, 1984, The Journal of clinical investigation.

IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells

B. Blom, H. Spits, S. Diehl, 2012, Immunology and cell biology.

SnapShot: innate lymphoid cells.

H. Spits, D. Artis, J. Mjösberg, 2013, Immunity.

CD70 represents the human ligand for CD27.

R. V. van Lier, S. Lens, R. Hintzen, 1994, International immunology.

Functional expression of B7/BB1 on activated T lymphocytes

L. Lanier, J. Phillips, H. Spits, 1993, The Journal of experimental medicine.

Functional Expression of B7/BB1 on Activated

L. Lanier, J. Phillips, H. Spits, 1993 .

Reactivity of cloned, expressed human FcγRIII isoforms with monoclonal antibodies which distinguish cell-type-specific and allelic forms of FcγRIII

A. Borne, G. Peltz, T. Huizinga, 1990 .

The T cell receptor/T3 complex.

H. Spits, D. Gold, P. J. van den Elsen, 1986, The Year in immunology.

Group 2 innate lymphoid cells show up in the skin

H. Spits, 2013, Immunology and cell biology.

Anticorps anti-cd9 thérapeutique

H. Spits, P. V. Helden, R. Schotte, 2017 .

TCR Gene Rearrangements and Expression of the Pre-T Cell Receptor Complex During Human T-Cell Differentiation

B. Blom, M. Heemskerk, J. Dongen, 1999 .

Presence of Host‐Reactive and MHC‐Restricted T Cells in a Transplanted Severe Combined Immunodeficient (SCID) Patient Suggest Positive Selection and Absence of Clonal Deletion

M. Roncarolo, H. Spits, H. Yssel, 1990, Immunological reviews.

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

Thijs J. Hagenbeek, H. Spits, T. Hagenbeek, 2008, Leukemia.

The aryl hydrocarbon receptor: a sentinel safeguarding the survival of immune cells in the gut.

H. Spits, J. Mjösberg, 2012, Immunity.

A family of T-cell receptor molecules expressed on T-cell clones with different specificities for allomajor histocompatibility antigens.

J. Borst, J. D. de Vries, H. Spits, 1986, Human immunology.

T cell clones which share T cell receptor epitopes differ in phenotype, function and specificity

D. Blanchard, J. D. de Vries, H. Spits, 1986, European journal of immunology.

Recognition of HLA-A2 by cytotoxic T lymphocytes after DNA transfer into human and murine cells.

M. van de Rijn, J. Seidman, H. Spits, 1984, Science.

HLA Class‐II‐restricted Mycobacterium lepraereactive T‐Cell Clones from Leprosy Patients Established with a Minimal Requirement for Autologous Mononuclear Cells

T. Ottenhoff, J. Haanen, P. Klatser, 1986, Scandinavian Journal of Immunology.

The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

Thijs J. Hagenbeek, J. Trapman, J. Nunès, 2004, The Journal of experimental medicine.

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas.

Thijs J. Hagenbeek, C. Supuran, V. Imbert, 2013, Cancer letters.

The Role of the Common Gamma Chain of the IL-2, IL-4, IL-7 and IL-15 Receptors in Development of Lymphocytes. Constitutive Expression of Bcl-2 does not Rescue the Developmental Defects in Gamma Common-Deficient Mice

B. Blom, H. Spits, P. Krimpenfort, 1997 .

Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.

L. Lanier, J. Phillips, H. Spits, 1992, Journal of immunology.

Human T cell lines differing in phenotype and specificity are reactive with the same anti-idiotypic antibody.

J. Borst, J. D. de Vries, H. Spits, 1986, Journal of immunology.

A cloned human T cell line cytotoxic for autologous and allogeneic B lymphoma cells

J. D. de Vries, H. Spits, H. Yssel, 1984, The Journal of experimental medicine.

REGULATION OF HUMAN NK ACTIVITY AGAINST ADHERENT TUMOR TARGET CELLS BY MONOCYTE SUBPOPULATIONS, INTERLEUKIN-1, AND INTERFERONS

H. Spits, C. Figdor, J. Vries, 1982 .

Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells.

B. Blom, L. Lanier, J. Phillips, 1997, Journal of immunology.

Characterization of triple negative clones isolated from post-natal human thymus.

H. Spits, T. Hori, Toshiyuki Hori, 1991, Advances in experimental medicine and biology.

PJA-BP expression and TCR delta deletion during human T cell differentiation.

J. V. van Dongen, B. Blom, A. Bogers, 1998, International immunology.

PJA-BP expression and TCR δ deletion during human T cell differentiation

B. Blom, A. Bogers, J. Dongen, 1998 .

Complex rearrangements within the human J delta‐C delta/J alpha‐C alpha locus and aberrant recombination between J alpha segments.

H. Spits, H. Yssel, T. Boehm, 1988, The EMBO journal.

The role of ILC subsets in cancer.

H. Spits, M. Bruchard, 2022, Seminars in immunology.

Generation and Maintenance of Cloned Human T Cell Lines

H. Spits, H. Yssel, 2005, Current protocols in immunology.

Another armament in gut immunity: lymphotoxin-mediated crosstalk between innate lymphoid and dendritic cells.

H. Spits, 2011, Cell host & microbe.

Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture

J. D. de Vries, H. Spits, D. Schols, 1994, The Journal of experimental medicine.

In search of T-cell progenitors in the human foetal liver.

M. Roncarolo, H. Spits, M. Muench, 1994, Research in immunology.

Human fetal liver-derived CD7+CD2lowCD3-CD56- clones that express CD3 gamma, delta, and epsilon and proliferate in response to interleukin-2 (IL-2), IL-3, IL-4, or IL-7: implications for the relationship between T and natural killer cells.

L. Lanier, J. Phillips, H. Spits, 1992, Blood.

Membranes of activated CD4+ T cells expressing T cell receptor (TcR) alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4.

H. Gascan, G. Aversa, J. D. de Vries, 1992, European journal of immunology.

Comparison of target antigens of monoclonal reagents OKT5, OKT8, and Leu2A, which inhibit effector function of human cytotoxic T lymphocytes.

P. Snow, H. Spits, C. Terhorst, 1983, Hybridoma.

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR.

B. Blom, H. Spits, M. Oosterwegel, 1999, Seminars in immunology.

Thymic stromal lymphopoietin induces early human B‐cell proliferation and differentiation

B. Blom, H. Spits, F. Scheeren, 2010, European journal of immunology.

Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2.

J. D. de Vries, H. Spits, X. Paliard, 1991, Cellular immunology.

Structural and functional aspects of the T-cell differentiation antigens T3, T6, and T8.

M. van de Rijn, P. Snow, J. Borst, 1983, Haematology and blood transfusion.

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response.

Feng Q. He, S. Durham, W. Fokkens, 2021, Immunity.

A Novel B4,ce6 htegrin-associated Epithelial Cell Antigen Involved in Natural Killer Cell and Antigen-specific Cytotoxic T Lymphocyte Cytotoxicity

L. Lanier, H. Spits, M. Azuma, 2003 .

Chimerism and tolerance to host and donor in severe combined immunodeficiencies transplanted with fetal liver stem cells.

J. D. de Vries, M. Roncarolo, H. Spits, 1993, The Journal of clinical investigation.

A novel beta 4, alpha 6 integrin-associated epithelial cell antigen involved in natural killer cell and antigen-specific cytotoxic T lymphocyte cytotoxicity

L. Lanier, J. Phillips, H. Spits, 1991, The Journal of experimental medicine.

Induction of phenotypic differentiation, interleukin 2 production, and PHA responsiveness of "immature" human thymocytes by interleukin 1 and phorbol ester.

C. Figdor, J. D. de Vries, H. Spits, 1983, Journal of immunology.

Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2.

J. D. Di Santo, H. Spits, N. Crellin, 2010, Immunity.

THE STABILITY OF CELLS

H. Spits, 2017 .

IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter

G. Klein, N. Nagy, L. Kis, 2009, Proceedings of the National Academy of Sciences.

Genomic organization of the human T-cell antigen-receptor alpha/delta locus.

J. Strominger, M. Krangel, J. D. de Vries, 1988, Proceedings of the National Academy of Sciences of the United States of America.

HUMAN T CELL LINES DIFFERING IN REACTIVE WITH THE SAME PHENOTYPE AND SPECIFICITY ARE ANTI-IDIOTYPIC ANTIBODY'

J. Borst, H. Spits, J. Vries, 1986 .

Do human TH1 and TH2 CD4+ clones exist?

R. de Waal Malefyt, J. D. de Vries, M. Roncarolo, 1991, Research in immunology.

Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection.

B. Blom, H. Spits, C. Uittenbogaart, 2004, Journal of immunology.

Target antigen of monoclonal reagent S5.7: comparison with T3 antigen.

J. Borst, H. Spits, G. Rovera, 1983, Hybridoma.

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.

B. Blom, H. Spits, M. V. van Oers, 2014, Blood.

susceptibility to graft-versus-host disease Activated innate lymphoid cells are associated with a reduced

B. Blom, H. Spits, J. Mjösberg, 2014 .

The low-affinity receptor for IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens

J. Banchereau, J. Bonnefoy, H. Spits, 1988, The Journal of experimental medicine.

Interleukin-4 mediates CDS induction on human CD4+ T-cell clones

H. Spits, X. Paliard, J. Vries, 1988, Nature.

Distribution and functional analysis of a 120- to 130-kDa T-cell surface antigen.

J. Borst, J. D. de Vries, H. Spits, 1987, Cellular immunology.

Early stages in the development of human T, natural killer and thymic dendritic cells

B. Blom, M. Heemskerk, J. Dongen, 1998, Immunological reviews.

Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage.

B. Blom, H. Spits, P. Res, 1997, Journal of immunology.

Corrigendum: Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming

A. Radbruch, A. Bakker, H. Spits, 2016, Nature Medicine.

Antigen recognition by MHC-incompatible cells of a human mismatched chimera

J. D. de Vries, M. Roncarolo, H. Spits, 1988, The Journal of experimental medicine.

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons y and a and prostaglandin E 2 ( IgE regulation / lymphokines / IgE-binding factors / CD 23 ) JMR 6

J. Banchereau, J. Bonnefoy, H. Spits, 2022 .

and Spi-B dendritic cell versus T-cell lineage decision through control of GATA-3 Delta-like1-induced Notch1 signaling regulates the human plasmacytoid

B. Blom, H. Spits, F. Scheeren, 2012 .

Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B.

B. Blom, H. Spits, F. Scheeren, 2006, Blood.

A chemo-enzymatically linked bispecific antibody retargets T cells to a sialylated epitope on CD43 in acute myeloid leukemia.

M. A. Gillissen, A. Bakker, H. Spits, 2019, Cancer research.

Clonal analysis of differential lymphokine production in peptide and superantigen induced T cell anergy.

J. Lamb, J. D. de Vries, H. Spits, 1991, International immunology.

Development of retrovirally marked human T progenitor cells into mature thymocytes.

F. Staal, H. Spits, P. Res, 1995, International immunology.

Isolation of Human Innate Lymphoid Cells

H. Spits, L. Krabbendam, M. Nagasawa, 2018, Current protocols in immunology.

Analysis of antigen specificity of human TCR gamma delta + T cells.

H. Spits, H. Yssel, J. de Vries, 1990, Research in immunology.

Introduction of T cell receptor (TCR)-alpha cDNA has differential effects on TCR-gamma delta/CD3 expression by PEER and Lyon-1 cells.

R. de Waal Malefyt, B. Alarcón, J. D. de Vries, 1989, Journal of immunology.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

David K. Finlay, Linda V. Sinclair, Thijs J. Hagenbeek, 2008, Nature Immunology.

Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

K. Okkenhaug, D. Cantrell, H. Spits, 2008, Nature Immunology.

Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA‐1, Mo‐1 and p!50,95

C. Figdor, F. Miedema, J. Borst, 1985, European journal of immunology.

Human CD5+ Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34+ Progenitor Cells Is Regulated by Id2

B. Blom, H. Spits, M. Nagasawa, 2017, Front. Immunol..

Id2 and Id3 Inhibit Development of Cd34+ Stem Cells into Predendritic Cell (Pre-Dc)2 but Not into Pre-Dc1

A. Bakker, H. Spits, C. Uittenbogaart, 2000, The Journal of experimental medicine.

A permanent human cytotoxic T-cell line with high killing capacity against a lymphoblastoid B-cell line shows preference for HLA A, B target antigens and lacks spontaneous cytotoxic activity.

J. D. de Vries, H. Spits, C. Terhorst, 1981, Cellular immunology.

Neuropilin-1 flags lung-resident type 2 innate lymphoid cells

H. Spits, 2022, Nature Immunology.

Evidence for controlled gene rearrangements and cytokine production during development of human TCR gamma delta+ lymphocytes.

M. Krangel, H. Spits, H. Yssel, 1991, Current topics in microbiology and immunology.

Triggering of cytotoxic T lymphocytes and NK cells via the Tp103 pathway is dependent on the expression of the T cell receptor/CD3 complex.

J. D. de Vries, H. Spits, B. Fleischer, 1988, Journal of immunology.

Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes.

J. Borst, J. D. de Vries, H. Spits, 1986, Journal of immunology.

Complex rearrangements within thehuman J- CI/J.- Calocus andaberrant recombination between J.segments

T. Rabbitts, H. Spits, H. Yssel, 1988 .

GATA2 haploinsufficient patients lack innate lymphoid cells that arise after hematopoietic cell transplantation

B. Blom, H. Spits, L. Krabbendam, 2022, Frontiers in Immunology.

Use of bicistronic retroviral vectors encoding the LacZ gene together with a gene of interest: a method to select producer cells and follow transduced target cells.

F. Staal, A. Bakker, H. Spits, 1996, Cancer gene therapy.

Comparative analysis of CD8 expressed on mature CD4+ CD8+ T cell clones cultured with IL-4 and that on CD8+ T cell clones: implication for functional significance of CD8 beta.

H. Spits, M. Ranes, T. Hori, 1991, International immunology.

Human ILC1: To Be or Not to Be

H. Spits, J. Mjösberg, J. Bernink, 2017, Immunity.

The role of the T cell receptor, CD8, and LFA-1 in different stages of the cytolytic reaction mediated by alloreactive T lymphocyte clones.

J. Borst, J. D. de Vries, H. Spits, 1987, Journal of immunology.

The role of T8 in the cytotoxic activity of cloned cytotoxic T lymphocyte lines specific for class II and class I major histocompatibility complex antigens.

J. D. de Vries, H. Spits, H. Yssel, 1985, Journal of immunology.

Cytotoxic activity and lymphokine production of T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-gamma delta+ CTL clones is affected by mutations at positions 152 and 156.

V. Engelhard, J. D. de Vries, H. Spits, 1990, Journal of immunology.

IL-7-mediated protection against minor-antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells.

E. Wils, H. Spits, B. Löwenberg, 2007, Haematologica.

Stem Cell Factor Consistently Improves Thymopoiesis after Experimental Transplantation of Murine or Human Hematopoietic Stem Cells in Immunodeficient Mice

E. Wils, H. Spits, J. Cornelissen, 2011, The Journal of Immunology.

Regulation by anti-CD2 monoclonal antibody of the activation of a human T cell clone induced by anti-CD3 or anti-T cell receptor antibodies.

J. D. de Vries, H. Spits, H. Yssel, 1987, Journal of immunology.

cell precursors in vivo Intrathymic and extrathymic development of human plasmacytoid dendritic

B. Blom, J. Seppen, H. Spits, 2013 .

The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development.

H. Spits, R. Schotte, F. Brière, 2003, Blood.

Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo.

B. Blom, J. Seppen, H. Spits, 2002, Blood.

Stem Cells into Predendritic Cell (Pre-DC)2 but Not into Pre-DC1: Evidence for a Lymphoid Origin of Pre-DC2

A. Bakker, H. Spits, C. Uittenbogaart, 2000 .

Distinct signals control the hematopoiesis of lymphoid-related dendritic cells.

G. Liu, H. Spits, K. Georgopoulos, 2000, Blood.

Evidence of innate lymphoid cell redundancy in humans

A. Fischer, C. Picard, N. Mahlaoui, 2016, Nature Immunology.

CD4 is involved in a post-binding event in the cytolytic reaction mediated by human CD4+ cytotoxic T lymphocyte clones.

J. D. de Vries, H. Spits, D. Blanchard, 1988, Journal of immunology.

Both Fc receptors and lymphocyte‐function‐associated antigen 1 on human Tγ lymphocytes are required for antibody‐dependent cellular cytotoxicity (killer cell activity)

F. Miedema, H. Spits, P. Tetteroo, 1984, European journal of immunology.

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

T. Schumacher, M. V. van Buuren, J. Beijnen, 2020, Journal for ImmunoTherapy of Cancer.

A comparative study of four cytochemical detection methods of concanavalin A binding sites on the cell membrane.

John G. Collard, H. Spits, J. Temmink, 1975, Experimental cell research.

Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3.

M. Heemskerk, A. Bakker, H. Spits, 1999, Blood.

Functionally distinct subsets of human gamma/delta T cells.

H. Spits, M. Brenner, C. Martínez, 1991, European journal of immunology.

The developmental relationship between NK cells and T cells.

L. Lanier, J. Phillips, H. Spits, 1992, Immunology today.

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

K. Camphausen, J. Schlom, J. Neefjes, 2006, The Journal of experimental medicine.

Innate lymphoid cells — a proposal for uniform nomenclature

Eric Vivier, Shigeo Koyasu, David Artis, 2013, Nature Reviews Immunology.

Human Telomerase Reverse Transcriptase-Transduced Human Cytotoxic T Cells Suppress the Growth of Human Melanoma in Immunodeficient Mice

Erik Hooijberg, Hergen Spits, T. Schumacher, 2004, Cancer Research.

Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones

H. Gascan, J. D. de Vries, M. Roncarolo, 1991, The Journal of experimental medicine.

The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development

B. Blom, H. Spits, R. Schotte, 2004, The Journal of experimental medicine.

Innate lymphoid cells in inflammatory bowel diseases.

H. Spits, J. Mjösberg, C. Peters, 2016, Immunology letters.

Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens

Mark S. Anderson, J. Marioni, V. van Unen, 2019, Front. Immunol..

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

L. Honigberg, Ashley M. Smith, A. Phillips, 2011, PloS one.

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

H. Spits, W. Fibbe, J. Grogan, 2009, Nature Immunology.

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

David K. Finlay, Linda V. Sinclair, Carmen Feijoo, 2009, The Journal of experimental medicine.

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model

M. Toribio, D. Scadden, F. Sánchez‐Madrid, 2018, The Journal of clinical investigation.

Neoantigen landscape dynamics during human melanoma–T cell interactions

T. Schumacher, S. Hadrup, J. Haanen, 2016, Nature.

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

Michael R Stratton, Arno Velds, Hergen Spits, 2014, Nature Medicine.

High-throughput identification of antigen-specific TCRs by TCR gene capture

T. Schumacher, D. Chudakov, C. Blank, 2013, Nature Medicine.

Reclassifying plasmacytoid dendritic cells as innate lymphocytes

F. Ginhoux, H. Spits, T. Ohteki, 2022, Nature Reviews Immunology.

Preferentially Stimulates Myeloid Cells Human Thymic Stromal Lymphopoietin

R. Kastelein, P. Reche, V. Soumelis, 2012 .

Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells1

R. de Waal Malefyt, R. Kastelein, P. Reche, 2001, The Journal of Immunology.

Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins

L. Lanier, A. Nagler, J. Phillips, 1992, The Journal of experimental medicine.

Generation of stable monoclonal antibody-producing BCR+ human memory B cells by genetic programming

Andreas Radbruch, A. Bakker, H. Spits, 2009, Nature Medicine.

myeloid-cell development fetal liver and thymus: CD7 expression in the early stages of T- and Phenotypic and functional analysis of T-cell precursors in the human

J. Phillips, J. Cupp, M. Roncarolo, 2011 .

Development of human lymphoid cells.

B. Blom, H. Spits, 2006, Annual review of immunology.

Early events in human intrathymic T-cell development.

J. Phillips, H. Spits, A. Galy, 1994, Research in immunology.

Human natural killer cell committed thymocytes and their relation to the T cell lineage

L. Lanier, J. Phillips, H. Spits, 1993, The Journal of experimental medicine.

Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development

H. Spits, A. Galy, S. Verma, 1993, The Journal of experimental medicine.

Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development.

J. Phillips, J. Cupp, M. Roncarolo, 1993, Blood.

STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation1

Hergen Spits, H. Spits, T. Beaumont, 2008, The Journal of Immunology.

Innate lymphoid cells: emerging insights in development, lineage relationships, and function.

Hergen Spits, H. Spits, T. Cupedo, 2012, Annual review of immunology.

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

G. Nolan, B. Blom, A. Bakker, 1997, The Journal of experimental medicine.

Development of human T and natural killer cells.

L. Lanier, J. Phillips, H. Spits, 1995, Blood.

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

H. Spits, U. Lindforss, E. Villablanca, 2020, Nature Communications.

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

H. Spits, U. Lindforss, E. Villablanca, 2020, Nature Communications.

Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

I. B. Borel Rinkes, C. Punt, S. Boj, 2022, Journal for ImmunoTherapy of Cancer.

Tumour-reactive B cells and antibody responses after allogeneic haematopoietic cell transplantation

M. A. Gillissen, H. Spits, M. Hazenberg, 2020, Immuno-oncology technology.

Identification of a Committed T Cell Precursor Population in Adult Human Peripheral Blood

M. Cella, H. Spits, M. Dessing, 1997, The Journal of experimental medicine.

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

H. Spits, J. P. Santo, 2011, Nature Immunology.

CD45RA+CD62L− ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs

Å. Keita, J. Söderholm, R. Pandey, 2022, Science Immunology.

CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease

C. Buskens, H. Spits, L. Krabbendam, 2021, Nature Communications.

Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells

H. Spits, R. D. de Vries, G. Magri, 2021, The Journal of experimental medicine.

Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector.

N. Taylor, P. Tiberghien, C. Ferrand, 2000, Blood.

Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients.

A. Berns, M. Gallee, W. Mooi, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Plasticity of innate lymphoid cell subsets

H. Spits, S. Bal, K. Golebski, 2020, Nature Reviews Immunology.

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Hergen Spits, Wytske J Fokkens, W. Fokkens, 2011, Nature Immunology.

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

H. Spits, E. Tran, N. Crellin, 2009, Nature Immunology.

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

C. Buskens, W. Bemelman, S. Meijer, 2013, Nature Immunology.

The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

Hergen Spits, Wytske J Fokkens, W. Fokkens, 2012, Immunity.

Human ectoenzyme-expressing ILC3: immunosuppressive innate cells that are depleted in graft-versus-host disease.

C. Buskens, W. Bemelman, B. Blom, 2019, Blood advances.

IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

W. Fokkens, S. Seys, H. Spits, 2019, Nature Communications.

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

Y. Shrestha, J. Koster, H. Spits, 2019, Nature Immunology.

Plasticity of innate lymphoid cell subsets

H. Spits, S. Bal, K. Golebski, 2020, Nature Reviews Immunology.

Human thymus regeneration and T cell reconstitution.

B. Blom, H. Spits, W. Dontje, 2007, Seminars in immunology.

Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.

B. Blom, H. Spits, E. Wijnands, 2004, Blood.

Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase1

Erik Hooijberg, Hergen Spits, J. Walboomers, 2000, The Journal of Immunology.

Telomerase levels control the lifespan of human T lymphocytes.

P. Lansdorp, H. Spits, H. Yssel, 2003, Blood.

Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of rapamycin) pathways control T lymphocyte trafficking

Ager, Thijs J. Hagenbeek, K. Okkenhaug, 2011 .

Experimental Models to Study Development and Function of the Human Immune System In Vivo

H. Spits, N. Legrand, K. Weijer, 2006, The Journal of Immunology.

Changing T cell specificity by retroviral T cell receptor display.

T N Schumacher, T. Schumacher, H. Spits, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Functionally distinct subsets of human γ/δ T cells

C. Martínez-A, H. Spits, M. Brenner, 1991 .

Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit.

Thijs J. Hagenbeek, S. Seshagiri, J. Stinson, 2014, Cancer letters.

IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.

C. Figdor, J. D. de Vries, H. Spits, 1988, Journal of immunology.

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

Thijs J. Hagenbeek, V. Imbert, J. Peyron, 2014, Leukemia.

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.

Thijs J. Hagenbeek, I. Ben-Sahra, F. Bost, 2013, Cancer letters.

Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?

H. Spits, É. Vivier, T. Cupedo, 2009, Nature Reviews Immunology.

Altered Frequencies and Functions of Innate Lymphoid Cells in Melanoma Patients Are Modulated by Immune Checkpoints Inhibitors

G. Viglietto, G. Madonna, D. Mallardo, 2022, Frontiers in Immunology.

Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases

W. Fokkens, D. Huylebroeck, Marjolein J. W. de Bruijn, 2021, Science Immunology.

Human innate lymphoid cells.

Hergen Spits, H. Spits, J. Mjösberg, 2016, The Journal of allergy and clinical immunology.

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.

R. de Waal Malefyt, J. Abrams, J. D. de Vries, 1992, Journal of immunology.

NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells.

A. Bakker, H. Spits, E. Hooijberg, 2000, Blood.

Genetic manipulation of B cells for the isolation of rare therapeutic antibodies from the human repertoire.

A. Bakker, H. Spits, T. Beaumont, 2014, Methods.

Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases

H. Spits, M. Shikhagaie, Kristine Germar, 2017, Nature Reviews Rheumatology.

Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2-/-γc-/-) mouse model

B. Berkhout, B. Blom, H. Spits, 2009, Gene Therapy.

development Stimulated plasmacytoid dendritic cells impair human T-cell

B. Blom, H. Spits, M. Spaargaren, 2013 .

Stimulated plasmacytoid dendritic cells impair human T-cell development.

B. Blom, H. Spits, M. Spaargaren, 2006, Blood.

Evidence of innate lymphoid cell redundancy in humans

A. Fischer, C. Picard, N. Mahlaoui, 2016, Nature Immunology.

Quantitative events determine the differentiation and function of helper T cells

Hergen Spits, H. Spits, A. O’Garra, 2011, Nature Immunology.

Tolerance to Alloantigens and Recognition for “Allo + X” Induced in Humans by Fetal Stem Cell Transplantation

M. Roncarolo, H. Spits, R. Bacchetta, 1994 .

T lymphocytes from human chimeras do recognize antigen in the context of allogeneic determinants of the major histocompatibility complex.

M. Roncarolo, H. Spits, J. Touraine, 1993, Immunology letters.

AML relapse after rituximab treatment for GvHD: crucial role for B cells in GvL responses

M. A. Gillissen, A. Bakker, H. Spits, 2016, Bone Marrow Transplantation.

Development and activation of regulatory T cells in the human fetus

B. Blom, H. Spits, T. Cupedo, 2005, European journal of immunology.

In vivo modulation of gene expression by lentiviral transduction in "human immune system" Rag2-/- gamma c -/- mice.

J. Karrich, B. Blom, H. Spits, 2010, Methods in molecular biology.

Experimental model for the study of the human immune system: production and monitoring of "human immune system" Rag2-/-gamma c-/- mice.

H. Spits, N. Legrand, K. Weijer, 2008, Methods in molecular biology.

AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses.

M. A. Gillissen, A. Bakker, H. Spits, 2018, Blood.

Human T4+ and T8+ cytotoxic T lymphocyte clones directed at products of different class II major histocompatibility complex loci.

J. D. de Vries, H. Spits, A. Thompson, 1983, Journal of immunology.

Therapeutic potential of genetically modified T-lymphocytes in Crohn's disease

S. Deventer, H. Spits, C. Montfrans, 2000 .

IL‐22‐producing CD4+ T cells: Middle‐men between the immune system and its environment

Hergen Spits, H. Spits, Sara Trifari, 2010, European journal of immunology.

Identification of human cytotoxic ILC3s

H. Spits, L. Krabbendam, J. Bernink, 2020, European journal of immunology.

Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules.

F. Spertini, R. Geha, H. Spits, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The role of ILC2 in pathology of type 2 inflammatory diseases.

H. Spits, J. Bernink, Kristine Germar, 2014, Current opinion in immunology.

Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression.

Hergen Spits, B. Blom, H. Spits, 2008, Blood.

Endogenous IFN-α Production by Plasmacytoid Dendritic Cells Exerts an Antiviral Effect on Thymic HIV-1 Infection1

B. Blom, H. Spits, C. Uittenbogaart, 2004, The Journal of Immunology.

Functional characterization of human IL-10.

R. de Waal Malefyt, H. Spits, H Spits, 1992, International archives of allergy and immunology.

T cell–independent development and induction of somatic hypermutation in human IgM+IgD+CD27+ B cells

H. Spits, F. Scheeren, T. Cupedo, 2008, The Journal of experimental medicine.

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

T. Huizinga, R. Toes, H. Spits, 2020, Science Translational Medicine.

The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation

H. Spits, D. Baeten, J. Cañete, 2017, Arthritis & rheumatology.

Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients.

T. Ottenhoff, J. Haanen, H. Spits, 1993, Journal of immunology.

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity.

H. Spits, K. Moore, D. Hsu, 1992, International immunology.

Reactivity of cloned, expressed human Fc gamma RIII isoforms with monoclonal antibodies which distinguish cell-type-specific and allelic forms of Fc gamma RIII.

G. Peltz, T. Huizinga, H. Spits, 1990, International immunology.

The role of Ca2+ and Mg2+ in the cytotoxic T lymphocyte reaction and in the secretion of N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester-serine esterase by human T cell clones.

J. D. de Vries, H. Spits, D. Blanchard, 1989, Journal of immunology.

Cell Surface Determinants Associated with the Interaction of Human CTL Clones and Autologous Tumor Cells

H. Spits, H. Yssel, J. Vries, 1985 .

Immunomodulation following vaccination with autologous, GM-CSF transduced and irradiated tumor cells in patients with advanced melanoma

M. Gallee, H. Spits, E. Rankin, 1997 .

Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity.

J. D. de Vries, H. Spits, J. D. Vries, 1984, Journal of immunology.

Cloning, expression, and crystallization of the Vδ domain of a human γδ T‐cell receptor

B. A. Fields, M. Lebedeva, R. Mariuzza, 1996, Protein science : a publication of the Protein Society.

Cloning, expression, and crystallization of the VS domain of a human y6 T-cell receptor

B. A. Fields, M. Lebedeva, R. Mariuzza, 1996 .

T cell precursors in man and mice.

B. Blom, H. Spits, P. Res, 1998, Critical reviews in immunology.

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

K. Arai, J. Banchereau, T. Yokota, 1988, Immunological reviews.

Progenitors Receptor Transfer into Hematopoietic Produced In Vitro Using Retroviral T Cell Functional Human Antigen-Specific T Cells

T. Schumacher, H. Spits, R. Schotte, 2007 .

Developmental stages in the human thymus.

H. Spits, P. Res, Hergen Spits">, 1999, Seminars in immunology.

Human T cell receptor gamma delta + T cells.

H. Spits, 1991, Seminars in immunology.

APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1

M. Hahne, H. Spits, D. Baeten, 2019, Front. Immunol..

Multiplex flow cytometry-based assay to study the breadth of antibody responses against E1E2 glycoproteins of hepatitis C virus.

N. Kootstra, A. Bakker, H. Spits, 2017, Journal of immunological methods.

Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance

B. Grady, A. Bakker, H. Spits, 2016, PloS one.

Natural killer or dendritic: what's in a name?

L. Lanier, H. Spits, 2007, Immunity.

The CD45 protein tyrosine phosphatase is required for the completion of the activation program leading to lymphokine production in the Jurkat human T cell line.

R. de Waal Malefyt, J. Peyron, H. Spits, 1991, International immunology.

Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies

J. Medema, C. Verrips, H. Spits, 2015, Molecular Cancer Therapeutics.

Effective Inhibition of Bone Morphogenetic ProteinFunctionbyHighlySpeci fi cLlama-Derived Antibodies

J. Medema, C. Verrips, H. Spits, 2015 .

Complexity of T cell receptor recognition sites for defined alloantigens.

J. Borst, J. D. de Vries, H. Spits, 1987, Journal of immunology.

Expression of the major histocompatibility antigens HLA-A2 and HLA-B7 by DNA-mediated gene transfer.

P. A. Biro, M. van de Rijn, H. Spits, 1983, Journal of Immunology.

In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells.

H. Spits, D. Schols, B. Vandekerckhove, 1994, Journal of immunology.

Generation and Characterization of Anti–Citrullinated Protein Antibody–Producing B Cell Clones From Rheumatoid Arthritis Patients

R. Toes, N. de Vries, L. Klareskog, 2019, Arthritis & rheumatology.

Polymorphism of Human Fc-Receptors for Mouse Igg1 and Igg2b

H. Spits, P. Capel, R. Koene, 1985 .

Human T cell leukemia/lymphoma virus type I infection of a CD4+ proliferative/cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells.

R. de Waal Malefyt, J. D. de Vries, H. Spits, 1989, Journal of immunology.

and XBP-1 expression Spi-B inhibits human plasma cell differentiation by repressing BLIMP1

B. Blom, H. Spits, F. Scheeren, 2013 .

Clonal analysis of human CD4-CD8-CD3- thymocytes highly purified from postnatal thymus.

H. Spits, T. Hori, 1991, Journal of immunology.

CD40 expressed on thymic epithelial cells provides costimulation for proliferation but not for apoptosis of human thymocytes.

H. Spits, D. Graf, E. M. Martínez Cáceres, 1996, Journal of immunology.

Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta+ and gamma delta+ human T cell clones isolated in IL-4.

H. Spits, D. Blanchard, H. Yssel, 1989, Journal of immunology.

Functional Human Antigen-Specific T Cells Produced In Vitro Using Retroviral T Cell Receptor Transfer into Hematopoietic Progenitors1

T. Schumacher, M. V. van Loenen, M. Heemskerk, 2007, The Journal of Immunology.

Regulatory role of the CD8 antigen in both CD3 and CD2 monoclonal antibody‐induced nonspecific cytotoxicity of class I‐ and class II‐allospecific cytotoxic T cell clones

H. Spits, G. V. van Seventer, K. C. Kuijpers, 1988, European journal of immunology.

PROPERTIES OF A PANEL OF MONOCLONAL ANTIBODIES WHICH REACT WITH THE HUMAN T CELL ANTIGEN RECEPTOR ON THE LEUKEMIC LINE T LYMPHOCYTES' HPB-ALL AND A SUBSET OF NORMAL PERIPHERAL BLOOD

J. Borst, H. Spits, D. Blanchard, 1986 .

Development of alphabeta T cells in the human thymus.

Hergen Spits, H. Spits, 2002, Nature reviews. Immunology.

The replacement of monocytes and interleukin-1 by phorbol ester in lectin-induced proliferation of human thymocytes and T cells.

P. Sminia, C. Figdor, J. D. de Vries, 1982, Immunobiology.

IL-4: Structure and Function

H. Spits, 1992 .

Innate immunity — phagocytes, natural killer cells and the complement system

C. Hack, H. Spits, D. Roos, 2005 .

Techniques for studying development of human natural killer cells and T cells.

H. Spits, P. Res, A. Jaleco, 2000, Methods in molecular biology.

Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

M. Stratton, S. Behjati, T. Schumacher, 2016, Nature Medicine.

Untransfected and SV40-transfected fetal and postnatal human thymic stromal cells. Analysis of phenotype, cytokine gene expression and cytokine production.

R. de Waal Malefyt, H. Spits, A. Galy, 1993, Thymus.

Use of a Novel Chimeric Mouse Model with a Functionally Active Human Immune System To Study Human Immunodeficiency Virus Type 1 Infection

B. Blom, H. Spits, I. Chen, 2007, Clinical and Vaccine Immunology.

Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins

P. S. Andersen, Eric P. Skaar, R. Vandlen, 2013, PLoS pathogens.

Reciprocal hybrid joints demonstrate successive V-J rearrangements on the same chromosome in the human TCR gamma locus.

M. Lefranc, M. Roncarolo, H. Spits, 1991, International immunology.

Human T cell leukemia virus type I prevents cell surface expression of the T cell receptor through down-regulation of the CD3-gamma, -delta, -epsilon, and -zeta genes.

R. de Waal Malefyt, B. Alarcón, J. D. de Vries, 1990, Journal of immunology.

Dispositifs et procédé de production d'anticorps à haute affinité

H. Spits, M. Kwakkenbos, K. Wagner, 2011 .

Reply to ‘Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature’

F. Ginhoux, H. Spits, T. Ohteki, 2023, Nature Reviews Immunology.

A SCID patient reconstituted with HLA-incompatible fetal stem cells as a model for studying transplantation tolerance.

J. D. de Vries, M. Roncarolo, H. Spits, 1991, Blood cells.

Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.

J. V. van Dongen, B. Blom, H. Spits, 1999, The EMBO journal.

Interleukin-10.

R. de Waal Malefyt, H. Spits, H. Yssel, 1992, Current opinion in immunology.

P035 The transcriptional co-activator bob.1 prevents terminal differentiation and induces costimulatory capacity of B cells in GC-like environment

H. Spits, D. Baeten, N. van Uden, 2018 .