Y. Kwon

发表

Crystal structure , conformational fixation , and entry-related interactions of mature ligand-free HIV-1 Env

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016 .

Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.

Alexander W. Sun, J. Sodroski, J. Mascola, 2012, Journal of medicinal chemistry.

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Young Do Kwon, Tongqing Zhou, Peter D. Kwong, 2009, Proceedings of the National Academy of Sciences.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2011, Nature.

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Young Do Kwon, Tongqing Zhou, Peter D. Kwong, 2012, Proceedings of the National Academy of Sciences.

Human zinc fingers as building blocks in the construction of artificial transcription factors

Young Do Kwon, Kyung-Soon Park, M. Hwang, 2003, Nature Biotechnology.

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

J. Mullikin, J. Mascola, Yicheng Guo, 2019, Cell.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016, Cell.

Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2013, Immunity.

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2015, Cell.

Cellular manipulation of human embryonic stem cells by TAT-PDX1 protein transduction.

S. Oh, H. Kim, S. Moon, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial.

J. Mascola, A. Namboodiri, R. Koup, 2019, The lancet. HIV.

Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

J. Sodroski, R. Wyatt, Judith M. LaLonde, 2008, Structure.

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

Chaim A. Schramm, Kenneth H. Zhou, J. Yates, 2020, Cell reports.

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

J. Mascola, E. Reinherz, G. Chuang, 2018, Cell reports.

β-Methanesulfonyl-L-valine as a novel, unnatural amino acid surrogate for P2 in the design of HIV protease inhibitors.

Y. Kwon, Ho-il Choi, J. Koh, 1996 .

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

Cinque S. Soto, B. Haynes, J. Mascola, 2017, Cell reports.

Eliminating antibody polyreactivity through addition of N‐linked glycosylation

B. Haynes, J. Mascola, G. Chuang, 2015, Protein science : a publication of the Protein Society.

Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins

M. Diamond, Zhilei Chen, L. Shapiro, 2022, bioRxiv.

Longitudinal Analysis Reveals Early Development of Three MPER‐Directed Neutralizing Antibody Lineages from an HIV‐1‐Infected Individual

Jonathan R. McDaniel, Chaim A. Schramm, Kenneth H. Zhou, 2019, Immunity.

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

J. Mullikin, J. Mascola, Yicheng Guo, 2019, Cell.

Association of the vascular endothelial growth factor (VEGF-1154G>A) polymorphism in patients with colorectal cancer

N. Kim, Y. Kwon, S. Chong, 2011, Genes & Genomics.

Rational Engraftment of Quaternary-Interactive Acidic Loops for Anti-HIV-1 Antibody Improvement

M. Sajadi, P. Kwong, Y. Kwon, 2021, Journal of Virology.

FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling

K. Kwack, Y. Kwon, Hee-jin Ahn, 2009, FEBS letters.

Antiviral effect of 18-mer-peptide (1b-4/21-C12) on Japanese encephalitis virus and Akabane virus

Y. Kwon, Ha-Hyun Kim, Dong-Kun Yang, 2022, Korean Journal of Veterinary Research.

Potential Side Effects of Dendritic Cells Pulsed with Allogenic Melanoma Cell Lysate in Mice

Shin-Young Park, Y. Kwon, Hyunah Lee, 2007, International journal of toxicology.

A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins

M. Diamond, Zhilei Chen, L. Shapiro, 2022, Nature Chemical Biology.

Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists

A. Debnath, P. Kwong, Y. Kwon, 2022, International journal of molecular sciences.

The use of green fluorescence gene (GFP)-modified rabbit mesenchymal stem cells (rMSCs) co-cultured with chondrocytes in hydrogel constructs to reveal the chondrogenesis of MSCs.

Y. Kwon, J. S. Park, K. Na, 2009, Biomaterials.

Discovery and characterization of novel microRNAs during endothelial differentiation of human embryonic stem cells.

Y. Kwon, Seong-Jun Choi, Jung Ki Yoo, 2012, Stem cells and development.

The molecular signature of in vitro senescence in human mesenchymal stem cells

Young Do Kwon, K. Kwack, Y. Kwon, 2010, Genes & Genomics.

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

B. Haynes, D. Ho, J. Mascola, 2016, Journal of Virology.

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

Chaim A. Schramm, Cinque S. Soto, T. Kepler, 2016, Cell.

Correction to Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

A. Debnath, P. Kwong, Y. Kwon, 2017, Journal of medicinal chemistry.

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

Young Do Kwon, Asim K Debnath, Peter D Kwong, 2017, Journal of medicinal chemistry.

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.

Young Do Kwon, Hongtao Zhang, Asim K Debnath, 2015, Journal of medicinal chemistry.

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

J. Foulke, M. Sajadi, P. Acharya, 2014, Journal of Virology.

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo

Young Do Kwon, Mario Roederer, Tongqing Zhou, 2014, Journal of Virology.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

J. Mascola, G. Chuang, M. Sastry, 2018, bioRxiv.

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains

Young Do Kwon, Tongqing Zhou, Gwo-Yu Chuang, 2013, Journal of Virology.

The Covalent SNAP Tag for Protein Display Quantification and Low-pH Protein Engineering.

Baoshan Zhang, L. Shapiro, P. Kwong, 2020, Journal of biotechnology.

, In Vivo Infection Improves Protection against Lentiviral In Vitro Neutralizing HIV-1 Antibody Enhanced Potency of a Broadly

Kyle E. Roberts, Cinque S. Soto, B. Donald, 2014 .

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

J. Mascola, Rui Chen, G. Chuang, 2018, Nature Medicine.

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

J. Mascola, Baoshan Zhang, N. Doria-Rose, 2021, mAbs.

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

Chaim A. Schramm, Kenneth H. Zhou, J. Yates, 2019, bioRxiv.

Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses

M. Sastry, G. Nabel, P. Acharya, 2010, National Institute of Allergy and Infectious Diseases, NIH.

Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility

Young Do Kwon, Tongqing Zhou, Lei Chen, 2009 .

Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.

R. Weiss, Reda Rawi, Baoshan Zhang, 2022, Structure.

Polymorphisms of TSER and MTHFR are associated with prognosis of fluoropyrimidine-based therapy in colorectal cancer patients

N. Kim, Y. Kwon, S. Bae, 2009 .

Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assembly.

W. Baumeister, P. Adams, B. Jap, 2004, Journal of molecular biology.

Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1.

A. Debnath, P. Kwong, Y. Kwon, 2012, Journal of medicinal chemistry.

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency

J. Mascola, Reda Rawi, Baoshan Zhang, 2023, mAbs.

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.

U. Baxa, J. Mascola, G. Chuang, 2017, Cell reports.

Small-Molecule CD 4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp 120

J. Sodroski, R. Wyatt, Judith M. LaLonde, 2018 .

Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

Andrew J. Schaub, J. Mascola, Reda Rawi, 2023, mAbs.

Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.

G. Shaw, F. Stricher, P. Kwong, 2008, Journal of molecular biology.

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.

A. Debnath, L. Iyer, Y. Kwon, 2018, European journal of medicinal chemistry.

Binding Mode Characterization of NBD Series CD4-Mimetic HIV-1 Entry Inhibitors by X-Ray Structure and Resistance Study

A. Debnath, P. Kwong, Yongping Yang, 2014, Antimicrobial Agents and Chemotherapy.

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.

Young Do Kwon, Joel R Courter, Peter D Kwong, 2011, Bioorganic & medicinal chemistry.

Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1.

J. Mascola, P. Acharya, M. Louder, 2013, Structure.

Corrigendum: Human zinc fingers as building blocks in the construction of artificial transcription factors

M. Hwang, K. Bae, W. Seol, 2003, Nature Biotechnology.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.

J. Mascola, G. Chuang, M. Sastry, 2018 .

Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.

A. Trkola, J. Weber, A. Plückthun, 2023, Nature structural & molecular biology.

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

A. Debnath, Judith M. LaLonde, P. Kwong, 2014, PloS one.

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo

Kyle E. Roberts, Cinque S. Soto, B. Donald, 2014, Journal of Virology.