N. O’Brien-Simpson

P. Ebeling, E. Reynolds, K. Walsh, 2013, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

Role of RgpA, RgpB, and Kgp Proteinases in Virulence of Porphyromonas gingivalis W50 in a Murine Lesion Model

N. Slakeski, S. Dashper, E. Reynolds, 2001, Infection and Immunity.

An efficient method for enumerating oral spirochetes using flow cytometry.

S. Dashper, E. Reynolds, K. Walsh, 2010, Journal of microbiological methods.

Bacteroides fragilis outer membrane vesicles preferentially activate innate immune receptors compared to their parent bacteria

A. Hill, N. O’Brien-Simpson, M. Kaparakis-Liaskos, 2022, Frontiers in Immunology.

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice.

A. Giraud, N. O’Brien-Simpson, L. Judd, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Celogentin mimetics as inhibitors of tubulin polymerization

E. Reynolds, N. O’Brien-Simpson, C. Hutton, 2019, Journal of peptide science : an official publication of the European Peptide Society.

Pentafulvene-Maleimide Cycloaddition for Bioorthogonal Ligation.

Wenyi Li, N. O’Brien-Simpson, A. Blencowe, 2021, Bioconjugate chemistry.

Candida virulence and ethanol-derived acetaldehyde production in oral cancer and non-cancer subjects.

S. Kolev, E. Reynolds, N. O’Brien-Simpson, 2016, Oral diseases.

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria.

E. Reynolds, A. O’Connor, D. Heath, 2020, ACS applied materials & interfaces.

Porphyromonas gingivalis outer membrane vesicles exclusively contain outer membrane and periplasmic proteins and carry a cargo enriched with virulence factors.

P. Veith, Yu-Yen Chen, E. Reynolds, 2014, Journal of proteome research.

Bionano Interaction Study on Antimicrobial Star-Shaped Peptide Polymer Nanoparticles.

G. Qiao, E. Reynolds, N. O’Brien-Simpson, 2016, ACS applied materials & interfaces.

C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1

Wenyi Li, N. O’Brien-Simpson, F. Separovic, 2021, Amino Acids.

Fluorescent Ion Efflux Screening Assay for Determining Membrane-Active Peptides

J. Wade, Wenyi Li, E. Reynolds, 2017 .

Covalent conjugation of cationic antimicrobial peptides with a β‐lactam antibiotic core

L. Otvos, J. Wade, Wenyi Li, 2018 .

Porphyromonas gulae has similar virulence and immunological characteristics to the 3 human periodontal pathogen

E. Reynolds, N. O’Brien-Simpson, J. Lenzo, 2016 .

Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection.

I. Barr, P. Veith, N. Slakeski, 2006, Vaccine.

Development and evaluation of a saliva-based chair-side diagnostic for the detection of Porphyromonas gingivalis

E. Reynolds, N. O’Brien-Simpson, I. Darby, 2015, Journal of oral microbiology.

Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure.

G. Qiao, E. Reynolds, N. O’Brien-Simpson, 2016, ACS macro letters.

Biocompatibility and Osteogenic/Calcification Potential of Casein Phosphopeptide‐amorphous Calcium Phosphate Fluoride

E. Reynolds, D. Manton, N. O’Brien-Simpson, 2017, Journal of endodontics.

The overview of antimicrobial peptide‐coated implants against oral bacterial infections

N. O’Brien-Simpson, A. Sloan, Li Ma, 2023, Aggregate.

Kgp and RgpB, but Not RgpA, Are Important for Porphyromonas gingivalis Virulence in the Murine Periodontitis Model

N. Slakeski, E. Reynolds, N. O’Brien-Simpson, 2007, Infection and Immunity.

The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis – Its Past, Present, and Future

J. Wade, Wenyi Li, N. O’Brien-Simpson, 2020 .

Engineering highly effective antimicrobial selenium nanoparticles through control of particle size.

A. O’Connor, D. Heath, N. O’Brien-Simpson, 2019, Nanoscale.

Chemical Modification of Cellulose Membranes for SPOT Synthesis

J. Wade, Wenyi Li, E. Reynolds, 2020 .

Using inorganic nanoparticles to fight fungal infections in the antimicrobial resistant era.

A. O’Connor, D. Heath, N. O’Brien-Simpson, 2023, Acta biomaterialia.

Oral Candida colonization in oral cancer patients and its relationship with traditional risk factors of oral cancer: a matched case-control study.

E. Reynolds, N. O’Brien-Simpson, D. Wiesenfeld, 2015, Oral oncology.

Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects.

A. O’Connor, D. Heath, N. O’Brien-Simpson, 2020, Biointerphases.

The development and validation of a rapid genetic method for species identification and genotyping of medically important fungal pathogens using high-resolution melting curve analysis.

E. Reynolds, N. O’Brien-Simpson, B. Peng, 2014, Molecular oral microbiology.

Physicochemical and immunological assessment of engineered pure protein particles with different redox states.

F. Caruso, E. Reynolds, N. O’Brien-Simpson, 2015, ACS nano.

Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model.

S. Dashper, E. Reynolds, N. O’Brien-Simpson, 2011, Molecular oral microbiology.

The Potential of Calcium Phosphate Nanoparticles as Adjuvants and Vaccine Delivery Vehicles

Wenyi Li, A. O’Connor, N. O’Brien-Simpson, 2021, Frontiers in Materials.

Host immune responses to Porphyromonas gingivalis antigens.

E. Reynolds, N. O’Brien-Simpson, R. Pathirana, 2010, Periodontology 2000.

Selenium nanoparticles as anti-infective implant coatings for trauma orthopedics against methicillin-resistant Staphylococcus aureus and epidermidis: in vitro and in vivo assessment

P. Tran, T. Webster, N. Bock, 2019, International journal of nanomedicine.

The Role of Multiphosphorylated Peptides in Mineralized Tissue Regeneration

K. Cross, E. Reynolds, N. O’Brien-Simpson, 2007, International Journal of Peptide Research and Therapeutics.

Antimicrobial activity of simplified mimics of celogentin C

E. Reynolds, N. O’Brien-Simpson, A. Chattopadhyay, 2017 .

Oxantel Disrupts Polymicrobial Biofilm Development of Periodontal Pathogens

S. Dashper, E. Reynolds, K. Walsh, 2013, Antimicrobial Agents and Chemotherapy.

Outer membrane proteome and antigens of Tannerella forsythia.

P. Veith, S. Dashper, E. Reynolds, 2009, Journal of proteome research.

Peptide Multimerization as Leads for Therapeutic Development

J. Wade, Wenyi Li, N. O’Brien-Simpson, 2021, Biologics.

Localization of Outer Membrane Proteins in Treponema denticola by Quantitative Proteome Analyses of Outer Membrane Vesicles and Cellular Fractions.

P. Veith, E. Reynolds, N. O’Brien-Simpson, 2019, Journal of proteome research.

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

M. Ragozzino, E. Reynolds, P. Toth, 2018, PloS one.

Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample

Michael J. Woods, J. Trinder, N. Allen, 2013, Brain, Behavior, and Immunity.

Porphyromonas gingivalis RgpA-Kgp Proteinase-Adhesin Complexes Penetrate Gingival Tissue and Induce Proinflammatory Cytokines or Apoptosis in a Concentration-Dependent Manner

E. Reynolds, N. O’Brien-Simpson, G. Walker, 2008, Infection and Immunity.

Antigens of bacteria associated with periodontitis.

P. Veith, S. Dashper, E. Reynolds, 2004, Periodontology 2000.

Adolescent temperament dimensions as stable prospective risk and protective factors for salivary C‐reactive protein

Benjamin W. Nelson, N. Allen, S. Whittle, 2018, British journal of health psychology.

Adolescent Sympathetic Activity and Salivary C-Reactive Protein: The Effects of Parental Behavior

Benjamin W. Nelson, N. Allen, L. Sheeber, 2017, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

L. Otvos, J. Wade, Wenyi Li, 2014, Amino Acids.

Porphyromonas gingivalis gingipains: the molecular teeth of a microbial vampire.

P. Veith, S. Dashper, E. Reynolds, 2003, Current protein & peptide science.

Adolescent-Onset Depression: Are Obesity and Inflammation Developmental Mechanisms or Outcomes?

N. Allen, M. Byrne, N. O’Brien-Simpson, 2015, Child psychiatry and human development.

Evaluation of Potential DnaK Modulating Proline-Rich Antimicrobial Peptides Identified by Computational Screening

J. Wade, Wenyi Li, N. O’Brien-Simpson, 2022, Frontiers in Chemistry.

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

A. Murphy, J. Hamilton, S. Dashper, 2017, Front. Cell. Infect. Microbiol..

Flow Cytometric Analysis of Adherence of Porphyromonas gingivalis to Oral Epithelial Cells

J. Hamilton, E. Reynolds, N. O’Brien-Simpson, 2007, Infection and Immunity.

Response of Porphyromonas gingivalis to Heme Limitation in Continuous Culture

I. Barr, C. Seers, P. Veith, 2008, Journal of bacteriology.

Monospecies and polymicrobial biofilms differentially regulate the phenotype of genotype-specific oral cancer cells

Mohd Hafiz Arzmi, S. Dashper, E. Reynolds, 2018, Carcinogenesis.

A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis.

E. Reynolds, K. Walsh, N. O’Brien-Simpson, 2020, Cytokine.

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

N. O’Brien-Simpson, Sean E. Lowe, L. Connal, 2015 .

Architectural Effects of Star‐Shaped “Structurally Nanoengineered Antimicrobial Peptide Polymers” (SNAPPs) on Their Biological Activity

G. Qiao, E. Reynolds, N. O’Brien-Simpson, 2018, Advanced healthcare materials.

Macrophage Depletion Abates Porphyromonas gingivalis–Induced Alveolar Bone Resorption in Mice

E. Reynolds, K. Walsh, N. O’Brien-Simpson, 2014, The Journal of Immunology.

Corrigendum to ‘Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample’ [Brain Behav. Immun. 34 (2013) 164–175]

Michael J. Woods, J. Trinder, N. Allen, 2020, Brain, Behavior, and Immunity.

GM‐CSF and uPA are required for Porphyromonas gingivalis‐induced alveolar bone loss in a mouse periodontitis model

J. Hamilton, E. Reynolds, K. Walsh, 2015, Immunology and cell biology.

Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System

J. Hamilton, P. Veith, E. Reynolds, 2015, The Journal of Biological Chemistry.

Identification of a periodontal pathogen and bihormonal cells in pancreatic islets of humans and a mouse model of periodontitis

B. Wicksteed, S. Green, T. Unterman, 2020, Scientific Reports.

Identification and Suppression of β-Elimination Byproducts Arising from the Use of Fmoc-Ser(PO3Bzl,H)-OH in Peptide Synthesis

E. Reynolds, N. O’Brien-Simpson, T. Attard, 2009, International Journal of Peptide Research and Therapeutics.

Synthesis of Phosphopeptides in the Fmoc Mode

E. Reynolds, N. O’Brien-Simpson, T. Attard, 2007, International Journal of Peptide Research and Therapeutics.

Characterization of proteinase-adhesin complexes of Porphyromonas gingivalis.

P. Veith, E. Reynolds, N. O’Brien-Simpson, 2006, Microbiology.

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis

E. Reynolds, N. O’Brien-Simpson, J. Lenzo, 2016, PloS one.

Peripheral memory T-cell profile is modified in patients undergoing periodontal management.

E. Reynolds, K. Walsh, N. O’Brien-Simpson, 2020, Journal of clinical periodontology.

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

E. Reynolds, N. O’Brien-Simpson, A. Mansell, 2017, Front. Immunol..

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

F. Caruso, Yu-Yen Chen, E. Reynolds, 2016, PloS one.

Bugs and Brains, the Gut and Mental Health Study: a mixed-methods study investigating microbiota composition and function in anxiety, depression and irritable bowel syndrome

N. Haslam, S. Whittle, J. Simmons, 2021, BMJ Open.

Protease-Activated Receptor 2 Has Pivotal Roles in Cellular Mechanisms Involved in Experimental Periodontitis

E. Reynolds, K. Walsh, N. O’Brien-Simpson, 2009, Infection and Immunity.

Polymerisation of a T Cell Epitope with an Immunostimulatory C3d Peptide Sequence Enhances Antigen Specific T Cell Responses

E. Reynolds, K. Walsh, N. O’Brien-Simpson, 2013, International Journal of Peptide Research and Therapeutics.

A Novel Porphyromonas gingivalis FeoB Plays a Role in Manganese Accumulation*

P. Veith, C. Butler, S. Dashper, 2005, Journal of Biological Chemistry.

Immunization with the RgpA-Kgp Proteinase-Adhesin Complexes of Porphyromonas gingivalis Protects against Periodontal Bone Loss in the Rat Periodontitis Model

N. Slakeski, E. Reynolds, B. Hoffmann, 2002, Infection and Immunity.

The SENSE Study (Sleep and Education: learning New Skills Early): a community cognitive-behavioural therapy and mindfulness-based sleep intervention to prevent depression and improve cardiac health in adolescence

R. Dahl, G. Murray, J. Trinder, 2015, BMC psychology.

Combating bacterial resistance by combination of antibiotics with antimicrobial peptides

J. Wade, N. O’Brien-Simpson, F. Separovic, 2019, Pure and Applied Chemistry.

Streptococcus mutans biofilm disruption by κ-casein glycopeptide.

S. Dashper, E. Reynolds, K. Walsh, 2013, Journal of dentistry.

The outer membrane protein LptO is essential for the O‐deacylation of LPS and the co‐ordinated secretion and attachment of A‐LPS and CTD proteins in Porphyromonas gingivalis

K. Goldie, P. Veith, Yu-Yen Chen, 2011, Molecular microbiology.

The Effect of Selective D- or Nα-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

John D. Wade, Laszlo Otvos, Frances Separovic, 2017, Front. Chem..

C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide.

L. Otvos, S. Yao, J. Wade, 2017, Chemistry.

Serum Immunoglobulin G (IgG) and IgG Subclass Responses to the RgpA-Kgp Proteinase-Adhesin Complex of Porphyromonas gingivalis in Adult Periodontitis

N. Slakeski, S. Cleal, E. Reynolds, 2000, Infection and Immunity.

Porphyromonas gingivalis Lipopolysaccharide Weakly Activates M1 and M2 Polarized Mouse Macrophages but Induces Inflammatory Cytokines

E. Reynolds, N. O’Brien-Simpson, A. Mansell, 2014, Infection and Immunity.

Fabrication of planarised conductively patterned diamond for bio-applications.

P. Tran, H. Meffin, K. Ganesan, 2014, Materials science & engineering. C, Materials for biological applications.

RgpA-Kgp Peptide-Based Immunogens Provide Protection againstPorphyromonas gingivalis Challenge in a Murine Lesion Model

E. Reynolds, N. O’Brien-Simpson, R. Paolini, 2000, Infection and Immunity.

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2

E. Reynolds, N. O’Brien-Simpson, A. Mansell, 2017, Infection and Immunity.

One Step Antimicrobial Coatings for Medical Device Applications Based on Low Fouling Polymers Containing Selenium Nanoparticles

N. Voelcker, A. O’Connor, C. Easton, 2023, SSRN Electronic Journal.

Tannerella forsythia Outer Membrane Vesicles Are Enriched with Substrates of the Type IX Secretion System and TonB-Dependent Receptors.

P. Veith, Yu-Yen Chen, E. Reynolds, 2015, Journal of proteome research.

Correction to: Comparison of the effectiveness of a tailored cognitive behavioural therapy with a supportive listening intervention for depression in those newly diagnosed with multiple sclerosis (the ACTION-MS trial): protocol of an assessor-blinded, active comparator, randomised controlled trial

T. Wijeratne, T. Kilpatrick, E. McDonald, 2020, Trials.

Histatin 5 is a substrate and not an inhibitor of the Arg- and Lys-specific proteinases of Porphyromonas gingivalis.

S. Dashper, E. Reynolds, N. O’Brien-Simpson, 1998, Biochemical and biophysical research communications.

Characterization of T Cell Responses to the RgpA-Kgp Proteinase-Adhesin Complexes of Porphyromonas gingivalis in BALB/c Mice1

E. Reynolds, N. O’Brien-Simpson, R. Pathirana, 2008, The Journal of Immunology.

Mice Porphyromonas gingivalis RgpA-Kgp Proteinase-Adhesin Complexes of Characterization of T Cell Responses to the

E. Reynolds, N. O’Brien-Simpson, R. Pathirana, 2008 .

Outer Membrane Vesicle-Host Cell Interactions

N. O’Brien-Simpson, A. Krachler, Natalie Sirisaengtaksin, 2019, Protein Secretion in Bacteria.

Outer Membrane Vesicle-Host Cell Interactions.

N. O’Brien-Simpson, A. Krachler, Natalie Sirisaengtaksin, 2019, Microbiology spectrum.

The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency

Yuning Hong, J. Wade, N. O’Brien-Simpson, 2023, Aggregate.

Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.

J. Wade, N. O’Brien-Simpson, A. Hung, 2022, European journal of medicinal chemistry.

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

N. Slakeski, K. Cross, E. Reynolds, 2016, npj Vaccines.

Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker

J. Wade, N. O’Brien-Simpson, F. Separovic, 2022, Chemical science.

Effect of a protease-activated receptor-2 antagonist (GB88) on inflammation-related loss of alveolar bone in periodontal disease.

D. Fairlie, N. O’Brien-Simpson, R. Pike, 2023, Journal of periodontal research.

Associations Between Observed Parenting Behavior and Adolescent Inflammation Two and a Half Years Later in a Community Sample

N. Allen, L. Sheeber, S. Whittle, 2017, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

J. Wade, Wenyi Li, N. O’Brien-Simpson, 2020, Frontiers in Chemistry.

Development and application of Diels-Alder adducts displaying AIE properties

Yuning Hong, N. O’Brien-Simpson, J. White, 2022, Cell Reports Physical Science.

Adolescent-Onset Depression: Are Obesity and Inflammation Developmental Mechanisms or Outcomes?

M. Byrne, N. O’Brien-Simpson, N. Allen, 2015, Child Psychiatry & Human Development.

Title : Parenting and adolescent health : Observed parenting behavior is associated with inflammation two and half years later in a community sample

N. Allen, L. Sheeber, S. Whittle, 2019 .

Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses

F. Caruso, E. Reynolds, N. O’Brien-Simpson, 2016 .

An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone Loss1

P. Veith, Yu-Yen Chen, E. Reynolds, 2005, The Journal of Immunology.