J. Bennett

发表

Supporting Online Material for Computational Design of Peptides That Target Transmembrane Helices

Gregory A Caputo, Bryan W Berger, W. DeGrado, 2007 .

Identification of Interacting Hot Spots in the β3 Integrin Stalk Using Comprehensive Interface Design*

Jason E. Donald, W. DeGrado, R. Litvinov, 2010, The Journal of Biological Chemistry.

Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex.

J. Bennett, L. Brass, S. Shattil, 1985, The Journal of biological chemistry.

The Activation State of αvβ3Regulates Platelet and Lymphocyte Adhesion to Intact and Thrombin-cleaved Osteopontin*

W. DeGrado, S. Mousa, G. Vilaire, 2000, The Journal of Biological Chemistry.

Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force.

Andrew R. Fisher, Valeri Barsegov, J. Weisel, 2011, Biophysical journal.

Resolving Two-dimensional Kinetics of the Integrin αIIbβ3-Fibrinogen Interactions Using Binding-Unbinding Correlation Spectroscopy*

Valeri Barsegov, Rustem I. Litvinov, John W. Weisel, 2012, The Journal of Biological Chemistry.

Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi

J. Weisel, O. Kim, M. Alber, 2017, Scientific Reports.

Blood orchestrates a leukocyte integrin trio

J. Bennett, 2007 .

Long range propagation of conformational changes in integrin alpha IIb beta 3.

J. Weisel, J. Bennett, M. Ginsberg, 1993, The Journal of biological chemistry.

Long range propagation of conformational changes in integrin α(IIb)β3

J. Weisel, Xiaoping Du, J. Bennett, 1993 .

Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3.

J. Weisel, V. Barsegov, R. Litvinov, 2017, Biochemistry.

UV-C irradiation gives platelets a sunburn.

J. Bennett, 2008, Blood.

Comment on Verhaar et al , page 4935 UVC irradiation gives platelets a sunburn

J. Bennett, 2008 .

Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism

Daniel W. Kulp, W. DeGrado, O. McCarty, 2009, Proceedings of the National Academy of Sciences.

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy.

A. Wand, W. DeGrado, J. Lear, 2002, Biochemistry.

Consensus motif for integrin transmembrane helix association

Alessandro Senes, William F. DeGrado, Daniel W. Kulp, 2009, Proceedings of the National Academy of Sciences.

De novo designed transmembrane peptides activating the &agr;5&bgr;1 integrin

C. Sanders, W. DeGrado, Hailin Hu, 2018, Protein engineering, design & selection : PEDS.

Regulation of platelet β3 integrins

J. Bennett, David T. Moore, 2010, Haematologica.

Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices.

W. DeGrado, P. Billings, J. Bennett, 2010, Journal of molecular biology.

Pro-thrombotic State Induced by Post-translational Modification of Fibrinogen by Reactive Nitrogen Species*

J. Weisel, S. Hazen, V. Muzykantov, 2004, Journal of Biological Chemistry.

Halofenate: a potent inhibitor of normal and hypersensitive platelets.

R. Colman, J. Sheridan, J. Bennett, 1976, The Journal of laboratory and clinical medicine.

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

G. Vilaire, J. Bennett, 1979, The Journal of clinical investigation.

Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller.

Cinque S. Soto, W. DeGrado, C. Soto, 2009, Blood.

Integrin Structure and Function in Hemostasis and Thrombosis

J. Bennett, 1991, Annals of the New York Academy of Sciences.

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

J. Hoxie, D. Cines, G. Vilaire, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets.

J. Bennett, R. Montgomery, D. Pidard, 1983, The Journal of biological chemistry.

Disorders of platelet function.

J. Bennett, M. Kołodziej, Michael A. Kolodziej, 1992, Disease-a-month : DM.

AJC Editor's consensus: Selective and nonselective nonsteroidal anti-inflammatory drugs and cardiovascular risk.

Gary W. Williams, W. Roberts, V. Strand, 2010, The American journal of cardiology.

Glycoprotein IIb/IIIa antagonists.

J. Bennett, K. Hook, 2012, Handbook of experimental pharmacology.

Novel platelet inhibitors.

J. Bennett, 2001, Annual review of medicine.

Blood coagulation and coagulation tests.

J. Bennett, Joel S. Bennett, 1984, The Medical clinics of North America.

Carbenicillin and penicillin G inhibit platelet function in vitro by impairing the interaction of agonists with the platelet surface.

J. Bennett, S. Shattil, M. McDonough, 1980, The Journal of clinical investigation.

The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa.

G. Vilaire, J. Bennett, M. McDonough, 1987, Blood.

The Platelet—Fibrinogen Interaction

J. Bennett, 1985 .

The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

J. Bennett, T. K. Gartner, T. Gartner, 1985, The Journal of biological chemistry.

Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles.

J. Weisel, P. Billings, R. Composto, 2012, Integrative biology : quantitative biosciences from nano to macro.

Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy.

J. Weisel, G. Vilaire, J. Bennett, 1992, The Journal of biological chemistry.

Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment

W. DeGrado, J. Bennett, David T. Moore, 2011, Proceedings of the National Academy of Sciences.

Agonist-activated αvβ3 on Platelets and Lymphocytes Binds to the Matrix Protein Osteopontin*

W. DeGrado, S. Mousa, G. Vilaire, 1997, The Journal of Biological Chemistry.

Additional considerations on measuring the binding strength of single ligand‐receptor pairs on cells: reply to a rebuttal

J. Weisel, R. Litvinov, J. Bennett, 2004, Journal of thrombosis and haemostasis : JTH.

Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis.

M. Poncz, G. Vilaire, J. Bennett, 1991, The Journal of biological chemistry.

Functional and structural correlations of individual αIIbβ3 molecules

J. Weisel, G. Vilaire, R. Litvinov, 2004 .

Concurrent signaling from Gαq‐ and Gαi‐coupled pathways is essential for agonist‐induced αvβ3 activation on human platelets

G. Vilaire, J. Bennett, S. Kunapuli, 2003, Journal of thrombosis and haemostasis : JTH.

Development and Use of Platelet Glycoprotein Antagonists in Heart Disease

J. Bennett, 2003 .

Functional and structural correlations of individual alphaIIbbeta3 molecules.

J. Weisel, G. Vilaire, R. Litvinov, 2004, Blood.

The genomic organization of platelet glycoprotein IIIa.

S. Lord, M. Poncz, J. Bennett, 1990, The Journal of biological chemistry.

Seismostratigraphy and Thermal Structure of Earth ’ s Core-Mantle Boundary Region

W. DeGrado, J. Lear, B. Berger, 2007 .

Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin.

W. DeGrado, S. Mousa, G. Vilaire, 1997, The Journal of biological chemistry.

Fibrinogen is necessary for platelet function in vivo after all

J. Bennett, 2003 .

b3-integrins in platelets

G. FitzGerald, G. Vilaire, J. Bennett, 2001 .

A Leu117 → Trp mutation within the RGD-peptide cross-linking region of β3 results in Glanzmann thrombasthenia by preventing αIIbβ3 export to the platelet surface

M. Poncz, G. Vilaire, J. Bennett, 1997 .

Inhibition of integrin α2β1 ameliorates glomerular injury.

W. DeGrado, Xiwu Chen, A. Pozzi, 2012, Journal of the American Society of Nephrology : JASN.

Are Antiplatelet Agents Beneficial in Essential Thrombocythemia? Maybe Yes, Probably No

J. Bennett, 2017, Annals of Internal Medicine.

A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3

B. Coller, M. Poncz, G. Vilaire, 2000 .

Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3.

M. Poncz, G. Vilaire, J. Bennett, 1996, Blood.

Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb.

P. Fortina, B. Coller, M. Poncz, 1994, The Journal of clinical investigation.

SPECIFICITY FOR HOMO-VERSUS HETERO-OLIGOMER FORMATION IN INTEGRIN TRANSMEMBRANE HELICES

W. DeGrado, P. Billings, J. Bennett, 2011 .

Pinning a tail on platelet thrombi.

J. Bennett, 2009, Blood.

RGD-containing Peptides Inhibit Fibrinogen Binding to Platelet αIIbβ3 by Inducing an Allosteric Change in the Amino-terminal Portion of αIIb *

M. Poncz, G. Vilaire, J. Bennett, 2001, The Journal of Biological Chemistry.

RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb).

M. Poncz, G. Vilaire, J. Bennett, 2001, The Journal of biological chemistry.

Structural biology of glycoprotein IIb-IIIa.

J. Bennett, 1996, Trends in cardiovascular medicine.

Aggregation of chymotrypsin-treated thrombasthenic platelets is mediated by fibrinogen binding to glycoproteins IIb and IIIa.

J. Soria, C. Soria, N. Kieffer, 1985, The Journal of laboratory and clinical medicine.

Advisory From the American Heart Association The Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): A Science

P. Greenland, D. Herrington, A. Daugherty, 2006 .

The Platelet Cytoskeleton Regulates the Affinity of the Integrin αIIbβ3 for Fibrinogen*

S. Zigmond, G. Vilaire, J. Bennett, 1999, The Journal of Biological Chemistry.

Determinants of the intracellular fate of truncated forms of the platelet glycoproteins IIb and IIIa.

M. Poncz, G. Vilaire, J. Bennett, 1993, The Journal of biological chemistry.

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

R. Eisman, S. Surrey, M. Poncz, 1987, The Journal of biological chemistry.

A role for prostaglandins and thromboxanes in the exposure of platelet fibrinogen receptors.

G. Vilaire, J. Bennett, J. Burch, 1981, The Journal of clinical investigation.

Platelets and their membranes in hemostasis: physiology and pathophysiology.

J. Bennett, S. Shattil, 1981, Annals of internal medicine.

Species differences in small molecule binding to (cid:1) IIb (cid:2) 3 are the result of sequence differences in 2 loops of the (cid:1) IIb (cid:2) propeller

Cinque S. Soto, W. DeGrado, M. Poncz, 2009 .

The relative role of PLC and PI3K in platelet activation

D. Eslin, Dianqing Wu, M. Poncz, 2017 .

in platelet activation γ and PI3K β The relative role of PLC

D. Eslin, Dianqing Wu, M. Poncz, 2013 .

Localization of human platelet membrane-associated actomyosin using the affinity label 5'-p-fluorosulfonylbenzoyl adenosine.

R. Colman, G. Vilaire, J. Bennett, 1981, The Journal of biological chemistry.

Cellular Interactions in Thrombosis, Hemostasis, and Inflammation: I Platelets/II Endothelial Cells

J. Bennett, Kenneth K. Wu, 1992 .

Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes.

M. Poncz, J. Bennett, P. Newman, 1991, Blood.

membrane glycoprotein IIb-IIIa complex Biochemical and functional consequences of dissociation of the platelet

Sanford, J. Bennett, Lawrence, 2005 .

Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex.

J. Bennett, S. Shattil, T. K. Gartner, 1988, The Journal of biological chemistry.

The molecular biology of platelet membrane proteins.

J. Bennett, 1990, Seminars in hematology.

Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy.

J. Weisel, R. Litvinov, J. Bennett, 2005, Biophysical journal.

The Platelet Integrin αIIbβ3 Differentially Interacts with Fibrin Versus Fibrinogen*

J. Weisel, R. Litvinov, J. Bennett, 2016, The Journal of Biological Chemistry.

Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction

W. DeGrado, J. Weisel, O. Kim, 2021, Blood advances.

Identification of the fibrinogen receptor on human platelets by photoaffinity labeling.

D. Cines, G. Vilaire, J. Bennett, 1982, The Journal of biological chemistry.

Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb-IIIa complex.

J. Bennett, L. Brass, S. Shattil, 1985, Blood.

Scientific Statement From the American Heart Association Use of Nonsteroidal Antiinflammatory Drugs : An Update for Clinicians: A

E. Antman, C. Furberg, A. Daugherty, 2007 .

Effect of Cytoplasmic Domain Mutations on the Agonist-stimulated Ligand Binding Activity of the Platelet Integrin αIIbβ3*

G. Vilaire, J. Bennett, E. Loh, 1996, The Journal of Biological Chemistry.

Disorders of platelet function: evaluation and treatment.

J. Bennett, Joel S. Bennett, 1991, Cleveland Clinic journal of medicine.

Both sides of the hypercoagulable state.

J. Bennett, 1997, Hospital practice.

Activation of Individual αIIbβ3 Integrin Molecules by Disruption of Transmembrane Domain Interactions in the Absence of Clustering

W. DeGrado, J. Weisel, G. Vilaire, 2006 .

Structure and function of the platelet integrin αIIbβ3

J. Bennett, Joel S. Bennett, 2005 .

Structure and function of the platelet integrin alphaIIbbeta3.

J. Bennett, Joel S Bennett, 2005, The Journal of clinical investigation.

Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association.

E. Antman, C. Furberg, A. Daugherty, 2007, Circulation.

Titelbild: The Design and Evaluation of Heparin-Binding Foldamers (Angew. Chem. 41/2005)

M. Klein, W. DeGrado, J. Winkler, 2005 .

The design and evaluation of heparin-binding foldamers.

M. Klein, W. DeGrado, J. Winkler, 2005, Angewandte Chemie.

Computational design of a β-peptide that targets transmembrane helices.

Ivan V. Korendovych, Feng Gai, William F. DeGrado, 2011, Journal of the American Chemical Society.

Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa.

D. Ledbetter, R. Nussbaum, B. Emanuel, 1988, The Journal of clinical investigation.

Abnormalities of cholesterol-phospholipid composition in platelets and low-density lipoproteins of human hyperbetalipoproteinemia.

R. Colman, J. Bennett, S. Shattil, 1977, The Journal of laboratory and clinical medicine.

Platelet hypersensitivity induced by cholesterol incorporation.

R. Colman, Sanford, J. Bennett, 1975, The Journal of clinical investigation.

The platelet cytoskeleton regulates the affinity of the integrin alpha(IIb)beta(3) for fibrinogen.

S. Zigmond, G. Vilaire, J. Bennett, 1999, The Journal of biological chemistry.

Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid.

W. DeGrado, J. Weisel, M. Mravic, 2021, Biochemistry.

The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets*

W. DeGrado, H. Roder, Hong Cheng, 2015, The Journal of Biological Chemistry.

Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

Renhao Li, William F. DeGrado, James D. Lear, 2003, Science.

Inherited Platelet δ-Storage Pool Disease in Dogs Causing Severe Bleeding: An Animal Model for a Specific ADP Deficiency

J. Bennett, M. Haskins, M. Callan, 1995, Thrombosis and Haemostasis.

Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.

W. DeGrado, J. Weisel, J. Lear, 2006, The Journal of biological chemistry.

Identification of adenine nucleotide binding proteins in human platelet membranes by affinity labeling with 5'-p-flurosulfonylbenzoyl adenosine.

R. Colman, J. Bennett, R. Colman, 1978, The Journal of biological chemistry.

Platelet Disorders: Diagnostic Tests and Their Interpretations

J. Bennett, M. O'Hara, S. Huntington, 2016 .

Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes.

M. Poncz, J. Bennett, P. Newman, 1991, Blood.

Vasoocclusion in sickle cell anemia: are platelets really involved?

J. Bennett, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Phosphorylated Pleckstrin Induces Cell Spreading via an Integrin-Dependent Pathway

J. Bennett, C. Abrams, Eve Marie Bauman, 2000, The Journal of cell biology.

Organization of the gene for platelet glycoprotein IIb.

R. Eisman, S. Surrey, M. Poncz, 1990, Biochemistry.

Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.

R. Eisman, M. Poncz, G. Vilaire, 1988, The Journal of clinical investigation.

Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.

M. Poncz, J. Bennett, D. Phillips, 1987, Biochemistry.

Effect of mutagenesis of GPIIb amino acid 273 on the expression and conformation of the platelet integrin GPIIb-IIIa.

M. Poncz, G. Vilaire, J. Bennett, 1996, Biochemistry.

Platelet‐Fibrinogen Interactions

J. Bennett, J S Bennett, 2001, Annals of the New York Academy of Sciences.

Shedding New Light on the Platelet Storage Lesion.

J. Bennett, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Structural basis for integrin alphaIIbbeta3 clustering.

Renhao Li, William F. DeGrado, W. DeGrado, 2004, Biochemical Society transactions.

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.

Renhao Li, W. DeGrado, J. Weisel, 2003, Science.

The structure and function of platelet integrins

P. Billings, B. Berger, J. Bennett, 2009, Journal of thrombosis and haemostasis : JTH.

Regulation of integrins in platelets

J. Bennett, 2015, Biopolymers.

Multi-Step Fibrinogen Binding to the Integrin αIIbβ3 Detected Using Force Spectroscopy

Rustem I. Litvinov, John W. Weisel, J. Weisel, 2005 .

Platelet Function Inhibitors in the Year 2000

S. Mousa, J. Bennett, 2001, Thrombosis and Haemostasis.

Measuring the binding strength of single ligand–receptor pairs on cells: rebuttal

J. Weisel, R. Litvinov, J. Bennett, 2004, Journal of thrombosis and haemostasis : JTH.

The use of nonsteroidal anti-inflammatory drugs (NSAIDs): a science advisory from the American Heart Association.

Philip Greenland, David Herrington, Harold Roberts, 2005, Circulation.

Effect of the Pl(A2) alloantigen on the function of beta(3)-integrins in platelets.

G. FitzGerald, G. Vilaire, J. Bennett, 2001, Blood.

The PIA2 alloantigen does not alter the affinity of GPIIb-IIIa for fibrinogen or RGD-containing peptides

G. Vilaire, J. Bennett, F. C. Lawson, 1997 .

Effect of deletion of glycoprotein IIb exon 28 on the expression of the platelet glycoprotein IIb/IIIa complex.

M. Poncz, G. Vilaire, J. Bennett, 1991, Blood.

Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer.

Daniel W. Kulp, W. DeGrado, J. Bennett, 2009, Journal of molecular biology.

The relative role of PLCbeta and PI3Kgamma in platelet activation.

D. Eslin, Dianqing Wu, M. Poncz, 2005, Blood.

Mechanisms of platelet adhesion and aggregation: an update.

J. Bennett, 1992, Hospital practice.

Small Molecule Inhibitors of Integrin α2β1

William F. DeGrado, W. DeGrado, J. Winkler, 2007 .

Arylamide derivatives as allosteric inhibitors of the integrin α2β1/type I collagen interaction

W. DeGrado, H. Yin, G. Vilaire, 2006 .

A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.

W. DeGrado, R. Iozzo, Sungwook Choi, 2009, The American journal of pathology.

Role for the Integrin 2 1 in Experimental and Developmental Angiogenesis

W. DeGrado, R. Iozzo, Sungwook Choi, 2009 .

Inhibition of Integrin a 2 b 1 Ameliorates Glomerular Injury

W. DeGrado, Xiwu Chen, A. Pozzi, 2012 .

Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction.

W. DeGrado, H. Yin, G. Vilaire, 2006, Bioorganic & medicinal chemistry letters.

Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi

J. Weisel, O. Kim, M. Alber, 2017, Scientific Reports.

α IIb β 3 (GPIIb/IIIa) Structure and Function

J. Bennett, 2017 .

Outside-in: peptide versus integrin.

J. Bennett, 2008, Blood.

Agonist-stimulated Ligand Binding by the Platelet Integrin αIIbβ3 in a Lymphocyte Expression System (*)

M. Poncz, G. Vilaire, J. Bennett, 1995, The Journal of Biological Chemistry.

Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering*

W. DeGrado, H. Yin, J. Bennett, 2016, The Journal of Biological Chemistry.

Regulation of αIIbβ3 Function in Human B Lymphocytes*

G. Vilaire, J. Bennett, E. Loh, 1998, The Journal of Biological Chemistry.

Binding strength and activation state of single fibrinogen-integrin pairs on living cells

J. Weisel, R. Litvinov, J. Bennett, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Carbenicillin and Penicillin G Impair Platelet Function by Inhibiting the Binding of Agonists to the Platelet Surface

G. Vilaire, J. Bennett, S. Shattil, 1979, Thrombosis and Haemostasis.

Computationally designed peptide inhibitors of protein-protein interactions in membranes.

Wei Li, Gregory A Caputo, W. DeGrado, 2008, Biochemistry.

Small molecule inhibitors of integrin alpha2beta1.

W. DeGrado, J. Winkler, Sungwook Choi, 2007, Journal of medicinal chemistry.

A push-pull mechanism for regulating integrin function.

W. DeGrado, Vikas Nanda, J. Lear, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Activation of Platelet αIIbβ3 by an Exogenous Peptide Corresponding to the Transmembrane Domain of αIIb*>

W. DeGrado, J. Weisel, J. Lear, 2006, Journal of Biological Chemistry.

Use of phage display to probe the evolution of binding specificity and affinity in integrins.

Renhao Li, W. DeGrado, Renhao Li, 2003, Protein engineering.

Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Inter-subunit Contacts.

W. DeGrado, J. Bennett, K. Fong, 2019, Biochemistry.

Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains

Renhao Li, A. Joshua Wand, William F. DeGrado, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Dotting the I of an I-domain

J. Bennett, 2004 .

A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface.

M. Poncz, G. Vilaire, J. Bennett, 1997, Blood.

A little bit of kindlin goes a long way.

J. Bennett, 2015, Blood.

Platelet αIIbβ3 activation: filling in the pieces.

J. Bennett, 2014, Blood.

Comment on Klapproth et al , page 2592 A little bit of kindlin goes a long

J. Bennett, 2015 .

Quantitative Analysis of Platelet αvβ3 Binding to Osteopontin Using Laser Tweezers*

J. Weisel, G. Vilaire, R. Litvinov, 2003, Journal of Biological Chemistry.

Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function

W. DeGrado, J. Weisel, M. Mravic, 2019, Proceedings of the National Academy of Sciences.

NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation

A. Wand, W. DeGrado, K. Valentine, 2010, Proceedings of the National Academy of Sciences.

Dimerization of the Transmembrane Domain of Integrin αIIb Subunit in Cell Membranes*

Vikas Nanda, Renhao Li, W. DeGrado, 2004, Journal of Biological Chemistry.

A naturally occurring mutation near the amino terminus of a IIb deﬁnes a new region involved in ligand binding to a IIb b 3

B. Coller, M. Poncz, G. Vilaire, 1999 .

The editor's roundtable: nonsteroidal antiinflammatory drugs and cardiovascular risk.

W. Roberts, M. Packer, V. Friedewald, 2008, The American journal of cardiology.

Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles.

J. Weisel, P. Billings, R. Composto, 2012, Integrative biology : quantitative biosciences from nano to macro.

Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering.

W. DeGrado, J. Weisel, G. Vilaire, 2006, Biochemistry.

Glanzmann Thrombasthenia Due to a Two Amino Acid Deletion in the Fourth Calcium-Binding Domain of a ! IIb : Demonstration of the Importance of Calcium-Binding Domains in the Conformation of a ! II , , pJ

Sanford, M. Poncz, G. Vilaire, 2002 .

A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.

L. Rauova, D. Essex, M. Poncz, 2021, Blood.

Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3.

J. Weisel, V. Barsegov, R. Litvinov, 2017, Biochemistry.

PLATELETS IN HEALTH AND DISEASE : PLATELET GPIIB-IIIA STRUCTURE AND FUNCTION : RECENT ADVANCES IN ANTIPLATELET THERAPY

S. Mousa, J. Bennett, 1996 .

Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer.

Daniel W. Kulp, W. DeGrado, J. Bennett, 2009, Journal of molecular biology.