G. Eelen

C. Mathieu, R. Bouillon, G. Eelen, 2003, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.

Huanming Yang, Jian Wang, L. Bolund, 2020, Cell metabolism.

Lipid availability determines skeletal progenitor cell fate via SOX9

P. Carmeliet, F. Maes, Dariusz Przybylski, 2020, Nature.

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

P. Carmeliet, D. Lambrechts, T. Rabelink, 2016, Cancer cell.

Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs.

C. Mathieu, R. Bouillon, C. Gysemans, 2007, Current medicinal chemistry.

PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D

C. Mathieu, R. Bouillon, R. O'Connor, 2014, Oncogene.

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

P. Carmeliet, M. Giugliano, Cicerone Tudor, 2016, Cell reports.

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

P. Carmeliet, A. Efeyan, H. Gerhardt, 2022, Nature Metabolism.

Mechanisms for the selective action of Vitamin D analogs

C. Mathieu, R. Bouillon, G. Eelen, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

P. Carmeliet, D. Lambrechts, B. Thienpont, 2018, Cell metabolism.

The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor (cid:1) /Progesterone Receptor (cid:1) /HER-2 (cid:1) Breast Carcinomas

K. Marchal, M. Christiaens, C. Wolf‐peeters, 2007 .

Unaltered Diabetes Presentation in NOD Mice Lacking the Vitamin D Receptor

C. Mathieu, R. Bouillon, C. Gysemans, 2008, Diabetes.

Analogs of calcitriol

R. Bouillon, G. Eelen, L. Verlinden, 2011 .

1,25-Dihydroxyvitamin D3 and the aging-related Forkhead Box O and Sestrin proteins in osteoblasts

R. Bouillon, G. Eelen, R. Gijsbers, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

P. Carmeliet, B. Schroen, R. V. van Leeuwen, 2017, Circulation.

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates.

Huanming Yang, Jian Wang, L. Bolund, 2020, Cancer cell.

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

P. Carmeliet, B. Thienpont, G. Carmeliet, 2022, Cell reports.

Altered Vitamin D receptor–coactivator interactions reflect superagonism of Vitamin D analogs

F. Claessens, R. Bouillon, G. Eelen, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

CD-ring modified vitamin D3 analogs and their superagonistic action

A. Muñoz, R. Bouillon, G. Eelen, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Antiproliferative and calcemic actions of trans-decalin CD-ring analogs of 1,25-dihydroxyvitamin D3.

C. Mathieu, R. Bouillon, J. Laureys, 2009, Anticancer research.

A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds

P. Carmeliet, Ming-Wei Wang, M. Dewerchin, 2022, Acta Pharmacologica Sinica.

1α,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130

K. Marchal, K. Engelen, R. Bouillon, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Characterization of the Condensin Component Cnap1 and Protein Kinase Melk as Novel E2F Target Genes Down-regulated by 1,25-Dihydroxyvitamin D3*

B. De Moor, K. Marchal, M. Bollen, 2005, Journal of Biological Chemistry.

Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast

P. Carmeliet, P. Neven, C. Desmedt, 2022, Nature Communications.

Microarray analysis of MCF-7 breast cancer cells treated with 1,25-dihydroxyvitamin D3 or a 17-methyl-D-ring analog.

B. De Moor, K. Marchal, K. Engelen, 2009, Anticancer research.

Microarray analysis of 1α,25-dihydroxyvitamin D3-treated MC3T3-E1 cells

C. Mathieu, R. Bouillon, G. Carmeliet, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

P. Carmeliet, H. Horlings, D. Lambrechts, 2022, Nature Communications.

Role and therapeutic potential of dietary ketone bodies in lymph vessel growth

P. Carmeliet, M. Dewerchin, G. Eelen, 2019, Nature Metabolism.

Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing Mcl-1-addicted cancer cells

M. Bootman, A. Voet, S. Tait, 2022, bioRxiv.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

P. Carmeliet, D. Eyre, G. Carmeliet, 2019, Nature.

Vitamin D and cancer

C. Mathieu, R. Bouillon, G. Carmeliet, 2013, Cell cycle.

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

P. Carmeliet, M. Sandri, Ping-Chih Ho, 2020, Nature.

Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation

R. DePinho, R. Bouillon, J. Paik, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction

D. Moras, F. Claessens, N. Rochel, 2005, Molecular Pharmacology.

Tumor vessel co-option probed by single-cell analysis.

P. Carmeliet, P. Vermeulen, L. Dirix, 2021, Cell reports.

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

P. Carmeliet, M. Monshouwer, C. Verfaillie, 2020, Nature Communications.

Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism

P. Carmeliet, C. Gysemans, G. Eelen, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

P. Carmeliet, J. Decruyenaere, C. Libert, 2020, EMBO molecular medicine.

Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis

P. Carmeliet, S. Morrison, G. Hannon, 2021, bioRxiv.

The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution

P. Carmeliet, D. Lambrechts, B. Weynand, 2022, Cardiovascular research.

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

P. Carmeliet, R. Deberardinis, J. Hofkens, 2013, Cell.

EndoDB: a database of endothelial cell transcriptomics data

Shawez Khan, Federico Taverna, Katerina Rohlenova, 2018, Nucleic Acids Res..

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

P. Carmeliet, F. le Noble, D. Lambrechts, 2016, The EMBO journal.

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

P. Carmeliet, P. van Damme, C. Verfaillie, 2019, Nature Communications.

Endothelial cell metabolism in normal and diseased vasculature.

Michael Simons, Guy Eelen, Peter Carmeliet, 2015, Circulation research.

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

P. Carmeliet, S. Morrison, G. Hannon, 2022, Nature.

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

L. Bolund, P. Carmeliet, T. Rabelink, 2019, Journal of the American Society of Nephrology : JASN.

A key role for transketolase-like 1 in tumor metabolic reprogramming

P. Carmeliet, M. Cascante, M. Antoniewicz, 2016, Oncotarget.

Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective.

Guy Eelen, Peter Carmeliet, P. Carmeliet, 2017, Vascular pharmacology.

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.

P. Carmeliet, A. Pascual-Montano, C. Verfaillie, 2015, Stem cell research.

Immunomodulation by endothelial cells — partnering up with the immune system?

P. Carmeliet, G. Eelen, J. Amersfoort, 2022, Nature Reviews Immunology.

Role of glutamine and interlinked asparagine metabolism in vessel formation

N. Yuldasheva, P. Carmeliet, R. Cubbon, 2017, The EMBO journal.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

P. Carmeliet, F. Gervasio, J. Hofkens, 2018, Nature.

FOXO1 couples metabolic activity and growth state in the vascular endothelium

P. Carmeliet, K. Rajewsky, H. Gerhardt, 2015, Nature.

Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells

P. Carmeliet, H. Gerhardt, J. Goveia, 2015, Nature.

The role of fatty acid β-oxidation in lymphangiogenesis

A. Luttun, P. Carmeliet, D. Lambrechts, 2016, Nature.

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

P. Carmeliet, S. Morrison, G. Hannon, 2022, Nature.

The impact of 1,25(OH)2D3 and its structural analogs on gene expression in cancer cells--a microarray approach.

R. Bouillon, G. Eelen, L. Verlinden, 2009, Anticancer research.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

P. Carmeliet, D. Eyre, G. Carmeliet, 2019, Nature.

The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃.

R. Bouillon, G. Eelen, D. Feldman, 2011, Best practice & research. Clinical endocrinology & metabolism.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

P. Carmeliet, F. Gervasio, J. Hofkens, 2018, Nature.

Basic and Therapeutic Aspects of Angiogenesis Updated.

P. Carmeliet, L. Treps, G. Eelen, 2020, Circulation research.

Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells

P. Carmeliet, P. Vermeulen, A. Reynolds, 2022, STAR protocols.

The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.

Kathleen Marchal, Annemieke Verstuyf, Guy Eelen, 2007, Cancer research.

Breast Carcinomas − / HER-2 − / Progesterone Receptor − Triple-Negative Estrogen Receptor Is Highly Expressed in Chk 1 The E 2 F-Regulated Gene

K. Marchal, M. Christiaens, C. Wolf‐peeters, 2007 .

Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration.

P. Carmeliet, G. Carmeliet, J. Goveia, 2016, Bone.

Lipid availability determines fate of skeletal progenitor cells via SOX9

P. Carmeliet, Dariusz Przybylski, D. Lambrechts, 2020, Nature.

1,25‐dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3‐E1 cells by direct regulation of cystathionine β‐synthase

S. Boonen, P. Lips, N. V. van Schoor, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Effects of 1α,25‐Dihydroxyvitamin D3 on the Expression of DNA Replication Genes

B. De Moor, K. Marchal, C. Mathieu, 2003 .

Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.

P. Carmeliet, K. Marchal, C. Mathieu, 2015, Cell reports.

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

P. Carmeliet, M. Sandri, Ping-Chih Ho, 2020, Nature.

NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins

C. Gysemans, G. Eelen, R. Derua, 2023, Cells.

CHAPTER 18 – The Vitamin D Hormone and its Nuclear Receptor: Mechanisms Involved in Bone Biology

R. Bouillon, G. Carmeliet, G. Eelen, 2006 .

Control of vessel sprouting by genetic and metabolic determinants

P. Carmeliet, J. Welti, G. Eelen, 2013, Trends in Endocrinology & Metabolism.

Interaction of endothelial cells with macrophages—linking molecular and metabolic signaling

P. Carmeliet, G. Eelen, Joanna Kalucka, 2017, Pflügers Archiv - European Journal of Physiology.

1 , 25-Dihydroxyvitamin D 3 Influences Cellular Homocysteine Levels in Murine Preosteoblastic MC 3 T 3E 1 Cells by Direct Regulation of Cystathionine b-Synthase

S. Boonen, P. Lips, R. Banerjee, 2011 .

The vitamin D hormone and its nuclear receptor: genomic mechanisms involved in bone biology

R. Bouillon, G. Carmeliet, G. Eelen, 1999 .

Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy

P. Neven, K. Marchal, M. Christiaens, 2008, Oncogene.

VEGFC targeted therapy reduces the CD34+ AML expansion by enhanced differentiation and apoptosis; A role for simultaneous glycolysis inhibition

P. Carmeliet, V. Guryev, H. Mahmud, 2018 .

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

P. Carmeliet, W. Robberecht, T. Dresselaers, 2016, Cell metabolism.

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

P. Carmeliet, M. Monshouwer, C. Verfaillie, 2020, Nature Communications.

Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis

P. Carmeliet, J. Goveia, Katerina Rohlenova, 2021, STAR protocols.

Prioritization and functional validation of target genes from single-cell transcriptomics studies

P. Carmeliet, Katerina Rohlenova, L. Schoonjans, 2023, Communications biology.

Vitamin D analogs and coactivators.

R. Bouillon, G. Eelen, L. Verlinden, 2006, Anticancer research.

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

P. Carmeliet, Wei Chen, J. Gariépy, 2023, Signal transduction and targeted therapy.

Vitamin D and cancer

G. Carmeliet, G. Eelen, L. Verlinden, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.

P. Carmeliet, A. Pascual-Montano, C. Verfaillie, 2015, Stem cell research.

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

P. Carmeliet, R. Deberardinis, J. Hofkens, 2013, Cell.

Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective.

P. Carmeliet, G. Eelen, F. Morales-Rodríguez, 2017, Vascular pharmacology.

Microarray analysis of 1alpha,25-dihydroxyvitamin D3-treated MC3T3-E1 cells.

C. Mathieu, R. Bouillon, G. Carmeliet, 2004, The Journal of steroid biochemistry and molecular biology.

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

P. Carmeliet, F. le Noble, D. Lambrechts, 2016, The EMBO journal.

Detailed protocol for a corneal thermal cauterization-based (lymph-)angiogenesis assay in mice

M. Dewerchin, G. Eelen, A. Bouché, 2023, MethodsX.

[New non-metabolic role for glutamine synthetase in angiogenesis].

G. Eelen, C. Dubois, P. Carmeliet, 2019, Medecine sciences : M/S.

QUIESCENT ENDOTHELIAL CELLS UPREGULATE FATTY ACID -OXIDATION FOR VASCULOPROTECTION VIA REDOX HOMEOSTASIS

D. Lambrechts, P. D. Zeeuw, B. Thienpont, 2019 .

The effects of 1alpha,25-dihydroxyvitamin D3 on the expression of DNA replication genes.

G. Carmeliet, G. Eelen, L. Verlinden, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.