X. Deupí

发表

Molecular signatures of G-protein-coupled receptors

M. Babu, A. Venkatakrishnan, C. Tate, 2013, Nature.

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

Xavier Deupi, Roger K. Sunahara, Brian T. DeVree, 2009, Proceedings of the National Academy of Sciences.

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.

B. Kobilka, X. Deupí, 2010, Physiology.

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

P. Gönczy, M. Steinmetz, R. Kammerer, 2016, Nature Cell Biology.

Quantification of structural distortions in the transmembrane helices of GPCRs.

Xavier Deupi, X. Deupí, 2012, Methods in molecular biology.

Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation.

L. Pardo, J. Ballesteros, X. Deupí, 2000, Biophysical journal.

The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein‐Coupled Receptors

Leonardo Pardo, Nicole Dölker, Mercedes Campillo, 2007, Chembiochem : a European journal of chemical biology.

Activation of CCR5 by Chemokines Involves an Aromatic Cluster between Transmembrane Helices 2 and 3*

Shoshana J. Wodak, Marc Parmentier, Leonardo Pardo, 2003, The Journal of Biological Chemistry.

Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR

P. Nogly, X. Deupí, G. Schertler, 2019, Proceedings of the National Academy of Sciences.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit

H. Stahlberg, T. Flock, R. Dawson, 2019, bioRxiv.

Figures and figure supplements Cryo-EM structure of the rhodopsin-G a i-bg complex reveals binding of the rhodopsin C-terminal tail to the g b subunit

H. Stahlberg, T. Flock, R. Dawson, 2019 .

Femtosecond-to-millisecond structural changes in a light-driven sodium pump

K. Nass, R. Kar, P. Nogly, 2020, Nature.

Ligand-regulated oligomerization of b 2 -adrenoceptors in a model lipid bilayer This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.Thislicensedoesn

L. Pardo, Brian T DeVree, R. Sunahara, 2009 .

Structure of b-Adrenergic Receptors

F. Brueckner, X. Deupí, J. Standfuss, 2013 .

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

D. Veprintsev, X. Deupí, G. Schertler, 2013, EMBO reports.

Structure of β-adrenergic receptors.

F. Brueckner, X. Deupí, G. Schertler, 2013, Methods in enzymology.

Ligands stabilize specific GPCR conformations: but how?

Xiao-dan Li, X. Deupí, G. Schertler, 2012, Structure.

Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting.

D. Häussinger, R. Schibli, X. Deupí, 2020, Journal of medicinal chemistry.

The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion

X. Deupí, N. Schwarz, A. Ludwig, 2017, PloS one.

Corrigendum: SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

P. Gönczy, M. Steinmetz, R. Kammerer, 2016, Nature Cell Biology.

Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

L. Pardo, J. Ballesteros, X. Deupí, 2002, Molecular pharmacology.

The counterion–retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation

X. Deupí, G. Schertler, A. Terakita, 2019, Communications Biology.

Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone

R. Schibli, X. Deupí, G. Schertler, 2021, Proceedings of the National Academy of Sciences.

Faculty Opinions recommendation of Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

X. Deupí, G. Schertler, 2011 .

Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants

O. Lichtarge, A. Bonnefond, T. Flock, 2022, ACS pharmacology & translational science.

A Molecular Pharmacologist’s Guide to G Protein–Coupled Receptor Crystallography

X. Deupí, C. Graaf, C. Piscitelli, 2015, Molecular Pharmacology.

β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells

U. Zabel, A. Inoue, X. Deupí, 2022, Nature Communications.

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

S. Grzesiek, D. Veprintsev, F. Brueckner, 2016, Nature.

Calcineurin-fusion facilitates Cryo-EM Structure Determination of a Family A GPCR

B. Kobilka, X. Deupí, Yang Du, 2022, bioRxiv.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

H. Stahlberg, T. Flock, R. Dawson, 2019, bioRxiv.

An Activation Switch in the Rhodopsin Family of G Protein-coupled Receptors

Leonardo Pardo, L. Pardo, S. Costagliola, 2005, Journal of Biological Chemistry.

Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity

T. Flock, C. Tate, P. Nogly, 2018, Science Advances.

Ultrafast structural changes direct the first molecular events of vision

S. Boutet, R. Neutze, K. Nass, 2022, bioRxiv.

The Two-Photon Reversible Reaction of the Bistable Jumping Spider Rhodopsin-1

X. Deupí, G. Schertler, J. Heberle, 2019, Biophysical journal.

Selective hydrolysis of 2,4-diaminopyrimidine systems: a theoretical and experimental insight into an old rule.

J. Borrell, J. Teixidó, X. Deupí, 2001, Journal of Organic Chemistry.

The TXP Motif in the Second Transmembrane Helix of CCR5

Shoshana J. Wodak, Marc Parmentier, Xavier Deupi, 2001, The Journal of Biological Chemistry.

Conformational activation of visual rhodopsin in native disc membranes

R. Neutze, G. Katona, X. Deupí, 2015, Science Signaling.

Conformational complexity of G-protein-coupled receptors.

Xavier Deupi, B. Kobilka, X. Deupí, 2007, Trends in pharmacological sciences.

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

Xavier Deupi, Gebhard Schertler, D. Oprian, 2011, Proceedings of the National Academy of Sciences.

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes

T. Sakmar, X. Deupí, G. Schertler, 2010, Nature.

Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology.

T. Sharpe, V. Olieric, R. Guixà-González, 2021, Structure.

Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology

V. Olieric, R. Guixà-González, X. Deupí, 2020, bioRxiv.

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

A. J. Venkatakrishnan, Gebhard F. X. Schertler, M. Madan Babu, 2016, Nature.

Arrestin-1 engineering facilitates complex stabilization with native rhodopsin

X. Deupí, G. Schertler, Aurélien Rizk, 2019, Scientific Reports.

Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish

Elliot J. Gerrard, T. Flock, X. Deupí, 2018, Proceedings of the National Academy of Sciences.

Probing Gαi1 protein activation at single–amino acid resolution

Tilman Flock, Dawei Sun, M Madan Babu, 2015, Nature Structural &Molecular Biology.

G Protein-Coupled Receptor Activation Based on X-ray Structural Studies

D. Veprintsev, X. Deupí, G. Schertler, 2013 .

An experimental strategy to probe Gq contribution to signal transduction in living cells

C. Müller, E. Kostenis, A. Inoue, 2021, The Journal of biological chemistry.

Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants

O. Lichtarge, B. Balkau, G. Charpentier, 2021, ACS pharmacology & translational science.

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

S. Grzesiek, H. Stahlberg, T. Maier, 2020, Science Advances.

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

Eric Trinquet, Bernard Pucci, Sébastien Granier, 2012, Proceedings of the National Academy of Sciences.

GPCRmd uncovers the dynamics of the 3D-GPCRome

Toni Giorgino, Gianni De Fabritiis, David E. Gloriam, 2019, bioRxiv.

Functional map of arrestin-1 at single amino acid resolution

R. Jaussi, X. Deupí, J. Standfuss, 2014, Proceedings of the National Academy of Sciences.

Serine and Threonine Residues Bend α-Helices in the χ1 = g− Conformation

Leonardo Pardo, Eric E. J. Haaksma, Xavier Deupi, 2000 .

An online resource for GPCR structure determination and analysis

Tilman Flock, Vignir Isberg, Christian Munk, 2019, Nature Methods.

Relation between sequence and structure in membrane proteins

Leonardo Pardo, Mireia Olivella, Xavier Deupí, 2013, Bioinform..

Coupling ligand structure to specific conformational switches in the β2-adrenoceptor

Xavier Deupi, B. Kobilka, X. Deupí, 2006, Nature chemical biology.

Influence of the g- conformation of Ser and Thr on the structure of transmembrane helices.

Leonardo Pardo, Nicole Dölker, Mercedes Campillo, 2010, Journal of structural biology.

Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity.

Leonardo Pardo, Nicole Dölker, Mercedes Campillo, 2007, Current topics in medicinal chemistry.

Ser and Thr Residues Modulate the Conformation of Pro-Kinked Transmembrane α-Helices

Leonardo Pardo, Mercedes Campillo, Xavier Deupi, 2004 .

Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices.

L. Pardo, J. Ballesteros, X. Deupí, 2004, Biophysical journal.

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

Leonardo Pardo, Xavier Deupi, L. Pardo, 2009, The EMBO journal.

Elucidating the Structure-Activity Relationship of the Pentaglutamic Acid Sequence of Minigastrin with Cholecystokinin Receptor Subtype 2.

R. Schibli, X. Deupí, M. Béhé, 2019, Bioconjugate chemistry.

Structural Insights for Homology Modeling of Chemokine Receptors

L. Pardo, X. Deupí, C. Govaerts, 2011 .

Structural insights into agonist-induced activation of G-protein-coupled receptors.

Xavier Deupi, X. Deupí, J. Standfuss, 2011, Current opinion in structural biology.

Charge-charge and cation-π interactions in ligand binding to G protein-coupled receptors

L. Pardo, X. Deupí, N. Dölker, 2007 .

GPCR-SAS: A web application for statistical analyses on G protein-coupled receptors sequences

Arnau Cordomí, Marlous Hoogstraat, Mercedes Campillo, 2018, PloS one.

Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

T. Flock, F. Damberger, D. Veprintsev, 2019, Nature Communications.

Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling

Y. Humeau, A. Lüthi, C. Genoud, 2014, PLoS biology.

A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation

Saskia Nijmeijer, Rob Leurs, Leonardo Pardo, 2011, Molecular Pharmacology.

A structural insight into the reorientation of transmembrane domains 3 and 5 during family A GPCR activation

L. Pardo, K. Sansuk, R. Leurs, 2010 .

Arrestin-1 engineering facilitates complex stabilization with native rhodopsin

X. Deupí, G. Schertler, Aurélien Rizk, 2019, Scientific Reports.

Allosterism and Collateral Efficacy Conformational complexity of G-protein-coupled receptors

B. Kobilka, X. Deupí, 2007 .

Activation of G protein-coupled receptors.

Xavier Deupi, B. Kobilka, X. Deupí, 2007, Advances in protein chemistry.

Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists*

Xavier Deupi, T. S. Kobilka, Foon Sun Thian, 2005, Journal of Biological Chemistry.

Conformational Plasticity of GPCR Binding Sites

L. Pardo, J. Ballesteros, Lei Shi, 2005 .

Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors.

C. Müller, E. Kostenis, R. Guixà-González, 2021, Pharmacological research.

A Molecular Pharmacologist’s Guide to G Protein–Coupled Receptor Crystallography

Chris de Graaf, Xavier Deupi, C. de Graaf, 2015, Molecular Pharmacology.

Conserved activation pathways in G-protein-coupled receptors.

X. Deupí, G. Schertler, J. Standfuss, 2012, Biochemical Society transactions.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

H. Stahlberg, T. Flock, R. Dawson, 2019, bioRxiv.

Characterization of a conformationally sensitive TOAC spin-labeled substance P

C. Nakaie, X. Deupí, A. Shafer, 2008, Peptides.

The counterion–retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation

X. Deupí, G. Schertler, A. Terakita, 2019, Communications Biology.

The counterion–retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation

X. Deupí, G. Schertler, A. Terakita, 2019, Communications Biology.

High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs

G. Schneider, C. Tate, R. Zenobi, 2021, Proceedings of the National Academy of Sciences.

Relevance of rhodopsin studies for GPCR activation.

X. Deupí, 2014, Biochimica et biophysica acta.

Distance-Dependent Cellular Uptake of Oligoproline-Based Homobivalent Ligands Targeting GPCRs-An Experimental and Computational Analysis.

R. Schibli, X. Deupí, M. Béhé, 2020, Bioconjugate chemistry.

Supplemental Information Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation

Jonas P. Winter, K. Mineev, A. Arseniev, 2014 .

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors

Leonardo Pardo, Tomas Perez-Acle, Xavier Deupi, 2011, PloS one.

The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin.

L. Pardo, M. Parmentier, J. Springael, 2007, Cellular signalling.

Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laser

G. Nelson, C. Gati, P. Nogly, 2015, Acta crystallographica. Section F, Structural biology communications.

Serine and Threonine Residues Bend a-Helices in the x 1 5 g 2 Conformation

L. Pardo, J. Ballesteros, X. Deupí, 2000 .

Influence of the environment in the conformation of alpha-helices studied by protein database search and molecular dynamics simulations.

Leonardo Pardo, Xavier Deupi, Mireia Olivella, 2002, Biophysical journal.

Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

T. Flock, F. Damberger, D. Veprintsev, 2019, Nature Communications.

The adhesion GPCR Adgrd1 is a prion protein receptor and a mediator of prion cytotoxicity

S. Hornemann, A. Aguzzi, R. Guixà-González, 2023, bioRxiv.

Crystal structure of Jumping Spider Rhodopsin-1 bound to 9-cis retinal

P. Nogly, X. Deupí, G. Schertler, 2019 .

Crystal structure of Jumping Spider Rhodopsin-1 bound to 9-cis retinal

P. Nogly, X. Deupí, G. Schertler, 2019 .

A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides

R. Schibli, X. Deupí, P. Grundler, 2023, EJNMMI Research.

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

S. Rasmussen, Brian T DeVree, R. Sunahara, 2009, Proceedings of the National Academy of Sciences.

Structure of β-adrenergic receptors.

F. Brueckner, X. Deupí, G. Schertler, 2013, Methods in enzymology.

MINIREVIEW—EXPLORING THE BIOLOGY OF GPCRS: FROM IN VITRO TO IN VIVO

X. Deupí, C. Piscitelli, J. Kean, 2015 .

Structural role of the T94I rhodopsin mutation in congenital stationary night blindness

X. Deupí, G. Schertler, Elsa C. Y. Yan, 2016, EMBO reports.

Structural role of the T 94 I rhodopsin mutation in congenital stationary night blindness

X. Deupí, G. Schertler, J. Standfuss, 2016 .

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

L. Pardo, Brian T DeVree, R. Sunahara, 2009, The EMBO journal.

TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in α-helix and β-barrel domains of membrane proteins

Arnau Cordomí, Leonardo Pardo, Mireia Olivella, 2015, BMC Bioinformatics.

GPCRmd uncovers the dynamics of the 3D-GPCRome

Toni Giorgino, Davide Provasi, Gianni De Fabritiis, 2020, Nature Methods.

GPCRmd uncovers the dynamics of the 3D-GPCRome

David E. Gloriam, Johanna K. S. Tiemann, J. C. Gómez-Tamayo, 2020 .