X. Rovira

发表

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

Jianfeng Liu, Xavier Rovira, J. Pin, 2015, Nature chemical biology.

Modeling the Binding and Function of Metabotropic Glutamate Receptors

J. Giraldo, J. Pin, J. Kniazeff, 2008, Journal of Pharmacology and Experimental Therapeutics.

Assessing receptor affinity for inverse agonists: Schild and Cheng-Prusoff methods revisited.

J. Giraldo, X. Rovira, D. Roche, 2007, Current drug targets.

Modelling the interdependence between the stoichiometry of receptor oligomerization and ligand binding for a coexisting dimer/tetramer receptor system

J. Giraldo, X. Rovira, M. Vivó, 2009, British journal of pharmacology.

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

J. Giraldo, J. Pin, X. Rovira, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

H. Daniel, E. Valjent, J. Pin, 2017, Nature Communications.

An allosteric modulator to control endogenous G protein-coupled receptors with light.

P. Gorostiza, J. Giraldo, J. Pin, 2014, Nature chemical biology.

Photocontrol of Endogenous Glycine Receptors In Vivo.

P. Bregestovski, P. Gorostiza, M. Alfonso-Prieto, 2020, Cell Chemical Biology.

Mechanistic Insights into Light-Driven Allosteric Control of GPCR Biological Activity.

Alice E. Berizzi, C. Goudet, X. Rovira, 2020, ACS pharmacology & translational science.

Photocontrol of endogenous glycine receptors in vivo

P. Bregestovski, P. Gorostiza, M. Alfonso-Prieto, 2019, bioRxiv.

Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Ligands

J. Pin, F. Acher, P. Rondard, 2018 .

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

P. Gorostiza, J. Giraldo, J. Pin, 2017, European journal of medicinal chemistry.

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

P. Gorostiza, J. Giraldo, J. Pin, 2016, Current neuropharmacology.

A double effect molecular switch leads to a novel potent negative allosteric modulator of metabotropic glutamate receptor 5

P. Gorostiza, J. Giraldo, J. Pin, 2014 .

Environmental levels of carbaryl impair zebrafish larvae behaviour: The potential role of ADRA2B and HTR2B.

J. Mestres, M. Faria, C. Barata, 2022, Journal of hazardous materials.

A photoswitchable ligand targeting β1-adrenoceptor enables light-control of the cardiac rhythm

M. Faria, K. L. Martinez, X. Rovira, 2022, bioRxiv.

The role of residue stability in transient protein–protein interactions involved in enzymatic phosphate hydrolysis. A computational study

Michael A. Johnston, J. Teyra, J. Bonet, 2005, Proteins: Structure, Function, and Bioinformatics.

Photoswitchable allosteric modulators for metabotropic glutamate receptors.

X. Rovira, A. Llebaria, X. Gómez-Santacana, 2022, Current opinion in pharmacology.

Photoswitchable antagonists for a precise spatiotemporal control of β2-adrenoceptors.

X. Rovira, A. Llebaria, M. Otero-Viñas, 2020, Journal of medicinal chemistry.

Allosteric modulation of metabotropic glutamate receptors by chloride ions

Y. de Koninck, J. Pin, F. Acher, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Activation Mechanism and Allosteric Properties of the GABAB Receptor

J. Pin, J. Kniazeff, P. Rondard, 2016 .

Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues

M. Faria, X. Rovira, A. Rodríguez-Sinovas, 2022, iScience.

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

L. Prézeau, J. Giraldo, J. Pin, 2017, eLife.

Complementing Kernel-Based Visualization of Protein Sequences with Their Phylogenetic Tree

Alfredo Vellido, Jesús Giraldo, Iván Olier, 2011, CIBB.

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

H. Daniel, E. Valjent, J. Pin, 2017, Nature Communications.

Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

E. Margeat, J. Pin, F. Acher, 2018, Neuropharmacology.

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

P. Gorostiza, J. Giraldo, J. Pin, 2016, Cell chemical biology.

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface

J. Pin, I. Brabet, P. Rondard, 2021, eLife.

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

J. Pin, P. Rondard, Li Xue, 2019, Nature Communications.

Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice

J. Hardelin, C. Dodé, X. Rovira, 2017, Human molecular genetics.

The catalytic power of enzymes: Conformational selection or transition state stabilization?

J. Giraldo, X. Rovira, D. Roche, 2006, FEBS letters.

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

E. Valjent, J. Giraldo, F. Ferraguti, 2018, Molecular Psychiatry.

FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor.

J. Pin, L. Lamarque, E. Trinquet, 2017, Cell chemical biology.

Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

C. Goudet, X. Rovira, A. Llebaria, 2018, Current opinion in pharmacology.

A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex

H. Daniel, X. Rovira, A. Llebaria, 2018, Front. Cell. Neurosci..

Concerted conformational changes control metabotropic glutamate receptor activity

E. Margeat, J. Pin, Emmanuel Bourrier, 2023, Science advances.

Dissecting conformational rearrangements and allosteric modulation in metabotropic glutamate receptor activation

E. Margeat, J. Pin, L. Lamarque, 2022, bioRxiv.

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

J. Giraldo, J. Pin, P. Rondard, 2017, eLife.

Structure, Dynamics, and Modulation of Metabotropic Glutamate Receptors

J. Pin, P. Rondard, C. Goudet, 2017 .

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways.

J. Giraldo, J. Pin, X. Rovira, 2010, Trends in pharmacological sciences.

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

F. Ciruela, P. Gorostiza, J. Giraldo, 2016, ACS central science.

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

J. Giraldo, J. Pin, C. Goudet, 2014, ChemMedChem.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

F. Ciruela, J. Giraldo, F. Nicoletti, 2017, eLife.

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

J. Pin, P. Rondard, Li Xue, 2019, Nature Communications.

Author response: Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

J. Giraldo, J. Pin, P. Rondard, 2017 .

Author response: Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

L. Prézeau, J. Giraldo, J. Pin, 2017 .

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

F. Ciruela, P. Gorostiza, J. Giraldo, 2016, ACS Central Science.

FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor.

J. Pin, L. Lamarque, E. Trinquet, 2017, Cell chemical biology.

Rearrangement of the transmembrane domain interfaces associated with the activation 1 of a GPCR hetero-oligomer 2 3

J. Pin, P. Rondard, Li Xue, 2020 .

Kernel generative topographic mapping of protein sequences

Jesús Giraldo, Martha Ivón Cárdenas, Alfredo Vellido Alcacena, 2012 .

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

J. Giraldo, J. Pin, E. Trinquet, 2017, eLife.