Jian Li

发表

Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.

Shaoyong Lu, Jian Zhang, Haiming Jiang, 2017, Nature chemical biology.

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.

Yechun Xu, Lele Zhao, Z. Miao, 2013, Journal of medicinal chemistry.

Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures

Shengzheng Wang, Jian Li, Yongqiang Zhang, 2015 .

Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo.

Jian Li, Xin Chen, Xi Yang, 2020, European journal of medicinal chemistry.

Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.

H. Almond, Jian Li, B. Maryanoff, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and anti-tumor activities of N'-benzylidene-2-(4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone derivatives.

Renxiao Wang, Jian Li, Zhen Liu, 2011, Bioorganic & medicinal chemistry letters.

Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents

Jian Li, Ruoxi Li, Lubing Jiang, 2020 .

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation

Hualiang Jiang, Honglin Li, Weiqiang Lu, 2009, Molecules.

Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism

Hualiang Jiang, Weihua Li, Jian Li, 2015, ChemMedChem.

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.

Shengzheng Wang, Jian Li, Guoqiang Dong, 2015, Journal of medicinal chemistry.

Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs

Jian Li, Xiang Xu, Fei Mao, 2016, Molecules.

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species

Jian Li, A. Moskalev, Keting Bao, 2021, Acta pharmaceutica Sinica. B.

Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.

Yechun Xu, Min Huang, M. Geng, 2014, European journal of medicinal chemistry.

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

Jian Li, Ruoxi Li, Keting Bao, 2021, Cell Death & Disease.

Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy.

Yun Tang, Yi Chen, Z. Miao, 2017, European journal of medicinal chemistry.

Structure-based Discovery of a Series of NSD2-PWWP1 Inhibitor

M. Geng, Jian Li, B. Xiong, 2021 .

Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.

Hualiang Jiang, Yun Tang, Jin Huang, 2017, Bioorganic & medicinal chemistry.

TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.

Xu Shen, J. Chen, Jinpei Zhou, 2018, Biochemical and biophysical research communications.

Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors.

Jian Li, Yuan-Ying Jiang, Wannian Zhang, 2018, European journal of medicinal chemistry.

Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice

Jian Li, A. Moskalev, Keting Bao, 2021, Oxidative medicine and cellular longevity.

Lactose induced redox-dependent senescence and activated Nrf2 pathway.

Jian Li, Keting Bao, Lanxin Zhang, 2019, International journal of clinical and experimental pathology.

Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation.

Hai-bin Luo, Jian Li, Yi-You Huang, 2018, Bioorganic & medicinal chemistry.

Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.

M. Huang, Min Huang, M. Geng, 2019, European journal of medicinal chemistry.

Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.

Q. Xiao, Feifei Chen, L. Lan, 2016, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation.

Jian Li, Yupeng Li, Tianfeng Xu, 2022, ACS medicinal chemistry letters.

Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents.

Zengrui Wu, Xiaoyan Chen, Jian Li, 2020, Journal of medicinal chemistry.

Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence.

Hualiang Jiang, Cai-Guang Yang, Q. Cao, 2016, Nature chemical biology.

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway

Jian Li, Keting Bao, Xiaofan Xu, 2022, Acta pharmaceutica Sinica. B.

1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: a novel cyclophilin A allosteric activator.

Hualiang Jiang, Ting Shi, Xu Shen, 2012, Biochemical and biophysical research communications.

Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.

Wei Wang, Wangsheng Li, Jian Li, 2022, European journal of medicinal chemistry.

Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.

Xiaomeng He, Shengzheng Wang, Jian Li, 2014, ACS medicinal chemistry letters.

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization

Hualiang Jiang, Jin Huang, Lei Liu, 2015, Molecules.

(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.

Jian Li, Judith Baker, Hong-tao Lu, 2005, Journal of medicinal chemistry.

Discovery of pyrazole as C-terminus of selective BACE1 inhibitors.

Yechun Xu, Li Li, Jian Li, 2013, European journal of medicinal chemistry.

Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives.

Changlin Zhou, Jian Li, Rui Wu, 2013, European journal of medicinal chemistry.

Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?

Weiliang Zhu, Jian Li, Honglin Li, 2011, Journal of medicinal chemistry.

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Ying Yu, Zhenting Gao, Wenzhong Yan, 2012, Journal of medicinal chemistry.

Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus

Weiqiang Lu, Jin Huang, Jian Li, 2015 .

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci.

Feifei Chen, L. Lan, Jian Li, 2018, Journal of medicinal chemistry.

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Honglin Li, Jin Huang, Jin Zhu, 2009, Journal of medicinal chemistry.

Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors.

Jian Li, Guoqiang Dong, Zhenyuan Miao, 2017, Journal of medicinal chemistry.

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors

L. Lan, Jian Li, Fei Mao, 2020, Medicinal research reviews.

Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis.

Jian Li, C. Sheng, Fei Mao, 2018, Bioorganic & medicinal chemistry.

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.

Yanliang Ren, Jian Wan, Jian Li, 2020, European journal of medicinal chemistry.

Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity

Jian Li, Fei Mao, Jin Zhu, 2014, Molecules.

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.

Min Huang, C. Luo, M. Geng, 2017, Journal of medicinal chemistry.

Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.

Zhuqing Zhang, Jian Ding, M. Geng, 2019, Journal of medicinal chemistry.

Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition.

Hualiang Jiang, Jin Huang, Lei Liu, 2015, Bioorganic & medicinal chemistry letters.

Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping.

Zhili Zuo, Weiliang Zhu, Oi Wah Liew, 2012, Journal of medicinal chemistry.

Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.

Luhua Lai, Jianfeng Pei, Jin Huang, 2009, Journal of medicinal chemistry.

Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB

Jian Li, Fei Mao, Yudong Wang, 2021, Frontiers in Oncology.

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy

Jian Li, Wen-Jun Li, Keting Bao, 2020, Aging.

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs).

Jian Li, Fei Mao, Jin Zhu, 2017, Journal of medicinal chemistry.

Drug repositioning by prediction of drug's anatomical therapeutic chemical code via network-based inference approaches

Weihua Li, Zengrui Wu, Chao Zhang, 2020, Briefings Bioinform..

Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

Jian Li, Lei Fan, Fei Mao, 2019, Acta pharmaceutica Sinica. B.

A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1

L. Cui, Jian Li, Jie Cui, 2020, Cell discovery.

Synthesis, Structure–Activity Relationship, and Pharmacophore Modeling Studies of Pyrazole‐3‐Carbohydrazone Derivatives as Dipeptidyl Peptidase IV Inhibitors

Hualiang Jiang, Guixia Liu, Yun Tang, 2012, Chemical biology & drug design.

Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis

Jian Li, H. Shang, Yixiang Xu, 2021, Protein & cell.

Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups.

Z. Miao, Jian Li, B. Xiong, 2018, European journal of medicinal chemistry.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma.

Jian Li, Xiaofan Xu, R. Jia, 2023, European journal of medicinal chemistry.

Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.

Feifei Chen, L. Lan, Jian Li, 2018, ACS medicinal chemistry letters.

Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections.

Feifei Chen, L. Lan, Jian Li, 2018, European journal of medicinal chemistry.

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo.

Feifei Chen, L. Lan, Jian Li, 2017, Journal of medicinal chemistry.

Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN).

Q. Xiao, Feifei Chen, L. Lan, 2016, Journal of medicinal chemistry.

Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy

Hualiang Jiang, Z. Miao, Jian Ding, 2017, Acta Pharmacologica Sinica.

HL005—A new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7

Xu Shen, Honglin Li, Hualiang Jiang, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Refinement and 3D‐QSAR Studies of Inhibitors of Cyclophilin A Containing Amide Linker

Hualiang Jiang, Yun Tang, Jian Li, 2008, QSAR & combinatorial science.

Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design, synthesis and biological evaluation

Hualiang Jiang, Yun Tang, Jin Huang, 2017, Chinese Chemical Letters.

Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors.

Shengzheng Wang, Jian Li, Shanchao Wu, 2016, Chemical communications.

Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation.

Jian Li, Haiyan Zhang, Wei Wang, 2017, ACS chemical neuroscience.

Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.

Jian Li, Zhengyu Lu, Naixia Zhang, 2016, Journal of medicinal chemistry.

Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent

Lei Wu, Jian Li, Hu Zhou, 2019, Acta pharmaceutica Sinica. B.

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.

Jian Li, Haiyan Zhang, Keting Bao, 2017, ACS chemical neuroscience.

Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents.

Jian Zhang, Jian Li, Haiyan Zhang, 2018, ACS chemical neuroscience.

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Yun Tang, Jian Li, Hai-Yan Zhang, 2018, European journal of medicinal chemistry.

The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel.

Hualiang Jiang, Jian Li, Zhaobing Gao, 2013, Toxicology letters.

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.

Yechun Xu, M. Geng, Jian Li, 2014, Bioorganic & Medicinal Chemistry Letters.

Discovery of candesartan cilexetic as a novel neddylation inhibitor for suppressing tumor growth.

Yi Sun, Junqian Zhang, Jian Li, 2019, European journal of medicinal chemistry.

Development of Second‐Generation Small‐Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy

Hualiang Jiang, Gang Chen, Jian Li, 2015, ChemMedChem.

Discovery of Piperidol Derivatives for Combinational Treatment of Azole-Resistant Candidiasis.

Jian Li, C. Sheng, Na Liu, 2021, ACS infectious diseases.

2-Amido-3-(1H-Indol-3-yl)-N-Substitued-Propanamides as a New Class of Falcipain-2 Inhibitors. 1. Design, Synthesis, Biological Evaluation and Binding Model Studies

Hualiang Jiang, Honglin Li, Weiqiang Lu, 2009, Molecules.

Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.

Jian Zhang, Jian Li, Wei Wang, 2018, Bioorganic & medicinal chemistry.

Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.

Q. Cao, L. Lan, Jian Li, 2022, European journal of medicinal chemistry.

Structure-based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.

Z. Miao, Jian Li, B. Xiong, 2019, Journal of medicinal chemistry.

Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer.

Jian Li, Fei Mao, Jin Zhu, 2020, Bioorganic & medicinal chemistry letters.

Drug Repurposing of Haloperidol: Discovery of New Benzocyclane Derivatives as Potent Antifungal Agents against Cryptococcosis and Candidiasis.

Jian Li, C. Sheng, Na Liu, 2019, ACS infectious diseases.

Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.

Shengzheng Wang, Jian Li, Zhenyuan Miao, 2017, Bioorganic & medicinal chemistry.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.

Shengzheng Wang, Jian Li, Yongqiang Zhang, 2014, ACS Medicinal Chemistry Letters.

Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.

Jian Li, Sui-Po Zhang, H. Breslin, 2004, Journal of medicinal chemistry.

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Hualiang Jiang, Xu Shen, Honglin Li, 2009, Journal of medicinal chemistry.

Discovery of new Syk inhibitors through structure-based virtual screening.

Jian Li, Bo-hua Li, Guoqiang Dong, 2017, Bioorganic & medicinal chemistry letters.

Identification of the new covalent allosteric binding site of FBPase with disulfiram derivatives toward glucose reduction.

Lingling Feng, Yanliang Ren, Jian Wan, 2020, Journal of medicinal chemistry.

Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat.

Jian Li, Yan Ding, Ruoxi Li, 2021, Journal of medicinal chemistry.

Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).

Jian Zhang, Jian Li, Haiyan Zhang, 2018, ACS Chemical Neuroscience.

Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity

Jian Li, Fei Mao, Jin Zhu, 2014, Molecules.

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

Jian Li, Keting Bao, Wenwen Liu, 2021, bioRxiv.

Feifei Chen, Jian Li, Fei Mao, 2017, Journal of medicinal chemistry.