G. Wilson

G. Wilson, M. Gillespie, Kathryn A. Ziel, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.

S. Bhushan, D. Lefer, G. Wilson, 2017, American journal of physiology. Heart and circulatory physiology.

Cytokines Induce Nitric Oxide-mediated mtDNA Damage and Apoptosis in Oligodendrocytes

N. Druzhyna, S. Ledoux, G. Wilson, 2005, Journal of Biological Chemistry.

Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells.

G. Wilson, V. Solodushko, Larysa V. Yuzefovych, 2012, Endocrinology.

Mitochondrial DNA Damage Mediates Hyperoxic Dysmorphogenesis in Rat Fetal Lung Explants

G. Wilson, M. Gillespie, S. Gebb, 2012, Neonatology.

Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs.

G. Wilson, M. Gillespie, V. Pastukh, 2011, American journal of physiology. Lung cellular and molecular physiology.

Repair of oxidative damage in nuclear DNA sequences with different transcriptional activities.

S. Ledoux, G. Wilson, V. Grishko, 1997, Mutation research.

Mitochondrial DNA Repair and Cell Injury

V. Bohr, S. Ledoux, G. Wilson, 1993 .

Heterogeneous repair of methylnitrosourea-induced alkali-labile sites in different DNA sequences.

V. Bohr, S. Ledoux, G. Wilson, 1991, Cancer research.

Catalytic activity of poly(ADP-ribose) polymerase is necessary for repair of N-methylpurines in nontranscribed, but not in transcribed, nuclear DNA sequences.

L. Ray, S. Chatterjee, N. Berger, 1996, Mutation research.

Preferential DNA repair of alkali-labile sites within the active insulin gene.

N. J. Patton, S. Ledoux, G. Wilson, 1990, The Journal of biological chemistry.

Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation in rats with metabolic syndrome

Yeong-Renn Chen, G. Wilson, J. Hardwick, 2022, Basic Research in Cardiology.

Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice

G. Wilson, M. Gillespie, J. Parker, 2014, Pharmaceuticals.

Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.

G. Wilson, M. Gillespie, J. Parker, 2013, American journal of physiology. Lung cellular and molecular physiology.

Mitochondrial DNA in beta-cells is a sensitive target for damage by nitric oxide.

N. J. Patton, S. Ledoux, G. Wilson, 1997, Diabetes.

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes.

A. Mates, A. Pearsall, G. Wilson, 2010, Osteoarthritis and cartilage.

The expression of Exonuclease III from E. coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress.

F. Robertson, S. Ledoux, G. Wilson, 2003, DNA repair.

Altering DNA base excision repair: Use of nuclear and mitochondrial‐targeted N‐methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents

N. Druzhyna, S. Ledoux, G. Wilson, 2007, Glia.

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage

Yeong-Renn Chen, M. Marzilli, G. Wilson, 2016, Basic Research in Cardiology.

Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance

D. Spitz, S. Ledoux, G. Wilson, 2005, Nucleic acids research.

The role of mitochondrial reactive oxygen species in cartilage matrix destruction

A. Pearsall, G. Wilson, V. Grishko, 2014, Molecular and Cellular Biochemistry.

Bending and breaking the code: dynamic changes in promoter integrity may underlie a new mechanism regulating gene expression.

G. Wilson, M. Gillespie, G. Wilson, 2007, American journal of physiology. Lung cellular and molecular physiology.

Repair of O6-Methylguanine in Rat Pancreatic β-Cells After Exposure to N-Methyl-N-Nitrosourea

S. Ledoux, G. Wilson, J. W. Nelson, 1993, Diabetes.

ventilator-induced lung injury in intact mice 8-oxoguanine DNA glycosylase 1 protects against Mitochondrial-targeted DNA repair enzyme

G. Wilson, M. Gillespie, B. Potter, 2016 .

Mitochondrial DNA in β-Cells Is a Sensitive Target for Damage by Nitric Oxide

N. J. Patton, S. Ledoux, G. Wilson, 1997, Diabetes.

Targeting repair proteins to the mitochondria of mammalian cells through stable transfection, transient transfection, viral transduction, and TAT-mediated protein transduction.

S. Ledoux, G. Wilson, C. Koczor, 2009, Methods in molecular biology.

Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes.

N. Venediktova, G. Wilson, M. Alexeyev, 2008, Gene therapy.

Contribution of Mitochondrial DNA Repair to Cell Resistance from Oxidative Stress*

D. Spitz, S. Ledoux, G. Wilson, 2005, Journal of Biological Chemistry.

Novel Fusion Protein Targeting Mitochondrial DNA Improves Pancreatic Islet Functional Potency and Islet Transplantation Outcomes

G. Wilson, J. S. Danobeitia, L. Fernandez, 2017, Cell transplantation.

A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions

G. Wilson, Rafik Z. Fayzulin, M. Alexeyev, 2015, Nucleic acids research.

Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa

G. Wilson, J. Simmons, M. Gillespie, 2017, Shock.

Effects of Hyaluronic Acid on Mitochondrial Function and Mitochondria-driven Apoptosis following Oxidative Stress in Human Chondrocytes

A. Mates, A. Pearsall, Min Xu, 2009, Journal of Biological Chemistry.

Mechanisms of Nitrosourea-Induced β-Cell Damage: Alterations in DNA

N. J. Patton, S. Ledoux, G. Wilson, 1986, Diabetes.

Glial cell type-specific responses to menadione-induced oxidative stress.

D. Spitz, S. Ledoux, G. Wilson, 2000, Free radical biology & medicine.

Glial cell‐specific differences in response to alkylation damage

S. Ledoux, G. Wilson, P. Fields, 1998, Glia.

Enhanced Mitochondrial DNA Repair Resuscitates Transplantable Lungs Donated After Circulatory Death.

M. Mulekar, G. Wilson, J. Simmons, 2019, The Journal of surgical research.

The maintenance of mitochondrial DNA integrity--critical analysis and update.

S. Ledoux, G. Wilson, M. Alexeyev, 2013, Cold Spring Harbor perspectives in biology.

Temozolomide-Mediated DNA Methylation in Human Myeloid Precursor Cells: Differential Involvement of Intrinsic and Extrinsic Apoptotic Pathways

K. Pollok, L. Mayo, M. Czader, 2013, Clinical Cancer Research.

Cancer Therapy : Preclinical Temozolomide-MediatedDNAMethylation inHumanMyeloid Precursor Cells : Differential Involvement of Intrinsic and Extrinsic Apoptotic Pathways

K. Pollok, L. Mayo, M. Czader, 2013 .

Mitochondrial DNA repair in aging and disease

N. Druzhyna, S. Ledoux, G. Wilson, 2008, Mechanisms of Ageing and Development.

The approaches for manipulating mitochondrial proteome

S. Ledoux, G. Wilson, M. Alexeyev, 2010, Environmental and molecular mutagenesis.

An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

R. Reiter, B. Poeggeler, J. Ghiso, 2000, Journal of Neural Transmission.

Enhancing Base Excision Repair of Mitochondrial DNA to Reduce Ischemic Injury Following Reperfusion

R. Simon, Tao Yang, R. Meller, 2018, Translational Stroke Research.

Receptor Tyrosine Kinase ErbB2 Translocates into Mitochondria and Regulates Cellular Metabolism

L. Pannell, Hao Liu, O. Fodstad, 2012, Nature Communications.

TAT-mediated protein transduction and targeted delivery of fusion proteins into mitochondria of breast cancer cells.

S. Ledoux, G. Wilson, M. Alexeyev, 2005, DNA repair.

Oxidative stress induces degradation of mitochondrial DNA

N. Venediktova, G. Wilson, M. Alexeyev, 2009, Nucleic acids research.

Human Mitochondrial Mutations and Repair

N. Druzhyna, S. Ledoux, G. Wilson, 2011 .

Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress

S. Ledoux, G. Wilson, M. Kelley, 2007, Journal of neurochemistry.

Mitochondrial DNA Damage and Repair

S. Ledoux, G. Wilson, I. Shokolenko, 2007 .

Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in l6 rat skeletal muscle cells.

S. Ledoux, G. Wilson, L. Rachek, 2007, Endocrinology.

Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine.

A. Pearsall, Min Xu, G. Wilson, 2010, The Journal of bone and joint surgery. American volume.

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

Koji Abe, Mikio Shoji, George Perry, 2003, Journal of neurochemistry.

Macrophage Activation, and Increased Angiogenic Growth Factors in Mice but Not in Rats Pregabalin-Treated Mice: Evidence of Increased Bicarbonate, Dysregulated Erythropoiesis, Key Components of the Mode of Action for Hemangiosarcoma Induction in

H. Yokota, R. Schroter, K. Uesugi, 2015 .

The role of mitochondrial reactive oxygen species in cartilage matrix destruction

A. Pearsall, G. Wilson, V. Grishko, 2014, Molecular and Cellular Biochemistry.

Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis.

M. Tan, G. Wilson, R. Arora, 2016, Cancer research.

Role of nitric oxide-induced mtDNA damage in mitochondrial dysfunction and apoptosis.

S. Ledoux, G. Wilson, L. Rachek, 2006, Free radical biology & medicine.

Nitric oxide-induced damage to mtDNA and its subsequent repair.

N. Druzhyna, S. Ledoux, G. Wilson, 1999, Nucleic acids research.

Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA.

G. Holmquist, S. Ledoux, G. Wilson, 1997, Nucleic acids research.

Endonuclease III and endonuclease VIII conditionally targeted into mitochondria enhance mitochondrial DNA repair and cell survival following oxidative stress.

S. Ledoux, G. Wilson, M. Alexeyev, 2004, Nucleic acids research.

Mitochondrial DNA Damage, Repair, Degradation and Experimental Approaches to Studying These Phenomena

S. Ledoux, G. Wilson, M. Alexeyev, 2011 .

Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes.

A. Pearsall, G. Wilson, V. Grishko, 2009, Osteoarthritis and cartilage.

Persistent damage induces mitochondrial DNA degradation.

G. Wilson, M. Alexeyev, I. Shokolenko, 2013, DNA repair.

Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.

Yun Wu, R. Nahta, Hao Liu, 2011, Cancer research.

Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation in rats with metabolic syndrome

Yeong-Renn Chen, G. Wilson, J. Hardwick, 2022, Basic Research in Cardiology.

Mutations in the passenger polypeptide can affect its partitioning between mitochondria and cytoplasm

G. Wilson, M. Alexeyev, I. Shokolenko, 2008, Molecular Biology Reports.

Mitochondrial DNA repair: A critical player in the response of cells of the CNS to genotoxic insults

N. Druzhyna, S. Ledoux, G. Wilson, 2007, Neuroscience.

Base excision repair of mitochondrial DNA damage in mammalian cells.

S. Ledoux, G. Wilson, 2001, Progress in nucleic acid research and molecular biology.

Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.

M. Smulson, N. Druzhyna, S. Ledoux, 2000, Diabetes.

41 – Mitochondrial DNA and Aging

S. Ledoux, G. Wilson, M. Alexeyev, 2006 .

24 Targeting DNA Repair Proteins to Mitochondria

S. Ledoux, G. Wilson, M. Kelley, 2002 .

Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes.

S. Ledoux, G. Wilson, M. Gillespie, 2001, American journal of physiology. Lung cellular and molecular physiology.

Conditional Targeting of the DNA Repair Enzyme hOGG1 into Mitochondria*

S. Ledoux, G. Wilson, M. Kelley, 2002, The Journal of Biological Chemistry.

Human mitochondrial transcription factor A possesses multiple subcellular targeting signals

G. Wilson, M. Alexeyev, I. Shokolenko, 2007, The FEBS journal.

Reactive oxidants from nitric oxide, oxidants and cellular signalling, and repair of oxidative DNA damage: A chemical pathology study section workshop

D. Liebler, G. L. Wilson, G. Wilson, 1998, Molecular carcinogenesis.

Aging: A mitochondrial DNA perspective, critical analysis and an update.

G. Wilson, M. Alexeyev, I. Shokolenko, 2014, World journal of experimental medicine.

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes.

S. Ledoux, G. Wilson, Larysa V. Yuzefovych, 2009, Toxicology and applied pharmacology.

Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.

S. Ledoux, G. Wilson, M. Gillespie, 2002, American journal of physiology. Lung cellular and molecular physiology.

Mitochondrial DNA Damage via Augmented Oxidative Stress Regulates Endoplasmic Reticulum Stress and Autophagy: Crosstalk, Links and Signaling

S. Ledoux, G. Wilson, Larysa V. Yuzefovych, 2013, PloS one.

The Amyloid β Protein Induces Oxidative Damage of Mitochondrial DNA

S. Ledoux, G. Wilson, M. Pappolla, 1997 .

The amyloid beta protein induces oxidative damage of mitochondrial DNA.

S. Ledoux, G. Wilson, M. Pappolla, 1997, Journal of neuropathology and experimental neurology.

Running title : mitochondrial DNA damage drives breast cancer progression

M. Tan, G. Wilson, R. Arora, 2015 .

Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion

J. Downey, G. Wilson, M. Gillespie, 2015, Basic Research in Cardiology.

Alzheimer β protein mediated oxidative damage of mitochondrial DNA: Prevention by melatonin

J Ghiso, B. Poeggeler, J. Ghiso, 1999, Journal of pineal research.

The “fast” and the “slow” modes of mitochondrial DNA degradation

G. Wilson, M. Alexeyev, I. Shokolenko, 2016, Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis.

Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone

G. Wilson, N. L. Julie, I. M. Julie, 2008, Diabetologia.

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease.

M. Chesselet, M. Vila, T. Dawson, 2009, Free radical biology & medicine.

Mitochondrial DNA Ligase Is Dispensable for the Viability of Cultured Cells but Essential for mtDNA Maintenance*

G. Wilson, S. Katyal, Rafik Z. Fayzulin, 2013, The Journal of Biological Chemistry.

alpha-complementation-enabled T7 expression vectors and their use for the expression of recombinant polypeptides for protein transduction experiments.

G. Wilson, M. Alexeyev, I. Shokolenko, 2004, Methods in molecular biology.

Deficiency of chaperonin 60 in Down's syndrome.

S. Ledoux, G. Wilson, M. Pappolla, 2002, Journal of Alzheimer's disease : JAD.

Mechanisms of nitrosourea-induced beta-cell damage. Alterations in DNA.

N. J. Patton, S. Ledoux, G. Wilson, 1986, Diabetes.

Abstract 3208: Overcoming cancer therapeutic resistance by targeting dysregulated glucose metabolism

Ming Zhou, Dihua Yu, J. Price, 2012 .