J. Busciglio

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Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Caine W. Wong, B. Yankner, J. Busciglio, 2002, Neuron.

Beta-amyloid, oxidative stress and down syndrome.

E. Head, J. Busciglio, I. Lott, 2006, Current Alzheimer research.

Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?

Luca Tiano, J. Busciglio, 2011, BioFactors.

Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease.

D. Wallace, J. Busciglio, I. Lott, 2016, Journal of Alzheimer's disease : JAD.

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

L. Groop, C. Ling, J. Fadista, 2016, PLoS genetics.

Different Conformations of Amyloid β Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

J. Busciglio, A. Deshpande, E. Mina, 2006, The Journal of Neuroscience.

Tyrosinated and detyrosinated microtubules in axonal processes of cerebellar macroneurons grown in culture

H. Barra, J. Busciglio, A. Cáceres, 1991, Journal of neuroscience research.

Fast axonal transport misregulation and Alzheimer’s Disease

J. Busciglio, G. Pigino, S. Brady, 2002, NeuroMolecular Medicine.

Tau isoform expression and regulation in human cortical neurons

J. Busciglio, A. Deshpande, Khin May Win, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

β‐Amyloid Neurotoxicity in Human Cortical Culture Is Not Mediated by Excitotoxins

B. Yankner, J. Busciglio, J. Yeh, 1993, Journal of neurochemistry.

Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene.

C. Decastro, J. Busciglio, D. Gabuzda, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of β‐Amyloid Production by Activation of Protein Kinase C

B. Yankner, J. Busciglio, D. Gabuzda, 1993 .

Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease

B. Sommer, M. Staufenbiel, Caine W. Wong, 1997, The Journal of Neuroscience.

Stress, Aging, and Neurodegenerative Disorders: Molecular Mechanisms a

J. Andersen, J. Busciglio, O. Toussaint, 1998, Annals of the New York Academy of Sciences.

An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats

O. Steward, Adriana B Ferreira, J. Busciglio, 1987, Brain Research.

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

Y. Hérault, Patricia Shaw, P. D. De Deyn, 2021, Molecular Syndromology.

Building the future therapies for DS : The Third International Conference of the T 21 Research Society

P. Deyn, Y. Hérault, M. Dierssen, 2021 .

Repurposing cell growth-regulating compounds identifies kenpaullone which ameliorates pathologic pain via normalization of inhibitory neurotransmission

J. Busciglio, R. Ji, W. Liedtke, 2019 .

Axonal transport hypothesis moves on to implicate presenilin: Alzheimer research forum live discussion.

C. Geula, F. LaFerla, A. Takashima, 2004, Journal of Alzheimer's disease : JAD.

Ganglioside-enhanced neurite growth: evidence for a selective induction of high-molecular-weight MAP-2

A. Ferreira, J. Busciglio, A. Cáceres, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau.

A. Ferreira, J. Busciglio, A. Cáceres, 1989, Brain research. Developmental brain research.

Fetal human cortical neurons grown in culture: morphological differentiation, biochemical correlates and development of electrical activity

C. Brosnan, H. Yeh, D. Kerkovich, 1999, International Journal of Developmental Neuroscience.

Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

Mark P Mattson, M. Mattson, J. Busciglio, 2003, The Journal of Neuroscience.

Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society

P. D. De Deyn, C. Lemere, M. Dierssen, 2018, Molecular Syndromology.

Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

I. Rivera, Z. Storchová, J. Busciglio, 2019, Cell reports.

Down Syndrome: Genes, Model Systems, and Progress towards Pharmacotherapies and Clinical Trials for Cognitive Deficits

K. Gardiner, J. Busciglio, G. Capone, 2013, Cytogenetic and Genome Research.

Intracellular Accumulation of Amyloid β and Mitochondrial Dysfunction in Down’s Syndrome

J. Busciglio, A. Pelsman, P. Helguera, 2004 .

GVS-111 prevents oxidative damage and apoptosis in normal and Down’s syndrome human cortical neurons

R. Ostrovskaya, T. Gudasheva, J. Busciglio, 2003, International Journal of Developmental Neuroscience.

An immunocytochemical and biochemical study of the microtubule-associated protein MAP-2 during post-lesion dendritic remodeling in the central nervous system of adult rats.

O. Steward, A. Ferreira, J. Busciglio, 1988, Brain research.

Cryopreservation of Cortical Tissue Blocks for the Generation of Highly Enriched Neuronal Cultures

J. Busciglio, P. Helguera, A. S. Rahman, 2010, Journal of visualized experiments : JoVE.

Neuronal Regulation of Presenilin-1 Processing

B. Yankner, J. Busciglio, H. Hartmann, 1998 .

Developmental Regulation of Presenilin-1 Processing in the Brain Suggests a Role in Neuronal Differentiation*

M. Staufenbiel, B. Yankner, J. Busciglio, 1997, The Journal of Biological Chemistry.

Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia

J. Busciglio, P. Coskun, 2012, Current gerontology and geriatrics research.

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

M. Beal, N. Kowall, B. Yankner, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Intracellular Accumulation of β-Amyloid in Cells Expressing the Swedish Mutant Amyloid Precursor Protein (*)

B. Yankner, J. Busciglio, P. Paganetti, 1995, The Journal of Biological Chemistry.

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

O. Ashur-Fabian, I. Gozes, J. Busciglio, 2007, Current pharmaceutical design.

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

P. Matsudaira, P. Matsudaira, B. Yankner, 1993, Proceedings of the National Academy of Sciences of the United States of America.

stabilization prevents critical oxidative damage in Down cells.

Alfredo, S. Cannas, J. Busciglio, 2018 .

Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

I. Kola, E. Wolvetang, P. Hertzog, 2003, Neurobiology of Disease.

Genetic removal of synaptic Zn2+ impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity

S. Catuara-Solarz, J. Busciglio, Ryan C. Bohannan, 2023, Frontiers in Neurology.

Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter

Yuan Gao, L. Birnbaumer, Junjie U. Guo, 2013, Proceedings of the National Academy of Sciences.

Low Cost Electrode Assembly for EEG Recordings in Mice

J. Busciglio, Ryan C. Bohannan, Emily C. Vogler, 2017, Front. Neurosci..

Disruption of zinc neuromodulation by Aß oligomers: therapeutic implications.

J. Busciglio, E. Vogler, 2014, Current pharmaceutical design.

A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses

R. Metherate, J. Busciglio, A. Deshpande, 2009, The Journal of Neuroscience.

Apoptosis induced by HIV-1 infection of the central nervous system.

U. de Girolami, U. Girolami, J. Busciglio, 1996, The Journal of clinical investigation.

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

J. Busciglio, G. Pigino, S. Brady, 2009, Proceedings of the National Academy of Sciences.

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

J. Sodroski, C. Mackay, W. Hofmann, 1997, Nature.

Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission

J. Busciglio, W. Liedtke, A. Bortsov, 2021, Nature Communications.

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

D. Chialvo, S. Cannas, K. Gardiner, 2018, Aging cell.

Adaptive downregulation of mitochondrial function in down syndrome.

G. Helguera, M. Hanna, J. Busciglio, 2013, Cell metabolism.

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

B. Yankner, J. Busciglio, 1995, Nature.

Coexpression of lactosyl and ganglioteraosyl gangliosides in rat cerebellar radial glial cells in culture

J. Busciglio, A. Cáceres, D. Gravotta, 1990, Journal of neuroscience research.

Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia.

J. Busciglio, D. Gabuzda, A. Lorenzo, 1998, Journal of neurovirology.

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

B. Yankner, J. Busciglio, A. Lorenzo, 1995, Neuron.

An immunocytochemical analysis of the ontogeny of the microtubule-associated proteins MAP-2 and Tau in the nervous system of the rat.

A. Ferreira, J. Busciglio, A. Cáceres, 1987, Brain research.

Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid β precursor protein

J. Busciglio, Gabriela Kedikian, A. Lorenzo, 2004, Neurobiology of Disease.

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.

P. Matsudaira, P. Matsudaira, B. Yankner, 1994, The Journal of biological chemistry.

ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons

E. Wolvetang, E. Head, J. Busciglio, 2005, The Journal of Neuroscience.

Evolution of neuroinflammation across the lifespan of individuals with Down syndrome.

M. Askenazi, T. Wisniewski, A. Cuello, 2020, Brain : a journal of neurology.

A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

J. Busciglio, P. Coskun, P. Helguera, 2010, PloS one.

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway.

I. Kola, E. Wolvetang, T. Wilson, 2003, Human molecular genetics.

Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid β-Induced Neuronal Dystrophy

E. Grace, J. Busciglio, Jorge Busciglio, 2003, The Journal of Neuroscience.

ETS 2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p 53 pathway

I. Kola, E. Wolvetang, T. Wilson, 2003 .

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

C. Rabiner, E. Grace, J. Busciglio, 2002, Neuroscience.

Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome

M. Hanna, J. Busciglio, Lucas J Sosa, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

P. Moreira, C. Oliveira, J. Busciglio, 2008, Free radical biology & medicine.

Phosphorylation of Actin-Depolymerizing Factor/Cofilin by LIM-Kinase Mediates Amyloid β-Induced Degeneration: A Potential Mechanism of Neuronal Dystrophy in Alzheimer's Disease

M. Staufenbiel, F. LaFerla, J. Busciglio, 2006, The Journal of Neuroscience.

Presenilin-1 Mutations Reduce Cytoskeletal Association, Deregulate Neurite Growth, and Potentiate Neuronal Dystrophy and Tau Phosphorylation

J. Busciglio, A. Pelsman, G. Pigino, 2001, The Journal of Neuroscience.

Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society

A. Granholm, J. Santoro, A. Rebillat, 2022, Molecular Syndromology.

Nerve growth factor metabolic dysfunction in Down's syndrome brains.

Ashley M. Fortress, A. Granholm, T. Wisniewski, 2014, Brain : a journal of neurology.

Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome.

K. Blennow, N. Bargalló, A. Lleó, 2023, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Signaling Mechanisms that Mediate Aβ Induced Neuronal Dysfunction

C. Cotman, J. Busciglio, 2007 .

Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome.

C. Tang, J. Busciglio, Maria D Torres, 2018, Free radical biology & medicine.

574 Localization and functional significance of presenilin S182

M. Staufenbiel, B. Yankner, J. Busciglio, 1996, Neurobiology of Aging.

Alzheimer research forum live discussion: Brain derived neurotrophic factor and Alzheimer's disease - What is the connection?

C. Cotman, N. Berchtold, G. Strobel, 2005 .

Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society

M. Dierssen, J. Delabar, K. Gardiner, 2016, Molecular Syndromology.

Methodological variables in the assessment of beta amyloid neurotoxicity

Bruce A. Yankner, Alfredo Lorenzo, B. Yankner, 1992, Neurobiology of Aging.

Live discussion. From here to there: AbetaPP as an axonal transport receptor--how could this explain neurodegeneration in AD. 15 July 2002.

J. Ashford, E. Mandelkow, M. Sudol, 2003, Journal of Alzheimer's disease : JAD.

Inhibition of beta-amyloid production by activation of protein kinase C.

B. Yankner, J. Busciglio, D. Gabuzda, 1993, Journal of neurochemistry.

Suppressing Aneuploidy-Associated Phenotypes Improves the Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells Fitness of Trisomy 21 Cells Let us know how access to this document benefits you.

I. Rivera, Z. Storchová, J. Busciglio, 2021 .

Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome

M. Hanna, J. Busciglio, K. Pfenninger, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.